LOCUS       NM_053505               3749 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 24 member 3 (Slc24a3),
            mRNA.
ACCESSION   NM_053505 XM_001054941 XM_342533
VERSION     NM_053505.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3749)
  AUTHORS   Yang,H., Ahn,C., Shin,E.K., Lee,J.S., An,B.S. and Jeung,E.B.
  TITLE     NCKX3 was compensated by calcium transporting genes and bone
            resorption in a NCKX3 KO mouse model
  JOURNAL   Mol Cell Endocrinol 454, 93-102 (2017)
   PUBMED   28602864
REFERENCE   2  (bases 1 to 3749)
  AUTHORS   Jalloul,A.H., Szerencsei,R.T. and Schnetkamp,P.P.
  TITLE     Cation dependencies and turnover rates of the human K-dependent
            Na-Ca(2) exchangers NCKX1, NCKX2, NCKX3 and NCKX4
  JOURNAL   Cell Calcium 59 (1), 1-11 (2016)
   PUBMED   26631410
REFERENCE   3  (bases 1 to 3749)
  AUTHORS   Yang,H., Kim,T.H., Lee,H.H., Choi,K.C. and Jeung,E.B.
  TITLE     Distinct expression of the calcium exchangers, NCKX3 and NCX1, and
            their regulation by steroid in the human endometrium during the
            menstrual cycle
  JOURNAL   Reprod Sci 18 (6), 577-585 (2011)
   PUBMED   21321244
REFERENCE   4  (bases 1 to 3749)
  AUTHORS   Yang,H., Yoo,Y.M., Jung,E.M., Choi,K.C. and Jeung,E.B.
  TITLE     Uterine expression of sodium/potassium/calcium exchanger 3 and its
            regulation by sex-steroid hormones during the estrous cycle of rats
  JOURNAL   Mol Reprod Dev 77 (11), 971-977 (2010)
   PUBMED   21104767
  REMARK    GeneRIF: NCKX3 may be involved in reproductive function during the
            estrous cycle in female rats.
REFERENCE   5  (bases 1 to 3749)
  AUTHORS   Lee,G.S., Choi,K.C. and Jeung,E.B.
  TITLE     K+-dependent Na+/Ca2+ exchanger 3 is involved in renal active
            calcium transport and is differentially expressed in the mouse
            kidney
  JOURNAL   Am J Physiol Renal Physiol 297 (2), F371-F379 (2009)
   PUBMED   19474185
REFERENCE   6  (bases 1 to 3749)
  AUTHORS   Yang,H., Lee,G.S., Yoo,Y.M., Choi,K.C. and Jeung,E.B.
  TITLE     Sodium/potassium/calcium exchanger 3 is regulated by the steroid
            hormones estrogen and progesterone in the uterus of mice during the
            estrous cycle
  JOURNAL   Biochem Biophys Res Commun 385 (2), 279-283 (2009)
   PUBMED   19464262
REFERENCE   7  (bases 1 to 3749)
  AUTHORS   Lytton,J.
  TITLE     Na+/Ca2+ exchangers: three mammalian gene families control Ca2+
            transport
  JOURNAL   Biochem J 406 (3), 365-382 (2007)
   PUBMED   17716241
  REMARK    Review article
REFERENCE   8  (bases 1 to 3749)
  AUTHORS   Dong,H., Jiang,Y., Triggle,C.R., Li,X. and Lytton,J.
  TITLE     Novel role for K+-dependent Na+/Ca2+ exchangers in regulation of
            cytoplasmic free Ca2+ and contractility in arterial smooth muscle
  JOURNAL   Am J Physiol Heart Circ Physiol 291 (3), H1226-H1235 (2006)
   PUBMED   16617138
  REMARK    GeneRIF: mRNA encoding NCKX3 and NCKX4 was demonstrated by RT-PCR
            and Northern blot in both rat mesenteric and aortic smooth muscle
            providing evidence for their role in mediating vascular tone.
REFERENCE   9  (bases 1 to 3749)
  AUTHORS   Kiedrowski,L., Czyz,A., Li,X.F. and Lytton,J.
  TITLE     Preferential expression of plasmalemmal K-dependent Na+/Ca2+
            exchangers in neurons versus astrocytes
  JOURNAL   Neuroreport 13 (12), 1529-1532 (2002)
   PUBMED   12218699
  REMARK    GeneRIF: Preferential expression of plasmalemmal K-dependent
            Na+/Ca2+ exchangers in neurons versus astrocytes.
