LOCUS       NM_019214               2853 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus solute carrier family 26 member 4 (Slc26a4),
            mRNA.
ACCESSION   NM_019214
VERSION     NM_019214.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2853)
  AUTHORS   Loffing,J., Pech,V., Loffing-Cueni,D., Abood,D.C., Kim,Y.H.,
            Chen,C., Pham,T.D., Verlander,J.W. and Wall,S.M.
  TITLE     Pendrin abundance, subcellular distribution, and function are
            unaffected by either alphaENaC gene ablation or by increasing ENaC
            channel activity
  JOURNAL   Pflugers Arch 475 (5), 607-620 (2023)
   PUBMED   36977894
  REMARK    GeneRIF: Pendrin abundance, subcellular distribution, and function
            are unaffected by either alphaENaC gene ablation or by increasing
            ENaC channel activity.
REFERENCE   2  (bases 1 to 2853)
  AUTHORS   Ochiai-Homma,F., Kuribayashi-Okuma,E., Tsurutani,Y., Ishizawa,K.,
            Fujii,W., Odajima,K., Kawagoe,M., Tomomitsu,Y., Murakawa,M.,
            Asakawa,S., Hirohama,D., Nagura,M., Arai,S., Yamazaki,O.,
            Tamura,Y., Fujigaki,Y., Nishikawa,T. and Shibata,S.
  TITLE     Characterization of pendrin in urinary extracellular vesicles in a
            rat model of aldosterone excess and in human primary aldosteronism
  JOURNAL   Hypertens Res 44 (12), 1557-1567 (2021)
   PUBMED   34326480
  REMARK    GeneRIF: Characterization of pendrin in urinary extracellular
            vesicles in a rat model of aldosterone excess and in human primary
            aldosteronism.
REFERENCE   3  (bases 1 to 2853)
  AUTHORS   Haggie,P.M., Phuan,P.W., Tan,J.A., Zlock,L., Finkbeiner,W.E. and
            Verkman,A.S.
  TITLE     Inhibitors of pendrin anion exchange identified in a small molecule
            screen increase airway surface liquid volume in cystic fibrosis
  JOURNAL   FASEB J 30 (6), 2187-2197 (2016)
   PUBMED   26932931
  REMARK    GeneRIF: These studies implicate the involvement of
            pendrin-facilitated chloride-bicarbonate exchange in the regulation
            of airway surface liquid volume and suggest the utility of pendrin
            inhibitors in inflammatory lung diseases.
REFERENCE   4  (bases 1 to 2853)
  AUTHORS   Calil-Silveira,J., Serrano-Nascimento,C., Kopp,P.A. and Nunes,M.T.
  TITLE     Iodide excess regulates its own efflux: a possible involvement of
            pendrin
  JOURNAL   Am J Physiol Cell Physiol 310 (7), C576-C582 (2016)
   PUBMED   26791486
  REMARK    GeneRIF: these data suggest that pendrin may have an important role
            in mediating iodide efflux in thyrocytes, especially under
            conditions of iodide excess.
REFERENCE   5  (bases 1 to 2853)
  AUTHORS   Lazo-Fernandez,Y., Aguilera,G., Pham,T.D., Park,A.Y.,
            Beierwaltes,W.H., Sutliff,R.L., Verlander,J.W., Pacak,K.,
            Osunkoya,A.O., Ellis,C.L., Kim,Y.H., Shipley,G.L., Wynne,B.M.,
            Hoover,R.S., Sen,S.K., Plotsky,P.M. and Wall,S.M.
  TITLE     Pendrin localizes to the adrenal medulla and modulates
            catecholamine release
  JOURNAL   Am J Physiol Endocrinol Metab 309 (6), E534-E545 (2015)
   PUBMED   26173457
  REMARK    GeneRIF: Pendrin is expressed in the adrenal medulla, where it
            blunts stress-induced catecholamine release.
