LOCUS       NM_053755               2850 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Rattus norvegicus solute carrier family 26 member 3 (Slc26a3),
            mRNA.
ACCESSION   NM_053755
VERSION     NM_053755.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2850)
  AUTHORS   Sarker,R., Tse,C.M., Lin,R., McNamara,G., Singh,V. and Donowitz,M.
  TITLE     mOrange2, a Genetically Encoded, pH Sensitive Fluorescent Protein,
            is an Alternative to BCECF-AM to Measure Intracellular pH to
            Determine NHE3 and DRA Activity
  JOURNAL   Cell Physiol Biochem 56 (1), 39-49 (2022)
   PUBMED   35076190
  REMARK    GeneRIF: mOrange2, a Genetically Encoded, pH Sensitive Fluorescent
            Protein, is an Alternative to BCECF-AM to Measure Intracellular pH
            to Determine NHE3 and DRA Activity.
REFERENCE   2  (bases 1 to 2850)
  AUTHORS   Chen,L. and Xu,W.
  TITLE     [Expression pattern of congenital chloride diarrhea pathogenic gene
            Slc26a3 in the reproductive tract of male rodents]
  JOURNAL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 31 (5), 654-658 (2014)
   PUBMED   25297603
  REMARK    GeneRIF: Data indicate that solute carrier family 26, member 3
            protein (Slc26a3) is expressed in male reproductive tract, and its
            expression pattern is related to the function.
REFERENCE   3  (bases 1 to 2850)
  AUTHORS   Chavez,J.C., Hernandez-Gonzalez,E.O., Wertheimer,E., Visconti,P.E.,
            Darszon,A. and Trevino,C.L.
  TITLE     Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6,
            the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse
            sperm capacitation
  JOURNAL   Biol Reprod 86 (1), 1-14 (2012)
   PUBMED   21976599
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2850)
  AUTHORS   Barmeyer,C., Ye,J.H., Sidani,S., Geibel,J., Binder,H.J. and
            Rajendran,V.M.
  TITLE     Characteristics of rat downregulated in adenoma (rDRA) expressed in
            HEK 293 cells
  JOURNAL   Pflugers Arch 454 (3), 441-450 (2007)
   PUBMED   17492310
  REMARK    GeneRIF: in addition to mediating pH-sensitive Cl(-) uptake, DRA
            may function as a modifier of other anion transport proteins
REFERENCE   5  (bases 1 to 2850)
  AUTHORS   Jacob,P., Rossmann,H., Lamprecht,G., Kretz,A., Neff,C., Lin-Wu,E.,
            Gregor,M., Groneberg,D.A., Kere,J. and Seidler,U.
  TITLE     Down-regulated in adenoma mediates apical Cl-/HCO3- exchange in
            rabbit, rat, and human duodenum
  JOURNAL   Gastroenterology 122 (3), 709-724 (2002)
   PUBMED   11875004
REFERENCE   6  (bases 1 to 2850)
  AUTHORS   Rajendran,V.M., Black,J., Ardito,T.A., Sangan,P., Alper,S.L.,
            Schweinfest,C., Kashgarian,M. and Binder,H.J.
  TITLE     Regulation of DRA and AE1 in rat colon by dietary Na depletion
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 279 (5), G931-G942 (2000)
   PUBMED   11052990
REFERENCE   7  (bases 1 to 2850)
  AUTHORS   Melvin,J.E., Park,K., Richardson,L., Schultheis,P.J. and Shull,G.E.
  TITLE     Mouse down-regulated in adenoma (DRA) is an intestinal
            Cl(-)/HCO(3)(-) exchanger and is up-regulated in colon of mice
            lacking the NHE3 Na(+)/H(+) exchanger
  JOURNAL   J Biol Chem 274 (32), 22855-22861 (1999)
   PUBMED   10428871
REFERENCE   8  (bases 1 to 2850)
  AUTHORS   Hoglund,P., Haila,S., Socha,J., Tomaszewski,L., Saarialho-Kere,U.,
            Karjalainen-Lindsberg,M.L., Airola,K., Holmberg,C., de la
            Chapelle,A. and Kere,J.
  TITLE     Mutations of the Down-regulated in adenoma (DRA) gene cause
            congenital chloride diarrhoea
  JOURNAL   Nat Genet 14 (3), 316-319 (1996)
   PUBMED   8896562
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF337809.1.
