LOCUS       NM_053501               1588 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus solute carrier family 25 member 14 (Slc25a14),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_053501
VERSION     NM_053501.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1588)
  AUTHORS   Yamada,H., Munetsuna,E., Yamazaki,M., Mizuno,G., Sadamoto,N.,
            Ando,Y., Fujii,R., Shiogama,K., Ishikawa,H., Suzuki,K., Shimono,Y.,
            Ohashi,K. and Hashimoto,S.
  TITLE     Maternal fructose-induced oxidative stress occurs viaTfam and Ucp5
            epigenetic regulation in offspring hippocampi
  JOURNAL   FASEB J 33 (10), 11431-11442 (2019)
   PUBMED   31314594
  REMARK    GeneRIF: Specificity protein 1 binding to the Ucp5 promoter regions
            was reduced by DNA methylation.
REFERENCE   2  (bases 1 to 1588)
  AUTHORS   Mortensen,O.H., Larsen,L.H., Orstrup,L.K., Hansen,L.H., Grunnet,N.
            and Quistorff,B.
  TITLE     Developmental programming by high fructose decreases
            phosphorylation efficiency in aging offspring brain mitochondria,
            correlating with enhanced UCP5 expression
  JOURNAL   J Cereb Blood Flow Metab 34 (7), 1205-1211 (2014)
   PUBMED   24756078
  REMARK    GeneRIF: maternal high-fructose diet during gestation and lactation
            has long-term effects (fetal programming) on brain mitochondrial
            function in aging rats, which appears to be linked to an increase
            in UCP5 protein levels.
REFERENCE   3  (bases 1 to 1588)
  AUTHORS   Guevara,R., Santandreu,F.M., Valle,A., Gianotti,M., Oliver,J. and
            Roca,P.
  TITLE     Sex-dependent differences in aged rat brain mitochondrial function
            and oxidative stress
  JOURNAL   Free Radic Biol Med 46 (2), 169-175 (2009)
   PUBMED   18992805
  REMARK    GeneRIF: expression levels are higher in aged female brain as
            compared to male one
REFERENCE   4  (bases 1 to 1588)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (bases 1 to 1588)
  AUTHORS   Mizuno,T., Miura-Suzuki,T., Yamashita,H. and Mori,N.
  TITLE     Distinct regulation of brain mitochondrial carrier protein-1 and
            uncoupling protein-2 genes in the rat brain during cold exposure
            and aging
  JOURNAL   Biochem Biophys Res Commun 278 (3), 691-697 (2000)
   PUBMED   11095970
REFERENCE   6  (bases 1 to 1588)
  AUTHORS   Kondou,S., Hidaka,S., Yoshimatsu,H., Tsuruta,Y., Itateyama,E. and
            Sakata,T.
  TITLE     Molecular cloning of rat brain mitochondrial carrier protein-1 cDNA
            and its up-regulation during postnatal development
  JOURNAL   Biochim Biophys Acta 1457 (3), 182-189 (2000)
   PUBMED   10773163
REFERENCE   7  (bases 1 to 1588)
  AUTHORS   Sanchis,D., Fleury,C., Chomiki,N., Goubern,M., Huang,Q.,
            Neverova,M., Gregoire,F., Easlick,J., Raimbault,S.,
            Levi-Meyrueis,C., Miroux,B., Collins,S., Seldin,M., Richard,D.,
            Warden,C., Bouillaud,F. and Ricquier,D.
  TITLE     BMCP1, a novel mitochondrial carrier with high expression in the
            central nervous system of humans and rodents, and respiration
            uncoupling activity in recombinant yeast
  JOURNAL   J Biol Chem 273 (51), 34611-34615 (1998)
   PUBMED   9852133
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1 and AF300424.1.