            Erratum:[Am J Physiol Endocrinol Metab. 2015 Nov 15;309(10):E885.
            doi: 10.1152/ajpendo.zh1-7433-corr.2015.. PMID: 26573274]
REFERENCE   6  (bases 1 to 2853)
  AUTHORS   Campbell,C., Cucci,R.A., Prasad,S., Green,G.E., Edeal,J.B.,
            Galer,C.E., Karniski,L.P., Sheffield,V.C. and Smith,R.J.
  TITLE     Pendred syndrome, DFNB4, and PDS/SLC26A4 identification of eight
            novel mutations and possible genotype-phenotype correlations
  JOURNAL   Hum Mutat 17 (5), 403-411 (2001)
   PUBMED   11317356
REFERENCE   7  (bases 1 to 2853)
  AUTHORS   Royaux,I.E., Wall,S.M., Karniski,L.P., Everett,L.A., Suzuki,K.,
            Knepper,M.A. and Green,E.D.
  TITLE     Pendrin, encoded by the Pendred syndrome gene, resides in the
            apical region of renal intercalated cells and mediates bicarbonate
            secretion
  JOURNAL   Proc Natl Acad Sci U S A 98 (7), 4221-4226 (2001)
   PUBMED   11274445
REFERENCE   8  (bases 1 to 2853)
  AUTHORS   Soleimani,M., Greeley,T., Petrovic,S., Wang,Z., Amlal,H., Kopp,P.
            and Burnham,C.E.
  TITLE     Pendrin: an apical Cl-/OH-/HCO3- exchanger in the kidney cortex
  JOURNAL   Am J Physiol Renal Physiol 280 (2), F356-F364 (2001)
   PUBMED   11208611
REFERENCE   9  (bases 1 to 2853)
  AUTHORS   Everett,L.A., Belyantseva,I.A., Noben-Trauth,K., Cantos,R.,
            Chen,A., Thakkar,S.I., Hoogstraten-Miller,S.L., Kachar,B., Wu,D.K.
            and Green,E.D.
  TITLE     Targeted disruption of mouse Pds provides insight about the
            inner-ear defects encountered in Pendred syndrome
  JOURNAL   Hum Mol Genet 10 (2), 153-161 (2001)
   PUBMED   11152663
REFERENCE   10 (bases 1 to 2853)
  AUTHORS   Everett,L.A., Morsli,H., Wu,D.K. and Green,E.D.
  TITLE     Expression pattern of the mouse ortholog of the Pendred's syndrome
            gene (Pds) suggests a key role for pendrin in the inner ear
  JOURNAL   Proc Natl Acad Sci U S A 96 (17), 9727-9732 (1999)
   PUBMED   10449762
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF167412.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF167412.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2853
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16"
     gene            1..2853
                     /gene="Slc26a4"
                     /gene_synonym="Pds"
                     /note="solute carrier family 26 member 4"
                     /db_xref="GeneID:29440"
                     /db_xref="RGD:3293"
     exon            1..185
                     /gene="Slc26a4"
                     /gene_synonym="Pds"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..2364
                     /gene="Slc26a4"
                     /gene_synonym="Pds"
                     /note="sodium-independent chloride/iodide transporter;
                     Pendred syndrome homolog; solute carrier family 26 (anion
                     exchanger), member 4"
                     /codon_start=1
                     /product="pendrin"
                     /protein_id="NP_062087.1"
                     /db_xref="GeneID:29440"
                     /db_xref="RGD:3293"
                     /translation="MAARDRRSEPPQLAEYSCSYAVSRPVYSELAFQQQRERRLPERR
                     TLRDSLARSCSCSRKRAFGALKALLPILDWLPKYRVKEWLLSDIISGVSTGLVGTLQG
                     MAYALLAAVPVQYGLYSAFFPILTYFVFGTSRHISVGPFPVVSLMVGSVVLSMAPDDH
                     FLVPSGNGSTLNTTTLDTGTRDAARVLLASTLTLLVGIIQLVFGGLQIGFIVRYLADP
                     LVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLIEIFQNIGDTNIADFIAGL
