LOCUS       NM_057102               1200 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus solute carrier family 25 member 5 (Slc25a5),
            mRNA.
ACCESSION   NM_057102
VERSION     NM_057102.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1200)
  AUTHORS   Terzenidou,M.E., Segklia,A., Kano,T., Papastefanaki,F.,
            Karakostas,A., Charalambous,M., Ioakeimidis,F., Papadaki,M.,
            Kloukina,I., Chrysanthou-Piterou,M., Samiotaki,M., Panayotou,G.,
            Matsas,R. and Douni,E.
  TITLE     Novel insights into SLC25A46-related pathologies in a genetic mouse
            model
  JOURNAL   PLoS Genet 13 (4), e1006656 (2017)
   PUBMED   28376086
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1200)
  AUTHORS   Maldonado,E.N., DeHart,D.N., Patnaik,J., Klatt,S.C., Gooz,M.B. and
            Lemasters,J.J.
  TITLE     ATP/ADP Turnover and Import of Glycolytic ATP into Mitochondria in
            Cancer Cells Is Independent of the Adenine Nucleotide Translocator
  JOURNAL   J Biol Chem 291 (37), 19642-19650 (2016)
   PUBMED   27458020
  REMARK    GeneRIF: knockdown of the major ANT isoforms, ANT2 and ANT3, did
            not collapse DeltaPsi after respiratory inhibition. These findings
            indicated that ANT did mediate mitochondrial ATP/ADP exchange in
            cancer cells.
            Erratum:[J Biol Chem. 2017 Oct 13;292(41):16969. doi:
            10.1074/jbc.A116.734814.. PMID: 29030537]
REFERENCE   3  (bases 1 to 1200)
  AUTHORS   Zanivan,S., Maione,F., Hein,M.Y., Hernandez-Fernaud,J.R.,
            Ostasiewicz,P., Giraudo,E. and Mann,M.
  TITLE     SILAC-based proteomics of human primary endothelial cell
            morphogenesis unveils tumor angiogenic markers
  JOURNAL   Mol Cell Proteomics 12 (12), 3599-3611 (2013)
   PUBMED   23979707
REFERENCE   4  (bases 1 to 1200)
  AUTHORS   Park,J.I., Kim,S.G., Baek,M.W., Park,T.J., Lim,I.K., Seo,Y.W. and
            Chun,S.Y.
  TITLE     B-cell translocation gene 2: expression in the rat ovary and
            potential association with adenine nucleotide translocase 2 in
            mitochondria
  JOURNAL   Mol Cell Endocrinol 367 (1-2), 31-40 (2013)
   PUBMED   23267836
  REMARK    GeneRIF: These findings demonstrate the gonadotropin stimulation of
            Btg2 in the ovary and, the physical interaction of Btg2 with Ant2
            in mitochondria.
REFERENCE   5  (bases 1 to 1200)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 1200)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   7  (bases 1 to 1200)
  AUTHORS   Ledesma,M.D., Da Silva,J.S., Schevchenko,A., Wilm,M. and Dotti,C.G.
  TITLE     Proteomic characterisation of neuronal sphingolipid-cholesterol
            microdomains: role in plasminogen activation
  JOURNAL   Brain Res 987 (1), 107-116 (2003)
   PUBMED   14499952
REFERENCE   8  (bases 1 to 1200)
  AUTHORS   Woodfield,K., Ruck,A., Brdiczka,D. and Halestrap,A.P.
  TITLE     Direct demonstration of a specific interaction between
            cyclophilin-D and the adenine nucleotide translocase confirms their
            role in the mitochondrial permeability transition
  JOURNAL   Biochem J 336 (Pt 2) (Pt 2), 287-290 (1998)
   PUBMED   9820802
REFERENCE   9  (bases 1 to 1200)
  AUTHORS   Shinohara,Y., Kamida,M., Yamazaki,N. and Terada,H.
  TITLE     Isolation and characterization of cDNA clones and a genomic clone
            encoding rat mitochondrial adenine nucleotide translocator
  JOURNAL   Biochim Biophys Acta 1152 (1), 192-196 (1993)
   PUBMED   8399300
REFERENCE   10 (bases 1 to 1200)
  AUTHORS   Brandolin,G., Le Saux,A., Trezeguet,V., Lauquin,G.J. and
            Vignais,P.V.
