LOCUS       NM_053500               2670 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus solute carrier family 25, member 27 (Slc25a27),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_053500
VERSION     NM_053500.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2670)
  AUTHORS   Huang,Z., Li,J., Du,S., Chen,G., Qi,Y., Huang,L., Xiao,L. and
            Tong,P.
  TITLE     Effects of UCP4 on the Proliferation and Apoptosis of Chondrocytes:
            Its Possible Involvement and Regulation in Osteoarthritis
  JOURNAL   PLoS One 11 (3), e0150684 (2016)
   PUBMED   26934480
  REMARK    GeneRIF: Silencing of UCP4 in primary chondrocytes significantly
            inhibited cell survival, but induced reactive oxygen species
            production and cell apoptosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2670)
  AUTHORS   Graw,J.A., von Haefen,C., Poyraz,D., Mobius,N., Sifringer,M. and
            Spies,C.D.
  TITLE     Chronic alcohol consumption increases the expression of uncoupling
            protein-2 and -4 in the brain
  JOURNAL   Alcohol Clin Exp Res 37 (10), 1650-1656 (2013)
   PUBMED   23800309
  REMARK    GeneRIF: A compensatory effect was found for UCP-4 (and UCP-2) in
            the brain during chronic alcohol consumption.
REFERENCE   3  (bases 1 to 2670)
  AUTHORS   Xu,Y., Liu,Y., Xia,C., Gao,P. and Liu,J.Z.
  TITLE     Evidence for involvement of uncoupling proteins in cerebral
            mitochondrial oxidative phosphorylation deficiency of rats exposed
            to 5,000 m high altitude
  JOURNAL   Neurochem Res 38 (2), 282-289 (2013)
   PUBMED   23266757
  REMARK    GeneRIF: After high altitude exposure, UCP-4 mRNA abundance is
            2.9-fold compared with the control; UCP-5 mRNA abundance is
            2.3-fold compared with the control.
REFERENCE   4  (bases 1 to 2670)
  AUTHORS   Smorodchenko,A., Rupprecht,A., Fuchs,J., Gross,J. and Pohl,E.E.
  TITLE     Role of mitochondrial uncoupling protein 4 in rat inner ear
  JOURNAL   Mol Cell Neurosci 47 (4), 244-253 (2011)
   PUBMED   21397696
  REMARK    GeneRIF: Data demonstrate that UCP4 expression is differently
            regulated during postnatal stages and is region-specific, and may
            play an important role in functional maturation of the rat inner
            ear.
REFERENCE   5  (bases 1 to 2670)
  AUTHORS   Gao,C.L., Ni,Y.H., Liu,G., Chen,X.H., Ji,C.B., Qin,D.N., Kou,C.Z.,
            Zhu,C., Zhang,C.M., Xia,Z.K. and Guo,X.R.
  TITLE     UCP4 overexpression improves fatty acid oxidation and insulin
            sensitivity in L6 myocytes
  JOURNAL   J Bioenerg Biomembr 43 (2), 109-118 (2011)
   PUBMED   21607879
  REMARK    GeneRIF: UCP4 overexpression reduced the insulin sensitivity and
            mitochondrial fatty acid oxidation of L6 myocytes.
REFERENCE   6  (bases 1 to 2670)
  AUTHORS   Zhang,M., Wang,B., Ni,Y.H., Liu,F., Fei,L., Pan,X.Q., Guo,M.,
            Chen,R.H. and Guo,X.R.
  TITLE     Overexpression of uncoupling protein 4 promotes proliferation and
            inhibits apoptosis and differentiation of preadipocytes
  JOURNAL   Life Sci 79 (15), 1428-1435 (2006)
   PUBMED   16716360
REFERENCE   7  (bases 1 to 2670)
  AUTHORS   Kitahara,T., Li,H.S. and Balaban,C.D.
  TITLE     Localization of the mitochondrial uncoupling protein family in the
            rat inner ear
  JOURNAL   Hear Res 196 (1-2), 39-48 (2004)
   PUBMED   15464300
  REMARK    GeneRIF: Mitochondrial UCPs (UCP2, UCP3, UCP4) may play both a
            protective role against oxidative damage and a thermal signaling
            role in the eighth nerve.
REFERENCE   8  (bases 1 to 2670)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 2670)
  AUTHORS   Stuart,J.A., Cadenas,S., Jekabsons,M.B., Roussel,D. and Brand,M.D.
