LOCUS       NM_020090               3550 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 24 member 1 (Slc24a1),
            mRNA.
ACCESSION   NM_020090 XM_346825
VERSION     NM_020090.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3550)
  AUTHORS   Jalloul,A.H., Szerencsei,R.T. and Schnetkamp,P.P.
  TITLE     Cation dependencies and turnover rates of the human K-dependent
            Na-Ca(2) exchangers NCKX1, NCKX2, NCKX3 and NCKX4
  JOURNAL   Cell Calcium 59 (1), 1-11 (2016)
   PUBMED   26631410
REFERENCE   2  (bases 1 to 3550)
  AUTHORS   Zheng,M., Gong,Y., Wang,X., Xie,Q., Tang,H., Wang,D. and Chen,X.
  TITLE     Alteration of intracellular calcium and its modulator SLC24A6 after
            experimental intracerebral hemorrhage
  JOURNAL   Acta Neurochir Suppl 118, 169-173 (2013)
   PUBMED   23564126
REFERENCE   3  (bases 1 to 3550)
  AUTHORS   Lytton,J.
  TITLE     Na+/Ca2+ exchangers: three mammalian gene families control Ca2+
            transport
  JOURNAL   Biochem J 406 (3), 365-382 (2007)
   PUBMED   17716241
  REMARK    Review article
REFERENCE   4  (bases 1 to 3550)
  AUTHORS   Altimimi,H.F. and Schnetkamp,P.P.
  TITLE     Na+/Ca2+-K+ exchangers (NCKX): functional properties and
            physiological roles
  JOURNAL   Channels (Austin) 1 (2), 62-69 (2007)
   PUBMED   18690016
  REMARK    Review article
REFERENCE   5  (bases 1 to 3550)
  AUTHORS   Li,X.F. and Lytton,J.
  TITLE     Differential expression of Na/Ca exchanger and Na/Ca + K exchanger
            transcripts in rat brain
  JOURNAL   Ann N Y Acad Sci 976, 64-66 (2002)
   PUBMED   12502535
  REMARK    GeneRIF: Differential expression in the rat brain
REFERENCE   6  (bases 1 to 3550)
  AUTHORS   Poon,S., Leach,S., Li,X.F., Tucker,J.E., Schnetkamp,P.P. and
            Lytton,J.
  TITLE     Alternatively spliced isoforms of the rat eye
            sodium/calcium+potassium exchanger NCKX1
  JOURNAL   Am J Physiol Cell Physiol 278 (4), C651-C660 (2000)
   PUBMED   10751314
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF176688.1.
            
            On May 4, 2006 this sequence version replaced XM_346825.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF176688.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132263 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3550
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..3550
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /note="solute carrier family 24 member 1"
                     /db_xref="GeneID:56814"
                     /db_xref="RGD:620080"
     exon            1..1795
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..3550
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /note="retinal rod Na-Ca+K exchanger;
                     Na(+)/K(+)/Ca(2+)-exchange protein 1;
                     sodium/calcium/potassium exchanger; solute carrier family
                     24 (sodium/potassium/calcium exchanger), member 1; retinal
                     Na/Ca,K exchanger"
                     /codon_start=1
                     /product="sodium/potassium/calcium exchanger 1"
                     /protein_id="NP_064475.1"
                     /db_xref="GeneID:56814"
                     /db_xref="RGD:620080"
                     /translation="MGKLIRMGTQERRLLRPKRLHWSRLLFFLGMLIIGSTYQHLRRP
