LOCUS       NM_022287               3414 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 26 member 1 (Slc26a1),
            mRNA.
ACCESSION   NM_022287
VERSION     NM_022287.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3414)
  AUTHORS   Yin,K., Lei,Y., Wen,X., Lacruz,R.S., Soleimani,M., Kurtz,I.,
            Snead,M.L., White,S.N. and Paine,M.L.
  TITLE     SLC26A Gene Family Participate in pH Regulation during Enamel
            Maturation
  JOURNAL   PLoS One 10 (12), e0144703 (2015)
   PUBMED   26671068
  REMARK    GeneRIF: Slc26a1, Slc26a6 and Slc26a7 are novel participants in the
            extracellular transport of bicarbonate during enamel maturation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3414)
  AUTHORS   Schnedler,N., Burckhardt,G. and Burckhardt,B.C.
  TITLE     Glyoxylate is a substrate of the sulfate-oxalate exchanger, sat-1,
            and increases its expression in HepG2 cells
  JOURNAL   J Hepatol 54 (3), 513-520 (2011)
   PUBMED   21093948
REFERENCE   3  (bases 1 to 3414)
  AUTHORS   Krick,W., Schnedler,N., Burckhardt,G. and Burckhardt,B.C.
  TITLE     Ability of sat-1 to transport sulfate, bicarbonate, or oxalate
            under physiological conditions
  JOURNAL   Am J Physiol Renal Physiol 297 (1), F145-F154 (2009)
   PUBMED   19369292
REFERENCE   4  (bases 1 to 3414)
  AUTHORS   Brzica,H., Breljak,D., Krick,W., Lovric,M., Burckhardt,G.,
            Burckhardt,B.C. and Sabolic,I.
  TITLE     The liver and kidney expression of sulfate anion transporter sat-1
            in rats exhibits male-dominant gender differences
  JOURNAL   Pflugers Arch 457 (6), 1381-1392 (2009)
   PUBMED   19002488
  REMARK    GeneRIF: Gender differences (males > females) in the expression of
            sat-1 protein in rat liver (and, possibly, kidneys) are caused by
            the female sex-hormone-driven inhibition at the posttranscriptional
            level
REFERENCE   5  (bases 1 to 3414)
  AUTHORS   Quondamatteo,F., Krick,W., Hagos,Y., Kruger,M.H.,
            Neubauer-Saile,K., Herken,R., Ramadori,G., Burckhardt,G. and
            Burckhardt,B.C.
  TITLE     Localization of the sulfate/anion exchanger in the rat liver
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 290 (5), G1075-G1081 (2006)
   PUBMED   16357056
  REMARK    GeneRIF: Sat-1 may be responsible for the uptake of inorganic
            sulfate from the blood into hepatocytes to enable sulfation
            reactions. In hepatocytes and endothelial cells, sat-1 may also
            supply sulfate for proteoglycan synthesis.
REFERENCE   6  (bases 1 to 3414)
  AUTHORS   Lee,A., Beck,L. and Markovich,D.
  TITLE     The mouse sulfate anion transporter gene Sat1 (Slc26a1): cloning,
            tissue distribution, gene structure, functional characterization,
            and transcriptional regulation thyroid hormone
  JOURNAL   DNA Cell Biol 22 (1), 19-31 (2003)
   PUBMED   12590734
REFERENCE   7  (bases 1 to 3414)
  AUTHORS   Xie,Q., Welch,R., Mercado,A., Romero,M.F. and Mount,D.B.
  TITLE     Molecular characterization of the murine Slc26a6 anion exchanger:
            functional comparison with Slc26a1
  JOURNAL   Am J Physiol Renal Physiol 283 (4), F826-F838 (2002)
   PUBMED   12217875
REFERENCE   8  (bases 1 to 3414)
  AUTHORS   Karniski,L.P., Lotscher,M., Fucentese,M., Hilfiker,H., Biber,J. and
            Murer,H.
  TITLE     Immunolocalization of sat-1 sulfate/oxalate/bicarbonate anion
            exchanger in the rat kidney
  JOURNAL   Am J Physiol 275 (1), F79-F87 (1998)
   PUBMED   9689008
REFERENCE   9  (bases 1 to 3414)
  AUTHORS   Bissig,M., Hagenbuch,B., Stieger,B., Koller,T. and Meier,P.J.
  TITLE     Functional expression cloning of the canalicular sulfate transport
            system of rat hepatocytes
  JOURNAL   J Biol Chem 269 (4), 3017-3021 (1994)
   PUBMED   8300633
REFERENCE   10 (bases 1 to 3414)
  AUTHORS   Meier,P.J., Valantinas,J., Hugentobler,G. and Rahm,I.
