LOCUS       NM_001399269            3684 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus solute carrier family 25 member 12 (Slc25a12),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001399269 XM_039106368
VERSION     NM_001399269.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3684)
  AUTHORS   Thangaratnarajah,C., Ruprecht,J.J. and Kunji,E.R.
  TITLE     Calcium-induced conformational changes of the regulatory domain of
            human mitochondrial aspartate/glutamate carriers
  JOURNAL   Nat Commun 5, 5491 (2014)
   PUBMED   25410934
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3684)
  AUTHORS   Durdiakova,J., Warrier,V., Baron-Cohen,S. and Chakrabarti,B.
  TITLE     Single nucleotide polymorphism rs6716901 in SLC25A12 gene is
            associated with Asperger syndrome
  JOURNAL   Mol Autism 5 (1), 25 (2014)
   PUBMED   24679184
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3684)
  AUTHORS   Zhao,X., Leon,I.R., Bak,S., Mogensen,M., Wrzesinski,K., Hojlund,K.
            and Jensen,O.N.
  TITLE     Phosphoproteome analysis of functional mitochondria isolated from
            resting human muscle reveals extensive phosphorylation of inner
            membrane protein complexes and enzymes
  JOURNAL   Mol Cell Proteomics 10 (1), M110.000299 (2011)
   PUBMED   20833797
REFERENCE   4  (bases 1 to 3684)
  AUTHORS   Sakurai,T., Ramoz,N., Barreto,M., Gazdoiu,M., Takahashi,N.,
            Gertner,M., Dorr,N., Gama Sosa,M.A., De Gasperi,R., Perez,G.,
            Schmeidler,J., Mitropoulou,V., Le,H.C., Lupu,M., Hof,P.R.,
            Elder,G.A. and Buxbaum,J.D.
  TITLE     Slc25a12 disruption alters myelination and neurofilaments: a model
            for a hypomyelination syndrome and childhood neurodevelopmental
            disorders
  JOURNAL   Biol Psychiatry 67 (9), 887-894 (2010)
   PUBMED   20015484
REFERENCE   5  (bases 1 to 3684)
  AUTHORS   Casimir,M., Rubi,B., Frigerio,F., Chaffard,G. and Maechler,P.
  TITLE     Silencing of the mitochondrial NADH shuttle component
            aspartate-glutamate carrier AGC1/Aralar1 in INS-1E cells and rat
            islets
  JOURNAL   Biochem J 424 (3), 459-466 (2009)
   PUBMED   19764902
  REMARK    GeneRIF: Results show that down-regulation of the key component of
            the malate-aspartate shuttle AGC1/Aralar1 reduced glucose-induced
            oxidative metabolism and insulin secretion in INS-1E cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3684)
  AUTHORS   Sinasac,D.S., Moriyama,M., Jalil,M.A., Begum,L., Li,M.X.,
            Iijima,M., Horiuchi,M., Robinson,B.H., Kobayashi,K., Saheki,T. and
            Tsui,L.C.
  TITLE     Slc25a13-knockout mice harbor metabolic deficits but fail to
            display hallmarks of adult-onset type II citrullinemia
  JOURNAL   Mol Cell Biol 24 (2), 527-536 (2004)
   PUBMED   14701727
REFERENCE   7  (bases 1 to 3684)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   8  (bases 1 to 3684)
  AUTHORS   del Arco,A., Morcillo,J., Martinez-Morales,J.R., Galian,C.,
            Martos,V., Bovolenta,P. and Satrustegui,J.
  TITLE     Expression of the aspartate/glutamate mitochondrial carriers
            aralar1 and citrin during development and in adult rat tissues
  JOURNAL   Eur J Biochem 269 (13), 3313-3320 (2002)
   PUBMED   12084073
  REMARK    GeneRIF: Expression of the aspartate/glutamate mitochondrial
            carriers aralar1 and citrin during development.
REFERENCE   9  (bases 1 to 3684)
  AUTHORS   Palmieri,L., Pardo,B., Lasorsa,F.M., del Arco,A., Kobayashi,K.,
            Iijima,M., Runswick,M.J., Walker,J.E., Saheki,T., Satrustegui,J.
            and Palmieri,F.
  TITLE     Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate
            transporters in mitochondria
  JOURNAL   EMBO J 20 (18), 5060-5069 (2001)
   PUBMED   11566871
REFERENCE   10 (bases 1 to 3684)
  AUTHORS   del Arco,A. and Satrustegui,J.
