LOCUS       NM_139100               1388 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus solute carrier family 25 member 3 (Slc25a3),
            transcript variant 2, mRNA.
ACCESSION   NM_139100
VERSION     NM_139100.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1388)
  AUTHORS   Ahmed,S.M., Theriault,B.L., Uppalapati,M., Chiu,C.W., Gallie,B.L.,
            Sidhu,S.S. and Angers,S.
  TITLE     KIF14 negatively regulates Rap1a-Radil signaling during breast
            cancer progression
  JOURNAL   J Cell Biol 199 (6), 951-967 (2012)
   PUBMED   23209302
REFERENCE   2  (bases 1 to 1388)
  AUTHORS   Nishi,Y., Fujimoto,S., Sasaki,M., Mukai,E., Sato,H., Sato,Y.,
            Tahara,Y., Nakamura,Y. and Inagaki,N.
  TITLE     Role of mitochondrial phosphate carrier in metabolism-secretion
            coupling in rat insulinoma cell line INS-1
  JOURNAL   Biochem J 435 (2), 421-430 (2011)
   PUBMED   21265734
  REMARK    GeneRIF: The Pi supply to mitochondria via PiC plays a critical
            role in ATP production and metabolism-secretion coupling in INS-1
            cells.
REFERENCE   3  (bases 1 to 1388)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 1388)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 1388)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
REFERENCE   6  (bases 1 to 1388)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 1388)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   8  (bases 1 to 1388)
  AUTHORS   Pratt,R.D., Ferreira,G.C. and Pedersen,P.L.
  TITLE     Mitochondrial phosphate transport. Import of the H+/Pi symporter
            and role of the presequence
  JOURNAL   J Biol Chem 266 (2), 1276-1280 (1991)
   PUBMED   1985946
REFERENCE   9  (bases 1 to 1388)
  AUTHORS   Ferreira,G.C., Pratt,R.D. and Pedersen,P.L.
  TITLE     Mitochondrial proton/phosphate transporter. An antibody directed
            against the COOH terminus and proteolytic cleavage experiments
            provides new insights about its membrane topology
  JOURNAL   J Biol Chem 265 (34), 21202-21206 (1990)
   PUBMED   2250020
REFERENCE   10 (bases 1 to 1388)
  AUTHORS   Ferreira,G.C., Pratt,R.D. and Pedersen,P.L.
  TITLE     Energy-linked anion transport. Cloning, sequencing, and
            characterization of a full length cDNA encoding the rat liver
            mitochondrial proton/phosphate symporter
  JOURNAL   J Biol Chem 264 (26), 15628-15633 (1989)
   PUBMED   2670944
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB577607.1 and BC070918.1.
            
            On Aug 1, 2012 this sequence version replaced NM_139100.1.
            
            Transcript Variant: This variant (2) has an alternate in-frame exon
            in place of an internal exon compared to variant 1. The resulting
            isoform (2) has the same N- and C-termini but is slightly shorter
            and has internal aa differences compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ229113.1, FQ210190.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-629               CB577607.1         1-629
            630-1388            BC070918.1         572-1330
FEATURES             Location/Qualifiers
     source          1..1388
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..1388
                     /gene="Slc25a3"
                     /gene_synonym="Phc"
                     /note="solute carrier family 25 member 3"
                     /db_xref="GeneID:245959"
                     /db_xref="RGD:70986"
     exon            1..98
                     /gene="Slc25a3"
                     /gene_synonym="Phc"
                     /inference="alignment:Splign:2.1.0"
     exon            99..244
                     /gene="Slc25a3"
                     /gene_synonym="Phc"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1173
                     /gene="Slc25a3"
