LOCUS       NM_017307               1669 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 25 member 1 (Slc25a1),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_017307
VERSION     NM_017307.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1669)
  AUTHORS   Majd,H., King,M.S., Smith,A.C. and Kunji,E.R.S.
  TITLE     Pathogenic mutations of the human mitochondrial citrate carrier
            SLC25A1 lead to impaired citrate export required for lipid,
            dolichol, ubiquinone and sterol synthesis
  JOURNAL   Biochim Biophys Acta Bioenerg 1859 (1), 1-7 (2018)
   PUBMED   29031613
REFERENCE   2  (bases 1 to 1669)
  AUTHORS   Nota,B., Struys,E.A., Pop,A., Jansen,E.E., Fernandez Ojeda,M.R.,
            Kanhai,W.A., Kranendijk,M., van Dooren,S.J., Bevova,M.R.,
            Sistermans,E.A., Nieuwint,A.W., Barth,M., Ben-Omran,T.,
            Hoffmann,G.F., de Lonlay,P., McDonald,M.T., Meberg,A., Muntau,A.C.,
            Nuoffer,J.M., Parini,R., Read,M.H., Renneberg,A., Santer,R.,
            Strahleck,T., van Schaftingen,E., van der Knaap,M.S., Jakobs,C. and
            Salomons,G.S.
  TITLE     Deficiency in SLC25A1, encoding the mitochondrial citrate carrier,
            causes combined D-2- and L-2-hydroxyglutaric aciduria
  JOURNAL   Am J Hum Genet 92 (4), 627-631 (2013)
   PUBMED   23561848
REFERENCE   3  (bases 1 to 1669)
  AUTHORS   Damiano,F., Gnoni,G.V. and Siculella,L.
  TITLE     Citrate carrier promoter is target of peroxisome
            proliferator-activated receptor alpha and gamma in hepatocytes and
            adipocytes
  JOURNAL   Int J Biochem Cell Biol 44 (4), 659-668 (2012)
   PUBMED   22249025
  REMARK    GeneRIF: binding of PPRE of CiC promoter by PPARalpha and
            PPARgammain vivo
REFERENCE   4  (bases 1 to 1669)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   5  (bases 1 to 1669)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 1669)
  AUTHORS   Capobianco,L., Bisaccia,F., Michel,A., Sluse,F.E. and Palmieri,F.
  TITLE     The N- and C-termini of the tricarboxylate carrier are exposed to
            the cytoplasmic side of the inner mitochondrial membrane
  JOURNAL   FEBS Lett 357 (3), 297-300 (1995)
   PUBMED   7835431
REFERENCE   7  (bases 1 to 1669)
  AUTHORS   Palmieri,F.
  TITLE     Mitochondrial carrier proteins
  JOURNAL   FEBS Lett 346 (1), 48-54 (1994)
   PUBMED   8206158
  REMARK    Review article
REFERENCE   8  (bases 1 to 1669)
  AUTHORS   Kaplan,R.S. and Mayor,J.A.
  TITLE     Structure, function and regulation of the tricarboxylate transport
            protein from rat liver mitochondria
  JOURNAL   J Bioenerg Biomembr 25 (5), 503-514 (1993)
   PUBMED   8132490
REFERENCE   9  (bases 1 to 1669)
  AUTHORS   Kaplan,R.S., Mayor,J.A. and Wood,D.O.
  TITLE     The mitochondrial tricarboxylate transport protein. cDNA cloning,
            primary structure, and comparison with other mitochondrial
            transport proteins
  JOURNAL   J Biol Chem 268 (18), 13682-13690 (1993)
   PUBMED   8514800
REFERENCE   10 (bases 1 to 1669)
  AUTHORS   Bisaccia,F., De Palma,A. and Palmieri,F.
  TITLE     Identification and purification of the tricarboxylate carrier from
            rat liver mitochondria
  JOURNAL   Biochim Biophys Acta 977 (2), 171-176 (1989)
   PUBMED   2804096
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB758644.1 and BC100077.1.
            
            On Oct 4, 2005 this sequence version replaced NM_017307.2.
