LOCUS       NM_030840               2235 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 26 member 5 (Slc26a5),
            mRNA.
ACCESSION   NM_030840
VERSION     NM_030840.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2235)
  AUTHORS   Costanzi,E., Coletti,A., Zambelli,B., Macchiarulo,A., Bellanda,M.
            and Battistutta,R.
  TITLE     Calmodulin binds to the STAS domain of SLC26A5 prestin with a
            calcium-dependent, one-lobe, binding mode
  JOURNAL   J Struct Biol 213 (2), 107714 (2021)
   PUBMED   33667636
  REMARK    GeneRIF: Calmodulin binds to the STAS domain of SLC26A5 prestin
            with a calcium-dependent, one-lobe, binding mode.
REFERENCE   2  (bases 1 to 2235)
  AUTHORS   Parham,K., Sohal,M., Petremann,M., Romanet,C., Broussy,A., Tran Van
            Ba,C. and Dyhrfjeld-Johnsen,J.
  TITLE     Noise-induced trauma produces a temporal pattern of change in blood
            levels of the outer hair cell biomarker prestin
  JOURNAL   Hear Res 371, 98-104 (2019)
   PUBMED   30529910
  REMARK    GeneRIF: These results suggest that there is a temporal pattern of
            change in serum prestin level after noise-induced hearing loss that
            is related to severity of hearing loss. Circulatory levels of
            prestin may be able to act as surrogate biomarker for hearing loss
            involving outer hair cell loss.
REFERENCE   3  (bases 1 to 2235)
  AUTHORS   Parham,K. and Dyhrfjeld-Johnsen,J.
  TITLE     Outer Hair Cell Molecular Protein, Prestin, as a Serum Biomarker
            for Hearing Loss: Proof of Concept
  JOURNAL   Otol Neurotol 37 (9), 1217-1222 (2016)
   PUBMED   27636386
  REMARK    GeneRIF: work, for the first time, provides proof of concept that
            the levels of prestin, an otologic serum biomarker, can change
            after acoustic trauma and hearing loss
REFERENCE   4  (bases 1 to 2235)
  AUTHORS   Lolli,G., Pasqualetto,E., Costanzi,E., Bonetto,G. and
            Battistutta,R.
  TITLE     The STAS domain of mammalian SLC26A5 prestin harbours an
            anion-binding site
  JOURNAL   Biochem J 473 (4), 365-370 (2016)
   PUBMED   26635354
  REMARK    GeneRIF: in chicken STAS, the anion-binding site is lacking because
            of a local structural rearrangement, indicating that the presence
            of the STAS anion-binding site is exclusive to mammalian prestin
REFERENCE   5  (bases 1 to 2235)
  AUTHORS   Hang,J., Pan,W., Chang,A., Li,S., Li,C., Fu,M. and Tang,J.
  TITLE     Synchronized Progression of Prestin Expression and Auditory
            Brainstem Response during Postnatal Development in Rats
  JOURNAL   Neural Plast 2016, 4545826 (2016)
   PUBMED   28097024
  REMARK    GeneRIF: Prestin expression first appeared at postnatal day 6 (P6)
            in the auditory brainstem and reached mature level by P14.
REFERENCE   6  (bases 1 to 2235)
  AUTHORS   Weber,T., Zimmermann,U., Winter,H., Mack,A., Kopschall,I.,
            Rohbock,K., Zenner,H.P. and Knipper,M.
  TITLE     Thyroid hormone is a critical determinant for the regulation of the
            cochlear motor protein prestin
  JOURNAL   Proc Natl Acad Sci U S A 99 (5), 2901-2906 (2002)
   PUBMED   11867734
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 May 28;99(11):7809]
REFERENCE   7  (bases 1 to 2235)
  AUTHORS   Oliver,D., He,D.Z., Klocker,N., Ludwig,J., Schulte,U.,
            Waldegger,S., Ruppersberg,J.P., Dallos,P. and Fakler,B.
  TITLE     Intracellular anions as the voltage sensor of prestin, the outer
            hair cell motor protein
  JOURNAL   Science 292 (5525), 2340-2343 (2001)
   PUBMED   11423665
REFERENCE   8  (bases 1 to 2235)
  AUTHORS   Ludwig,J., Oliver,D., Frank,G., Klocker,N., Gummer,A.W. and
            Fakler,B.
  TITLE     Reciprocal electromechanical properties of rat prestin: the motor
            molecule from rat outer hair cells
  JOURNAL   Proc Natl Acad Sci U S A 98 (7), 4178-4183 (2001)
   PUBMED   11274441
REFERENCE   9  (bases 1 to 2235)
  AUTHORS   Belyantseva,I.A., Adler,H.J., Curi,R., Frolenkov,G.I. and Kachar,B.
  TITLE     Expression and localization of prestin and the sugar transporter
            GLUT-5 during development of electromotility in cochlear outer hair
            cells
  JOURNAL   J Neurosci 20 (24), RC116 (2000)
   PUBMED   11125015
REFERENCE   10 (bases 1 to 2235)
  AUTHORS   Bostjancic,W., Braun,J.S., Reheis,G., Weisshaar,D., Akkerman,J.W.,
            Banauch,D. and Koller,P.U.