                     LTIIVCMAVKELNDRFKHKIPVPIPIEVIVTIIATAISYGANLEANYNAGIVKSIPSG
                     FLPPVLPSVGLFSDMLAASFSIAVVAYAIAVSVGKVYATKHDYIIDGNQEFIAFGISN
                     VFSGFFSCFVATTALSRTAVQESTGGKTQVAGLISAVIVMVAIVALGKLLEPLQKSVL
                     AAVVIANLKGMFMQVCDVPRLWKQNKTDAVIWVFTCIMSIILGLDLGLLAGLLFGLLT
                     VVLRVQFPSWNGLGSVPSTDIYKSITHYKNLEEPEGVKILRFSSPIFYGNVDGFKKCV
                     KSTVGFDAIRVYNKRLKALRRIQKLIKKGQLRATKNGIISDVGSSNNAFEPDEDVEEP
                     EELDIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVLDCGAVSFLDVVGVRSLRMIVKE
                     FQRIDVNVYFALLQDDVLEKMEQCGFFDDNIRKDRFFLTVHDAILYLQNQAKSREGQD
                     SLLETITLIQDCKDPLELMEAEINEEELDVQDEAMRRLAS"
     exon            186..325
                     /gene="Slc26a4"
                     /gene_synonym="Pds"
                     /inference="alignment:Splign:2.1.0"
     exon            326..436
                     /gene="Slc26a4"
                     /gene_synonym="Pds"
                     /inference="alignment:Splign:2.1.0"
     exon            437..621
                     /gene="Slc26a4"
                     /gene_synonym="Pds"
                     /inference="alignment:Splign:2.1.0"
     exon            622..786
                     /gene="Slc26a4"
                     /gene_synonym="Pds"
                     /inference="alignment:Splign:2.1.0"
     exon            787..939
                     /gene="Slc26a4"
                     /gene_synonym="Pds"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1022
                     /gene="Slc26a4"
                     /gene_synonym="Pds"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1170
                     /gene="Slc26a4"
                     /gene_synonym="Pds"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1284
                     /gene="Slc26a4"
                     /gene_synonym="Pds"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1362
                     /gene="Slc26a4"
                     /gene_synonym="Pds"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1458
                     /gene="Slc26a4"
                     /gene_synonym="Pds"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1565
                     /gene="Slc26a4"
                     /gene_synonym="Pds"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1635
                     /gene="Slc26a4"
                     /gene_synonym="Pds"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1728
                     /gene="Slc26a4"
                     /gene_synonym="Pds"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1824
                     /gene="Slc26a4"
                     /gene_synonym="Pds"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..2055
                     /gene="Slc26a4"
                     /gene_synonym="Pds"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2110
                     /gene="Slc26a4"
                     /gene_synonym="Pds"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2256
                     /gene="Slc26a4"
                     /gene_synonym="Pds"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2340
                     /gene="Slc26a4"
                     /gene_synonym="Pds"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2853
                     /gene="Slc26a4"
                     /gene_synonym="Pds"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggtcctccg gttcacaggc catggcagcg cgggaccgca ggtcggagcc gccgcagctc