            
            On Feb 21, 2013 this sequence version replaced NM_053755.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF337809.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2850              AF337809.1         6-2855
FEATURES             Location/Qualifiers
     source          1..2850
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16"
     gene            1..2850
                     /gene="Slc26a3"
                     /note="solute carrier family 26 member 3"
                     /db_xref="GeneID:114629"
                     /db_xref="RGD:620623"
     exon            1..96
                     /gene="Slc26a3"
                     /inference="alignment:Splign:2.1.0"
     exon            97..316
                     /gene="Slc26a3"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..2459
                     /gene="Slc26a3"
                     /note="down-regulated in adenoma; solute carrier family 26
                     (anion exchanger), member 3"
                     /codon_start=1
                     /product="chloride anion exchanger"
                     /protein_id="NP_446207.1"
                     /db_xref="GeneID:114629"
                     /db_xref="RGD:620623"
                     /translation="MIEAIGNQYVVARPVYSTKAFGEEFKKTYGHHKTFLDHLKGCCS
                     CSSQKAKKIALSLFPIASWLPAYKIKEWLLSDIVSGISTGLVAVLQGLAFALLVNIPP
                     AYGLYAAFFPVITYFFLGTSRHISVGPFPVLSMMVGVVVTRVASGSDTSPALSSSSAE
                     NDSMIEEKVMVAASVTVLSGIIQLLLGVLQIGFVVIYLSESLISGFTTAAAIHVLVSQ
                     LKFMLQLTVPAHSDPFSIFKVLESVFSQIQKTNIADLVTSVIILVVVFVVKEINQRYR
                     SKLPVPIPIELIMTVIATGISYGCNFEQRFGVAVVGNMSLGFQPPITPSVEVFQDTIG
                     DCFGIAIVGFAVAFSVASVYSLKYDYPIDGNQELIALGVSNIFTGAFKGFAGSTALSR
                     SGVQESTGGKTQVAGLLSAVIVLIVIVAIGFLLQPLQKSVLAALALGNLKGMLMQFAE
                     IGRLWKKDKYDCLIWIMTFIFAIVLGLGLGLAASVAFQLLTIVFRTQFPKCSTLANVG
                     RSNIYKNKKNYADVYEPEGVKIFRCPSPIYFANIGFFKQKLIDAVGFNPLRILRKRNK
                     ALKKIRKLQKQGLIQVTPKGFICTSDGFKDSDEELDNNQIEELDQPINTTDLPFEIDW
                     NADLPLNITIPKISLHSLILDFSAVSFLDISSMRGLRTILQEFIRIKVDVYIVGTDDD
                     FIDKLARCEFFDDEVTDSIFFLTIHDAILHIWMKKDYSTSKFNSSQEKERKFDFTINT
                     NGGLRNRECQVPVETKF"
     exon            317..456
                     /gene="Slc26a3"
                     /inference="alignment:Splign:2.1.0"
     exon            457..567
                     /gene="Slc26a3"
                     /inference="alignment:Splign:2.1.0"
     exon            568..734
                     /gene="Slc26a3"
                     /inference="alignment:Splign:2.1.0"
     exon            735..899
                     /gene="Slc26a3"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1052
                     /gene="Slc26a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1135
                     /gene="Slc26a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1283
                     /gene="Slc26a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1397
                     /gene="Slc26a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1475
                     /gene="Slc26a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1571
                     /gene="Slc26a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1678
                     /gene="Slc26a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1748
                     /gene="Slc26a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1841
                     /gene="Slc26a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1937
                     /gene="Slc26a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2171
                     /gene="Slc26a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2226
                     /gene="Slc26a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2369