  TITLE     [Pre-stained slides for differential blood counts (author's
            transl)]
  JOURNAL   Dtsch Med Wochenschr 102 (33), 1175-1177 (1977)
   PUBMED   70328
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ303372.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ303372.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN09345238 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2235
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..2235
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /note="solute carrier family 26 member 5"
                     /db_xref="GeneID:83819"
                     /db_xref="RGD:69334"
     CDS             1..2235
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /note="prestin (motor protein); solute carrier family 26
                     (anion exchanger), member 5"
                     /codon_start=1
                     /product="prestin"
                     /protein_id="NP_110467.1"
                     /db_xref="GeneID:83819"
                     /db_xref="RGD:69334"
                     /translation="MDHAEENEIPAETQKYLVERPIFSHPVLQERLHVKDKVTDSIGD
                     KLKQAFTCTPKKVRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFA
                     MLAAVPPVFGLYSSFYPVIMYCFFGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPG
                     GVNATNGTEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAA
                     VHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGK
                     EFNERFKEKLPAPIPLEFFAVVMGTGISAGFNLHESYSVDVVGTLPLGLLPPANPDTS
                     LFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELIALGICNSIGSLFQTFS
                     ISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKG
                     MFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQSPSY
                     TVLGQLPDTDVYIDIDAYEEVKEIPGIKIFQINAPIYYANSDLYSSALKRKTGVNPAI
                     IMGARRKAMRKYAKEVGNANIANATVVKVDAEVDGENATKPEEEDDEVKFPPIVIKTT
                     FPEELQRFLPQGENIHTVILDFTQVNFMDSVGVKTLAGIVKEYGDVGIYVYLAGCSAQ
                     VVNDLTSNRFFENPALKELLFHSIHDAVLGSQVREAMAEQETTVLPPQEDMEPNATPT
                     TPEA"
     exon            1..152
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            153..292
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            293..403
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            404..570
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            571..735
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            736..888
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            889..971
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1119
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1233
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1311
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1407
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1514
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1584
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1677
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1785
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1986
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2041
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2235
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggatcatg ctgaagaaaa tgaaattcct gcagagactc agaagtacct cgtggaaagg
       61 cctatcttca gtcatccggt cctccaggag aggctgcacg tcaaggacaa agtcacagac
      121 tccatcgggg ataagctgaa gcaggcattc acgtgcactc ctaaaaaagt aagaaacatc
      181 atctacatgt tcttgcccat cactaagtgg ttgccagcat ataaattcaa ggagtatgtg
      241 ctgggtgact tggtctcggg cataagcact ggggtgcttc agctccccca aggcttagcc
      301 ttcgcgatgc tggcagctgt gcctccggtg ttcggcctgt actcctcatt ttaccccgtt
      361 atcatgtact gtttctttgg aacctccaga cacatatcta taggtccttt tgcggttatt
      421 agcttgatga ttggaggtgt ggctgtccgc ttggtaccgg atgacatcgt tatcccagga
      481 ggagtaaatg caaccaatgg gacggaagcc agagatgcgt taagggtcaa agtcgccatg
      541 tccgttaccc tactttcagg aatcattcag ttttgcctag gtgtctgtag gtttggattt
      601 gtggccatat acctcacgga gccgctagtg cgaggcttta ccacggcggc ggctgtgcac
      661 gtgttcacct ccatgttaaa atacctgttt ggggtcaaaa ctaagcggta cagtgggatc
      721 ttctcagtgg tgtatagtac cgtggctgtg ctgcagaatg ttaaaaacct caacgtgtgt
      781 tccctaggcg tcggcctcat ggtttttggt ttgctgttgg gtggcaagga gtttaatgag
      841 agatttaaag agaaactgcc agcgcccatt cctctagagt tctttgctgt ggtgatgggg
      901 accggcattt ctgcagggtt taacttgcac gagtcctaca gcgtggatgt cgttgggaca
      961 cttcctctgg gactactccc acccgccaac ccggacacca gcctgttcca cctcgtgtac
     1021 gtggacgcca ttgccatcgc cattgttggg ttttcagtga cgatctccat ggccaaaacc
     1081 ttggcaaata agcatggcta ccaggttgat ggcaaccagg agctcattgc cttgggaata
     1141 tgcaactcca tcggatctct cttccagacc ttctcaatct cttgctcctt gtctcgaagc
     1201 cttgttcagg aaggaactgg agggaagaca cagcttgcag gttgcttggc ctcactgatg
     1261 atcctgctgg tcatattagc cactggattc ctctttgagt cattacccca ggccgtgctt
     1321 tccgccattg tgattgtcaa cctgaaagga atgttcatgc agttctcaga cctgcccttt
     1381 ttctggagaa ccagcaaaat cgagttgacc atctggctca ccacctttgt gtcctccctg
     1441 ttcctgggct tggactatgg actgattact gctgtgatca ttgctctgct cactgtgatt
     1501 tacagaacac agagtccgag ctacacagtc ctgggacagc tccctgacac cgatgtatac
     1561 attgacattg atgcctatga ggaggtgaaa gaaattcctg gaataaaaat attccaaata
     1621 aatgccccaa tttactatgc aaatagcgac ttgtacagca gcgcactgaa aagaaagact
     1681 ggcgtgaacc cagcaatcat catgggagca agaagaaagg ccatgaggaa gtacgcgaag
     1741 gaggttggaa atgccaacat agctaacgcg actgttgtca aagtggatgc agaagtagat
     1801 ggagaaaatg ctacgaagcc tgaagaagag gacgacgaag tcaaatttcc cccaatagtc
     1861 atcaaaacaa catttcctga agagctgcag aggtttttgc cccaggggga aaatatccac
     1921 actgtcattc tagacttcac gcaggtcaat tttatggatt ctgttggagt gaaaactctg
     1981 gctgggattg tgaaagagta cggcgatgtt ggaatttatg tgtacttagc aggatgcagt
     2041 gcacaagttg tgaatgacct caccagcaac cgtttttttg aaaatcctgc cttaaaggag
     2101 cttctgttcc acagtatcca tgacgcggtc ttgggcagcc aagtccgtga ggcgatggct
     2161 gagcaagaaa ccacggttct gcctccccag gaagatatgg agcccaatgc cacgcccacc
     2221 acaccggaag cataa
//
