LOCUS       NM_001127544            3433 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 25 member 24 (Slc25a24),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001127544 XM_001072301 XM_227597
VERSION     NM_001127544.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3433)
  AUTHORS   Ehmke,N., Graul-Neumann,L., Smorag,L., Koenig,R., Segebrecht,L.,
            Magoulas,P., Scaglia,F., Kilic,E., Hennig,A.F., Adolphs,N.,
            Saha,N., Fauler,B., Kalscheuer,V.M., Hennig,F., Altmuller,J.,
            Netzer,C., Thiele,H., Nurnberg,P., Yigit,G., Jager,M., Hecht,J.,
            Kruger,U., Mielke,T., Krawitz,P.M., Horn,D., Schuelke,M.,
            Mundlos,S., Bacino,C.A., Bonnen,P.E., Wollnik,B.,
            Fischer-Zirnsak,B. and Kornak,U.
  TITLE     De Novo Mutations in SLC25A24 Cause a Craniosynostosis Syndrome
            with Hypertrichosis, Progeroid Appearance, and Mitochondrial
            Dysfunction
  JOURNAL   Am J Hum Genet 101 (5), 833-843 (2017)
   PUBMED   29100093
REFERENCE   2  (bases 1 to 3433)
  AUTHORS   Yang,Q., Bruschweiler,S. and Chou,J.J.
  TITLE     A self-sequestered calmodulin-like Ca(2) sensor of mitochondrial
            SCaMC carrier and its implication to Ca(2)-dependent ATP-Mg/P(i)
            transport
  JOURNAL   Structure 22 (2), 209-217 (2014)
   PUBMED   24332718
REFERENCE   3  (bases 1 to 3433)
  AUTHORS   Amigo,I., Traba,J., Gonzalez-Barroso,M.M., Rueda,C.B.,
            Fernandez,M., Rial,E., Sanchez,A., Satrustegui,J. and Del Arco,A.
  TITLE     Glucagon regulation of oxidative phosphorylation requires an
            increase in matrix adenine nucleotide content through Ca2+
            activation of the mitochondrial ATP-Mg/Pi carrier SCaMC-3
  JOURNAL   J Biol Chem 288 (11), 7791-7802 (2013)
   PUBMED   23344948
REFERENCE   4  (bases 1 to 3433)
  AUTHORS   Traba,J., Del Arco,A., Duchen,M.R., Szabadkai,G. and Satrustegui,J.
  TITLE     SCaMC-1 promotes cancer cell survival by desensitizing
            mitochondrial permeability transition via ATP/ADP-mediated matrix
            Ca(2+) buffering
  JOURNAL   Cell Death Differ 19 (4), 650-660 (2012)
   PUBMED   22015608
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473952.1.
            
            On or before May 23, 2008 this sequence version replaced
            XM_001072301.1, XM_227597.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ221591.1, BC162022.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3433
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q41"
     gene            1..3433
                     /gene="Slc25a24"
                     /note="solute carrier family 25 member 24"
                     /db_xref="GeneID:310791"
                     /db_xref="RGD:1311982"
     exon            1..247
                     /gene="Slc25a24"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1492
                     /gene="Slc25a24"
                     /note="solute carrier family 25 (mitochondrial carrier,
                     phosphate carrier), member 24"
                     /codon_start=1
                     /product="calcium-binding mitochondrial carrier protein
