LOCUS       NM_001100515            2947 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 25, member 46 (Slc25a46),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001100515 XM_001059020 XM_214589
VERSION     NM_001100515.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2947)
  AUTHORS   Santo-Domingo,J., Lassueur,S., Galindo,A.N., Alvarez-Illera,P.,
            Romero-Sanz,S., Caldero-Escudero,E., de la Fuente,S., Dayon,L. and
            Wiederkehr,A.
  TITLE     SLC25A46 promotes mitochondrial fission and mediates resistance to
            lipotoxic stress in INS-1E insulin-secreting cells
  JOURNAL   J Cell Sci 136 (8) (2023)
   PUBMED   36942724
  REMARK    GeneRIF: SLC25A46 promotes mitochondrial fission and mediates
            resistance to lipotoxic stress in INS-1E insulin-secreting cells.
REFERENCE   2  (bases 1 to 2947)
  AUTHORS   Li,Z., Peng,Y., Hufnagel,R.B., Hu,Y.C., Zhao,C., Queme,L.F.,
            Khuchua,Z., Driver,A.M., Dong,F., Lu,Q.R., Lindquist,D.M.,
            Jankowski,M.P., Stottmann,R.W., Kao,W.W.Y. and Huang,T.
  TITLE     Loss of SLC25A46 causes neurodegeneration by affecting
            mitochondrial dynamics and energy production in mice
  JOURNAL   Hum Mol Genet 26 (19), 3776-3791 (2017)
   PUBMED   28934388
REFERENCE   3  (bases 1 to 2947)
  AUTHORS   Terzenidou,M.E., Segklia,A., Kano,T., Papastefanaki,F.,
            Karakostas,A., Charalambous,M., Ioakeimidis,F., Papadaki,M.,
            Kloukina,I., Chrysanthou-Piterou,M., Samiotaki,M., Panayotou,G.,
            Matsas,R. and Douni,E.
  TITLE     Novel insights into SLC25A46-related pathologies in a genetic mouse
            model
  JOURNAL   PLoS Genet 13 (4), e1006656 (2017)
   PUBMED   28376086
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2947)
  AUTHORS   Duchesne,A., Vaiman,A., Castille,J., Beauvallet,C., Gaignard,P.,
            Floriot,S., Rodriguez,S., Vilotte,M., Boulanger,L., Passet,B.,
            Albaric,O., Guillaume,F., Boukadiri,A., Richard,L., Bertaud,M.,
            Timsit,E., Guatteo,R., Jaffrezic,F., Calvel,P., Helary,L.,
            Mahla,R., Esquerre,D., Pechoux,C., Liuu,S., Vallat,J.M.,
            Boichard,D., Slama,A. and Vilotte,J.L.
  TITLE     Bovine and murine models highlight novel roles for SLC25A46 in
            mitochondrial dynamics and metabolism, with implications for human
            and animal health
  JOURNAL   PLoS Genet 13 (4), e1006597 (2017)
   PUBMED   28376083
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2947)
  AUTHORS   Wan,J., Steffen,J., Yourshaw,M., Mamsa,H., Andersen,E.,
            Rudnik-Schoneborn,S., Pope,K., Howell,K.B., McLean,C.A.,
            Kornberg,A.J., Joseph,J., Lockhart,P.J., Zerres,K., Ryan,M.M.,
            Nelson,S.F., Koehler,C.M. and Jen,J.C.
  TITLE     Loss of function of SLC25A46 causes lethal congenital
            pontocerebellar hypoplasia
  JOURNAL   Brain 139 (11), 2877-2890 (2016)
   PUBMED   27543974
REFERENCE   6  (bases 1 to 2947)
  AUTHORS   Abrams,A.J., Hufnagel,R.B., Rebelo,A., Zanna,C., Patel,N.,
            Gonzalez,M.A., Campeanu,I.J., Griffin,L.B., Groenewald,S.,
            Strickland,A.V., Tao,F., Speziani,F., Abreu,L., Schule,R.,
            Caporali,L., La Morgia,C., Maresca,A., Liguori,R., Lodi,R.,
            Ahmed,Z.M., Sund,K.L., Wang,X., Krueger,L.A., Peng,Y., Prada,C.E.,
            Prows,C.A., Schorry,E.K., Antonellis,A., Zimmerman,H.H.,
            Abdul-Rahman,O.A., Yang,Y., Downes,S.M., Prince,J., Fontanesi,F.,
            Barrientos,A., Nemeth,A.H., Carelli,V., Huang,T., Zuchner,S. and
            Dallman,J.E.