                     QNPPSMWTKVSSQQPIKLAIRDLPNDEITVTDKDPPEASSEVEGEMLAPQDTVIIGEA
                     APSIAMEDTPNPPITTKITPTSLKNNYSPTTAGTRRQKENIPPTPSRAPSHFISTSGR
                     QRVKSYTPKPRGGRKSSSPTHTREEGRMHTPSPAGAPRTISPTSTEKDSETTATYRML
                     EPRSERTAGKTSLKRMVPNTRTFLTREVETDLVTSPSLVGKNTLGSPRRGERNSSTTP
                     LRAVLQPTPATSEEQVTASIRMGSTPATTEGSTAAQRIGNPLSGTSTPAVRIASVTDR
                     EKRPSTAHGTLVTPQVKAVLTTQVHRCVVVKPAPAVPMTPSPSMTAILFPEAPTSGPS
                     ALPPGWPNLHPKAEYPPDLFSVEDRRQGWVVLHIFGMTYVFVALAIVCDEYFVPALGV
                     ITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIG
                     TCALFSREILNLTWWPLFRDVSFYILDLSMLIVFFLDSLIAWWESLLLLLAYALYVFT
                     MKWNKQIERWVKEQLSRRPVAKVMALGDLSKPSDGAIEENEQQDNKKLKLPSVLTRGS
                     SSASLHNSIIRSTIYHLMLHSLDPLGEARPSKDKQESLNQEARVLPQTKAESSSDEEE
                     PAELPAVTVTPAPAPEDKGDQEEDPGCQEDVDEAEHRGDMTGEEGERETEAEGKKDEE
                     GETEAERKEDGQEEETETKGKEKQEGETESEGKDEQEGETEAEGKEADHEGETEAEGK
                     EVEHEGETEAEGTEDEQEGETEAEGKEVEQEGETEAEGKEVEHEVETEAERKETNHEG
                     ETEAEGKEADHEGETEAEGNVEHQGETEAEGKVEHEGETEAGEKDEHEGQSETQADDT
                     EVKDGEGEAEANAEDQCETAQGEKGADGGGGSDGGDSEEEEDEEDEEEEEEEEEEEEE
                     EESEEPLSLEWPESRQKQAIYLFLLPIVFPLWLTIPDVRRQEARKFFVITFLGSIIWI
                     AMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSS
                     VGSNIFDITVGLPVPWLLFSLINALQPIPVSSNGLFCAIVLLFLMLLFVIFSIASCKW
                     RMNKILGFTMFLLYFVFLVISVMLEDRIISCPVSV"
     exon            1796..1849
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1958
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2042
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2134
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..3043
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3133
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /inference="alignment:Splign:2.1.0"
     exon            3134..3300
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /inference="alignment:Splign:2.1.0"
     exon            3301..3550
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caccatgggg aaattgatca ggatggggac gcaggagagg cggttactcc gaccaaagag
       61 gcttcattgg agtcgcctcc ttttcttcct gggaatgttg atcattggtt ccacttatca
      121 gcacctgagg agaccccaga atcccccttc aatgtggaca aaagtctcct cacagcagcc
      181 tattaaactg gccatcaggg acctccccaa tgatgagata acagtgacag acaaagaccc
      241 tccagaggct agctctgaag tggagggtga gatgctagca ccccaagaca cagtgatcat
      301 aggtgaagca gcacctagca tagcaatgga ggacaccccc aatccaccca taacaaccaa
      361 gatcactcca acgtcactaa agaacaatta tagccccaca acagctggca cgaggagaca
      421 aaaagaaaac attccaccca cacctagcag agcaccgagt cacttcatct caacttcagg
      481 cagacagaga gtgaaaagct ataccccaaa acccagggga ggaaggaaga gctccagccc
      541 aactcacacc agggaagaag gaaggatgca taccccatcc ccagcaggtg cgccccgcac
      601 catcagcccc acatcaacag agaaagacag tgaaaccacg gcaacctata ggatgttgga
      661 gcccagatct gagagaacag caggaaaaac ttctctcaag agaatggttc cgaacacccg
      721 gactttctta acacgcgaag tagaaacaga cctcgtgact tctccaagtt tggtggggaa
      781 gaacaccctg ggaagtccta gaagaggaga aagaaacagc tctaccactc ccctgcgagc
      841 agtcctgcag cctacccctg ccacctctga ggagcaagtg acggcaagca tcaggatggg