  TITLE     Chemical, immunological, enzymatic, and genetic approaches to
            studying the arrangement of the peptide chain of the ADP/ATP
            carrier in the mitochondrial membrane
  JOURNAL   J Bioenerg Biomembr 25 (5), 459-472 (1993)
   PUBMED   8132486
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Nov 27, 2020 this sequence version replaced NM_057102.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D12771.1, FQ229438.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               JAXUCZ010000021.1  120897616-120897772
            158-644             JAXUCZ010000021.1  120898770-120899256
            645-785             JAXUCZ010000021.1  120899792-120899932
            786-1200            JAXUCZ010000021.1  120900269-120900683
FEATURES             Location/Qualifiers
     source          1..1200
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq34"
     gene            1..1200
                     /gene="Slc25a5"
                     /gene_synonym="Ant2"
                     /note="solute carrier family 25 member 5"
                     /db_xref="GeneID:25176"
                     /db_xref="RGD:620353"
     exon            1..157
                     /gene="Slc25a5"
                     /gene_synonym="Ant2"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..943
                     /gene="Slc25a5"
                     /gene_synonym="Ant2"
                     /note="solute carrier family 25 (mitochondrial carrier;
                     adenine nucleotide translocator), member 5; ANT 2; ADP,ATP
                     carrier protein 2"
                     /codon_start=1
                     /product="ADP/ATP translocase 2"
                     /protein_id="NP_476443.1"
                     /db_xref="GeneID:25176"
                     /db_xref="RGD:620353"
                     /translation="MTDAAVSFAKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQ
                     ITADKQYKGIIDCVVRIPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGG
                     VDKRTQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKAGAEREFKGLGDC
                     LVKIYKSDGIKGLYQGFNVSVQGIIIYRAAYFGIYDTAKGMLPDPKNTHIFISWMIAQ
                     SVTAVAGLTSYPFDTVRRRMMMQSGRKGTDIMYTGTLDCWRKIARDEGGKAFFKGAWS
                     NVLRGMGGAFVLVLYDEIKKYT"
     exon            158..644
                     /gene="Slc25a5"
                     /gene_synonym="Ant2"
                     /inference="alignment:Splign:2.1.0"
     exon            645..785
                     /gene="Slc25a5"
                     /gene_synonym="Ant2"
                     /inference="alignment:Splign:2.1.0"
     exon            786..1200
                     /gene="Slc25a5"
                     /gene_synonym="Ant2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagtcctgt cctgcagtcg cctgcctctt cttttttgct ttcaacatga cagatgccgc
       61 tgtgtccttc gccaaggact tcttggctgg tggagtggcc gcggccatct ccaagacggc
      121 ggtagcaccc atcgagcggg tcaagctgct gctgcaggtg cagcacgcca gcaagcaaat
      181 cacggcagat aagcaataca agggcatcat agactgcgtg gttcgtatcc ccaaggaaca
      241 gggagtcctg tccttctggc gtggcaacct ggccaatgtc atcagatact tccccaccca
      301 ggctctcaac ttcgccttca aagataaata caagcagatc tttttgggtg gtgtggacaa
      361 gaggacccag ttttggcggt actttgcagg gaacctggca tcaggtggtg ctgctggggc
      421 cacatccttg tgctttgtgt accctcttga ttttgcccgt acccgtctag cagctgatgt
      481 gggcaaagct ggagctgaaa gggaattcaa aggccttggt gactgcctgg ttaagatcta
      541 caaatctgat gggattaagg gcctgtacca aggctttaat gtgtcagtgc agggcattat
      601 catctaccgt gctgcctact tcggtatcta tgacactgca aagggaatgc tcccggatcc
      661 caagaatact cacatcttca tcagctggat gattgcacag tctgtcactg ctgttgctgg
      721 cctaacttct tatccttttg acacggttcg ccgtcgtatg atgatgcagt ctggacgcaa
      781 aggaactgat atcatgtata caggcacgct tgactgctgg cggaagatcg ctcgagacga
      841 aggaggcaag gcctttttca agggtgcatg gtccaacgtt ctcagaggca tgggtggtgc
      901 ctttgtgctt gtcttgtatg atgaaatcaa gaagtacaca taattatgtc ctaggtgttc
      961 tccccgagaa caggcatgtt gtataataga ccatattctt gaacattctg gacagattct
     1021 ctgggcttgt ctgttttatc aatggcaact atttaccagt tgaaaagtgg gaagcaataa
     1081 tattcatctg accagttttc tcttaaagcc atttccataa tgacaataat gatgggactc
     1141 aattatattt tttatttcag tcactcctga taataaaaaa ttgaagaaat aaaaatatcc
//
