LOCUS       NM_057127               2877 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus solute carrier family 26 member 2 (Slc26a2),
            mRNA.
ACCESSION   NM_057127
VERSION     NM_057127.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2877)
  AUTHORS   Cai,T., Yang,L., Cai,W., Guo,S., Yu,P., Li,J., Hu,X., Yan,M.,
            Shao,Q., Jin,Y., Sun,Z.S. and Luo,Z.J.
  TITLE     Dysplastic spondylolysis is caused by mutations in the diastrophic
            dysplasia sulfate transporter gene
  JOURNAL   Proc Natl Acad Sci U S A 112 (26), 8064-8069 (2015)
   PUBMED   26077908
REFERENCE   2  (bases 1 to 2877)
  AUTHORS   Makitie,O., Geiberger,S., Horemuzova,E., Hagenas,L., Mostrom,E.,
            Nordenskjold,M., Grigelioniene,G. and Nordgren,A.
  TITLE     SLC26A2 disease spectrum in Sweden - high frequency of recessive
            multiple epiphyseal dysplasia (rMED)
  JOURNAL   Clin Genet 87 (3), 273-278 (2015)
   PUBMED   24598000
REFERENCE   3  (bases 1 to 2877)
  AUTHORS   Barbosa,M., Sousa,A.B., Medeira,A., Lourenco,T., Saraiva,J.,
            Pinto-Basto,J., Soares,G., Fortuna,A.M., Superti-Furga,A.,
            Mittaz,L., Reis-Lima,M. and Bonafe,L.
  TITLE     Clinical and molecular characterization of Diastrophic Dysplasia in
            the Portuguese population
  JOURNAL   Clin Genet 80 (6), 550-557 (2011)
   PUBMED   21155763
REFERENCE   4  (bases 1 to 2877)
  AUTHORS   Chapman,J.M. and Karniski,L.P.
  TITLE     Protein localization of SLC26A2 (DTDST) in rat kidney
  JOURNAL   Histochem Cell Biol 133 (5), 541-547 (2010)
   PUBMED   20369363
  REMARK    GeneRIF: DTDST protein expression was limited to the microvillus
            membrane of proximal tubule cells in the renal cortex but absent in
            glomeruli and other nephron segments. DTDST may play a role in
            proximal tubule sulfate transport.
REFERENCE   5  (bases 1 to 2877)
  AUTHORS   Lamb,R., Thomson,W., Ogilvie,E.M. and Donn,R.
  CONSRTM   British Society of Paediatric and Adolescent Rheumatology
  TITLE     Positive association of SLC26A2 gene polymorphisms with
            susceptibility to systemic-onset juvenile idiopathic arthritis
  JOURNAL   Arthritis Rheum 56 (4), 1286-1291 (2007)
   PUBMED   17393463
REFERENCE   6  (bases 1 to 2877)
  AUTHORS   Hastbacka,J., Kerrebrock,A., Mokkala,K., Clines,G., Lovett,M.,
            Kaitila,I., de la Chapelle,A. and Lander,E.S.
  TITLE     Identification of the Finnish founder mutation for diastrophic
            dysplasia (DTD)
  JOURNAL   Eur J Hum Genet 7 (6), 664-670 (1999)
   PUBMED   10482955
REFERENCE   7  (bases 1 to 2877)
  AUTHORS   Satoh,H., Susaki,M., Shukunami,C., Iyama,K., Negoro,T. and
            Hiraki,Y.
  TITLE     Functional analysis of diastrophic dysplasia sulfate transporter.
            Its involvement in growth regulation of chondrocytes mediated by
            sulfated proteoglycans
  JOURNAL   J Biol Chem 273 (20), 12307-12315 (1998)
   PUBMED   9575183
REFERENCE   8  (bases 1 to 2877)
  AUTHORS   Hastbacka,J., Superti-Furga,A., Wilcox,W.R., Rimoin,D.L., Cohn,D.H.
            and Lander,E.S.
  TITLE     Atelosteogenesis type II is caused by mutations in the diastrophic
            dysplasia sulfate-transporter gene (DTDST): evidence for a
            phenotypic series involving three chondrodysplasias
  JOURNAL   Am J Hum Genet 58 (2), 255-262 (1996)
   PUBMED   8571951
REFERENCE   9  (bases 1 to 2877)
  AUTHORS   Superti-Furga,A., Hastbacka,J., Wilcox,W.R., Cohn,D.H., van der
            Harten,H.J., Rossi,A., Blau,N., Rimoin,D.L., Steinmann,B.,
            Lander,E.S. and Gitzelmann,R.