REFERENCE   10 (bases 1 to 3749)
  AUTHORS   Kraev,A., Quednau,B.D., Leach,S., Li,X.F., Dong,H., Winkfein,R.,
            Perizzolo,M., Cai,X., Yang,R., Philipson,K.D. and Lytton,J.
  TITLE     Molecular cloning of a third member of the potassium-dependent
            sodium-calcium exchanger gene family, NCKX3
  JOURNAL   J Biol Chem 276 (25), 23161-23172 (2001)
   PUBMED   11294880
  REMARK    Erratum:[J Biol Chem. 2006 Mar 31;281(13):8996]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Feb 11, 2021 this sequence version replaced NM_053505.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.13254.1, AY009158.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-198               JAXUCZ010000003.1  153005418-153005615
            199-327             JAXUCZ010000003.1  153078984-153079112
            328-404             JAXUCZ010000003.1  153300631-153300707
            405-479             JAXUCZ010000003.1  153359865-153359939
            480-564             JAXUCZ010000003.1  153367456-153367540
            565-668             JAXUCZ010000003.1  153367889-153367992
            669-743             JAXUCZ010000003.1  153434406-153434480
            744-769             JAXUCZ010000003.1  153445011-153445036
            770-823             JAXUCZ010000003.1  153460535-153460588
            824-957             JAXUCZ010000003.1  153465915-153466048
            958-1118            JAXUCZ010000003.1  153468049-153468209
            1119-1380           JAXUCZ010000003.1  153469691-153469952
            1381-1547           JAXUCZ010000003.1  153476308-153476474
            1548-1662           JAXUCZ010000003.1  153479433-153479547
            1663-1775           JAXUCZ010000003.1  153480825-153480937
            1776-1841           JAXUCZ010000003.1  153497885-153497950
            1842-3749           JAXUCZ010000003.1  153502590-153504497
FEATURES             Location/Qualifiers
     source          1..3749
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..3749
                     /gene="Slc24a3"
                     /gene_synonym="Nckx3"
                     /note="solute carrier family 24 member 3"
                     /db_xref="GeneID:85267"
                     /db_xref="RGD:69256"
     exon            1..198
                     /gene="Slc24a3"
                     /gene_synonym="Nckx3"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1988
                     /gene="Slc24a3"
                     /gene_synonym="Nckx3"
                     /note="Na(+)/K(+)/Ca(2+)-exchange protein 3;
                     potassium-dependent sodium-calcium exchanger NCKX3
                     (SLC24A3); solute carrier family 24
                     (sodium/potassium/calcium exchanger), member 3"
                     /codon_start=1
                     /product="sodium/potassium/calcium exchanger 3"
                     /protein_id="NP_445957.2"
                     /db_xref="GeneID:85267"
                     /db_xref="RGD:69256"
                     /translation="MPPPGDQDRARRRSRRRRRDLLLSQLCFLASVALLLWSLSSLRE
                     QKELDLMDLIGEDRKWMVGRKLMQVNDTLTSEDAGLRSSKNCTEPALHEFPRDIFSNE
                     DRRQGAVVLHVLCAMYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSA
                     PELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVALSSWCLLRDSIY
                     YTLSVVALIVFIYDEKVSWWESLVLVLMYLIYIIIMKYNACIHQCFERRTKGAGNMVN
                     GLANNAEIDDSSNCDATVVLLKKANFHRKASVIMVDELLSAYPHQLSFSEAGLRIMIT
                     SHFPPKTRLSMASRMLINERQRLINSRAYTNGESEVAIKIPIKHTVENGTGPSSAPDR
                     GVNGTRRDDIVAEADNETENENEDENNENDEEEDEDDDEGPYTPFDPPSGKLETVKWA
                     FTWPLSFVLYFTVPNCNKPHWEKWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPD
                     VIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLA
                     VDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCGCLFLYGVFLCFS
                     IMTEFNVFTFVNLPMCGD"
     exon            199..327
                     /gene="Slc24a3"
                     /gene_synonym="Nckx3"
                     /inference="alignment:Splign:2.1.0"
     exon            328..404
                     /gene="Slc24a3"
                     /gene_synonym="Nckx3"
                     /inference="alignment:Splign:2.1.0"
     exon            405..479
                     /gene="Slc24a3"
                     /gene_synonym="Nckx3"
                     /inference="alignment:Splign:2.1.0"
     exon            480..564
                     /gene="Slc24a3"
                     /gene_synonym="Nckx3"
                     /inference="alignment:Splign:2.1.0"
     exon            565..668
                     /gene="Slc24a3"
                     /gene_synonym="Nckx3"
                     /inference="alignment:Splign:2.1.0"
     exon            669..743
                     /gene="Slc24a3"
                     /gene_synonym="Nckx3"
                     /inference="alignment:Splign:2.1.0"
     exon            744..769
                     /gene="Slc24a3"
                     /gene_synonym="Nckx3"
                     /inference="alignment:Splign:2.1.0"
     exon            770..823
                     /gene="Slc24a3"
                     /gene_synonym="Nckx3"
                     /inference="alignment:Splign:2.1.0"
     exon            824..957
                     /gene="Slc24a3"
                     /gene_synonym="Nckx3"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1118
                     /gene="Slc24a3"
                     /gene_synonym="Nckx3"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1380
                     /gene="Slc24a3"
                     /gene_synonym="Nckx3"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1547
                     /gene="Slc24a3"
                     /gene_synonym="Nckx3"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1662
                     /gene="Slc24a3"
                     /gene_synonym="Nckx3"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1775
                     /gene="Slc24a3"
                     /gene_synonym="Nckx3"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1841
                     /gene="Slc24a3"
                     /gene_synonym="Nckx3"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..3749
                     /gene="Slc24a3"
                     /gene_synonym="Nckx3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgcccg cgacccgagc ggacgccgcc cgccagggac gccgcccggc cgtccgagga
       61 tgccgccgcc gggcgaccag gaccgcgcgc gccgccgcag ccgccgccgg cggagggacc
      121 ttctgctgag ccagctctgc ttcctggctt cggtggcgct gctgctctgg tcgctgtcga
      181 gcctgcgaga gcagaaggaa cttgacctca tggatctcat cggggaagat agaaaatgga
      241 tggtggggag gaagctgatg caggtgaatg atacactgac ttctgaagat gcaggactcc
      301 ggagcagcaa gaactgcaca gagccagccc tgcatgaatt ccccagggac atcttctcca
      361 atgaagaccg acgacaagga gcggtggtac tccacgtgct ctgtgccatg tatatgttct
      421 atgcactggc catcgtgtgc gatgacttct tcgtcccatc cttggaaaag atctgtgagc
      481 gcctccacct cagtgaagat gtggcaggag ccaccttcat ggcagcaggc agctcggccc
      541 cggagctctt cacatcggtc ataggagtct tcatcacaaa gggggatgtg ggagtcggca
      601 ccatcgtggg ctctgctgtg ttcaacatcc tgtgcatcat tggcgtctgc gggctctttg
      661 caggacaggt cgtggctctt tcttcctggt gcctgctgag ggattccatc tactacacac
      721 tgtctgtggt cgcactcatt gtgttcattt atgatgaaaa ggtttcttgg tgggaatctc
      781 tagtccttgt gctgatgtac ctcatctata tcatcatcat gaaatacaat gcgtgcatac