  TITLE     Mutations in SLC25A46, encoding a UGO1-like protein, cause an optic
            atrophy spectrum disorder
  JOURNAL   Nat Genet 47 (8), 926-932 (2015)
   PUBMED   26168012
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166810.1.
            
            On or before Jun 8, 2008 this sequence version replaced
            XM_001059020.1, XM_214589.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166810.1, FQ234554.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2947
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..2947
                     /gene="Slc25a46"
                     /gene_synonym="RGD1305072"
                     /note="solute carrier family 25, member 46"
                     /db_xref="GeneID:291709"
                     /db_xref="RGD:1305072"
     exon            1..342
                     /gene="Slc25a46"
                     /gene_synonym="RGD1305072"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1316
                     /gene="Slc25a46"
                     /gene_synonym="RGD1305072"
                     /codon_start=1
                     /product="mitochondrial outer membrane protein SLC25A46"
                     /protein_id="NP_001093985.1"
                     /db_xref="GeneID:291709"
                     /db_xref="RGD:1305072"
                     /translation="MHPRRPEGFDGLGYRGGVRDDPAFGGPFHARSFGSGTELGHWVT
                     TPPDIPGSRNLHWGEKSPSYGVPSAPPTLEGPAEEPFPGGGDGPRPGRSSEQLNRFAG
                     FGIGLASLFTENVLAHPCIVLRRQCQVNYHARHYHLTPFSVINIMYSFNKTQGPRALW
                     KGMGSTFIVQGVTLGAEGIISEFTPLPREVSQKWNPKQIGEHLLLKCLTYMVAMPFYS
                     ASLIETVQSEIIRDNTGILECVKEGIGRVIGLGVPHSKRLLPLFSLIFPTVLHGVLHY
                     IISSIIQKIVLLILKRKTCSSHLAESTSPMQNMLDAYFPELIANFAASLCSDVILYPL
                     ETVLHRLHIQGTRTIIDNTDLGYEVLPINTQYEGMRDCVNTIKQEEGVFGFYKGFGAV
                     IIQYTLHATILQITKIIYSTLLQNSI"
     exon            343..385
                     /gene="Slc25a46"
                     /gene_synonym="RGD1305072"
                     /inference="alignment:Splign:2.1.0"
     exon            386..443
                     /gene="Slc25a46"
                     /gene_synonym="RGD1305072"
                     /inference="alignment:Splign:2.1.0"
     exon            444..521
                     /gene="Slc25a46"
                     /gene_synonym="RGD1305072"
                     /inference="alignment:Splign:2.1.0"
     exon            522..622
                     /gene="Slc25a46"
                     /gene_synonym="RGD1305072"
                     /inference="alignment:Splign:2.1.0"
     exon            623..679
                     /gene="Slc25a46"
                     /gene_synonym="RGD1305072"
                     /inference="alignment:Splign:2.1.0"
     exon            680..737
                     /gene="Slc25a46"
                     /gene_synonym="RGD1305072"
                     /inference="alignment:Splign:2.1.0"
     exon            738..2917
                     /gene="Slc25a46"
                     /gene_synonym="RGD1305072"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcggtggag gcctgggctc agtgggccgg cctctctcgt cctcgtccgc ccgttcgaga
       61 tgcatccgcg gcgccctgag ggcttcgacg gcttgggcta ccggggaggc gtgcgggacg
      121 atccggcttt cggcggcccc ttccatgcgc gctccttcgg ttcagggacg gaactgggcc
      181 actgggtgac aacacccccg gacatcccgg gcagccgcaa cctgcactgg ggcgagaaaa
