LOCUS       NM_133418               1916 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus solute carrier family 25 member 10 (Slc25a10),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_133418
VERSION     NM_133418.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1916)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   2  (bases 1 to 1916)
  AUTHORS   Huypens,P., Pillai,R., Sheinin,T., Schaefer,S., Huang,M.,
            Odegaard,M.L., Ronnebaum,S.M., Wettig,S.D. and Joseph,J.W.
  TITLE     The dicarboxylate carrier plays a role in mitochondrial malate
            transport and in the regulation of glucose-stimulated insulin
            secretion from rat pancreatic beta cells
  JOURNAL   Diabetologia 54 (1), 135-145 (2011)
   PUBMED   20949348
  REMARK    GeneRIF: The studies also suggest that malate transport by DIC is
            (1) a critical component of NADPH production mediated by
            pyruvate-cycling and (2) regulates GSIS.
REFERENCE   3  (bases 1 to 1916)
  AUTHORS   Kamga,C.K., Zhang,S.X. and Wang,Y.
  TITLE     Dicarboxylate carrier-mediated glutathione transport is essential
            for reactive oxygen species homeostasis and normal respiration in
            rat brain mitochondria
  JOURNAL   Am J Physiol Cell Physiol 299 (2), C497-C505 (2010)
   PUBMED   20538765
  REMARK    GeneRIF: Dicarboxylate carrier-mediated glutathione transport is
            essential for brain mitochondria to maintain reactive oxygen
            species homeostasis and normal respiratory functions.
REFERENCE   4  (bases 1 to 1916)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (bases 1 to 1916)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   6  (bases 1 to 1916)
  AUTHORS   Das,K., Lewis,R.Y., Combatsiaris,T.P., Lin,Y., Shapiro,L.,
            Charron,M.J. and Scherer,P.E.
  TITLE     Predominant expression of the mitochondrial dicarboxylate carrier
            in white adipose tissue
  JOURNAL   Biochem J 344 Pt 2 (Pt 2), 313-320 (1999)
   PUBMED   10567211
REFERENCE   7  (bases 1 to 1916)
  AUTHORS   Fiermonte,G., Palmieri,L., Dolce,V., Lasorsa,F.M., Palmieri,F.,
            Runswick,M.J. and Walker,J.E.
  TITLE     The sequence, bacterial expression, and functional reconstitution
            of the rat mitochondrial dicarboxylate transporter cloned via
            distant homologs in yeast and Caenorhabditis elegans
  JOURNAL   J Biol Chem 273 (38), 24754-24759 (1998)
   PUBMED   9733776
REFERENCE   8  (bases 1 to 1916)
  AUTHORS   Palmieri,L., Palmieri,F., Runswick,M.J. and Walker,J.E.
  TITLE     Identification by bacterial expression and functional
            reconstitution of the yeast genomic sequence encoding the
            mitochondrial dicarboxylate carrier protein
  JOURNAL   FEBS Lett 399 (3), 299-302 (1996)
   PUBMED   8985166
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 26, 2020 this sequence version replaced NM_133418.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ223355.1, BC081734.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               JAXUCZ010000010.1  106264396-106264518
            124-243             JAXUCZ010000010.1  106267040-106267159
            244-358             JAXUCZ010000010.1  106267567-106267681
            359-407             JAXUCZ010000010.1  106267767-106267815
            408-449             JAXUCZ010000010.1  106268055-106268096
            450-493             JAXUCZ010000010.1  106269044-106269087
            494-564             JAXUCZ010000010.1  106269274-106269344
            565-657             JAXUCZ010000010.1  106269678-106269770
            658-735             JAXUCZ010000010.1  106269999-106270076
            736-792             JAXUCZ010000010.1  106270585-106270641
            793-1916            JAXUCZ010000010.1  106270734-106271857
FEATURES             Location/Qualifiers
     source          1..1916
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..1916
                     /gene="Slc25a10"
                     /gene_synonym="Dic"
                     /note="solute carrier family 25 member 10"
                     /db_xref="GeneID:170943"
                     /db_xref="RGD:621430"
     exon            1..123
                     /gene="Slc25a10"
                     /gene_synonym="Dic"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..894
                     /gene="Slc25a10"
                     /gene_synonym="Dic"
                     /note="solute carrier family 25 (mitochondrial carrier;
                     dicarboxylate transporter), member 10"
                     /codon_start=1
                     /product="mitochondrial dicarboxylate carrier"