      841 accagtgctt cgaaaggagg acgaaaggtg ctgggaacat ggtcaacgga ctggccaata
      901 acgccgaaat cgatgacagc agcaactgcg atgccactgt ggtgctactt aagaaagcca
      961 atttccaccg caaagcgtca gtgatcatgg tggatgagct gctgtctgcc tacccacacc
     1021 agctctcttt ctctgaggct ggccttcgaa taatgatcac aagccacttt cctcccaaga
     1081 cccggctctc catggccagt cgcatgttaa tcaatgagag acaaagactg ataaacagca
     1141 gggcatatac caatggggaa tctgaagtgg ccatcaaaat cccaattaag cacactgtgg
     1201 agaatggaac agggcccagc agtgccccag acaggggtgt gaatggaacc cggagggacg
     1261 acatagttgc tgaggctgac aatgagacag agaacgagaa tgaagacgag aacaatgaga
     1321 atgacgagga ggaggatgaa gatgatgatg aaggccccta cacgccattc gaccccccct
     1381 ctggcaaact ggaaactgtg aaatgggcat tcacctggcc cctgagtttt gtcttgtact
     1441 tcactgtccc caactgtaac aagccccact gggagaagtg gtttatggtg acgtttgctt
     1501 cctctacact gtggattgca gccttctcct acatgatggt gtggatggtt accatcatcg
     1561 gctacaccct agggatccct gatgtcatca tggggatcac cttcctggct gccggaacca
     1621 gcgtgcccga ctgcatggcc agcctcattg tagccagaca agggatgggg gacatggctg
     1681 tgtccaattc cattgggagc aacgtgtttg acatcttgat tgggcttggc cttccctggg
     1741 ctctgcagac tctggctgtg gattatggat cctatattcg gctgaacagc agagggctca
     1801 tctactccgt gggcttgctc ctggcctctg tctttgtcac ggtgtttggc gttcacctga
     1861 acaagtggca gctggacaag aagctgggct gtggatgcct cttcctgtat ggcgtgttcc
     1921 tctgcttctc catcatgacg gagttcaacg tgttcacctt tgtgaacttg cccatgtgtg
     1981 gggactaatg attgaccagg tcacctgccg aggcccaggt ccttcttttc tgtgcaatac
     2041 gagacccggc cgcacccgag tcatgcggcc cctcaacggc cgcggcgtcc gtctctcccg
     2101 tgctgtctgc gggcctgtcc tggtggtcta ggctctccct gccacctcct ttgctcccaa
     2161 actcccttgg tcctacctcc cagccagccc ccctcaccca cccaccccat tcctgtgtct
     2221 tcttccgtgt gaagacgtcc accatccaca tgaattttca agctccatat ttgaacggtg
     2281 actgagattc tagaacaaaa ctggctgcta actggcccaa gccaggcaca acttactcca
     2341 atccctcctc ctttttttaa gttatttcac agaagatacc ctaatttatg accagagact
     2401 ttgaggaaac aggagagggt ccgctgatgg caggaagtat tgggtttgtt ttgtttggga
     2461 gtgattccta ggttaccggg tttgggaaat ggtttaattt gagggggttc attgtttctt
     2521 tacttttctt tcagagacag aggactcccc tcgagtcttc tctcactggg ctctggctta
     2581 atagatggtc cacagattgt actgtctcct gggggagaat ccaggcacgt tgggaattta
     2641 ataattagtt gggaaaccac tgagcgagac caccaggaat agatgcatga catgacattt
     2701 ttctgctcaa ggacacatca ctaaagtcct gaaggcttca cctgggggtg gggggtgtaa
     2761 ggtgttagag gaagaaacct gcttctcaca tgttcactat gcccatctcc ctcccaacta
     2821 ggttctttct agtttttcaa gcaatagttc tcgcctgcct aaggcctttg acaggaagac
     2881 cctgactaac tgtaaggcac caggcagtca acgacagaaa cttccccagt gtgtgagtcc
     2941 ttgacatgtg ctcttgttgc ttggcatttg tggtgacagg gagtgacccc agaggctatc
     3001 actgtgctct ggacagaagt tacagacact ggtttcttgg aaaatgaaga gaagcacatt
     3061 ttgcacagat gtcgtcaatg aagtcccaat ttgccacttg gtatcgagta cactggaccc
     3121 tgacagctgg ctcttgagca aacatccttc ctcacaggat gccaccaata agctagccag
     3181 tttcatccct cccgtcccag agggatggcc agggagggag gaagcagaga actgctgcat
     3241 tgaaaaccac agaatgggtt cacctcagac tggctcaagg gcacaagtta ttgtgaacat
     3301 ttcgccaatc actgctcaac cgccctgcta gatttttcta tgatgctgaa ttattatgca
     3361 gaataactcc accaagttga gatacaccca tgcttgttac acttgtattt attgaaactg
     3421 tggattcttg cccgcccgtg ctctcccttg tatttacttt aagcactgat cacttatcat
     3481 ccactcggta tggttttccc agtcccttgt acacatcctg gtttgaattg taaaaaataa
     3541 cctgctacag actggttgaa cgtttctgtc tgagctgcaa gccaaggggt ggcgtcaacc
     3601 gaggaccagg agtggaaatc acccatttgg gctctcagag ctaagacaca cttactgatt
     3661 tggttgcaca ttttgcactg gtttatggcg attgttttct tggacgaatg gtgtaaaata
     3721 aacttctctg ttctgtatcc tccctcaaa
//