                     /gene_synonym="Phc"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; solute carrier family 25 (mitochondrial
                     carrier; adenine nucleotide translocator), member 3;
                     phosphate carrier protein, mitochondrial; PTP; phosphate
                     transport protein; solute carrier family 25 (mitochondrial
                     carrier, phosphate carrier), member 3"
                     /codon_start=1
                     /product="solute carrier family 25 member 3 isoform 2
                     precursor"
                     /protein_id="NP_620800.2"
                     /db_xref="GeneID:245959"
                     /db_xref="RGD:70986"
                     /translation="MFSSVAHLARANPFNAPHLQLVHDVSGPRSPPGPPRRSRHLAAA
                     AVEEYSCEFGSMKYYALCGFGGVLSCGLTHTAVVPLDLVKCRMQVDPQKYKGIFNGFS
                     ITLKEDGVRGLAKGWAPTLIGYSMQGLCKFGFYEVFKALYSNILGEENTYLWRTSLYL
                     AASASAEFFADIALAPMEAAKVRIQTQPGYANTLREAVPKMYKEEGLNAFYKGVAPLW
                     MRQIPYTMMKFACFERTVEALYKFVVPKPRSECTKAEQLVVTFVAGYIAGVFCAIVSH
                     PADSVVSVLNKEKGSTASQVLQRLGFRGVWKGLFARIIMIGTLTALQWFIYDSVKVYF
                     RLPRPPPPEMPESLKKKLGLTE"
     exon            245..366
                     /gene="Slc25a3"
                     /gene_synonym="Phc"
                     /inference="alignment:Splign:2.1.0"
     exon            367..546
                     /gene="Slc25a3"
                     /gene_synonym="Phc"
                     /inference="alignment:Splign:2.1.0"
     exon            547..728
                     /gene="Slc25a3"
                     /gene_synonym="Phc"
                     /inference="alignment:Splign:2.1.0"
     exon            729..901
                     /gene="Slc25a3"
                     /gene_synonym="Phc"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1012
                     /gene="Slc25a3"
                     /gene_synonym="Phc"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1348
                     /gene="Slc25a3"
                     /gene_synonym="Phc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgctgcgcg aagggcacgg atcttcgggc ggggaggaca ttcggcctct gtgagccgca
       61 accttgccca gcgagcggtt gggtgttcgc catcttagga ggatgttctc gtccgtagcg
      121 cacctggcgc gggcgaaccc cttcaacgcg ccacatctgc agctggtgca cgatgtgtcg
      181 ggtccccgca gccccccagg tccgccccgg cgttcccgcc acctggctgc cgccgccgtg
      241 gaagagtaca gttgtgaatt tggctccatg aagtattatg cactgtgtgg ctttggtggg
      301 gtcttaagtt gtgggctgac acacactgct gttgttcctc tggatttagt aaaatgccgc
      361 atgcaggtgg accctcagaa gtacaagggc atatttaatg gtttctccat tacattgaaa
      421 gaagatggcg ttcgtggttt ggctaaagga tgggccccaa ctttgattgg ctattccatg
      481 caagggctct gcaaattcgg cttttatgaa gtcttcaaag ccttatatag caacatactt
      541 ggtgaggaga acacctatct gtggcgtaca tcactgtatc tagctgcttc tgccagtgct
      601 gagttctttg ctgacattgc cctggctcct atggaagctg ctaaagttcg aattcaaacc
      661 cagcctggct atgccaacac actgagggaa gctgtcccca aaatgtataa agaagaaggc
      721 ttaaatgcgt tctacaaggg tgttgctcct ctgtggatga gacagatccc atacaccatg
      781 atgaagttcg cctgctttga acggactgtt gaagctttgt acaaatttgt ggttcctaag
      841 ccccgaagtg aatgtacaaa ggcagagcag ctggttgtga catttgtggc aggttacata
      901 gccggagtct tttgtgcgat tgtctctcac cctgctgact ctgtggtctc tgtgctgaat
      961 aaagagaaag gcagcactgc ctctcaggtc ctgcagaggc ttggctttag aggtgtatgg
     1021 aaggggctct tcgcccgaat catcatgatt ggcactctga cggcactgca gtggttcatc
     1081 tatgactctg tgaaggtcta cttcaggctc cctcgccctc ctccacctga gatgccagag
     1141 tctctgaaga agaagcttgg gttaactgag tagatataca tcaaagtaac atggactgaa
     1201 tctgcttgtt gatcagtgtt gaaagtgcaa aggaactttt atatatttga caatgtagga
     1261 aatgtctgtt cctgatacaa ttactgtagt acccttgctt aaagcaagag tttcaaactt
     1321 actgctaaat aaacccatct attcatgaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1381 aaaaaaaa
//
