LOCUS       NM_001419624            3059 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus solute carrier family 25 member 13 (Slc25a13),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001419624 XM_008762739
VERSION     NM_001419624.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3059)
  AUTHORS   Thangaratnarajah,C., Ruprecht,J.J. and Kunji,E.R.
  TITLE     Calcium-induced conformational changes of the regulatory domain of
            human mitochondrial aspartate/glutamate carriers
  JOURNAL   Nat Commun 5, 5491 (2014)
   PUBMED   25410934
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3059)
  AUTHORS   Contreras,L., Gomez-Puertas,P., Iijima,M., Kobayashi,K., Saheki,T.
            and Satrustegui,J.
  TITLE     Ca2+ Activation kinetics of the two aspartate-glutamate
            mitochondrial carriers, aralar and citrin: role in the heart
            malate-aspartate NADH shuttle
  JOURNAL   J Biol Chem 282 (10), 7098-7106 (2007)
   PUBMED   17213189
REFERENCE   3  (bases 1 to 3059)
  AUTHORS   McKenna,M.C., Waagepetersen,H.S., Schousboe,A. and Sonnewald,U.
  TITLE     Neuronal and astrocytic shuttle mechanisms for
            cytosolic-mitochondrial transfer of reducing equivalents: current
            evidence and pharmacological tools
  JOURNAL   Biochem Pharmacol 71 (4), 399-407 (2006)
   PUBMED   16368075
  REMARK    Review article
REFERENCE   4  (bases 1 to 3059)
  AUTHORS   Sinasac,D.S., Moriyama,M., Jalil,M.A., Begum,L., Li,M.X.,
            Iijima,M., Horiuchi,M., Robinson,B.H., Kobayashi,K., Saheki,T. and
            Tsui,L.C.
  TITLE     Slc25a13-knockout mice harbor metabolic deficits but fail to
            display hallmarks of adult-onset type II citrullinemia
  JOURNAL   Mol Cell Biol 24 (2), 527-536 (2004)
   PUBMED   14701727
REFERENCE   5  (bases 1 to 3059)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   6  (bases 1 to 3059)
  AUTHORS   Lasorsa,F.M., Pinton,P., Palmieri,L., Fiermonte,G., Rizzuto,R. and
            Palmieri,F.
  TITLE     Recombinant expression of the Ca(2+)-sensitive aspartate/glutamate
            carrier increases mitochondrial ATP production in
            agonist-stimulated Chinese hamster ovary cells
  JOURNAL   J Biol Chem 278 (40), 38686-38692 (2003)
   PUBMED   12851387
REFERENCE   7  (bases 1 to 3059)
  AUTHORS   Palmieri,L., Pardo,B., Lasorsa,F.M., del Arco,A., Kobayashi,K.,
            Iijima,M., Runswick,M.J., Walker,J.E., Saheki,T., Satrustegui,J.
            and Palmieri,F.
  TITLE     Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate
            transporters in mitochondria
  JOURNAL   EMBO J 20 (18), 5060-5069 (2001)
   PUBMED   11566871
REFERENCE   8  (bases 1 to 3059)
  AUTHORS   Yasuda,T., Yamaguchi,N., Kobayashi,K., Nishi,I., Horinouchi,H.,
            Jalil,M.A., Li,M.X., Ushikai,M., Iijima,M., Kondo,I. and Saheki,T.
  TITLE     Identification of two novel mutations in the SLC25A13 gene and
            detection of seven mutations in 102 patients with adult-onset type
            II citrullinemia
  JOURNAL   Hum Genet 107 (6), 537-545 (2000)
   PUBMED   11153906
REFERENCE   9  (bases 1 to 3059)
  AUTHORS   Del Arco,A., Agudo,M. and Satrustegui,J.
  TITLE     Characterization of a second member of the subfamily of
            calcium-binding mitochondrial carriers expressed in human
            non-excitable tissues
  JOURNAL   Biochem J 345 Pt 3 (Pt 3), 725-732 (2000)
   PUBMED   10642534
REFERENCE   10 (bases 1 to 3059)
  AUTHORS   Kobayashi,K., Sinasac,D.S., Iijima,M., Boright,A.P., Begum,L.,
            Lee,J.R., Yasuda,T., Ikeda,S., Hirano,R., Terazono,H.,
            Crackower,M.A., Kondo,I., Tsui,L.C., Scherer,S.W. and Saheki,T.
