LOCUS       NM_145677               3150 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus solute carrier family 25 member 25 (Slc25a25),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_145677
VERSION     NM_145677.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3150)
  AUTHORS   Amigo,I., Traba,J., Gonzalez-Barroso,M.M., Rueda,C.B.,
            Fernandez,M., Rial,E., Sanchez,A., Satrustegui,J. and Del Arco,A.
  TITLE     Glucagon regulation of oxidative phosphorylation requires an
            increase in matrix adenine nucleotide content through Ca2+
            activation of the mitochondrial ATP-Mg/Pi carrier SCaMC-3
  JOURNAL   J Biol Chem 288 (11), 7791-7802 (2013)
   PUBMED   23344948
REFERENCE   2  (bases 1 to 3150)
  AUTHORS   Tewari,S.G., Dash,R.K., Beard,D.A. and Bazil,J.N.
  TITLE     A biophysical model of the mitochondrial ATP-Mg/P(i) carrier
  JOURNAL   Biophys J 103 (7), 1616-1625 (2012)
   PUBMED   23062354
  REMARK    GeneRIF: a biophysical model of the APC
REFERENCE   3  (bases 1 to 3150)
  AUTHORS   Anunciado-Koza,R.P., Zhang,J., Ukropec,J., Bajpeyi,S., Koza,R.A.,
            Rogers,R.C., Cefalu,W.T., Mynatt,R.L. and Kozak,L.P.
  TITLE     Inactivation of the mitochondrial carrier SLC25A25 (ATP-Mg2+/Pi
            transporter) reduces physical endurance and metabolic efficiency in
            mice
  JOURNAL   J Biol Chem 286 (13), 11659-11671 (2011)
   PUBMED   21296886
REFERENCE   4  (bases 1 to 3150)
  AUTHORS   del Arco,A. and Satrustegui,J.
  TITLE     Identification of a novel human subfamily of mitochondrial carriers
            with calcium-binding domains
  JOURNAL   J Biol Chem 279 (23), 24701-24713 (2004)
   PUBMED   15054102
REFERENCE   5  (bases 1 to 3150)
  AUTHORS   Hagen,T., Lagace,C.J., Modica-Napolitano,J.S. and Aprille,J.R.
  TITLE     Permeability transition in rat liver mitochondria is modulated by
            the ATP-Mg/Pi carrier
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 285 (2), G274-G281 (2003)
   PUBMED   12851217
  REMARK    GeneRIF: ATP magnesium phosphate carrier, by regulating the matrix
            adenine nucleotide content, can modulate the sensitivity of rat
            liver mitochondria to undergo permeability transition
REFERENCE   6  (bases 1 to 3150)
  AUTHORS   Mashima,H., Ueda,N., Ohno,H., Suzuki,J., Ohnishi,H., Yasuda,H.,
            Tsuchida,T., Kanamaru,C., Makita,N., Iiri,T., Omata,M. and
            Kojima,I.
  TITLE     A novel mitochondrial Ca2+-dependent solute carrier in the liver
            identified by mRNA differential display
  JOURNAL   J Biol Chem 278 (11), 9520-9527 (2003)
   PUBMED   12645546
  REMARK    GeneRIF: may play an important role in regulating the function of
            hepatocytes rather than in differentiation in vivo
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY043169.1.