      901 tagcacccca gcaaccactg aaggttctac tgctgcccag agaattggca atcccttgtc
      961 cggaactagt acaccagctg ttagaattgc ctcagtcacg gacagggaaa agagaccttc
     1021 cacagcacac ggcaccctag taactcccca agtcaaggca gtcctgacca cacaggtcca
     1081 ccgctgtgtg gttgtgaagc cagccccagc tgtacccatg accccatctc cgagcatgac
     1141 agccatcctg ttcccagagg cacctacttc cggtccctca gccttgccgc ctggctggcc
     1201 aaacctccac cccaaggcgg agtatccccc agacctgttc agtgtggagg atcgacgcca
     1261 gggctgggtg gtcctacaca tcttcggtat gacgtacgtg tttgtggcct tggccatcgt
     1321 gtgtgatgag tactttgtcc cagccctggg ggtcatcacg gacaagcttc agatctccga
     1381 ggatgtggcc ggggccacat tcatggctgc cggaggctca gcccctgagc tcttcacctc
     1441 tctcattggt gtctttatct cccatagcaa tgtgggtatt ggtaccatcg tgggctctgc
     1501 tgtgttcaac atcctttttg tcatcggcac ctgcgccctc ttctcccggg agatcctcaa
     1561 cctcacctgg tggcccctgt tccgagatgt ctccttctac atccttgact tgtctatgct
     1621 catagtcttt ttcctggata gtctcattgc ctggtgggag agcctgctgc tgctgctggc
     1681 ctacgctctc tatgtgttca ccatgaagtg gaacaagcag attgaacgct gggtgaaaga
     1741 gcagcttagc aggaggccag tagccaaagt catggctcta ggagacctca gcaagcccag
     1801 tgatggtgcc attgaggaaa atgaacaaca ggataacaag aagctgaagc tcccgtctgt
     1861 gctgacccga gggagcagct cggcctccct gcacaacagc atcatccgca gcaccatcta
     1921 ccacctcatg ctccacagct tggaccccct gggggaagcc cgcccctcca aggacaagca
     1981 ggaaagtttg aatcaggaag ccagagtcct cccccagacc aaagcagaaa gcagctcaga
     2041 cgaggaggag ccagccgagc tccctgcggt cacggtcact ccagcccctg ctccagagga
     2101 caagggagat caggaggagg atccaggctg ccaggaagat gtggatgagg ctgaacacag
     2161 aggagacatg acaggtgaag agggtgaaag ggaaaccgag gcagaaggaa aaaaagatga
     2221 agaaggggaa actgaggcag aaaggaaaga agatggtcaa gaagaagaaa ctgagacaaa
     2281 agggaaagag aaacaagaag gggaaactga gtcagaagga aaagatgaac aagaagggga
     2341 aactgaggca gaaggaaaag aagctgacca tgaaggggaa actgaggcag aaggaaaaga
     2401 ggttgaacat gaaggggaaa ctgaagcaga aggaacagaa gatgaacaag aaggggaaac
     2461 tgaggcagaa ggaaaagaag ttgaacaaga aggggaaact gaggcagaag gaaaagaagt
     2521 tgaacatgaa gtggaaactg aggcagaaag aaaagaaact aaccatgaag gggaaactga
     2581 ggcagaagga aaagaagctg accatgaagg ggaaacagag gcagaaggaa atgttgaaca
     2641 tcaaggggaa actgaggcag aaggaaaagt tgaacatgag ggggaaaccg aggcaggaga
     2701 aaaagatgag catgaagggc aaagtgagac ccaagcagac gacactgagg tgaaagatgg
     2761 tgagggtgaa gcagaagcca atgctgaaga tcaatgtgag accgcccaag gtgagaaagg
     2821 tgcagacggt ggagggggaa gtgatggagg ggacagtgaa gaagaggagg atgaagagga
     2881 tgaagaggag gaggaagagg aggaagagga ggaagaggag gaggaaagtg aggagcctct
     2941 gtccttggaa tggcctgaga gcaggcagaa gcaggctatc tacctctttc tcctgcccat
     3001 cgtgttccca ctgtggctga caatacctga tgtacggagg caggaggcca ggaagttttt
     3061 tgtcatcacc ttcctgggat ccatcatctg gatagccatg ttctcatacc tcatggtgtg
     3121 gtgggctcac caggttggtg aaaccattgg gatttctgaa gagattatgg gtttgacgat
     3181 cctagcggca ggcacttcaa ttcctgacct catcaccagt gtgatcgttg cccggaaagg
     3241 cctgggagac atggccgtgt caagctcggt gggcagtaac atatttgata tcacagtggg
     3301 cctgcctgtc ccctggctcc tgttctccct catcaatgcg ctgcagccta tccctgtcag
     3361 cagcaacggc ctgttctgtg ccattgtctt gctgtttctc atgctcctgt ttgtgatctt
     3421 ctcaatcgct tcgtgtaaat ggagaatgaa caagatcctg ggcttcacca tgttccttct
     3481 ctactttgtg ttcctggtga tcagtgtgat gttagaagat cgcatcatat cctgccctgt
     3541 atctgtctga
//