  TITLE     Mitochondrial proton leak and the uncoupling protein 1 homologues
  JOURNAL   Biochim Biophys Acta 1504 (1), 144-158 (2001)
   PUBMED   11239491
  REMARK    Review article
REFERENCE   10 (bases 1 to 2670)
  AUTHORS   Mao,W., Yu,X.X., Zhong,A., Li,W., Brush,J., Sherwood,S.W.,
            Adams,S.H. and Pan,G.
  TITLE     UCP4, a novel brain-specific mitochondrial protein that reduces
            membrane potential in mammalian cells
  JOURNAL   FEBS Lett 443 (3), 326-330 (1999)
   PUBMED   10025957
  REMARK    Erratum:[FEBS Lett 1999 Apr 23;449(2-3):293]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053500.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ300162.1, SRR26643298.48033.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               JAXUCZ010000009.1  24804308-24804453
            147-338             JAXUCZ010000009.1  24807475-24807666
            339-423             JAXUCZ010000009.1  24810088-24810172
            424-546             JAXUCZ010000009.1  24814242-24814364
            547-659             JAXUCZ010000009.1  24818351-24818463
            660-744             JAXUCZ010000009.1  24822185-24822269
            745-837             JAXUCZ010000009.1  24824036-24824128
            838-940             JAXUCZ010000009.1  24824698-24824800
            941-2670            JAXUCZ010000009.1  24828288-24830017
FEATURES             Location/Qualifiers
     source          1..2670
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q13"
     gene            1..2670
                     /gene="Slc25a27"
                     /gene_synonym="Ucp4"
                     /note="solute carrier family 25, member 27"
                     /db_xref="GeneID:85262"
                     /db_xref="RGD:620787"
     exon            1..146
                     /gene="Slc25a27"
                     /gene_synonym="Ucp4"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1012
                     /gene="Slc25a27"
                     /gene_synonym="Ucp4"
                     /note="uncoupling protein UCP-4"
                     /codon_start=1
                     /product="mitochondrial uncoupling protein 4"
                     /protein_id="NP_445952.1"
                     /db_xref="GeneID:85262"
                     /db_xref="RGD:620787"
                     /translation="MPFPEEESLQPLTQRWPRTSKFLLSGCAATVAELATFPLDLTKT
                     RLQMQGEAALAKLGDGAMESAPYRGMMRTALGIVQEEGFLKLWQGVTPAIYRHVVYSG
                     GRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKR
                     RLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWIPNIQRAALVNMGDLTTYDTVKHYLV
                     LNTALEDNIATHGLSSLCSGLVASILGTPADVIKSRIMNQPRDKQGRGLLYKSSTDCV
                     IQAVQGEGFLSLYKGFLPSWLRMTPWSMVFWLTYEKIRQLSGVSPF"
     exon            147..338
                     /gene="Slc25a27"
                     /gene_synonym="Ucp4"
                     /inference="alignment:Splign:2.1.0"
     exon            339..423
                     /gene="Slc25a27"
                     /gene_synonym="Ucp4"
                     /inference="alignment:Splign:2.1.0"
     exon            424..546
                     /gene="Slc25a27"
                     /gene_synonym="Ucp4"
                     /inference="alignment:Splign:2.1.0"
     exon            547..659
                     /gene="Slc25a27"
                     /gene_synonym="Ucp4"
                     /inference="alignment:Splign:2.1.0"
     exon            660..744
                     /gene="Slc25a27"
                     /gene_synonym="Ucp4"
                     /inference="alignment:Splign:2.1.0"
     exon            745..837
                     /gene="Slc25a27"
                     /gene_synonym="Ucp4"