  TITLE     Molecular cloning of Aralar, a new member of the mitochondrial
            carrier superfamily that binds calcium and is present in human
            muscle and brain
  JOURNAL   J Biol Chem 273 (36), 23327-23334 (1998)
   PUBMED   9722566
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000115.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001399269.2.
            
            On Jan 5, 2022 this sequence version replaced XM_039106368.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR8487231.153339.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                JACYVU010000115.1  49648621-49648662   c
            43-96               JACYVU010000115.1  49647636-49647689   c
            97-239              JACYVU010000115.1  49623052-49623194   c
            240-355             JACYVU010000115.1  49612119-49612234   c
            356-495             JACYVU010000115.1  49602863-49603002   c
            496-642             JACYVU010000115.1  49594470-49594616   c
            643-781             JACYVU010000115.1  49591986-49592124   c
            782-875             JACYVU010000115.1  49591063-49591156   c
            876-960             JACYVU010000115.1  49587471-49587555   c
            961-1042            JACYVU010000115.1  49576238-49576319   c
            1043-1201           JACYVU010000115.1  49574386-49574544   c
            1202-1254           JACYVU010000115.1  49571395-49571447   c
            1255-1335           JACYVU010000115.1  49571075-49571155   c
            1336-1476           JACYVU010000115.1  49562278-49562418   c
            1477-1615           JACYVU010000115.1  49559991-49560129   c
            1616-1774           JACYVU010000115.1  49557095-49557253   c
            1775-1865           JACYVU010000115.1  49556895-49556985   c
            1866-3684           JACYVU010000115.1  49553987-49555805   c
FEATURES             Location/Qualifiers
     source          1..3684
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q22"
     gene            1..3684
                     /gene="Slc25a12"
                     /gene_synonym="Aralar1; RGD1561141"
                     /note="solute carrier family 25 member 12"
                     /db_xref="GeneID:362145"
                     /db_xref="RGD:1305181"
     exon            1..42
                     /gene="Slc25a12"
                     /gene_synonym="Aralar1; RGD1561141"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..2064
                     /gene="Slc25a12"
                     /gene_synonym="Aralar1; RGD1561141"
                     /note="solute carrier family 25 (aspartate/glutamate
                     carrier), member 12; solute carrier family 25
                     (mitochondrial carrier, Aralar), member 12;
                     calcium-binding mitochondrial carrier protein Aralar1"
                     /codon_start=1
                     /product="electrogenic aspartate/glutamate antiporter
                     SLC25A12, mitochondrial"
                     /protein_id="NP_001386198.1"
                     /db_xref="GeneID:362145"
                     /db_xref="RGD:1305181"
                     /translation="MAVKVHTTKRGDPHELRNIFLQYASTEVDGEHYMTPEDFVQRYL
                     GLYNDPNSNPKIVQLLAGVADQTKDGLISYQEFLAFESVLCAPDSMFIVAFQLFDKSG
                     NGEVTFENVKEIFGQTIIHHHIPFNWDCEFIRLHFGHNRKKHLNYVEFTQFLQELQLE
                     HARQAFALKDKSKSGMISGLDFSDVMVTIRSHMLTPFVEENLVSAAGGSTSHQVSFSY
                     FNAFNSLLNNMELVRKIYSTLAGTRKDIEVTKEEFAQSAIRYGQVTPLEIDILYQLAD
                     LYNASGRLTLADIERIAPLAEGALPYNLAELQRQQSPGLGRPIWLQIAESAYRFTLGS
                     VAGAVGATAVYPIDLVKTRMQNQRGTGSVVGELMYKNSFDCFKKVLRYEGFFGLYRGL
                     IPQLIGVAPEKAIKLTVNDFVRDKFTRRDGSIPLPAEILAGGCAGGSQVIFTNPLEIV
                     KIRLQVAGEITTGPRVSALNVLQDLGLFGLYKGAKACFLRDIPFSAIYFPVYAHCKLL
