LOCUS       NM_053515               1290 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus solute carrier family 25 member 4 (Slc25a4),
            mRNA.
ACCESSION   NM_053515
VERSION     NM_053515.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1290)
  AUTHORS   Yang,M., Xu,Y., Heisner,J.S., Sun,J., Stowe,D.F., Kwok,W.M. and
            Camara,A.K.S.
  TITLE     Peroxynitrite nitrates adenine nucleotide translocase and
            voltage-dependent anion channel 1 and alters their interactions and
            association with hexokinase II in mitochondria
  JOURNAL   Mitochondrion 46, 380-392 (2019)
   PUBMED   30391711
  REMARK    GeneRIF: Taken together, peroxynitrite produced during cardiac
            ischemia and reperfusion injury can nitrate tyrosine residues of
            two key mitochondrial membrane proteins involved in bioenergetics
            and energy transfer via binding to hexokinase 2 to contribute to
            mitochondrial and cellular dysfunction.
REFERENCE   2  (bases 1 to 1290)
  AUTHORS   Thompson,K., Majd,H., Dallabona,C., Reinson,K., King,M.S.,
            Alston,C.L., He,L., Lodi,T., Jones,S.A., Fattal-Valevski,A.,
            Fraenkel,N.D., Saada,A., Haham,A., Isohanni,P., Vara,R.,
            Barbosa,I.A., Simpson,M.A., Deshpande,C., Puusepp,S., Bonnen,P.E.,
            Rodenburg,R.J., Suomalainen,A., Ounap,K., Elpeleg,O., Ferrero,I.,
            McFarland,R., Kunji,E.R. and Taylor,R.W.
  TITLE     Recurrent De Novo Dominant Mutations in SLC25A4 Cause Severe
            Early-Onset Mitochondrial Disease and Loss of Mitochondrial DNA
            Copy Number
  JOURNAL   Am J Hum Genet 99 (4), 860-876 (2016)
   PUBMED   27693233
  REMARK    Erratum:[Am J Hum Genet. 2016 Dec 1;99(6):1405. doi:
            10.1016/j.ajhg.2016.11.001.. PMID: 27912046]
REFERENCE   3  (bases 1 to 1290)
  AUTHORS   Klumpe,I., Savvatis,K., Westermann,D., Tschope,C., Rauch,U.,
            Landmesser,U., Schultheiss,H.P. and Dorner,A.
  TITLE     Transgenic overexpression of adenine nucleotide translocase 1
            protects ischemic hearts against oxidative stress
  JOURNAL   J Mol Med (Berl) 94 (6), 645-653 (2016)
   PUBMED   27080394
  REMARK    GeneRIF: ANT1 overexpression compensates impaired adenine
            nucleotide translocase activity under oxygen-restricted conditions
REFERENCE   4  (bases 1 to 1290)
  AUTHORS   Korotkov,S.M., Konovalova,S.A., Brailovskaya,I.V. and Saris,N.E.
  TITLE     To involvement the conformation of the adenine nucleotide
            translocase in opening the Tl(+)-induced permeability transition
            pore in Ca(2+)-loaded rat liver mitochondria
  JOURNAL   Toxicol In Vitro 32, 320-332 (2016)
   PUBMED   26835787
  REMARK    GeneRIF: Our data suggest that conformational changes of ANT may be
            directly involved in the opening of the Tl(+)-induced mitochondrial
            permeability transition pore in the inner membrane of Ca(2+)-loaded
            rat liver mitochondria
REFERENCE   5  (bases 1 to 1290)
  AUTHORS   Winter,J., Klumpe,I., Heger,J., Rauch,U., Schultheiss,H.P.,
            Landmesser,U. and Dorner,A.
  TITLE     Adenine nucleotide translocase 1 overexpression protects
            cardiomyocytes against hypoxia via increased ERK1/2 and AKT
            activation
  JOURNAL   Cell Signal 28 (1), 152-159 (2016)
   PUBMED   26548633
  REMARK    GeneRIF: Adenine nucleotide translocase 1 overexpression protects
            cardiomyocytes against hypoxia
REFERENCE   6  (bases 1 to 1290)
  AUTHORS   Esposito,L.A., Melov,S., Panov,A., Cottrell,B.A. and Wallace,D.C.
  TITLE     Mitochondrial disease in mouse results in increased oxidative
            stress
  JOURNAL   Proc Natl Acad Sci U S A 96 (9), 4820-4825 (1999)
   PUBMED   10220377
REFERENCE   7  (bases 1 to 1290)
  AUTHORS   Woodfield,K., Ruck,A., Brdiczka,D. and Halestrap,A.P.
  TITLE     Direct demonstration of a specific interaction between
            cyclophilin-D and the adenine nucleotide translocase confirms their
            role in the mitochondrial permeability transition
  JOURNAL   Biochem J 336 (Pt 2) (Pt 2), 287-290 (1998)
   PUBMED   9820802
REFERENCE   8  (bases 1 to 1290)
  AUTHORS   Grado,A., Manchado,C., Iglesias,R., Giralt,M., Villarroya,F.,
            Mampel,T. and Vinas,O.
  TITLE     Muscle/heart isoform of mitochondrial adenine nucleotide
            translocase (ANT1) is transiently expressed during perinatal
            development in rat liver
  JOURNAL   FEBS Lett 421 (3), 213-216 (1998)
   PUBMED   9468308
REFERENCE   9  (bases 1 to 1290)
  AUTHORS   Shinohara,Y., Kamida,M., Yamazaki,N. and Terada,H.