  TITLE     The gene mutated in adult-onset type II citrullinaemia encodes a
            putative mitochondrial carrier protein
  JOURNAL   Nat Genet 22 (2), 159-163 (1999)
   PUBMED   10369257
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Apr 13, 2023 this sequence version replaced XM_008762739.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.12386.1,
                                           SRR26360172.2845966.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               JAXUCZ010000004.1  35328239-35328360   c
            123-176             JAXUCZ010000004.1  35300807-35300860   c
            177-319             JAXUCZ010000004.1  35290274-35290416   c
            320-435             JAXUCZ010000004.1  35262849-35262964   c
            436-575             JAXUCZ010000004.1  35239468-35239607   c
            576-722             JAXUCZ010000004.1  35227732-35227878   c
            723-861             JAXUCZ010000004.1  35223104-35223242   c
            862-955             JAXUCZ010000004.1  35222370-35222463   c
            956-1040            JAXUCZ010000004.1  35222079-35222163   c
            1041-1128           JAXUCZ010000004.1  35218205-35218292   c
            1129-1287           JAXUCZ010000004.1  35217622-35217780   c
            1288-1340           JAXUCZ010000004.1  35204287-35204339   c
            1341-1421           JAXUCZ010000004.1  35202694-35202774   c
            1422-1562           JAXUCZ010000004.1  35179947-35180087   c
            1563-1701           JAXUCZ010000004.1  35158111-35158249   c
            1702-1860           JAXUCZ010000004.1  35147222-35147380   c
            1861-1951           JAXUCZ010000004.1  35147038-35147128   c
            1952-3059           JAXUCZ010000004.1  35145721-35146828   c
FEATURES             Location/Qualifiers
     source          1..3059
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q21"
     gene            1..3059
                     /gene="Slc25a13"
                     /gene_synonym="RGD1565889"
                     /note="solute carrier family 25 member 13"
                     /db_xref="GeneID:362322"
                     /db_xref="RGD:1565889"
     exon            1..122
                     /gene="Slc25a13"
                     /gene_synonym="RGD1565889"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..2138
                     /gene="Slc25a13"
                     /gene_synonym="RGD1565889"
                     /note="isoform 1 is encoded by transcript variant 1;
                     solute carrier family 25 (mitochondrial carrier, adenine
                     nucleotide translocator), member 13; calcium-binding
                     mitochondrial carrier protein Aralar2; solute carrier
                     family 25, member 13 (citrin); solute carrier family 25
                     (aspartate/glutamate carrier), member 13; electrogenic
                     aspartate/glutamate antiporter SLC25A13, mitochondrial"
                     /codon_start=1
                     /product="electrogenic aspartate/glutamate antiporter
                     SLC25A13, mitochondrial isoform 1"
                     /protein_id="NP_001406553.1"
                     /db_xref="GeneID:362322"
                     /db_xref="RGD:1565889"
                     /translation="MAAAKVALTKRADPAELKAIFLKYASIEKNGEFFMSPHDFVTRY
                     LNIFGESQPNPKTVELLSGVVDQTKDGLISFQEFVAFESVLCAPDALFMVAFQLFDKA
                     GKGEVTFEDVRQVFGQTTIHQHIPFNWDSEFVQLHFGKERKRHLTYAEFTQFLLEIQL
                     EHAKQAFVQRDNAKTGKVTAIDFRDIMVTIRPHVLTPFVEECLVAAAGGTRSHQVSFS