                     /inference="alignment:Splign:2.1.0"
     exon            838..940
                     /gene="Slc25a27"
                     /gene_synonym="Ucp4"
                     /inference="alignment:Splign:2.1.0"
     exon            941..2670
                     /gene="Slc25a27"
                     /gene_synonym="Ucp4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccaggcgac tagcggtgcc cactggtcct gacctgctgc tgaatgcctt tccctgagga
       61 ggagtcgcta cagccactca cgcagagatg gccccggacc agcaagttcc tactgtccgg
      121 ctgcgccgca accgtggccg agctagcaac ctttcccctc gatctcacaa aaacccgact
      181 ccagatgcaa ggagaagctg cccttgctaa gctgggagat ggtgcgatgg aatccgcccc
      241 ttacaggggc atgatgcgca cggccctggg gattgtccag gaggaaggct tcctaaagtt
      301 gtggcaagga gtgacgcccg ccatttacag acacgtagtg tactctggag gtcggatggt
      361 cacctacgaa catctccggg aagttgtgtt tggcaaaagt gaagatgaac attatcccct
      421 ctggaagtcc gtcattggag ggatgatggc tggcgtcatc ggacagtttt tagccaaccc
      481 cactgacctc gtgaaggtcc agatgcaaat ggaagggaaa cgtagactgg aagggaaacc
      541 cttgagattc cggggagtac atcacgcgtt tgcaaaaatc ttagctgaag gaggaatccg
      601 tgggctttgg gcaggctgga tacccaatat tcagagagca gcacttgtga acatgggaga
      661 tttaaccact tacgacacag tgaagcacta cctggtattg aacacagcac ttgaagacaa
      721 tatcgccact cacggcttat ccagtttgtg ttctggactg gtggcttcta ttctgggaac
      781 accagccgat gtcatcaaaa gccgaataat gaaccaacct cgagacaaac aaggaagagg
      841 gcttttgtat aagtcatcaa ctgactgcgt gatccaggct gttcaaggag aaggcttcct
      901 gagcctgtat aaaggctttc taccctcctg gctgagaatg accccttggt caatggtgtt
      961 ctggcttact tatgaaaaaa tcagacagct gagtggagtc agtccattct aagcccctaa
     1021 agctagagtg ctccttgtca ctgagcaaga gcaacacagg cccctatcat ttctacctct
     1081 ttaggaagat actttactcc acagagactg cgatttgcag ggggcaacac tttatccctc
     1141 tctggaaacc ggagttctct ctgactcctc cttttatcta agagcaatct gtctggtcca
     1201 gtctcacgag accaaccact gagacacagc cgaggcgtct gctaaagaag ggaaacccag
     1261 accactttga ccttgggcca ggaggtttgg actctgagcc gctgatctgt gcaggagcat
     1321 ctgccttaga tgagttgcca gagggagcca gcatctgaga cccggataga cgtcagcgat
     1381 gcggaagact gttgcgctta gggaacgttt aacttctgcg ccagtatgta ttgttgcagt
     1441 ctgacaactg cttttcggcc agcagagcgc acgcactgta atcttcaggg aggcaaacga
     1501 gaagtcacga ataaacatct tgaattttcc tagtgctcaa agaagtcgct ttaccttttc
     1561 acgcaaggag gacggaaaga catgagaggc aacttgaagt ggtgttggat ggcagggcga
     1621 gaggctcctc gctgctgggt ctgcttttgc gggtgctctt attggctacc actccttcat
     1681 gcatgctaga gcctagtgat atcctctgat ggccacagtc tgccagcggg agcagaacgc
     1741 ttgctgcgta acccatccca ttacaaccca catttgtccg tagctctgag aagcataacc
     1801 aagggaacca caacatactt gcctgcgatt cagctcccag ggtgtcctta gcaagcacct
     1861 catacagtca cccagctctc cggggatgtt ttgggagcaa actcactccc tcgggtctcc
     1921 atctatatct ctctgttacg gagaggagag ggcagtgaga gctagagagc tcagatgcca
     1981 agccaaaact tccagaagcc cgagtgttaa tcattgtgaa tctaatccat ccctgcctga
     2041 agtatggcaa gagttcacca tccgcgggtc atgataatcc ctccagtctt cgaatcgggt
     2101 ccttttccct ctttctacaa gggtttctcc agagtcacct acacacctgc tcccccagcc
     2161 tcagacacag ggcatttggg gatgaatggc tacagcttga aggtaacgtc tggggctatt
     2221 actagagaaa ctgtgagcac tcgggcccaa ggtggatctg agagccaacc aagtagctgt
     2281 catgatggat agattgctca cttgtgtgta caagcagcat cctcggtgct gcctgaatga
     2341 gcggatggag aatcactgcc attgcaaagg aggaagaagc acacctttaa agacctctcc
     2401 acgtgcggac ccgtctcgct tttctactta ctgaaggtgg agtttgatcc ctgcacctct
     2461 tcgggtttcc cacctgtctg ttgcattcat tgacccgcaa ttgagttgct aaatatatat
     2521 atatatatat atatatgtag cctatattat gtgcttaagt ccccaagtgt tcgctttggg
     2581 gaaattttgg gtttttttct atgttttcta atgtgtatga ctaagtaaca atgaagtcaa
     2641 acaattacat gcaaactcga ctgtgaaaaa
//