                     SCaMC-1"
                     /protein_id="NP_001121016.1"
                     /db_xref="GeneID:310791"
                     /db_xref="RGD:1311982"
                     /translation="MLRWLRAFVLPTAVCQDAEPPTRYETLFRALDRNGDGVVDIGEL
                     QQGLQSLGIPLGQAAEEKIFTTGDVNKDGKLDFEEFMKYLKDHEKKMKLAFKSLDKNN
                     DGKIEPFEIVQSLQMLGLNISEKQAELILQSIDSDGTMTVDWNEWRDYFLFNPVTDIE
                     EIIRFWKHSTGIDIGDSLTIPDEFTEDEKKSGQWWRQLLAGGVAGAVSRTSTAPLDRL
                     KVMMQVHGSKSMNIFGGFRQMVKEGGIRSLWRGNGINVIKIAPETAVKFWAYEQYKKL
                     LTEEGQKLGTSERFISGSMAGATAQTFIYPMEVLKTRLAVAKTGQYSGIYGCAKKILK
                     HEGFRAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVVVLLGCGAL
                     SSTCGQLASYPLALVRTRMQAQATTEGAPQLSMVGLFQRIVSKEGVSGLYRGITPNFM
                     KVLPAVGISYVVYENMKQTLGVAQK"
     exon            248..374
                     /gene="Slc25a24"
                     /inference="alignment:Splign:2.1.0"
     exon            375..462
                     /gene="Slc25a24"
                     /inference="alignment:Splign:2.1.0"
     exon            463..574
                     /gene="Slc25a24"
                     /inference="alignment:Splign:2.1.0"
     exon            575..733
                     /gene="Slc25a24"
                     /inference="alignment:Splign:2.1.0"
     exon            734..880
                     /gene="Slc25a24"
                     /inference="alignment:Splign:2.1.0"
     exon            881..988
                     /gene="Slc25a24"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1156
                     /gene="Slc25a24"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1307
                     /gene="Slc25a24"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..3433
                     /gene="Slc25a24"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcactccacc aggcctcagc actcggatcc tgcctcgcca gctcgccgcg aattcccccc
       61 gaccatgctg cgctggctgc gggccttcgt gctgcccacc gccgtctgcc aggacgcgga
      121 gccgcccacg cgctacgaga cgctcttccg ggcgctggac cgcaatgggg acggcgtggt
      181 ggatatcgga gagctgcagc aggggctgca gagcctgggc atcccgctgg gccaggccgc
      241 cgaggagaaa attttcacca ctggcgatgt caacaaagat gggaaactgg attttgaaga
      301 atttatgaaa tacctgaaag accatgagaa gaaaatgaaa ttagcattta aaagtctgga
      361 caagaataat gacgggaaaa tcgagccttt tgaaatcgtc cagtctctcc agatgctggg
      421 cttaaatatt tctgaaaagc aagcagagct gattcttcaa agcatcgact ctgacgggac
      481 catgaccgtg gactggaatg aatggaggga ttactttttg tttaaccctg tgacagacat
      541 tgaggaaatt attcgtttct ggaaacactc tactggaatt gacataggcg atagtttaac
      601 tattccggat gaattcacag aagatgagaa aaaatcagga cagtggtgga ggcagctcct
      661 ggcaggaggt gtggctggcg ctgtctccag gacaagcacc gctcctttgg atcgcctaaa
      721 ggtcatgatg caggttcacg gttccaaatc aatgaacata tttggaggct ttcggcagat
      781 ggtaaaggaa ggaggaatcc gttctctttg gagaggaaat ggcatcaatg tcattaaaat
      841 agctccagag acagccgtta agttctgggc gtatgaacag tataagaaac tgcttaccga
      901 ggaaggacaa aaattaggga cctctgagag gttcatttct ggttccatgg ctggagcaac