                     YFNGFNSLLNNMELIRKIYSTLAGSRKDVEVTKEEFALAAQKFGQVTPMEVDILFQLA
                     DLYEPRGRMTLADIERIAPLEEGMLPFNLAEAQRQQKASGDAARPFLLQLAESAYRFG
                     LGSIAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLY
                     RGLLPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLLAEIFAGGCAGGSQVIFTNPL
                     EIVKIRLQVAGEITTGPRVSALSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHV
                     KASFANEDGQVSPGSLLLAGAIAGMPAASLVTPADVIKTRLQVAARAGQTTYSGVTDC
                     FRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYELLQRWFYVDFGGVKPVGSELVP
                     KSRITLPAPNPDHVGGYKLAVATFAGIENKFGLYLPLFKPSASTSKVTAVGS"
     exon            123..176
                     /gene="Slc25a13"
                     /gene_synonym="RGD1565889"
                     /inference="alignment:Splign:2.1.0"
     exon            177..319
                     /gene="Slc25a13"
                     /gene_synonym="RGD1565889"
                     /inference="alignment:Splign:2.1.0"
     exon            320..435
                     /gene="Slc25a13"
                     /gene_synonym="RGD1565889"
                     /inference="alignment:Splign:2.1.0"
     exon            436..575
                     /gene="Slc25a13"
                     /gene_synonym="RGD1565889"
                     /inference="alignment:Splign:2.1.0"
     exon            576..722
                     /gene="Slc25a13"
                     /gene_synonym="RGD1565889"
                     /inference="alignment:Splign:2.1.0"
     exon            723..861
                     /gene="Slc25a13"
                     /gene_synonym="RGD1565889"
                     /inference="alignment:Splign:2.1.0"
     exon            862..955
                     /gene="Slc25a13"
                     /gene_synonym="RGD1565889"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1040
                     /gene="Slc25a13"
                     /gene_synonym="RGD1565889"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1128
                     /gene="Slc25a13"
                     /gene_synonym="RGD1565889"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1287
                     /gene="Slc25a13"
                     /gene_synonym="RGD1565889"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1340
                     /gene="Slc25a13"
                     /gene_synonym="RGD1565889"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1421
                     /gene="Slc25a13"
                     /gene_synonym="RGD1565889"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1562
                     /gene="Slc25a13"
                     /gene_synonym="RGD1565889"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1701
                     /gene="Slc25a13"
                     /gene_synonym="RGD1565889"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1860
                     /gene="Slc25a13"
                     /gene_synonym="RGD1565889"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..1951
                     /gene="Slc25a13"
                     /gene_synonym="RGD1565889"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..3059
                     /gene="Slc25a13"
                     /gene_synonym="RGD1565889"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaatcaccg cccccacctc tgcctggacg ggaagtgagt cgccggggtc cctagtgcaa
       61 tccaaccaga cagcaggtct caaagctgcc tgtaccccgg ccgaagcatg gcggccgcca
      121 aggtggcttt aaccaagaga gcagatccag ctgagcttaa agcaatattt ttgaagtatg
      181 caagcattga aaaaaatggt gaatttttta tgtcacctca tgactttgtc actcggtatt