                     /protein_id="NP_596909.1"
                     /db_xref="GeneID:170943"
                     /db_xref="RGD:621430"
                     /translation="MAEARTSRWYFGGLASCGAACCTHPLDLLKVHLQTQQEVKLRMT
                     GMALQVVRTDGFLALYNGLSASLCRQMTYSLTRFAIYETMRDYMTKDSQGPLPFYSKV
                     LLGGISGLTGGFVGTPADLVNVRMQNDMKLPLSQRRNYSHALDGLYRVAREEGLKKLF
                     SGATMASSRGALVTVGQLSCYDQAKQLVLSTGYLSDNIFTHFLSSFIAGGCATFLCQP
                     LDVLKTRLMNSKGEYQGVFHCAVETAKLGPQAFFKGLVPAGVRLVPHTVLTFMFLEQL
                     RKHFGIKVAT"
     exon            124..243
                     /gene="Slc25a10"
                     /gene_synonym="Dic"
                     /inference="alignment:Splign:2.1.0"
     exon            244..358
                     /gene="Slc25a10"
                     /gene_synonym="Dic"
                     /inference="alignment:Splign:2.1.0"
     exon            359..407
                     /gene="Slc25a10"
                     /gene_synonym="Dic"
                     /inference="alignment:Splign:2.1.0"
     exon            408..449
                     /gene="Slc25a10"
                     /gene_synonym="Dic"
                     /inference="alignment:Splign:2.1.0"
     exon            450..493
                     /gene="Slc25a10"
                     /gene_synonym="Dic"
                     /inference="alignment:Splign:2.1.0"
     exon            494..564
                     /gene="Slc25a10"
                     /gene_synonym="Dic"
                     /inference="alignment:Splign:2.1.0"
     exon            565..657
                     /gene="Slc25a10"
                     /gene_synonym="Dic"
                     /inference="alignment:Splign:2.1.0"
     exon            658..735
                     /gene="Slc25a10"
                     /gene_synonym="Dic"
                     /inference="alignment:Splign:2.1.0"
     exon            736..792
                     /gene="Slc25a10"
                     /gene_synonym="Dic"
                     /inference="alignment:Splign:2.1.0"
     exon            793..1916
                     /gene="Slc25a10"
                     /gene_synonym="Dic"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggggtcgg gccaggtcgc tgctgctctg gccatggctg aggcacgcac gtctcgctgg
       61 tactttggag ggctggcttc ctgcggagct gcctgctgca cgcaccctct agacctgctc
      121 aaggtgcatt tgcagaccca acaggaggtg aagcttcgaa tgactggaat ggcactgcag
      181 gtggtgcgaa ccgatggctt cctggcactc tacaatggcc tgagtgcctc gctgtgcagg
      241 cagatgacct actccctgac ccggttcgct atctacgaga ccatgcggga ctacatgacc
      301 aaggacagcc aggggcctct ccccttctac agcaaggtgt tgctgggcgg catcagtggt
      361 ttaactggag gcttcgtggg gaccccagca gatttggtca atgtcaggat gcagaatgac
      421 atgaagctgc ccctgagcca gcgccgcaac tactctcacg ccctggatgg tctgtaccgt
      481 gtagcccgtg aagaaggcct gaagaagctc ttctctggag caaccatggc atccagccgt
      541 ggggccctcg tcactgtggg ccagctgtcc tgctacgacc aggccaagca gctggttctc
      601 agtactgggt acctgagtga caacattttc acccacttcc tctccagttt cattgcgggc
      661 ggatgtgcca catttctctg ccagcccctg gacgtgctga agactcgctt gatgaactcc
      721 aagggcgagt atcagggtgt tttccattgt gccgtggaga cagcaaagct tggaccacag
      781 gcctttttca agggtctcgt tcctgcgggc gtccgtctcg tcccccacac cgtgcttacc
      841 ttcatgttcc tggagcagct gcggaagcac ttcggtatca aagtggcaac ctgacaccgc
      901 cagggacacc tgggctgcgc tcagtcgctg tgctgagccc cttggaagag taggaaggga
      961 gtgggctccc ttcctccttg gcctgggccc gtgctgatcc ctagcagatt cctgttcttc
     1021 ccacccttgg gctgctggct acgccttccg accctgcctt ggccccactg aagtggcacc
     1081 tctgccctac tggctcccag gctctcccca ctgggacgtc ccatcttcct acccgatgat
     1141 tcactcagaa gaggtctggc ctggctggtg tcactgtccc cacctccctg gctgctaccc
     1201 tgccctgcct gtcaagcccg gagaagctga gtacacttcc tgctcctgct ggcccactga
     1261 acagcttcca cccaggactt gggtagtgtg gcagggtaca gcccctggca gcttctgctt
     1321 accaaatgac tagagcacgc acgcacacac atacacgcat gcacttacgt cacaagaggg
     1381 accaccgtgc agtgttctgg aaggtagtgc cttcaggaga gggaacaggg cagcagcaca
     1441 gatcaccagc aaacgccatg accgcggagt ccggagaaag tacctggggt tccctgtgca
     1501 cctcccgtgc tcagcgttgg ctgctttaag agtcagtttt gcggaaccct cctactcagc
     1561 agccactacc atcatcagga actggctgtg tccctcatac acctgtgccc tcccttgcct
     1621 ggcttccccc agggccaggg gctcatgctg gagctggggc tatgatggat tcattctatg
     1681 tgtcctccta ggacctgtct tcccgtatgg caggggtcac ccctcaccat ccctcaggct
     1741 tcaaagcagc ctgttttccc tcaaattggg gttgtgtgta tatcaacgtg aggttgggcc
     1801 ctgtgcccgt ttgcctcccc tcagcaccag gccctcaccc aggaggtgca ggaggtggca
     1861 gtgggcccag gggcactgcc tacatctctc ttcaggatct aataaaccaa gtggcc
//
