LOCUS       NP_113931                670 aa            linear   ROD 03-APR-2024
DEFINITION  sodium/potassium/calcium exchanger 2 [Rattus norvegicus].
ACCESSION   NP_113931 XP_579529
VERSION     NP_113931.1
DBSOURCE    REFSEQ: accession NM_031743.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 670)
  AUTHORS   Zhou,X.G., He,H. and Wang,P.J.
  TITLE     A critical role for miR-135a-5p-mediated regulation of SLC24A2 in
            neuropathic pain
  JOURNAL   Mol Med Rep 22 (3), 2115-2122 (2020)
   PUBMED   32582988
  REMARK    GeneRIF: A critical role for miR135a5pmediated regulation of
            SLC24A2 in neuropathic pain.
REFERENCE   2  (residues 1 to 670)
  AUTHORS   Jalloul,A.H., Szerencsei,R.T. and Schnetkamp,P.P.
  TITLE     Cation dependencies and turnover rates of the human K-dependent
            Na-Ca(2) exchangers NCKX1, NCKX2, NCKX3 and NCKX4
  JOURNAL   Cell Calcium 59 (1), 1-11 (2016)
   PUBMED   26631410
REFERENCE   3  (residues 1 to 670)
  AUTHORS   Ginger,R.S., Askew,S.E., Ogborne,R.M., Wilson,S., Ferdinando,D.,
            Dadd,T., Smith,A.M., Kazi,S., Szerencsei,R.T., Winkfein,R.J.,
            Schnetkamp,P.P. and Green,M.R.
  TITLE     SLC24A5 encodes a trans-Golgi network protein with
            potassium-dependent sodium-calcium exchange activity that regulates
            human epidermal melanogenesis
  JOURNAL   J Biol Chem 283 (9), 5486-5495 (2008)
   PUBMED   18166528
REFERENCE   4  (residues 1 to 670)
  AUTHORS   Lytton,J.
  TITLE     Na+/Ca2+ exchangers: three mammalian gene families control Ca2+
            transport
  JOURNAL   Biochem J 406 (3), 365-382 (2007)
   PUBMED   17716241
  REMARK    Review article
REFERENCE   5  (residues 1 to 670)
  AUTHORS   Altimimi,H.F. and Schnetkamp,P.P.
  TITLE     Na+/Ca2+-K+ exchangers (NCKX): functional properties and
            physiological roles
  JOURNAL   Channels (Austin) 1 (2), 62-69 (2007)
   PUBMED   18690016
  REMARK    Review article
REFERENCE   6  (residues 1 to 670)
  AUTHORS   Kiedrowski,L., Czyz,A., Li,X.F. and Lytton,J.
  TITLE     Preferential expression of plasmalemmal K-dependent Na+/Ca2+
            exchangers in neurons versus astrocytes
  JOURNAL   Neuroreport 13 (12), 1529-1532 (2002)
   PUBMED   12218699
  REMARK    GeneRIF: Preferential expression of plasmalemmal K-dependent
            Na+/Ca2+ exchangers in neurons versus astrocytes.
REFERENCE   7  (residues 1 to 670)
  AUTHORS   Lee,S.H., Kim,M.H., Park,K.H., Earm,Y.E. and Ho,W.K.
  TITLE     K+-dependent Na+/Ca2+ exchange is a major Ca2+ clearance mechanism
            in axon terminals of rat neurohypophysis
  JOURNAL   J Neurosci 22 (16), 6891-6899 (2002)
   PUBMED   12177187
REFERENCE   8  (residues 1 to 670)
  AUTHORS   Dong,H., Light,P.E., French,R.J. and Lytton,J.
  TITLE     Electrophysiological characterization and ionic stoichiometry of
            the rat brain K(+)-dependent NA(+)/CA(2+) exchanger, NCKX2
  JOURNAL   J Biol Chem 276 (28), 25919-25928 (2001)
   PUBMED   11342562
REFERENCE   9  (residues 1 to 670)
  AUTHORS   Prinsen,C.F., Szerencsei,R.T. and Schnetkamp,P.P.