      241 tgaatatttt tggagaaagc cagcccaacc cgaagactgt ggaactgtta agcggtgtgg
      301 tggatcagac caaagatggg ttaatatcct tccaagaatt tgtagcgttc gaatctgtcc
      361 tgtgtgctcc ggatgccttg tttatggtgg ccttccagct gtttgacaaa gctggcaaag
      421 gagaggttac ttttgaggac gtcaggcaag tttttggaca gacgacaatt catcaacata
      481 ttccgtttaa ctgggattca gaattcgtcc aactacattt tggaaaagag agaaaaagac
      541 accttacata tgcagagttc actcagtttt tgttggaaat acagttggag cacgcaaagc
      601 aagcctttgt gcaacgagac aatgccaaga cgggaaaagt cacagccatt gacttccggg
      661 acatcatggt gaccatccgt cctcatgtcc tgactccttt tgttgaagaa tgtctagtag
      721 ctgccgctgg aggcacgaga tctcatcaag tcagtttctc ctattttaat ggatttaatt
      781 cgctccttaa caacatggag ctcattagga agatctacag caccctggct ggcagcagga
      841 aagatgtgga ggtgactaag gaggagtttg ctctggcagc ccagaagttt ggtcaggtta
      901 cacccatgga agttgacatc ttgtttcagt tagcggattt atatgagccg agggggcgca
      961 tgaccttagc agacattgag cggattgccc ctctagagga aggaatgttg cccttcaact
     1021 tggctgaggc ccagaggcag cagaaggcct cgggtgatgc tgctcggccc tttcttctac
     1081 agctggcaga gtcggcctac aggtttggac tgggttctat tgctggagcg gtcggagcta
     1141 ctgccgtgta tcccatcgat cttgtgaaga ctcgaatgca gaaccagcga tcaaccggct
     1201 cttttgtggg agagctcatg tacaaaaaca gctttgactg ttttaagaaa gtgctccgct
     1261 acgagggctt ctttggactg tacagaggtt tgctgccaca gttgctggga gtcgccccgg
     1321 agaaggccat aaaacttaca gtgaatgatt ttgtgagaga taagttcatg cacaaagatg
     1381 gctccgtccc acttttggca gagatttttg ctggaggctg tgctggaggc tcccaagtga
     1441 ttttcacaaa tcctttagaa atagtcaaga ttcgcttaca agtggctgga gagatcacca
     1501 ctggcccccg cgtcagcgct ctgtcggtgg ttcgagacct ggggttcttt ggcatctaca
     1561 agggtgccaa agcgtgcttt ctgcgggaca ttcctttctc ggccatctac ttcccatgct
     1621 atgcccatgt gaaggcttcc tttgcgaatg aagatgggca ggtcagcccc ggaagcctgc
     1681 tcttagctgg tgctattgct ggtatgcctg ccgcatcttt agtgacccct gctgatgtta
     1741 tcaagactag attacaggtg gctgcccggg ctggccaaac cacttacagc ggtgtgacag
     1801 actgcttcag aaagatactt cgggaagaag gccccaaagc cttgtggaaa ggagctggtg
     1861 ctcgagtctt ccgctcctca ccgcagtttg gtgtcacctt gcttacttac gaactgctgc
     1921 agcgatggtt ctacgtcgat tttggaggcg tgaagcccgt gggatctgag ctggttccta
     1981 aatctcggat tactctgccc gctcccaatc ctgaccacgt agggggctat aaactggcag
     2041 ttgcaacatt tgcgggcatt gaaaacaagt tcggacttta cctacctctc tttaagccat
     2101 cagcatctac ctcaaaagtg accgctgtgg gctcataggg ggactgaccc ggatgtggct
     2161 ggaaaattga ttggaaccac aacaagcctc gtcagggttt gaagcatggc tccgcccctt
     2221 ccgcatctgt cccatttaaa ttcaggtcaa tgcttcttat attaaatgca atcattcatt
     2281 ttctggattt tttttgtagc aagatcatgt ggaattattc ctaattattc tttggcacgc
     2341 tgcccgtaac ctgtgtttgt atcttttaaa tactgggatt tggtcaatac taaacttgat
     2401 ctggagtaag tctgaaggga aatgagggag gtctcctacc cggatgatgg tctcactgat
     2461 gctactgaaa ggcagccatg gtttctaaaa gagttccgag tatgtttaaa gtagtagaaa
     2521 gctaggtatg tatttataaa aatgaaaaac actggaaggg gggggaaatc caaatatcta
     2581 gcctggactc aaattttaaa catgcacaaa tttggcctct ggattatatt atgaagattt
     2641 tatgtgaaac atgttttttc ataatgaaaa ccacattgag gatgtttagc aatcattctc
     2701 ttactatacc aagtctacta gggaaacatt tcgaatgtta aggaagtgct ttggcctttt
     2761 tattatagag acagaagaaa ttctactcct gagcatactg atttgggcta aatatgtata
     2821 tgatgagcac atattgattc caagtctaag agtcgctgta agaatgatgt acgcccctct
     2881 ttgctggtac caccctcctc cagtccccat ggttggcacc cattcacatt taaaatccac
     2941 tttcttgaat catgtcagac aaatatactc ttaagtctat atttaatttg gggtgccatg
     3001 aattatggtc agaggcctgt gtgtctgtga agggaaaaat aaaactattt ttaaagcca
//