  TITLE     Achondrogenesis type IB is caused by mutations in the diastrophic
            dysplasia sulphate transporter gene
  JOURNAL   Nat Genet 12 (1), 100-102 (1996)
   PUBMED   8528239
REFERENCE   10 (bases 1 to 2877)
  AUTHORS   Hastbacka,J., de la Chapelle,A., Mahtani,M.M., Clines,G.,
            Reeve-Daly,M.P., Daly,M., Hamilton,B.A., Kusumi,K., Trivedi,B.,
            Weaver,A. et al.
  TITLE     The diastrophic dysplasia gene encodes a novel sulfate transporter:
            positional cloning by fine-structure linkage disequilibrium mapping
  JOURNAL   Cell 78 (6), 1073-1087 (1994)
   PUBMED   7923357
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D82883.1.
            
            [WARNING] On Aug 27, 2024 this sequence was replaced by
            NM_057127.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D82883.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132273, SAMD00132291
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2877
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..2877
                     /gene="Slc26a2"
                     /gene_synonym="Dtdst"
                     /note="solute carrier family 26 member 2"
                     /db_xref="GeneID:117267"
                     /db_xref="RGD:620622"
     exon            1..219
                     /gene="Slc26a2"
                     /gene_synonym="Dtdst"
                     /inference="alignment:Splign:2.1.0"
     exon            220..354
                     /gene="Slc26a2"
                     /gene_synonym="Dtdst"
                     /inference="alignment:Splign:2.1.0"
     exon            355..484
                     /gene="Slc26a2"
                     /gene_synonym="Dtdst"
                     /inference="alignment:Splign:2.1.0"
     exon            485..1206
                     /gene="Slc26a2"
                     /gene_synonym="Dtdst"
                     /inference="alignment:Splign:2.1.0"
     CDS             508..2727
                     /gene="Slc26a2"
                     /gene_synonym="Dtdst"
                     /note="diastrophic dysplasia protein homolog; solute
                     carrier family 26 (sulfate transporter), member 2; solute
                     carrier family 26 (anion exchanger), member 2"
                     /codon_start=1
                     /product="sulfate transporter"
                     /protein_id="NP_476468.1"
                     /db_xref="GeneID:117267"
                     /db_xref="RGD:620622"
                     /translation="MSSENKEQHNLSPRDLPEEAYGFPPELPLGAQRGSSTDLRQFEP
                     SDRRRAFRRIHMELHEKPDTNIRQLVMRKLQKSCQCNATKIRNRIFDFFPVLRWLPKY
                     DLKKNILGDMMSGLIVGILLVPQSIAYSLLAGQEPIYGLYTSFFASIIYFLFGTSRHI
                     SVGIFGILCLMIGEVVDRELHKACPDIDTTSSSIAMFSNGCVVVNHTLDGLCDKSCYA
                     IKIGSTVTFMAGVYQVAMGFFQVGFVSVYLSDALLSGFVTGASFTILTSQAKYLLGLS
                     LPRSNGVGSVITTWIHIFRNIHKTNICDLITSLLCLLVLVPTKELNEYFKSKLPAPIP
                     TELIVVVAATLASHFGKLNENYNSSIAGQIPTGFMPPQAPDWSLIPNVAVDAIAISII
                     GFAITVSLSEMFAKKHGYTVKANQEMYAIGFCNIIPSFFHCITTSAALAKTLVKESTG
                     CQTQLSAIVTSLVLLLVLLLIAPLFYSLQKCVLGVITIVNLRGALLKFRDLPKMWRLS
                     RMDTVIWFVTMLSSALLSTEIGLLVGVCFSMFCVILRTQMPKISLLGLEEESEIFESI
                     STYKNLRSKSGIKVFRFIAPLYYINKECFKSALYKKTLNPVLVKAAWKKAAKRKLKEE
                     TVTFHGDPDEVSMQLSHDPLELHTVVIDCSAIQFLDTAGIHTLKEVRRDYEAIGIQVL
                     LAQCNPSVRDSLAKGEYCKKEEENLLFYSLSEAVAFAEESQKEKGVCVVNGLSLSGD"
     exon            1207..2877
                     /gene="Slc26a2"