            
            On Mar 15, 2021 this sequence version replaced NM_053501.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF300424.1, SRR26643289.45207.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                JAXUCZ010000021.1  132685609-132685645
            38-1588             AF300424.1         2-1552
FEATURES             Location/Qualifiers
     source          1..1588
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq36"
     gene            1..1588
                     /gene="Slc25a14"
                     /gene_synonym="Bmcp1"
                     /note="solute carrier family 25 member 14"
                     /db_xref="GeneID:85263"
                     /db_xref="RGD:621433"
     exon            1..60
                     /gene="Slc25a14"
                     /gene_synonym="Bmcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            61..306
                     /gene="Slc25a14"
                     /gene_synonym="Bmcp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..1209
                     /gene="Slc25a14"
                     /gene_synonym="Bmcp1"
                     /note="brain mitochondrial carrier protein 1; solute
                     carrier family 25 (mitochondrial carrier, brain), member
                     14"
                     /codon_start=1
                     /product="brain mitochondrial carrier protein 1 precursor"
                     /protein_id="NP_445953.1"
                     /db_xref="GeneID:85263"
                     /db_xref="RGD:621433"
                     /translation="MGIFPGIILIFLRVKFATAAVIVSGHQKSSALSHEMSGLNWKPF
                     VYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDVRFKEIKYRGMFHALFRIYREEGILA
                     LYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIAN
                     PTDVLKIRMQAQGSLFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVY
                     DITKKHLIVSGMLGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLY
                     KGTLDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKRLQI"
     exon            307..400
                     /gene="Slc25a14"
                     /gene_synonym="Bmcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            401..548
                     /gene="Slc25a14"
                     /gene_synonym="Bmcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            549..643
                     /gene="Slc25a14"
                     /gene_synonym="Bmcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            644..729
                     /gene="Slc25a14"
                     /gene_synonym="Bmcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            730..825
                     /gene="Slc25a14"
                     /gene_synonym="Bmcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            826..950
                     /gene="Slc25a14"
                     /gene_synonym="Bmcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1086
                     /gene="Slc25a14"
                     /gene_synonym="Bmcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1167
                     /gene="Slc25a14"
                     /gene_synonym="Bmcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1588
                     /gene="Slc25a14"
                     /gene_synonym="Bmcp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggtggcgt ttcctactgt ggtagcctcc gcttcccagt cgtctgctga gcttgagcag
       61 ctgagtccct tccctgtctt tcactcttct ggcatcggtg gctttacttc ttcgattgag
      121 ctctgcttcc tcgacccccc cgggaggccg cctccttcag gcgcctccct tctctctacg
      181 aactcgctct gacagccgag gaactggcaa gatcctgtac ccagagggtg aatgggtatc
      241 tttcctggaa taatcctaat ttttctaagg gtgaagtttg caacggcagc agtgattgta
      301 agcggacatc agaaaagttc cgctttaagc catgagatgt ctggtctgaa ctggaaacct
      361 tttgtgtatg gcggccttgc ctctattgtt gccgagttcg gcactttccc tgtggatctt
      421 actaaaacac ggctgcaagt ccaaggtcag agtatcgatg tccgtttcaa agaaataaaa
      481 tatagaggga tgtttcacgc cttgttccga atctatagag aagaaggcat cttggccctg
      541 tattcgggaa ttgcccctgc tttactaaga caggcatcat atggcaccat caaaattggt
      601 atttatcaaa gcttgaagcg attatttgta gaacgtttgg aagatgagac tctcctaatt
      661 aatatgatct gtggagtagt gtcaggagtg atttcatcta ctattgccaa ccccactgat
      721 gttctaaaga ttcgaatgca ggctcaagga agcttgttcc aagggagcat gattggcagc
      781 ttcatagata tataccagca ggaaggcacc aggggtctgt ggagaggtgt ggtcccaact
      841 gctcagcgtg ctgccatcgt tgtgggagta gagttgccag tttatgatat taccaagaag
      901 cacctgatag tttcgggaat gctgggagac acaattttaa cacactttgt ttccagcttt
      961 acctgtggtt tggctggggc tctggcatct aaccctgtgg atgtggtgag aactcgaatg
     1021 atgaatcaga gggcaatagt gggacatgtg gacctctaca agggtacttt ggatggtatt
     1081 ttaaagatgt ggaaacatga gggatttttt gcactctata aaggattttg gccaaactgg
     1141 cttcgacttg gaccctggaa catcattttt tttattacgt atgagcagct caagaggctt
     1201 cagatctaag aactggaaat ccatcagccc agccctgctg ccctttctac cgttcctctt
     1261 tgtgttcctg atgtattttg acaaagatgt gtgtgtttac agaaccagca gtctcgcagg
     1321 gcccctgact gaagagtagt aggacgactt aagtttatgc atttgtgttc cctcttccct
     1381 gagaagaagt ttcgacattg agagtgtgac cccagattgg tgtcttctgt gaagatggat
     1441 actgatgggt gacattcaaa agggcctcct ttttaactgt agcttcaatg tagttggttt
     1501 tcccgagaca ggctacagca gcaggctacc ggcacagtta ctgctatgtg tgtttttgac
     1561 ctcagttctc attaaagtat ttattgat
//
