LOCUS       NM_001044280            1982 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus solute carrier family 25 member 18 (Slc25a18),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001044280 XM_001058858
VERSION     NM_001044280.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1982)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1982)
  AUTHORS   Casimir,M., Lasorsa,F.M., Rubi,B., Caille,D., Palmieri,F., Meda,P.
            and Maechler,P.
  TITLE     Mitochondrial glutamate carrier GC1 as a newly identified player in
            the control of glucose-stimulated insulin secretion
  JOURNAL   J Biol Chem 284 (37), 25004-25014 (2009)
   PUBMED   19584051
REFERENCE   3  (bases 1 to 1982)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB726923.1, BC094517.1 and BG380364.1.
            
            On Aug 31, 2012 this sequence version replaced NM_001044280.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094517.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                CB726923.1         2-56
            56-1961             BC094517.1         1-1906
            1962-1982           BG380364.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..1982
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1982
                     /gene="Slc25a18"
                     /note="solute carrier family 25 member 18"
                     /db_xref="GeneID:681896"
                     /db_xref="RGD:1590470"
     exon            1..225
                     /gene="Slc25a18"
                     /inference="alignment:Splign:2.1.0"
     exon            226..308
                     /gene="Slc25a18"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..1236
                     /gene="Slc25a18"
                     /note="glutamate carrier 2, mitochondrial; GC-2;
                     glutamate/H(+) symporter 2; solute carrier family 25
                     (mitochondrial carrier), member 18; solute carrier family
                     25 (glutamate carrier), member 18"
                     /codon_start=1
                     /product="mitochondrial glutamate carrier 2"
                     /protein_id="NP_001037745.2"
                     /db_xref="GeneID:681896"
                     /db_xref="RGD:1590470"
                     /translation="MIACRMSSQDLSITAKLINGGIAGLVGVTCVFPIDLAKTRLQNQ
                     QGKDVYKGMTDCLVKTARAEGFLGMYRGAAVNLTLVTPEKAIKLAANDFLRQLLMQDG
                     TQRNLKMEMLAGCGAGICQVVITCPMEMLKIQLQDAGRLAVCQQASASATPTSRPYST
                     GSTSTHRRPSATLIAWELLRTQGLSGLYRGLGATLLRDIPFSIIYFPLFANLNQLGVS
                     ELTGKASFTHSFVAGCAAGSVSAVAVTPLDVLKTRIQTLKKGLGEDTYRGVTDCARKL
                     WTQEGAAAFMKGAGCRALVIAPLFGIAQGVYFIGIGERILKCFE"
     exon            309..431
                     /gene="Slc25a18"
                     /inference="alignment:Splign:2.1.0"
     exon            432..487
                     /gene="Slc25a18"
                     /inference="alignment:Splign:2.1.0"
     exon            488..578
                     /gene="Slc25a18"
                     /inference="alignment:Splign:2.1.0"
     exon            579..697
                     /gene="Slc25a18"
                     /inference="alignment:Splign:2.1.0"
     exon            698..863
                     /gene="Slc25a18"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1018
                     /gene="Slc25a18"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1094
                     /gene="Slc25a18"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1965
                     /gene="Slc25a18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1765..1770
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a18"
     polyA_site      1785
                     /gene="Slc25a18"
     polyA_site      1965
                     /gene="Slc25a18"
ORIGIN      
        1 agaatcctgt cagctcattt ctgaccacat aggaccattc gccctagtct gtccagttaa
       61 agctgggaag agttgtttga agcagtgaag tcagctcctt caccaagagt tttcaccatg
      121 agaaggagtt aagtctttat aggaaggcaa agacaagatc caacacagcc tggcctggag
      181 tataccaaaa actgagatgt ggagtgactc ctaaccacct tgtcacatct gcctgtgaag
      241 gccccacaac ctgtgtcctg ggagctgtcg tggatgatcg cctgcaggat gtccagccag
      301 gacctgagca tcactgcaaa actcatcaat ggaggtatag caggtctcgt gggggtgacc
      361 tgcgtgttcc ccattgacct tgccaaaacc cgactgcaga accagcaagg gaaagatgtg
      421 tacaaaggaa tgacagattg cctggtgaag actgcacgtg ccgagggctt cttgggcatg
      481 taccgagggg ctgcagtgaa cctcaccctg gtcactccag aaaaagcaat caagttggca
      541 gccaatgact tcttgaggca gctgctcatg caagatggga cccagcggaa cctgaagatg
      601 gagatgctgg ccggatgtgg ggctggaata tgccaggtgg tgatcacctg tcccatggaa
      661 atgctcaaga tccagctgca ggatgccggc cgcttagctg tctgtcagca ggcttctgcc
      721 tcagccacgc ccacctcccg gccctacagc actggctcga cttccaccca caggcgccca
      781 tcggccaccc tcattgcctg ggagctgctc cgcactcagg gcctctctgg tctctacagg
      841 ggactgggtg ctactctcct cagagacatt cctttctcca tcatctactt ccctttgttt
      901 gcaaacctga accaacttgg ggtcagcgag ctcactggca aggcctcctt cacacactcc
      961 tttgtggcag gctgtgcagc aggctctgtc tcggccgtag ctgtcacccc tctggatgtt
     1021 ctgaagactc gaatccagac cctcaagaaa ggcctgggtg aggacaccta caggggagtc
     1081 actgactgtg ccaggaaact ctggacccag gagggagcag cagccttcat gaagggagca
     1141 ggctgccgtg ccctggtcat agcccccctc ttcgggattg cccagggtgt ctacttcatc
     1201 ggcattggag agcgcatctt aaagtgcttt gaataattga tgtgttactt cttgctgtca
     1261 cctctggccc tagggaacca ggcggcagtg ctgaagttta ggatgcccac cctgatgtag
     1321 tacatggtct ctaacttgta gtgctacctc agaagaaatg acccatttta ctaagtgagt
     1381 agagccctca tctcccttta taactaagct ttgtggttcg gcctaccagg gatgttcaga
     1441 agccccaacc acctatgtcc agcaatagaa ttggccttgt gtattatggc aggaccgtgt
     1501 acagtaagac agaagggctg ttccacccta acattcccac cgtaggcgag tgcagcacag
     1561 acccgtcctg tgagggttta ctgttaatgc tagccctgat gctgtaacag gtcagaagtg
     1621 tccctgggct gactgtgcac cctcccgagc atcacccata gtgaggcgag cctgaatgag
     1681 cacttggcag ctgtcctgcc agattcccat cctgaagtac gggcccagat ccctccgaat
     1741 ggatgcttgt gcaacatgct ctgaaataaa gctggttaaa tccttgtcct gtgatcagca
     1801 cagcagtgag cacaacacag agtgacattc tgcagaacca agctgtagct tctagggccc
     1861 cgcagtccac actatcttcc cactgctgct caagagtgag agtggttggg ggccaatttt
     1921 acactggagt ttggcttttt taaaaaataa ttatgcacta atttaaaaaa aaaaaaaaaa
     1981 aa
//