            
            Summary: This gene encodes a member of the mitochondrial carrier
            family. The encoded protein is responsible for the movement of
            tricarboxylates, such as citrate, across the inner mitochondrial
            membrane. It is essential to the bioenergetics of hepatic cells,
            supplying the cytoplasm with a carbon source for fatty acid and
            sterol biosynthesis, and NAD+ for the glycolytic pathway. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100077.1, SRR8487231.133895.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 CB758644.1         15-22
            9-16                CB758644.1         24-31
            17-1669             BC100077.1         1-1653
FEATURES             Location/Qualifiers
     source          1..1669
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..1669
                     /gene="Slc25a1"
                     /gene_synonym="Cic; Ctp; Slc20a3"
                     /note="solute carrier family 25 member 1"
                     /db_xref="GeneID:29743"
                     /db_xref="RGD:3703"
     exon            1..208
                     /gene="Slc25a1"
                     /gene_synonym="Cic; Ctp; Slc20a3"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1050
                     /gene="Slc25a1"
                     /gene_synonym="Cic; Ctp; Slc20a3"
                     /note="tricarboxylate transport protein, mitochondrial;
                     mitochondrial tricarboxylate carrier; citrate transporter)
                     member 1; citrate transport protein; citrate carrier;
                     solute carrier family 25 (mitochondrial carrier, citrate
                     transporter), member 1"
                     /codon_start=1
                     /product="tricarboxylate transport protein, mitochondrial
                     precursor"
                     /protein_id="NP_059003.1"
                     /db_xref="GeneID:29743"
                     /db_xref="RGD:3703"
                     /translation="MAAPRAPRALTAAAPGSGKAKLTHPGKAILAGGLAGGIEICITF
                     PTEYVKTQLQLDERANPPRYRGIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAAVRF
                     GMFEFLSNHMRDAQGRLDSRRGLLCGLGAGVAEAVVVVCPMETVKVKFIHDQTSSNPK
                     YRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFVMTSLRNWYQGDNPNKPM
                     NPLITGVFGAVAGAASVFGNTPLDVIKTRMQGLEAHKYRNTLDCGVQILKNEGPKAFY
                     KGTVPRLGRVCLDVAIVFVIYDEVVKLLNKVWKTD"
     exon            209..316
                     /gene="Slc25a1"
                     /gene_synonym="Cic; Ctp; Slc20a3"
                     /inference="alignment:Splign:2.1.0"
     exon            317..416
                     /gene="Slc25a1"
                     /gene_synonym="Cic; Ctp; Slc20a3"
                     /inference="alignment:Splign:2.1.0"
     exon            417..555
                     /gene="Slc25a1"
                     /gene_synonym="Cic; Ctp; Slc20a3"
                     /inference="alignment:Splign:2.1.0"
     exon            556..640
                     /gene="Slc25a1"
                     /gene_synonym="Cic; Ctp; Slc20a3"
                     /inference="alignment:Splign:2.1.0"
     exon            641..745
                     /gene="Slc25a1"
                     /gene_synonym="Cic; Ctp; Slc20a3"
                     /inference="alignment:Splign:2.1.0"
     exon            746..861
                     /gene="Slc25a1"
                     /gene_synonym="Cic; Ctp; Slc20a3"
                     /inference="alignment:Splign:2.1.0"
     exon            862..935
                     /gene="Slc25a1"
                     /gene_synonym="Cic; Ctp; Slc20a3"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1643
                     /gene="Slc25a1"
                     /gene_synonym="Cic; Ctp; Slc20a3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1623..1628
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a1"
                     /gene_synonym="Cic; Ctp; Slc20a3"
     polyA_site      1643
                     /gene="Slc25a1"
                     /gene_synonym="Cic; Ctp; Slc20a3"
ORIGIN      
        1 cgggaccaga attggtcgcg gtctctgtag cctccggccc cgttgctttc cgagtgcccc
       61 gcgccggagg ctcggacccg aggtcgacgc cgggcgcccc tcctcctgcc cgccatggct
      121 gcgcctcgcg caccccgcgc tctgacggct gccgctcccg ggtccgggaa agccaaactg
      181 acgcaccccg ggaaggcgat cctagcaggc ggcctggctg gaggcatcga aatctgcatc
      241 accttcccga ccgaatacgt gaagactcaa ctacagctag atgaacgcgc gaacccaccg
      301 cggtaccggg gcattgggga ctgcgtgcgg caaactgtcc gcagccatgg cgtcctgggc
      361 ctgtaccgcg gcctcagctc cttgctctac ggctccatcc ccaaggcggc tgtcaggttt
      421 gggatgttcg agttcctcag caaccacatg cgggatgccc aaggtagact ggacagcagg
      481 agaggactgc tgtgcggtct gggtgccggc gtggcagagg cagtggtagt cgtgtgcccc
      541 atggagaccg tgaaggtgaa attcatccat gaccagactt cctccaatcc aaagtaccga
      601 ggatttttcc atggggttag agagattgtt cgggaacaag ggctaaaggg gacataccaa
      661 ggcctcacag ctactgtact gaagcagggc tcaaaccaag ccatccgatt cttcgtcatg
      721 acctccctac gcaactggta ccaaggagac aaccccaaca agcctatgaa cccactgatc
      781 accggggtct ttggagctgt cgcaggtgca gccagtgtct ttgggaacac acccttggat
      841 gtgatcaaga ccaggatgca gggcctggag gcacacaaat accggaacac cctggactgt
      901 ggagtgcaga tcctgaagaa tgaggggccc aaggcattct acaagggcac cgttccccgg
      961 ctgggccgag tctgcctgga cgtggccatc gtattcgtca tctatgatga agtggtgaag
     1021 ctgctcaata aagtgtggaa gacggactaa ccctggaggg tgcaatgggg cgtcccagct
     1081 cctccaggcc acctactctt gacgattcca gtgcagtagt gccaaaaggc cccttccttt
     1141 gtccctcaag ttctgtggcc tggtgtgtca tagtgactgt catgtgttcc ttagtactgt
     1201 actcccatgt ggtctatgtg taacactact attgtatctg tgtccagcct ggccgtggct
     1261 gggtgtctct ttggcctgtg aagacgtgct cacttaccca tgtgcttgct tgtgagccat
     1321 gtgcctgttt catgttctat gtcatgtgac cctgtgcccc acttcctggg gtgcctatgt
     1381 gccctggtcc atggccttgg agccatggtc aggtcacagt ccggtgcctt ccacccccta
     1441 tggcaagggc gccctgccct ggcctaccac agctgcctct gggcttcggc ctggcttcac
     1501 cgcattccag gggctatagg cccccctgct tctcccgcca ttggccttaa atggccctcg
     1561 ggccctccct ctgcccggaa cagggtggca ccagccactc tcaggaccac cttgccaagg
     1621 agaataaacc ggatcctgtt gcaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