       61 gccgagtaca gctgcagcta tgcggtgtcg cggccggtgt acagcgagct cgccttccag
      121 cagcagcgcg agcggcgcct gccggagcgc aggacgctgc gggacagcct ggcgcggagc
      181 tgcagttgct caagaaagag agcgtttggt gcgctgaagg ctctcctgcc cattctggac
      241 tggctcccaa aataccgagt caaggaatgg ctactcagtg atatcatctc tggagttagc
      301 actgggttag taggtaccct gcaagggatg gcttatgctc tgctagctgc agttcctgtt
      361 caatatggtc tctactctgc ctttttcccc atcctgacgt attttgtctt tggaacatca
      421 agacacatct ccgttggccc tttccccgtg gtcagcttaa tggtggggtc cgttgttctg
      481 agcatggctc cggatgacca ctttcttgtg cccagtggta acggaagtac cttgaacaca
      541 accacattgg acaccggaac cagagatgcc gcacgagtgt tgcttgccag caccctcact
      601 cttctggttg gaatcataca gctggtgttt ggaggtttgc agattggatt catagtgagg
      661 tacttggcag accctttggt tggcggattc acaaccgccg ccgccttcca agtgctggtc
      721 tcacagctga agatcgtgct caatgtctca accaaaaact acaacggtgt cctctccatt
      781 atctacacac taatcgagat ttttcaaaat atcggtgaca ccaatattgc tgacttcatt
      841 gctgggttac tgaccatcat cgtctgtatg gctgttaagg aattaaacga tcgatttaaa
      901 cacaaaatcc cagtcccgat tcctatagaa gtgattgtga caattatcgc caccgccatt
      961 tcctatgggg ccaacttgga agcaaattac aatgcaggca ttgttaagtc catcccaagt
     1021 gggttcttgc ctcctgtact gccgtctgtg ggcctgtttt ctgacatgct ggctgcttcc
     1081 ttttccattg ccgtggtggc ttacgctatt gcagtgtctg tagggaaagt ctacgccacc
     1141 aagcatgact acatcatcga tgggaaccag gaattcattg ccttcgggat aagcaacgtc
     1201 ttctctggat ttttttcctg ttttgtggct accactgctc tgtctcgaac ggctgtccag
     1261 gagagcactg gggggaagac acaggtggca ggcctcatct cagctgtgat tgtgatggtc
     1321 gcgatcgttg ccctggggaa gcttctggaa cccttgcaga agtctgtctt ggcagccgtc
     1381 gtcattgcca acctgaaagg gatgtttatg caggtgtgtg atgttcctcg tctgtggaag
     1441 cagaataaga ctgatgccgt tatctgggtg tttacatgca taatgtccat cattctgggg
     1501 ctggacctcg gtttgctggc tggtctttta tttggactac tgactgtggt cctgagagtt
     1561 cagttccctt cgtggaatgg ccttggaagt gtccccagca cagacatcta caaaagtatc
     1621 acacattata aaaaccttga agagcctgaa ggggtgaaga tcctgagatt ttccagtccc
     1681 attttttatg gcaatgtcga tggttttaaa aaatgcgtca agtcaacagt tggatttgat
     1741 gccattagag tatataacaa gaggctgaaa gcactaagaa gaatacagaa actcatcaaa
     1801 aaaggacaac tcagggcaac caagaacggg attataagtg acgttggctc atcaaataac
     1861 gcttttgagc ctgatgaaga tgtcgaagag ccagaggagc ttgatatccc aaccaaggaa
     1921 attgagattc aagtggactg gaactctgaa ctcccggtga aagtgaatgt cccgaaggtg
     1981 ccaatccaca gcctggtgct ggactgtgga gctgtgtcct tcctggatgt ggtaggagtg
     2041 aggtcactgc gaatgattgt caaagaattt cagaggattg atgtgaatgt gtactttgct
     2101 ttgcttcaag acgatgtact agaaaagatg gagcagtgtg ggttctttga tgacaacatt
     2161 aggaaggaca gattcttcct gacagttcat gatgccatac tctacctgca gaaccaggcc
     2221 aaatccaggg agggccagga ttccctgcta gagacgatca ctctcattca agactgcaaa
     2281 gatcctcttg aactgatgga agcagagata aatgaggaag agcttgatgt tcaggatgag
     2341 gccatgcgta gacttgcctc ctgagagggc tgaggagttg gtcagcgagg actgctaggc
     2401 agaacctggc catcagccca ctctctacac tgactgtttc tttgcactta agcagccatg
     2461 cccttgctgt tacgttaaaa taggtgcttt ctgaagcgtc ttaggcagcc caccagaaac
     2521 ctttgtcatt tctacggtta aatgcggaaa caaacagctt agctctaaaa tatccaaagc
     2581 atgagcatta cccctgagga ttagcagtgt ccggacgtgc tgctgtcgcc cactgtgtgc
     2641 tgctgatgcc acggcaggtt tgctgtctgt gtccacaggg gctccgtctg ttgacccaac
     2701 agcctctgtg ggcaggtgag ttaggaaggg ctaatcacag agattcctga cttactctga
     2761 attccatggg ttgtgttggt cacagtgaga gaggtaaagt agaattactg tgtattcatt
     2821 agtaggcttt aaagaaaata aaaccaatct ttt
//