      241 gcccttcgta cggtgtgccg tccgcgcccc cgacgctcga gggccccgcg gaggagccct
      301 ttcccggcgg cggcgacggc ccgcggccgg gacggagcag cgaacagttg aatagatttg
      361 ctggatttgg tattggactt gcaagtctct ttacagaaaa tgtactggcc catccttgta
      421 ttgttttacg ccgccaatgc caggtcaatt accatgctcg gcattaccat ctcactccat
      481 tttcagttat caacattatg tatagcttca acaaaactca gggaccaaga gccctgtgga
      541 aaggaatggg aagcacattt attgttcagg gagtcacact tggagcagaa ggcatcatta
      601 gtgagtttac acctttacca agggaggttt cacagaaatg gaaccctaaa caaataggtg
      661 aacaccttct cctgaaatgc ctaacgtaca tggtggccat gcctttctat tcagcaagtc
      721 tgatcgaaac agtacagagt gagataatcc gagataatac tggcatcctg gaatgtgtta
      781 aagaaggaat tggacgggtg ataggcttgg gagtgcctca cagcaaacgc cttcttccac
      841 tgttttcatt gatcttccca acagtgctgc atggagttct ccattacatc atcagctcca
      901 tcattcagaa gattgtcctt ctaattctga agagaaagac ctgtagtagc cacctagccg
      961 agagcactag ccccatgcag aatatgctgg atgcttattt tccagaactt attgctaact
     1021 ttgccgccag cctttgctct gacgtgatac tttacccgtt ggaaacagtt ctgcatcgtc
     1081 ttcatattca aggaacacgc acaataattg acaatacaga ccttggttat gaagtacttc
     1141 caattaatac gcagtatgag ggaatgagag actgtgtaaa taccatcaag caggaagaag
     1201 gagtgtttgg tttttataaa gggtttggtg ctgttatcat acagtataca ttgcatgcaa
     1261 ccatcttaca gattaccaaa attatttact ccacacttct tcagaatagc atttgagatt
     1321 taggttctgt gattggctga tccaaaagac gtggtctgga taatttgcta tgacatttca
     1381 agtaataaaa gtaaaatact gcgtggaaag aaatgggctg ggaattaaga ctgtggaaaa
     1441 gctcatgctg attattctga cttcttattt ttcttaaggc atagatacat agatacatat
     1501 atataatact ggatcaaaac aaacctttcc aaaattaaaa acttaataaa ggtaatactt
     1561 taaatttaaa atgtaaagtt acattttagt ataacactca tgctgaagta aaattgatcc
     1621 tgggtagaaa caaaaatgta tcaagtataa aatgaaatcg caatgacttg aatctatttt
     1681 actgacttta atgtttgtta tatgtttgtt gaacttggac tcaggtcatt gtgttaatgc
     1741 ttgaagcaat ggacagtgtt ggattttacc ttcgagcaaa tagattatat catcattgaa
     1801 aacaaacctt aagattagat ttggcactgt gtaagcagtg attgaagggt tctaaattgt
     1861 atttaaccat tttatttgct gtatatattt attatatgga gtcgtgtgtg tatttgtgtc
     1921 caggtaactt gggatttcct gcatccctgc aagttttcat agaccagttt attgcatcaa
     1981 gtgaagagaa actctttctg cttgaacatc aagaataaga catcacaatg ccagaaaata
     2041 gctttcttgt ctgcatcata tccggtgttt cagtgtcaga aacttgaaat ttgtcacatg
     2101 cttgtgacat cgggatcatc agatgatttc tagagctact tttaaagata cctaacaatc
     2161 atggcagcca ttaccgtttc cacacgtatc taaggagcct agcttgtcct tcatttctaa
     2221 aagaacttat cctagaggga gcaaggtgaa agttctcctg ggatctgtgc ctcctgctca
     2281 ccataaacaa tcactgcact ctttcttttt tctttccgtg tgtgtgtgtg tgtgtgtgtg
     2341 tgtgtgtgtg tgtgtgtgtg tgtaaagttt tattctccaa ataagctacc atgaagataa
     2401 aagtgaacat tcttgttact ttctatttaa acttgcttgg ataagtactg atttaaaata
     2461 aaaacttcat aggaaatttg cccttatgtt ttatggagga gggggaggag ccactatatt
     2521 tcaacaaatg aaacttgtta atcggtttaa taaagtcgat gtgttcccac agtggattag
     2581 actttgtaat gaagtgatgt atagttcctg accactcatg cagcatttag catttcattt
     2641 cttcatgggt gtgctcaagt ttacaaacac tgaagtacag tgcctgcggg tgtcgcccaa
     2701 tctcgaatgc atgcaaacta aaactgatgt tacgtgttaa gtgtcacaga gtgtgtgtac
     2761 ctcgaccgat cagagtggga gcttaacgtg gatgtgaaaa gcatgaagca gtgtgtaagt
     2821 agaagctgtc cttccagtct gcgtgttaat tctgaagtct ctgatgtgat gtcaactctt
     2881 caattcctca aaagggaaat aaatgctgtt gatcacaaaa aaaaaaaaaa aaaaaaaaaa
     2941 aaaaaaa
//