            
            [WARNING] On Jul 17, 2024 this sequence was replaced by
            NM_145677.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY043169.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3150
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p11"
     gene            1..3150
                     /gene="Slc25a25"
                     /gene_synonym="Mcsc; Pcscl; SCaMC-2"
                     /note="solute carrier family 25 member 25"
                     /db_xref="GeneID:246771"
                     /db_xref="RGD:628666"
     exon            1..259
                     /gene="Slc25a25"
                     /gene_synonym="Mcsc; Pcscl; SCaMC-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1510
                     /gene="Slc25a25"
                     /gene_synonym="Mcsc; Pcscl; SCaMC-2"
                     /note="calcium-binding mitochondrial carrier protein
                     SCaMC-2; ATP-Mg/Pi carrier; mitochondrial ATP-Mg/Pi
                     carrier protein; small calcium-binding mitochondrial
                     carrier protein 2; peroxisomal Ca(2+)-dependent solute
                     carrier-like protein; solute carrier family 25
                     (mitochondrial carrier, phosphate carrier), member 25;
                     peroxisomal Ca-dependent solute carrier-like protein;
                     mitochondrial Ca2+-dependent solute carrier; mitochondrial
                     calcium-dependent solute carrier; short calcium-binding
                     mitochondrial carrier protein 2"
                     /codon_start=1
                     /product="mitochondrial adenyl nucleotide antiporter
                     SLC25A25"
                     /protein_id="NP_663710.1"
                     /db_xref="GeneID:246771"
                     /db_xref="RGD:628666"
                     /translation="MLCLCLYVPIAGEAQTEFQYFESKGLPTELKSIFKLSVFIPSQE
                     FSTYRQWKQKIVQAGDKDLDGQLDFEEFVHYLQDHEKKLRLVFKSLDKKNDGRIDAQE
                     IMQSLRDLGVKISEQQAEKILKSMDKNGTMTIDWNEWRDYHLLHPVENIPEIILYWKH
                     STIFDVGENLTVPDEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHA
                     SRSNNMCIIGGFTQMIREGGAKSLWRGNGINVLKIAPESAIKFMAYEQMKRLVGSDQE
                     TLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCAKRILAKEGVAA
                     FYKGYIPNMLGIIPYAGIDLAVYETLKNTWLQRYAVNSADPGVFVLLACGTISSTCGQ
                     LASYPLALVRTRMQAQASIEGAPEVTMSSLFKQILRTEGAFGLYRGLAPNFMKVIPAV
                     SISYVVYENLKITLGVQSR"
     exon            260..386
                     /gene="Slc25a25"
                     /gene_synonym="Mcsc; Pcscl; SCaMC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            387..474
                     /gene="Slc25a25"
                     /gene_synonym="Mcsc; Pcscl; SCaMC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            475..586
                     /gene="Slc25a25"
                     /gene_synonym="Mcsc; Pcscl; SCaMC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            587..745
                     /gene="Slc25a25"
                     /gene_synonym="Mcsc; Pcscl; SCaMC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            746..898
                     /gene="Slc25a25"
                     /gene_synonym="Mcsc; Pcscl; SCaMC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1006
                     /gene="Slc25a25"
                     /gene_synonym="Mcsc; Pcscl; SCaMC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1174
                     /gene="Slc25a25"
                     /gene_synonym="Mcsc; Pcscl; SCaMC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1325
                     /gene="Slc25a25"
                     /gene_synonym="Mcsc; Pcscl; SCaMC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..3136
                     /gene="Slc25a25"
                     /gene_synonym="Mcsc; Pcscl; SCaMC-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3115..3120
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a25"
