LOCUS       NM_001007674            1496 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Rattus norvegicus solute carrier family 25 member 19 (Slc25a19),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001007674 XM_221118
VERSION     NM_001007674.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1496)
  AUTHORS   Ramamoorthy,K., Sabui,S., Manzon,K.I., Balamurugan,A.N. and
            Said,H.M.
  TITLE     miR-122-5p is involved in posttranscriptional regulation of the
            mitochondrial thiamin pyrophosphate transporter (SLC25A19) in
            pancreatic acinar cells
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 325 (4), G347-G355 (2023)
   PUBMED   37529835
  REMARK    GeneRIF: miR-122-5p is involved in posttranscriptional regulation
            of the mitochondrial thiamin pyrophosphate transporter (SLC25A19)
            in pancreatic acinar cells.
REFERENCE   2  (bases 1 to 1496)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   3  (bases 1 to 1496)
  AUTHORS   Lindhurst,M.J., Fiermonte,G., Song,S., Struys,E., De Leonardis,F.,
            Schwartzberg,P.L., Chen,A., Castegna,A., Verhoeven,N.,
            Mathews,C.K., Palmieri,F. and Biesecker,L.G.
  TITLE     Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate
            depletion, embryonic lethality, CNS malformations, and anemia
  JOURNAL   Proc Natl Acad Sci U S A 103 (43), 15927-15932 (2006)
   PUBMED   17035501
  REMARK    GeneRIF: mitochondria of Slc25a19(-/-) and Amish lethal
            microcephaly cells have undetectable and markedly reduced thiamine
            pyrophosphate content, respectively
REFERENCE   4  (bases 1 to 1496)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (bases 1 to 1496)
  AUTHORS   Rosenberg,M.J., Agarwala,R., Bouffard,G., Davis,J., Fiermonte,G.,
            Hilliard,M.S., Koch,T., Kalikin,L.M., Makalowska,I., Morton,D.H.,
            Petty,E.M., Weber,J.L., Palmieri,F., Kelley,R.I., Schaffer,A.A. and
            Biesecker,L.G.
  TITLE     Mutant deoxynucleotide carrier is associated with congenital
            microcephaly
  JOURNAL   Nat Genet 32 (1), 175-179 (2002)
   PUBMED   12185364
REFERENCE   6  (bases 1 to 1496)
  AUTHORS   Iacobazzi,V., Ventura,M., Fiermonte,G., Prezioso,G., Rocchi,M. and
            Palmieri,F.
  TITLE     Genomic organization and mapping of the gene (SLC25A19) encoding
            the human mitochondrial deoxynucleotide carrier (DNC)
  JOURNAL   Cytogenet Cell Genet 93 (1-2), 40-42 (2001)
   PUBMED   11474176
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079002.1.