  TITLE     Bicarbonate sulfate exchange in canalicular rat liver plasma
            membrane vesicles
  JOURNAL   Am J Physiol 253 (4 Pt 1), G461-G468 (1987)
   PUBMED   3661708
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085735.1.
            
            On Jun 3, 2007 this sequence version replaced NM_022287.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085735.1, L23413.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3414
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..3414
                     /gene="Slc26a1"
                     /gene_synonym="sat-1"
                     /note="solute carrier family 26 member 1"
                     /db_xref="GeneID:64076"
                     /db_xref="RGD:620136"
     exon            1..18
                     /gene="Slc26a1"
                     /gene_synonym="sat-1"
                     /inference="alignment:Splign:2.1.0"
     exon            19..633
                     /gene="Slc26a1"
                     /gene_synonym="sat-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..2157
                     /gene="Slc26a1"
                     /gene_synonym="sat-1"
                     /note="sulfate/carbonate antiporter; canalicular sulfate
                     transporter; solute carrier family 26 (anion exchanger),
                     member 1; solute carrier family 26 (sulfate transporter),
                     member 1"
                     /codon_start=1
                     /product="sulfate anion transporter 1"
                     /protein_id="NP_071623.2"
                     /db_xref="GeneID:64076"
                     /db_xref="RGD:620136"
                     /translation="MDASPEPPQKGGTLVLVRRQPPVSQGLLETLKARLKKSCTCSMP
                     CAQALVQGLFPVIRWLPQYRLKEYLAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSL
                     YTSFFANLIYFLMGTSRHVNVGIFSLLCLMVGQVVDRELQLAGFDPSQDSLGPGNNDS
                     TLNNTATLTVGLQDCGRDCHAIRIATALTLMAGLYQVLMGILRLGFVSTYLSQPLLDG
                     FAMGASVTILTSQAKHLLGVRIPRHQGLGMVIHTWLSLLQNVGQANLCDVVTSAVCLA
                     VLLTAKELSDRYRHYLKVPVPTELLVIVVATIASHFGQLHTRFGSSVAGNIPTGFVAP
                     QIPDPKIMWSVALDAMSLALVGSAFSISLAEMFARSHGYSVSANQELLAVGCCNVLPA
                     FFHCFATSAALSKTLVKIATGCQTQLSSVVSAAVVLLVLLVLAPLFHDLQRCVLACII
                     VVSLRGALRKVKDLPQLWRLSPADALVWVATAATCVLVSIEAGLLAGVFFSLLSLAGR
                     TQRPRAALLARIGDSTFYEDAAEFEGLLPPPEVRVFRFTGPLYYANKDFFLRSLYSLT
                     GLDAGYSATRKDRGTEVGVSNRSLVDRKDLGSVSSGDGLVVPLAFGFHTVVIDCAPLL
                     FLDVAGMATLKDLRKNYRALDITLLLACCSPSVRDTLRKGGFLGEDQGTEEELLFPSV
                     HSAVETACARREELMAADSAL"
     exon            634..3391
                     /gene="Slc26a1"
                     /gene_synonym="sat-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccggcctgg tgtcccagat tagccaaaga gcctggtgtg acaggatgga tgcttctcct
       61 gagcccccgc agaagggcgg gacactggta ctggtccgac ggcagccccc tgtgtcccag
      121 ggcttgctgg aaacactgaa ggccaggctg aagaagagct gcacctgcag tatgccatgc
      181 gctcaggctc tggtgcaagg tctgtttcct gtcatacgct ggctgcccca gtaccgcctt
      241 aaggaatacc tggcaggtga tgtcatgtcg ggattggtca ttggcattat cctggtgcca
      301 caggccatag cctactcact gctggctggg ttgcagccca tctacagtct ctacacttcc
      361 ttcttcgcca accttatcta cttcctcatg ggtacctccc gccacgttaa tgtgggcatc
      421 ttcagcctgc tgtgtctcat ggtgggtcag gtggtggacc gagaactcca gttggctggc
      481 tttgacccct cccaggattc tctagggccc gggaacaatg acagcaccct caacaacaca
      541 gccacactga cagttgggct acaggactgt gggcgggact gccatgccat tcgtatcgcc