                     LADENGHVGGINLLTAGAMAGVPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRK
                     ILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELLQRWFYIDFGGLKPSGSEPTPKSR
                     IADLPPANPDHIGGYRLATATFAGIENKFGLYLPKFKSPGVAAAQPKVAAAAQ"
     exon            43..96
                     /gene="Slc25a12"
                     /gene_synonym="Aralar1; RGD1561141"
                     /inference="alignment:Splign:2.1.0"
     exon            97..239
                     /gene="Slc25a12"
                     /gene_synonym="Aralar1; RGD1561141"
                     /inference="alignment:Splign:2.1.0"
     exon            240..355
                     /gene="Slc25a12"
                     /gene_synonym="Aralar1; RGD1561141"
                     /inference="alignment:Splign:2.1.0"
     exon            356..495
                     /gene="Slc25a12"
                     /gene_synonym="Aralar1; RGD1561141"
                     /inference="alignment:Splign:2.1.0"
     exon            496..642
                     /gene="Slc25a12"
                     /gene_synonym="Aralar1; RGD1561141"
                     /inference="alignment:Splign:2.1.0"
     exon            643..781
                     /gene="Slc25a12"
                     /gene_synonym="Aralar1; RGD1561141"
                     /inference="alignment:Splign:2.1.0"
     exon            782..875
                     /gene="Slc25a12"
                     /gene_synonym="Aralar1; RGD1561141"
                     /inference="alignment:Splign:2.1.0"
     exon            876..960
                     /gene="Slc25a12"
                     /gene_synonym="Aralar1; RGD1561141"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1042
                     /gene="Slc25a12"
                     /gene_synonym="Aralar1; RGD1561141"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1201
                     /gene="Slc25a12"
                     /gene_synonym="Aralar1; RGD1561141"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1254
                     /gene="Slc25a12"
                     /gene_synonym="Aralar1; RGD1561141"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1335
                     /gene="Slc25a12"
                     /gene_synonym="Aralar1; RGD1561141"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1476
                     /gene="Slc25a12"
                     /gene_synonym="Aralar1; RGD1561141"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1615
                     /gene="Slc25a12"
                     /gene_synonym="Aralar1; RGD1561141"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1774
                     /gene="Slc25a12"
                     /gene_synonym="Aralar1; RGD1561141"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1865
                     /gene="Slc25a12"
                     /gene_synonym="Aralar1; RGD1561141"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..3684
                     /gene="Slc25a12"
                     /gene_synonym="Aralar1; RGD1561141"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcgctcgt tcccggcttc cgagcacagc atggcggtca aggtgcacac aaccaaacga
       61 ggtgatcctc atgagctgag aaacatattc ctacagtatg ccagcaccga ggtggacgga
      121 gagcattaca tgactccgga agacttcgtt caacgctacc ttggcctgta caatgatccg
      181 aacagcaacc caaagatcgt gcagctcttg gcaggagtag ctgatcaaac caaggatggg
      241 ttgatctcct atcaagagtt tttggcattt gaatctgttc tatgtgctcc agattccatg
      301 ttcatagtgg ctttccaact gtttgacaag agtggaaatg gagaggtgac atttgaaaat
      361 gtcaaggaga ttttcggaca gactattatc catcaccaca tcccctttaa ctgggactgc
      421 gagttcatcc ggctgcactt tgggcacaac cgcaagaagc acctgaacta tgtggaattc
      481 actcagttcc tccaggaatt gcaattggag cacgcaaggc aagcctttgc gctgaaagac
      541 aagagcaaaa gcggcatgat ctcaggcctg gatttcagtg atgtcatggt caccatccgg
      601 tcccacatgc tcactccttt tgtggaggag aacctagtct cagctgctgg agggagtacc