  TITLE     Molecular cloning and functional expression of the
            potassium-dependent sodium-calcium exchanger from human and chicken
            retinal cone photoreceptors
  JOURNAL   J Neurosci 20 (4), 1424-1434 (2000)
   PUBMED   10662833
REFERENCE   10 (residues 1 to 670)
  AUTHORS   Tsoi,M., Rhee,K.H., Bungard,D., Li,X.F., Lee,S.L., Auer,R.N. and
            Lytton,J.
  TITLE     Molecular cloning of a novel potassium-dependent sodium-calcium
            exchanger from rat brain
  JOURNAL   J Biol Chem 273 (7), 4155-4162 (1998)
   PUBMED   9461611
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 4, 2005 this sequence version replaced XP_579529.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1292906.1,
                                           SRR26360190.684217.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..670
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q32"
     Protein         1..670
                     /product="sodium/potassium/calcium exchanger 2"
                     /note="retinal cone Na-Ca+K exchanger;
                     Na(+)/K(+)/Ca(2+)-exchange protein 2; potassium-dependent
                     sodium-calcium exchanger; solute carrier family 24
                     (sodium/potassium/calcium exchanger), member 2"
                     /calculated_mol_wt=74526
     Site            39..59
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O54701.1)"
     Region          67..86
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O54701.1)"
     Region          91..122
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O54701.1)"
     Region          <99..670
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     Site            112
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O54701.1)"
     Site            134..154
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O54701.1)"
     Region          175..215
                     /region_name="Alpha-1"
                     /note="propagated from UniProtKB/Swiss-Prot (O54701.1)"
     Site            180..200
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O54701.1)"
     Site            206..226
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O54701.1)"
     Site            245..265
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O54701.1)"
     Site            267..287
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O54701.1)"
     Region          312..335
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O54701.1)"
     Site            337
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O54701.1)"
     Site            341
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O54701.1)"
     Region          394..414
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O54701.1)"
     Region          450..471
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O54701.1)"
     Site            507..527
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O54701.1)"
     Site            543..563
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O54701.1)"
     Region          550..581
                     /region_name="Alpha-2"
                     /note="propagated from UniProtKB/Swiss-Prot (O54701.1)"
     Site            579..599
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O54701.1)"
     Site            612..632
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O54701.1)"
     Site            640..660
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O54701.1)"
     CDS             1..670
                     /gene="Slc24a2"
                     /gene_synonym="Nckx2"
                     /coded_by="NM_031743.4:307..2319"
                     /db_xref="GeneID:84550"
                     /db_xref="RGD:628650"
ORIGIN      
        1 mdlhqsatvr llqewcshes psgcrrhynt rkklklirvi glvmglvavs tvpfsisaft
       61 etysqnnrge asdvtgpraa pghrqrtlld lndkirdytp qppasqedrs engtdhaqgd
      121 ypkdvfslee rrkgaiilhv igmiymfial aivcdeffvp sltviteklg isddvagatf
      181 maaggsapel ftsligvfia hsnvgigtiv gsavfnilfv igmcalfsre ilnltwwplf
      241 rdvsfyivdl imliiffldn vimwweslll ltayfayvvf mkfnvqverw vkqminrnkv
      301 vkvtvseaqa kastagdkee ptlpnkprlq rggssaslhn slmrnsifql mihtldplae
      361 elgsygklky ydtmteegrf rekasilhki akkkcqvden erqngaanhv dyaaekielp
      421 nststevemt psseasepvq ngnlshsiea adapqateta eedddqplsl swpsntrkqi
      481 tflivlpivf plwitlpdvr kpaskkffpi tffgsitwia vfsylmvwwa hqvgetigis
      541 eeimgltila agtsipdlit svivarkglg dmavsssvgs nifditvglp lpwllytiih
      601 rfkpvtvssn glfcaivllf imlifvilsi alckwrmnki lgfimfglyf aflvvsvlle
      661 dkvlecpvsi
//