                     /gene="Slc26a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2435
                     /gene="Slc26a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2835
                     /gene="Slc26a3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccaagcaga tgggtctata ctgtctccca gaacaggact tctttatctc aaaaactccc
       61 cactgttgct gaaggtccac actgaagtat atccaggcat tttaacctgc taacagccag
      121 aaagaagcgc tcaccacata gtttcaaagg tcttcccatt tgccactgtc accagggaag
      181 gcaaaatgat cgaagccata gggaatcagt atgtggtggc cagaccggtg tattccacaa
      241 aggctttcgg agaggagttt aagaagacat acggacatca caagacattc ctggatcatc
      301 tcaaagggtg ttgtagctgc tcctcacaaa aggccaagaa aattgccctg tctttgttcc
      361 ccatagcatc ttggttgcca gcatacaaga taaaggaatg gcttctcagt gacatcgtct
      421 ctggcatcag cactgggctg gtggctgtgc tgcaaggttt agcatttgct ctgctggtca
      481 acatccctcc tgcctatggg ttgtacgcag cctttttccc agttatcacc tacttcttct
      541 tgggcacatc tagacacata tctgtgggtc cgtttccagt tctgagcatg atggtgggag
      601 ttgtagttac aagagtggcc tcgggctccg atacttctcc agcattgtcc tcaagctcgg
      661 cagaaaatga ttcaatgata gaggagaagg taatggtggc cgcatcggtg actgttcttt
      721 ctggaatcat tcagttgctc ctgggggttc tgcagatagg ctttgtggtg atatacctat
      781 ccgagtccct aatcagcggc ttcaccacgg ctgctgccat tcacgttctg gtttctcaac
      841 tgaaattcat gctacagctg acggtcccag cacacagcga cccattctct atattcaaag
      901 tcctggagtc agtcttctca caaattcaga agacgaacat cgcagacctg gtgacatctg
      961 tgattatcct cgtggtcgtg tttgtcgtca aggaaatcaa ccagcgctac aggagcaagc
     1021 ttccggtgcc catccccatc gaactcatca tgactgtaat tgcaacaggc atatcctatg
     1081 gctgtaactt tgaacagagg tttggcgtgg ccgtggttgg gaacatgagt cttgggtttc
     1141 aaccccctat tacccccagt gtggaagttt tccaagacac cataggagac tgctttggca
     1201 ttgcgattgt cggctttgcc gtggcctttt cagttgctag cgtgtattcc ctcaaatacg
     1261 attatcccat tgatggcaac caggagttaa ttgccttggg ggtgagcaac atattcactg
     1321 gagctttcaa aggatttgca gggagcacag ccctttccag atcaggggtt caggagagca
     1381 cgggaggcaa aacacaggtc gcggggcttc tctcggctgt cattgtgctg atagtcatag
     1441 ttgccatcgg atttctcctg cagcctctac aaaagtctgt cctggcagct ctggcgcttg
     1501 gaaacttgaa gggaatgctg atgcagtttg ccgagatagg caggctgtgg aaaaaggata
     1561 aatacgattg tttaatctgg atcatgacct tcatctttgc catcgtcctt gggctcggat
     1621 taggcctggc agcaagtgtg gcatttcagc tcctaactat tgtgttcagg acccaattcc
     1681 caaaatgcag cacactggct aatgttggaa ggagcaacat ctacaagaat aaaaaaaatt
     1741 atgctgacgt ttatgagcca gaaggagtga aaattttcag atgtccgtct ccaatctact
     1801 tcgcaaacat tggtttcttt aagcagaaac ttattgacgc tgttggcttt aacccacttc
     1861 gaattctacg caagcgcaat aaagctttga agaaaatccg aaaactgcag aagcaaggac
     1921 tgatacaagt gacacctaaa ggatttatat gcacctctga tggcttcaaa gactctgatg
     1981 aagaattgga caacaaccag atagaagaac tggatcagcc gatcaatacc acggacctgc
     2041 cctttgaaat agactggaac gccgatctcc ccctcaacat caccatcccc aaaatcagcc
     2101 tccacagcct catcctcgat ttttcagcag tatccttcct tgacatctcc tcaatgaggg
     2161 gcctcagaac gattttacaa gagtttatta ggatcaaggt ggacgtatat attgtgggaa
     2221 ccgatgatga tttcattgac aaacttgctc ggtgtgaatt ctttgatgac gaagtcacag
     2281 actcaatatt tttcttaaca atccatgatg ctattttgca tatttggatg aagaaggact
     2341 acagcacttc aaagttcaat tccagccagg aaaaagaaag gaaatttgac tttaccataa
     2401 atacaaatgg aggattacgt aatcgggaat gtcaggtacc agttgaaacg aaattctaat
     2461 caagctacaa ttcggaagga ttctcctctg tcataacaaa aacaacttta tacctaggaa
     2521 gctattgcta agttcatacg ttgtatgaat ggtattttta tttgacagaa ttatgtttca
     2581 aactttggaa cgagattgtt ctagtatggt atatttttca catatctagt tatgaaatta
     2641 tgtacatatt actaattttc taccttgtag actgtcaaag gtagaaaagt attgtgtttg
     2701 tatgtatttt tttgtagcac tgacagattc ctatccaagt cattatctcc atgctcaatg
     2761 ttttatggtg tatttacacc gctgctttga ctctaattta tacaggtcat gctaatatat
     2821 ctctatttta aacaaaaaaa aaaaaaaaaa
//