                     /gene_synonym="Dtdst"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgggcctt gccgggttcc ttccgcacct ttcctacggt gaccatggct agctgctgcc
       61 tccttggggc cggaccatgg gcggggacgg ttgccggggt attaaaggga agctcgcccg
      121 cggccagact gcctgtaccc gtgcggcggc gtccctgcag ccaagtcttg ccggaggacg
      181 tgccgtggga gcccgtgtct ggcggactgg agcattaagg agtaaagttg ctgctttaaa
      241 gacatcatct tctggcttcc attaagtcca ggacatgtgc tgtattcctg tctttgttcc
      301 tccataagtg atgtgtgtct gtcttcagaa gcaccctctg agtaacagtg attggtttag
      361 aaaaacctct tgaccaaagg ctactccaga caggaagtaa ctcaagcagg ctcaggagag
      421 caggaagtga gaagacagat gctgagttaa tgaccagcac actaacctgt ttgagttgct
      481 cagggaagta aagcatctgt ctccagaatg tcttcagaaa ataaagagca gcataatctt
      541 tcaccaaggg acttacctga agaagcctat ggcttcccac ctgagctccc cctgggggct
      601 caaagaggat caagcactga cttaaggcag tttgagccca gtgatcggag aagagctttt
      661 cgtaggatcc acatggaact ccatgagaaa ccagatacta acatcagaca gcttgtcatg
      721 agaaagcttc agaagagttg ccagtgtaat gcaaccaaaa tcagaaatag gatttttgat
      781 ttttttcctg ttttgaggtg gctcccaaaa tatgatctga agaaaaacat tttaggtgac
      841 atgatgtctg gcctgattgt gggtatattg ttggtgcccc agtctattgc ttactccctg
      901 ttggctggcc aggaacctat ctatggtctg tacacatcat tttttgccag cattatttac
      961 ttcctgtttg gtacctcccg ccacatctct gtgggcattt ttggaatact gtgccttatg
     1021 attggtgagg tagttgaccg agaactacat aaagcctgcc ctgacattga tactacatca
     1081 tcttccatag caatgttttc aaatggatgt gtggtagtaa accatacatt agacggactc
     1141 tgtgacaaaa gctgttatgc aattaaaatt ggcagcactg tgacattcat ggctggagtt
     1201 tatcaggtag ccatgggctt ctttcaagtg ggctttgtgt ctgtctacct ctcagatgcc
     1261 ttgctgagcg ggtttgtcac tggtgcctcc ttcaccatcc tcacgtctca ggccaagtac
     1321 ctcctggggc tgagccttcc tcggagcaat ggtgtaggct cagtcattac tacctggatc
     1381 cacatcttca gaaatattca taagaccaac atctgtgacc tcatcaccag ccttttgtgt
     1441 ctcctggtcc ttgtgccaac caaagaactc aacgaatact tcaagtccaa gctcccggca
     1501 ccaattccaa ctgagctcat tgtcgttgtg gcagccacat tggcttctca ttttggaaaa
     1561 ctcaatgaga attacaattc cagtattgcc gggcaaattc ccaccgggtt tatgccaccc
     1621 caagcgccag actggagcct cattcctaat gtggctgttg atgccatagc tatttctatc
     1681 attggttttg ctatcactgt atcactttct gagatgtttg ccaagaaaca tggctacacg
     1741 gtgaaagcca atcaggaaat gtatgccatt ggcttttgca atatcatacc ctccttcttc
     1801 cactgcataa ctactagtgc cgcccttgca aagacactgg ttaaagagtc aacaggttgc
     1861 cagacccaac tgtccgctat agtgacatcc ctcgttcttc tgttggtcct tctgctaata
     1921 gctcccttat tctattccct ccaaaaatgt gtccttggtg tgatcaccat tgtaaatctc
     1981 cggggtgcac ttctgaaatt tagagacctg ccaaagatgt ggaggctcag cagaatggac
     2041 acagttatct ggtttgtgac gatgctgtcc tctgctctgt taagcactga aataggcctg
     2101 ctcgttgggg tttgtttttc aatgttttgt gtgattctcc gtactcagat gccaaagatt
     2161 tcactgcttg gtttggaaga agaatctgaa atcttcgagt ccatctccac ttacaagaac
     2221 cttcggagta agtcaggcat caaggttttc cgcttcatag cccctctcta ctacataaac
     2281 aaagaatgct ttaaatcagc tttgtacaag aaaacgctaa acccagtctt ggtaaaagca
     2341 gcctggaaaa aggcagcaaa aaggaaactg aaagaggaaa cagtgacttt ccatggggac
     2401 ccggatgaag tctcaatgca gctttcccat gatcccttgg agctgcacac cgttgtgatt
     2461 gactgtagtg caatacagtt tttggataca gcagggatcc acacactgaa agaagttcgc
     2521 cgggattatg aagccattgg tatccaggtt ttactggctc agtgcaatcc ttctgtgagg
     2581 gattccttag ccaaaggaga atattgcaaa aaggaagaag aaaatcttct cttctacagt
     2641 ttgtctgaag cagtagcttt tgcagaagag tctcagaagg agaaaggagt gtgtgtggtc
     2701 aatggtttga gtctttctgg tgactgagaa aattaatgag tctctctggt gactgggaaa
     2761 gctaatagaa ggaagaagag tgtcttgcca gtttcagtgt gcggcatttt ctcctgtgaa
     2821 ggaggaagca gtgtacacgt gagatggctt cctttgcagc tagcctttcg atagtct
//