      961 tgcacagacc tttatttatc ccatggaggt tttgaaaacc cggctagctg tagccaaaac
     1021 tggacaatac tctggaatat atggttgtgc caagaagatt ttgaaacatg aaggctttag
     1081 agccttttac aaaggctatg ttcccaattt actaggtatc attccttacg caggcattga
     1141 tctcgccgtg tacgagcttt tgaagtcgta ttggctggat aactttgcaa aagactctgt
     1201 caaccctggt gtggtggtgc tgctgggctg cggagccctg tccagcacct gtgggcagct
     1261 ggccagctat cctctggctc tggtgaggac tcgcatgcag gcacaagcca ccacagaggg
     1321 agccccacag ctcagcatgg ttggcctttt tcagcgaata gtctccaagg aaggagtgtc
     1381 aggactttac agaggcatca ccccaaactt catgaaggtg ctccctgccg tgggcatcag
     1441 ctatgtggtg tatgaaaaca tgaagcagac gctaggagta gctcagaagt gagcggtccc
     1501 agcctttgct tttccacgat gaccgaggct gtagtgcccc ccagtgactc ctgggattgc
     1561 agcaagtcta tcacaaaaga agctgatttc cccaccaaag ggaagagtgt agggtgatcg
     1621 cctcaagcct ttgggttcag ttttgtacct tcagtaatgt tctgaatcat agttttagtg
     1681 aagaaaccac aaaattgtac tttatttttg ctgatagaga tctctgccct gcaccaaatc
     1741 tgaaaatgca ctggcttacg ctgaaatcat tttgcgtggt aggacaataa atcatcaacc
     1801 tttgttccca ttggttccag ttcatatcga tttgttttta cacaaatttt taaaaaatcc
     1861 aaaatgatca gaaagccctg ggacttaaat tgtttttttt tttatatata tatattttgg
     1921 atgtctttgt agatgtaatg accccaacgg agacattagt agaaaaatca ctatatttaa
     1981 aatcgagcgt gcagagttta tctccttgtc tgtaagcaga ataggagtta tagaagccac
     2041 attcagtgac aggagcggtg ctgtcatgtg catttcagtg gacatgcttc tatttgccct
     2101 gctgtttggc ccccagtttt agaccttgat tgacattgtt gtcacattat tgacaggaga
     2161 caggtcattt gggagatcct atttatttga agatcctatt tattcggtca ttgctttgaa
     2221 acgcatcatt gatcaaaacc gtgacttgta ccatgtccca gagagcatct tggttttgtt
     2281 cattttttat gagtttaatc aaattttctt aatcaggaag gctccttggg accttcatag
     2341 taagctgaag ctgctcttct cctcacctga gtgttgattt caggtcaatg gccggcaccc
     2401 tcacttccct cttactgttg aagtctctga acctgtggtt ctcaaatgga gcggcgcaaa
     2461 gctaaggcac cagcgcattt cagtagcagg atatatccat cttacgtgtt ttaatgaaag
     2521 gtgcagtctg tggtcatatg cgtctacatg ttcacttgcc tcaacattga ggaaggtgac
     2581 agaaaatttg taacatgtaa aagcattcaa ttttttaaac taaagctgat tttttagtca
     2641 gttatctttt atgatttgtt ttaaaactta gaagaaaaat cttatttctt ctataagaag
     2701 ataatcttag cccagcagga ttggcacatg cctgtagtcc tagcactcag gaggcagagg
     2761 caggcggatc tctgagttca aggtcagcct ggtggagagt tccagggcag ccagggctac
     2821 accgagaaac cctgtctcca aaacaaaaac gaaaacaaat aaacaaatga agatatttta
     2881 acattttaag atttagtcca tgttctcatt tgatttctgg taatttctgt acggttgctt
     2941 tctgaaaact gtagtagaaa tctttgcctt taacctacct acctacctct tttatttttt
     3001 gaaccaaaga gaaagatggc cttgtgttca tgaagttatt ctaaaacata gcttgatttg
     3061 tagtacggat gcctgctagt gtcttggtat ttttgtactt tataaggaaa ggaagggact
     3121 ctattgtact ttggagtaat acatagaagg acagatgtag gtacatgatt cactcctttt
     3181 ttacttgtaa caattatgaa aatgcacaat tctgttaatg tctttggaat tttaagctgg
     3241 taaaaactat gaaaatagcc atacttcatt atgaaattaa attgcccccc cagcatacat
     3301 gtgtaaggta tgactggttc gttcatctgt acatcttgta tcttttggga gaaaaaactg
     3361 tcctgttgat cacagcttat tctgatattg ctacacagtt actgctcatt tgtattaaag
     3421 atatttgtct gtt
//