            
            On Nov 29, 2004 this sequence version replaced XM_221118.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079002.1, SRR8487226.104023.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1496
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..1496
                     /gene="Slc25a19"
                     /note="solute carrier family 25 member 19"
                     /db_xref="GeneID:303676"
                     /db_xref="RGD:1359554"
     exon            1..33
                     /gene="Slc25a19"
                     /inference="alignment:Splign:2.1.0"
     exon            34..203
                     /gene="Slc25a19"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1028
                     /gene="Slc25a19"
                     /note="mitochondrial uncoupling protein 1; solute carrier
                     family 25 (mitochondrial deoxynucleotide carrier), member
                     19; solute carrier family 25 (mitochondrial thiamine
                     pyrophosphate carrier), member 19"
                     /codon_start=1
                     /product="mitochondrial thiamine pyrophosphate carrier"
                     /protein_id="NP_001007675.1"
                     /db_xref="GeneID:303676"
                     /db_xref="RGD:1359554"
                     /translation="MVGYDAKADARSNSKLEVAVAGSVSGFVTRALISPLDVIKIRFQ
                     LQLERVCPSDPNAKYHGILQAAKQILQEEGPRAFWKGHVPAQILSIGYGAVQFLAFEE
                     LTELLYQANLYQTHQFSAHFVCGGLSAGTATLTVHPVDVLRTRLAAQGEPKIYSNLRE
                     AIRTMYRTEGPFVFYKGLTPTVIAIFPYAGLQFSCYRSLKRAYDWIMPPDGKQTGNLK
                     NLLCGCGSGVISKTLTYPLDLFKKRLQVRGFEHARSAFGQVRSYRGLLDLAQQVLQHE
                     GTRGFFKGLSPSLMKAALSTGFMFFWYELFCNLFHCIRREDR"
     exon            204..359
                     /gene="Slc25a19"
                     /inference="alignment:Splign:2.1.0"
     exon            360..530
                     /gene="Slc25a19"
                     /inference="alignment:Splign:2.1.0"
     exon            531..714
                     /gene="Slc25a19"
                     /inference="alignment:Splign:2.1.0"
     exon            715..845
                     /gene="Slc25a19"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1475
                     /gene="Slc25a19"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctggaggag tccggccgag cctaaagtat cagcctgata ctcatggacg ttggacagac
       61 cagaggcagg gatggttggc tatgatgcca aagcagatgc caggagtaac tccaagttgg
      121 aggtggcggt ggcgggatca gtgtcaggat ttgtcactcg tgccctgatc agccctttgg
      181 atgtcatcaa gatccgattc cagctccagc ttgaacgcgt gtgtccaagt gaccccaatg
      241 ccaaatacca cggaatcctc caggcggcca agcagattct gcaagaagag ggcccaagag
      301 cattctggaa aggacatgtt ccagcccaga tcctgtccat aggctatgga gccgtccaat
      361 ttttggcctt tgaagaactg actgaactgc tttaccaagc caacttgtat caaacccacc
      421 agttctcagc gcactttgta tgtggtggcc tgtctgccgg tacagccacc ctcaccgtgc
      481 accccgtgga tgtcctgcgc acccgccttg cagctcaggg ggagcccaag atctacagca
      541 atctgagaga ggccatacgc accatgtata ggacggaggg ccctttcgtc ttctacaaag
      601 gcttgactcc cactgtgatc gccatcttcc catacgcggg cttgcagttc tcctgctacc
      661 gttccttgaa acgcgcttat gactggatca tgccgccaga cggaaagcaa acagggaacc
      721 ttaaaaacct gctttgtggc tgtggatctg gagtcatcag caagaccctt acgtatcccc
      781 tggacctctt caagaagcgc ctgcaggtgc ggggctttga acatgcccga tctgcctttg
      841 gccaggttcg gagctacagg ggcctcttgg acctcgccca gcaggtgcta caacatgaag
      901 gcacccgggg cttcttcaag ggcctgtccc ccagtctgat gaaggctgca ctctccactg
      961 gcttcatgtt cttctggtat gagctcttct gtaacctctt ccattgcata aggagggaag
     1021 acagatagct gtgaggcagg aggggcctac ggtctgcact gaaggcccct cccccaacaa
     1081 gacttggctc caagctcata ctgaacaatg gctgctgcct ggttggcctt ctaggccagc
     1141 tgctgtgcgc atgaagagtc atccagagct gaaggcaaaa gaaggcaagg aagggccttt
     1201 gctgaacaga atgaagagag aagggagtgc ttgcactgta gaaagaaggc cgtggggaag
     1261 gagcctggtg cctggtgtgt ctctcctctg accagcctaa cctggaagga actgaccatc
     1321 ttttttgtag tcctggtttt ggggagaaca ctccctagtc ctggtaggac cacactggag
     1381 tgcagacagg tgggatcggg ctttttgcag aattctgacc tccacaactt ggtctgtttc
     1441 tcctgccaac ttatttaata gacattaaag taaaaaaaaa aaaaaaaaaa aaaaaa
//