      661 tcacaccaag ttagcttctc ctacttcaac gcgtttaact ccctgctcaa caatatggag
      721 ctggttcgca agatctacag cactctggcc ggcacaagga aagacattga agttaccaag
      781 gaggagtttg cccagagtgc catacgctat ggacaggtta ccccattaga aattgacatc
      841 ctataccagc ttgctgacct atacaatgct tcagggcgct tgactctggc agacatcgag
      901 agaatagctc cgctggctga gggggcctta ccttacaacc tggcagagct tcagaggcag
      961 caatcccccg gcttgggcag acctatctgg ctccagattg ccgagtctgc atacaggttc
     1021 actctgggct cagtggcagg agctgtgggg gccactgcgg tctatcccat agacctggtg
     1081 aagacccgga tgcaaaacca gcgcggcaca ggctctgtgg tcggggagct gatgtataaa
     1141 aacagctttg actgttttaa gaaagtgtta cgttatgagg gtttctttgg actgtaccga
     1201 ggtctgatcc cacagctgat aggagttgca ccagaaaaag ccattaagct aacagttaat
     1261 gattttgtcc gggacaaatt taccagaaga gatggctcca tcccactgcc tgcagaaatt
     1321 cttgctggag gttgcgctgg aggctcgcag gtcatcttta ccaatcctct ggagatagtg
     1381 aagattcgcc ttcaggtagc cggagagatc accacaggac ccagagtcag tgctctgaat
     1441 gtgcttcagg acttgggact ttttgggctg tacaagggtg ccaaagcgtg tttcctccga
     1501 gacattccct tctccgcgat ctattttccc gtgtatgctc actgcaaact cctcctggcg
     1561 gatgagaacg gacacgtggg aggtatcaat ctcctaacag ccggagccat ggcaggtgtg
     1621 cctgctgctt ctctggtgac ccctgctgat gttatcaaga caagactgca agtggccgcc
     1681 agggctggcc agacaacata cagcggggtc attgactgtt tccgaaagat tctccgggaa
     1741 gaagggccgt cggcattctg gaaagggact gcagctcgag tgttccggtc ctcgcctcag
     1801 tttggtgtca ctctggttac ctacgagctt ctgcagcggt ggttttacat agattttgga
     1861 ggcctgaaac cttctggctc agaaccaaca ccaaagtcac gcatcgcaga cctccctcct
     1921 gccaacccgg accacatcgg cggctacaga cttgccacag ccactttcgc tggcatcgaa
     1981 aacaagtttg gcctttacct ccccaagttt aagtctcctg gcgtagctgc ggctcagccc
     2041 aaggtggcgg cagcagctca atgacatagc aactacagac cgaggcccgg gaagatgggc
     2101 ggtaccctgt ccagtcagct gcgtgtggta ctgtctgcgc tggggtcaac aaccttctac
     2161 acgacctcta catgtattgt ttataaagtg agcataagcc cagggagaac cacagtgcag
     2221 tttcgagctt tagtcttatt tgttgaaatg ttttctgagc cttggcatga attctgtgtt
     2281 ctagactccg cttcgcacag cttgtaccta cagtgactgt acatatgttg tacatctttg
     2341 tacagagaca ccttggcacc tcctcccaac gaatcacgtt tatagacatg taacgctgtt
     2401 ccgagtggct tggactgtac agaatgtttt gaaagtgttt tactaagaat catataagaa
     2461 taaatgtact aaagttaaat tcattctcct cttagtggct tacagaaatc aagcctcagt
     2521 gttgaatgta tccagtttca ggttttttgg gtttttttgt ttttttgttt tttttttgtt
     2581 ctggaatagg aaggtatttg ctgataaaag gcagagcaaa acttaatgct catggcattc
     2641 agtaagaaat gcttggaaaa gtgtgtgccc attgggtgtc gggaggacca gcataactca
     2701 tgggctgctg tgttcccagt aatgtacaca cacacacaca cacacacaca cacacacaca
     2761 cacacacaca cacacacaca cacatacaca gatatacaca caccacacac accacacaca
     2821 cacacacaga tacacacaca catacacaca catacacaca catacacaga tacacacaca
     2881 caccacacac accacacaca cacacacaga tacacactca cacacacaga tacacacaca
     2941 catacacaca catacacaca catacacaca cagatacaca tacacagata cacacacaca
     3001 tacacacaca tacacatacc acacacacac cacacacaca cacacagata cacactcaca
     3061 cacacagata cacacacaca caccacacac acacatacac acacagatac acacacacag
     3121 atacacacac acatacacac acacatacac ataccacaca cacacacacc acacacacag
     3181 atacacacac agatacacac atacaccaca cacacacaca tacgcacaca tacacacaca
     3241 tacacacaca cacacaccac acacttacac acacacacac acacacagga acagggtgag
     3301 ctccagctgg taactctcat gggctgctat gttcccagta atgcacgcgc gcacacacac
     3361 acacagacca cacacacaca catacacacc acacacacat gcacacacat acacacacat
     3421 cacacacaca catacacaca cacacataca catacacacc acacacacat gcacacacat
     3481 acacacacac cacacacacc acacacacac acacacacac acacaccaca cacacacagg
     3541 aacagggtga gctccagcac ggcttgctta gttttacatt tcctatgcag gaaggtaaaa
     3601 gtcaggatgt tgaaagagta aagtctggaa gtttcccttc gtaaagtatg acatgaatca
     3661 aaaataaaag cacaccaaga cgtc
//