      601 actgccctca ctctgatggc cgggctttat caggtcctca tggggatcct ccggctgggc
      661 ttcgtgtcta cctatctctc gcaacccctg ctcgatggct ttgctatggg agcttctgtg
      721 accatcttga cttctcaggc taaacacctg ctgggcgtgc ggatccctcg gcaccagggc
      781 ctaggcatgg tgatccacac ttggctgagc ttgctgcaga acgtgggaca ggctaatctg
      841 tgtgatgtgg tcaccagtgc cgtgtgcctg gcagtgctgc tgacagctaa ggaactctcg
      901 gatcgctatc gacactatct gaaagtgcca gtgcccacag agctattagt tattgtggtg
      961 gccacgattg cgtcccattt tggacagctc catacacggt ttggctcgag tgtggccggc
     1021 aacattccca ctggttttgt ggccccacag ataccagacc ctaagataat gtggagtgtg
     1081 gccctggatg ccatgtccct ggccctcgtg ggctcagcct tctccatctc cttggcagaa
     1141 atgtttgcac gtagtcatgg ctactctgtc agtgccaacc aagagctgct agctgtgggc
     1201 tgttgcaacg tgctgcctgc cttcttccac tgttttgcca ctagtgctgc tctgtccaaa
     1261 actctggtga agatagccac tggctgccag acccagttgt ccagtgtggt cagtgctgct
     1321 gtggtgttgc tggtgctgct ggtgctggcg ccattgtttc acgatctgca gcggtgtgtg
     1381 ttagcttgca tcattgtcgt cagcctgagg ggggcgctgc gcaaggtgaa ggatctccca
     1441 caactttggc ggctaagccc tgcggacgca ctggtctggg tggctactgc agcgacctgt
     1501 gttctagtca gcatcgaggc tgggctatta gctggggtgt tcttctcact gctcagcctg
     1561 gcaggccgca cgcagcgtcc acgggctgcc cttctggctc gaattggaga ctcgaccttc
     1621 tatgaggatg ctgctgagtt tgagggcctc ctgcccccgc ccgaggtgcg agtgttccgt
     1681 ttcacaggtc cgctctacta tgccaacaag gatttcttcc ttcggtcact ctacagtctg
     1741 acagggctgg atgctgggta ctcagccacc aggaaggatc ggggcacaga ggtgggtgtc
     1801 agtaacagaa gtcttgttga ccgcaaggat ctgggttcag tgagcagtgg ggatgggctg
     1861 gttgtacccc tggcatttgg tttccacaca gtggtcattg actgtgcacc actgctgttc
     1921 ctggatgtgg ctggcatggc cacattgaag gacctgcgca aaaactacag ggccctggac
     1981 atcaccctgc ttctggcttg ctgcagtccc tcagtgagag acacactgag aaaagggggc
     2041 ttccttgggg aagaccaggg aactgaagag gagctgctgt tccccagtgt acacagcgct
     2101 gtggagacag catgtgcccg ccgtgaggag ctgatggctg ctgactctgc cctctagcag
     2161 ggcccgcttc ctcaagagcc aagacctgtg tccacgagcc agtcctgagc tcttttgtag
     2221 gagtgacatg aatgataaag tcattataga taaatccttg gaccgccttt gccctggaga
     2281 agccagggaa ctccaagtag gaaaggaaag tgcagtaccc ttaacacatt ggaggattcc
     2341 aaacattcag tgattgaggc gctctacctc tgagcccact gctgccccct ggtgcctatt
     2401 caaccctagt agttgcaccc acacacatga ttccctcagc caacacagtg cccagtttga
     2461 tagtctgttt atgttgtcat ctgaaacaga gtcctgcaaa ttatatgacc tccatgatgc
     2521 caaaaggaca ctttcccatt ccctgaacca tcgggtacca gatgtgagct gaatatgtgg
     2581 ccacacctca agggtctgaa tttccgaaag gcctccttag gcctggtgct catcttgatt
     2641 ggacccttgc aaaggcagcc acctgctcca gagtcacagt ccagtgtcac tgtctaaccg
     2701 atgtgactga cataacctca acctgacttt cgggcacaat gtcccaatac agcttatact
     2761 ggtaaccaca acgtggcgta tgtatggtac aaagccaggc acagtagaca cttaccccat
     2821 tctgctgtac ttctaagaaa acctcaggag gaaaccacct gtgctccatc cagggcctgc
     2881 ctttggcaca gccaagcaga cattcccctc ctcctctgcc caacaggatg ctctaactgg
     2941 aagcacaccc cagccctgtg cactaccatg attctccccc acccacagcc cagcattgtg
     3001 ttccacagct ggccccaaaa acgtcagctc caccatctcg gctctcttaa aacaagctct
     3061 gaccagcaat tcccagggta cccatttcag cgtcacccac ctggctgtga tgaggtccag
     3121 cagccagtgt atccggacct gctcaatgcc actgtgaggc acagcaccta tgtaggcaag
     3181 gttcagttgc tggtcccaac taaggtcgta ctggtcagcc tggtcgtgag gcagtggggg
     3241 gctagggata ggacaaagaa gtgaagtgtt tgtcctaagc aggggcctgc atcataccag
     3301 actttacaca tgttatcacc tgactaccta gacccttgag gatgaactgt gtatctccag
     3361 aatgtatgat aaagtagccc actaaccaga aaaaaaaaaa aaaaaaaaaa aaaa
//