  TITLE     Isolation and characterization of cDNA clones and a genomic clone
            encoding rat mitochondrial adenine nucleotide translocator
  JOURNAL   Biochim Biophys Acta 1152 (1), 192-196 (1993)
   PUBMED   8399300
REFERENCE   10 (bases 1 to 1290)
  AUTHORS   Brandolin,G., Le Saux,A., Trezeguet,V., Lauquin,G.J. and
            Vignais,P.V.
  TITLE     Chemical, immunological, enzymatic, and genetic approaches to
            studying the arrangement of the peptide chain of the ADP/ATP
            carrier in the mitochondrial membrane
  JOURNAL   J Bioenerg Biomembr 25 (5), 459-472 (1993)
   PUBMED   8132486
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Nov 27, 2020 this sequence version replaced NM_053515.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ213027.1, FQ214384.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               JAXUCZ010000016.1  52805521-52805740
            221-707             JAXUCZ010000016.1  52807015-52807501
            708-848             JAXUCZ010000016.1  52807985-52808125
            849-1290            JAXUCZ010000016.1  52808875-52809316
FEATURES             Location/Qualifiers
     source          1..1290
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q11"
     gene            1..1290
                     /gene="Slc25a4"
                     /gene_synonym="Ant1"
                     /note="solute carrier family 25 member 4"
                     /db_xref="GeneID:85333"
                     /db_xref="RGD:620352"
     exon            1..220
                     /gene="Slc25a4"
                     /gene_synonym="Ant1"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..1006
                     /gene="Slc25a4"
                     /gene_synonym="Ant1"
                     /note="ANT 1; ADP,ATP carrier protein 1; adenine
                     nucleotide translocator 1; mitochondrial adenine
                     nucleotide translocator; solute carrier family 25
                     (mitochondrial adenine nucleotide translocator) member 4;
                     solute carrier family 25 (mitochondrial carrier; adenine
                     nucleotide translocator), member 4"
                     /codon_start=1
                     /product="ADP/ATP translocase 1"
                     /protein_id="NP_445967.2"
                     /db_xref="GeneID:85333"
                     /db_xref="RGD:620352"
                     /translation="MGDQALSFLKDFLAGGIAAAVSKTAVAPIERVKLLLQVQHASKQ
                     ISAEKQYKGIIDCVVRIPKEQGFLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGG
                     VDRHKQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKGSSQREFNGLGDC
                     LTKIFKSDGLKGLYQGFSVSVQGIIIYRAAYFGVYDTAKGMLPDPKNVHIIVSWMIAQ
                     SVTAVAGLVSYPFDTVRRRMMMQSGRKGADIMYTGTVDCWRKIAKDEGAKAFFKGAWS
                     NVLRGMGGAFVLVLYDEIKKYV"
     exon            221..707
                     /gene="Slc25a4"
                     /gene_synonym="Ant1"
                     /inference="alignment:Splign:2.1.0"
     exon            708..848
                     /gene="Slc25a4"
                     /gene_synonym="Ant1"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1290
                     /gene="Slc25a4"
                     /gene_synonym="Ant1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggtcccttc gcgtcgtgca gggacggaga ccgggtggcg gtgcctggcc gggcgtaggc
       61 aagagcaaaa gagcggctcc ttgcagactg tgcgcgcccg gctttcagca tgggggatca
      121 ggctttgagc ttccttaagg acttcctggc aggtggcatc gccgccgccg tctccaagac
      181 cgcggtcgcc ccgatcgaga gggtcaaact gctgctgcag gtccagcatg ccagcaaaca
      241 gatcagtgca gagaaacagt acaaaggcat cattgattgt gtcgtgagaa tccccaagga
      301 gcagggcttt ctctccttct ggaggggtaa cctggccaac gtgatccggt acttccccac
      361 ccaagctctc aacttcgcct tcaaggacaa gtacaagcag atcttcctgg gaggtgtgga
      421 tcgtcataag cagttctggc gctacttcgc tggtaacctg gcctctggtg gggcagctgg
      481 ggctacctcc ctctgcttcg tctacccact ggactttgct aggaccaggc tggctgccga
      541 cgtgggcaag ggatcttccc agcgtgagtt caatgggctg ggtgactgtc tcaccaagat
      601 cttcaagtct gatggcctga agggtctcta ccagggtttc agtgtctctg tgcagggcat
      661 catcatctac agagctgcct acttcggagt ctatgacact gccaagggga tgctgccaga
      721 ccccaagaat gtgcacatta ttgtgagctg gatgattgcc cagagtgtga cagccgtggc
      781 ggggctggtg tcctatccat ttgacactgt ccgtcgtagg atgatgatgc agtctggccg
      841 gaaaggggct gatattatgt acacggggac agttgactgc tggaggaaga ttgcaaaaga
      901 tgaaggagcc aaagctttct tcaaaggtgc ttggtccaac gtactgagag gcatgggggg
      961 tgcttttgta ttggtattgt atgatgagat caaaaaatat gtgtaatgct caagttcaca
     1021 ggttcacaga tccattgtgt ggtttaacag actattctta aggaaataaa aaaagacaga
     1081 tcatggataa aaccagacca taaggaatac ctcagaaaaa tgcttcattg agtattcatt
     1141 taaccacaaa agtattttgt atttatttta catttagatt cccacagcaa acagaagata
     1201 gcttatcata cttgttcaat taattaactg aagaactgat gctgaataag taactcaatg
     1261 tgactcatta ataaagacta ctcagtacac
//