                     /gene_synonym="Mcsc; Pcscl; SCaMC-2"
ORIGIN      
        1 ggcatatctt gtgctagttt cccaggaacc cggcattccc tactcttgac ttctgccggc
       61 acttgctcct ggtggtagct gagcaccggg tctcaccagc atgctctgcc tgtgcctgta
      121 tgtgcccatc gctggagagg ctcagactga attccaatac tttgagtcca aggggcttcc
      181 caccgagctg aaatccatct tcaaactcag tgtctttatc ccctctcagg agttctccac
      241 ataccgccaa tggaagcaga aaattgtgca agcaggtgac aaggaccttg atgggcaact
      301 ggacttcgaa gagtttgtac attacctcca agaccatgag aaaaaactga ggctggtgtt
      361 taagagtctg gacaaaaaga atgatgggcg aatcgatgct caggagatca tgcagtccct
      421 gcgggatctg ggtgtcaaga tctctgaaca gcaggcggag aagattctta agagcatgga
      481 taagaatggg acaatgacca tcgactggaa cgagtggagg gactaccacc tcctgcaccc
      541 tgtggagaac atccctgaga tcatcctgta ctggaagcac tcgacgatct tcgatgttgg
      601 tgagaatctg acagtcccag atgagttcac agtggaggag aggcagacag ggatgtggtg
      661 gaggcacctg gtggcaggag gtggtgcagg ggcagtttcc agaacctgca ctgcccccct
      721 ggacagactg aaggtgctca tgcaggtcca tgcctcccgc agcaacaaca tgtgcatcat
      781 aggtggattc acacagatga ttcgagaagg gggcgccaag tccctctgga ggggcaatgg
      841 catcaatgtc ctcaaaattg cccctgagtc agccatcaag ttcatggcat atgagcagat
      901 gaaacgcctt gttggtagtg atcaggagac gctgaggatc cacgaaaggc tagtggcagg
      961 ctccttggct ggggccattg cccagagtag catctaccca atggaggttc tgaagacccg
     1021 aatggccctg cggaaaacag gccagtactc gggaatgctg gactgtgcca agaggatcct
     1081 ggctaaagag ggtgtggctg ccttctataa aggctacatc cccaacatgc tggggatcat
     1141 cccgtatgcg ggcatcgatc tagctgtcta tgagacattg aaaaatacct ggctacagcg
     1201 ctatgctgta aacagtgcag accctggcgt gtttgttctc ctggcctgtg gcacaatctc
     1261 cagtacctgt ggccaactgg ccagctaccc actagccctg gtcaggactc ggatgcaggc
     1321 acaagcctcc attgagggtg cacctgaggt aaccatgagc agcctcttca aacagattct
     1381 gcggactgag ggggcctttg ggctctaccg ggggctggcc cccaacttca tgaaggtgat
     1441 tccagctgtg agcatcagct acgtggtcta cgagaacctg aagatcaccc tgggcgtgca
     1501 gtctcggtga cgggagggtg gcggacttgg tgaccctggg ctgcagccca gggtgtgcag
     1561 ccgcctcatt ctgtgaatgt gccaacacta agctgactta cccaagctgt gaaacccagg
     1621 atgctgcagg ggacgggcag ggagctgcaa gcgctgggct ggtcctgctg acctggcaga
     1681 cctttgtgtc tcttccaagg aagacctgtg gacattcctt ggggtccagg ggtcagtaag
     1741 atgtgggctc ctgcacctag agacaggacg ttttccacag tgcctgccag gtagcgagct
     1801 tggatgccag cttagctctt ccatctcgtc acgcaacctg acctcagcca tggcatccct
     1861 ctggtccaaa gagcattcct gtgcccctca tctcttccca ctgatgcgct ggggtaggaa
     1921 gtgggcccac ccccactctt atccttctgt ccatcttccc tcagtgctgc tcttccaaac
     1981 ctggttccca agctgtagca tccatgagga ctgtggtacg ggaagctgga gaagtaccat
     2041 tatgtcctcg ctcgcctatt ctgagctcac cagcaaggcc acctggatgc gcccaggtcc
     2101 tcaggcaccg gctgcctgac accatggtgc atggctttgc taaaagctag tgctagaacc
     2161 tggaacccag aggatttgtg ctgcctgcat gggcctaatg tcctctgagc tgcccctaaa
     2221 ccctgtcagg actggcacca gctcgtgccc acactcatgg tggttctgtg gtgagagggt
     2281 gggcagggtg tctgctccag gtctgctgct ctggtgagaa gatgctgaag gccttaatta
     2341 tgtcttactg ggtaaaggat ttggttcaga aggacaagct ggacactgca cgtgccacac
     2401 tttcagagag cctgggggaa agtgtgttct gagggccctg tggggccaag ggggaccagc
     2461 ctcacattcc acacgtgtgc cactctgctt ggagcctatt tattttgtat ttatttgaac
     2521 agagttatgt cctaactatt tttatagatt tgtttaatta atagcctgtc attttcaagt
     2581 tcattttttt tattcatatt tatgttcatg gttgattgta ccttcctgtc accagctggt
     2641 ggggcatggg gagacaaggt agaaaagtgg ccacagagtg accttacctg ctgcccacac
     2701 tgacggcatg tccgtctcac aggaaacaga aggaaaggca cagggaggac tcttcaggcc
     2761 aggtagggta gtgggaaagg tggcgacttc ttgacattct ttcctggacc gggaggtttt
     2821 ctttattttg cccttttgga aaacacggca gtgaggtgct tcattcacca ggaatttggt
     2881 gtgagggtga ggactgaagg gcctgccttc cccaacctgt gacctggtct cgctcctggc
     2941 ccgagactgc ccatgctcaa tgagtggcca gctggccact tggcaatcat gcctccattg
     3001 ccccagaatg gcctgatgag gaaaatccaa ataggatgca aagatcaatg caaaagtcac
     3061 cagtctgcat agtctgtgct gtaactggag tttgtcaaag acgagcaacc ttctaataaa
     3121 gtcgcttcaa atgtgaaaaa aaaaaaaaaa
//
