LOCUS       NM_017316               6314 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus solute carrier family 23 member 2 (Slc23a2),
            mRNA.
ACCESSION   NM_017316
VERSION     NM_017316.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6314)
  AUTHORS   Salazar,K., Martinez,F., Perez-Martin,M., Cifuentes,M.,
            Trigueros,L., Ferrada,L., Espinoza,F., Saldivia,N., Bertinat,R.,
            Forman,K., Oviedo,M.J., Lopez-Gambero,A.J., Bonansco,C.,
            Bongarzone,E.R. and Nualart,F.
  TITLE     SVCT2 Expression and Function in Reactive Astrocytes Is a Common
            Event in Different Brain Pathologies
  JOURNAL   Mol Neurobiol 55 (7), 5439-5452 (2018)
   PUBMED   28942474
  REMARK    GeneRIF: SVCT2 is heterogeneously induced in reactive astrogliosis
            generated in different pathologies affecting the central nervous
            system.
REFERENCE   2  (bases 1 to 6314)
  AUTHORS   Tian,H., Ye,X., Hou,X., Yang,X., Yang,J. and Wu,C.
  TITLE     SVCT2, a potential therapeutic target, protects against oxidative
            stress during ethanol-induced neurotoxicity via JNK/p38 MAPKs,
            NF-kappaB and miRNA125a-5p
  JOURNAL   Free Radic Biol Med 96, 362-373 (2016)
   PUBMED   27085842
  REMARK    GeneRIF: We speculate that SVCT2, possibly regulated by JNK/p38
            MAPKs, NF-kappaB signaling and miR-125a-5p, has a neuroprotective
            effect against EtOH-induced oxidative stress. Promotion of SVCT2
            expression or stimulation of SVCT2 activity may be a promising
            therapeutic strategy for the prevention of EtOH-associated
            neurodegeneration.
REFERENCE   3  (bases 1 to 6314)
  AUTHORS   Iwata,N., Okazaki,M., Xuan,M., Kamiuchi,S., Matsuzaki,H. and
            Hibino,Y.
  TITLE     Orally administrated ascorbic acid suppresses neuronal damage and
            modifies expression of SVCT2 and GLUT1 in the brain of diabetic
            rats with cerebral ischemia-reperfusion
  JOURNAL   Nutrients 6 (4), 1554-1577 (2014)
   PUBMED   24739976
  REMARK    GeneRIF: Expression of SVCT2 was upregulated in neurons after
            middle cerebral artery occlusion and reperfusion in the nondiabetic
            cortex, accompanied by an increase in total ascorbic acid in the
            tissue, and these responses were suppressed in the diabetic rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6314)
  AUTHORS   Hierro,C., Monte,M.J., Lozano,E., Gonzalez-Sanchez,E., Marin,J.J.
            and Macias,R.I.
  TITLE     Liver metabolic/oxidative stress induces hepatic and extrahepatic
            changes in the expression of the vitamin C transporters SVCT1 and
            SVCT2
  JOURNAL   Eur J Nutr 53 (2), 401-412 (2014)
   PUBMED   23708151
  REMARK    GeneRIF: metabolic/oxidative stress in the liver induce different
            responses in the expression of ascorbic acid transporters SVCT1 and
            SVCT2 in intrahepatic and extrahepatic tissues, which may affect
            the overall bioavailability and cellular uptake of this vitamin
REFERENCE   5  (bases 1 to 6314)
  AUTHORS   Ludke,A.R., Sharma,A.K., Akolkar,G., Bajpai,G. and Singal,P.K.
  TITLE     Downregulation of vitamin C transporter SVCT-2 in
            doxorubicin-induced cardiomyocyte injury
  JOURNAL   Am J Physiol Cell Physiol 303 (6), C645-C653 (2012)
   PUBMED   22763122
  REMARK    GeneRIF: Expression and localization of sodium-dependent vitamin C
            transporter-2 in the sarcolemma is reduced by doxorubicin, a change
            blunted by vitamin C supplementation.
REFERENCE   6  (bases 1 to 6314)
  AUTHORS   Sotiriou,S., Gispert,S., Cheng,J., Wang,Y., Chen,A.,
            Hoogstraten-Miller,S., Miller,G.F., Kwon,O., Levine,M.,
            Guttentag,S.H. and Nussbaum,R.L.
  TITLE     Ascorbic-acid transporter Slc23a1 is essential for vitamin C
            transport into the brain and for perinatal survival
  JOURNAL   Nat Med 8 (5), 514-517 (2002)
   PUBMED   11984597
REFERENCE   7  (bases 1 to 6314)
  AUTHORS   Wang,Y., Mackenzie,B., Tsukaguchi,H., Weremowicz,S., Morton,C.C.
            and Hediger,M.A.
  TITLE     Human vitamin C (L-ascorbic acid) transporter SVCT1
  JOURNAL   Biochem Biophys Res Commun 267 (2), 488-494 (2000)
   PUBMED   10631088
REFERENCE   8  (bases 1 to 6314)
  AUTHORS   Daruwala,R., Song,J., Koh,W.S., Rumsey,S.C. and Levine,M.
  TITLE     Cloning and functional characterization of the human
            sodium-dependent vitamin C transporters hSVCT1 and hSVCT2
  JOURNAL   FEBS Lett 460 (3), 480-484 (1999)
   PUBMED   10556521
REFERENCE   9  (bases 1 to 6314)
  AUTHORS   Rajan,D.P., Huang,W., Dutta,B., Devoe,L.D., Leibach,F.H.,
            Ganapathy,V. and Prasad,P.D.
  TITLE     Human placental sodium-dependent vitamin C transporter (SVCT2):
            molecular cloning and transport function
  JOURNAL   Biochem Biophys Res Commun 262 (3), 762-768 (1999)
   PUBMED   10471399
REFERENCE   10 (bases 1 to 6314)
  AUTHORS   Tsukaguchi,H., Tokui,T., Mackenzie,B., Berger,U.V., Chen,X.Z.,
            Wang,Y., Brubaker,R.F. and Hediger,M.A.
  TITLE     A family of mammalian Na+-dependent L-ascorbic acid transporters
  JOURNAL   Nature 399 (6731), 70-75 (1999)
   PUBMED   10331392
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF080453.1, JAXUCZ010000003.1 and AA964954.1.
            
            On Sep 28, 2011 this sequence version replaced NM_017316.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF080453.1, SRR26360194.1044660.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2259              AF080453.1         1-2259
            2260-5933           JAXUCZ010000003.1  139755948-139759621 c
            5934-6314           AA964954.1         1-381               c
FEATURES             Location/Qualifiers
     source          1..6314
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..6314
                     /gene="Slc23a2"
                     /gene_synonym="SVCT2"
                     /note="solute carrier family 23 member 2"
                     /db_xref="GeneID:50622"
                     /db_xref="RGD:619876"
     exon            1..66
                     /gene="Slc23a2"
                     /gene_synonym="SVCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            67..315
                     /gene="Slc23a2"
                     /gene_synonym="SVCT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..2154
                     /gene="Slc23a2"
                     /gene_synonym="SVCT2"
                     /note="sodium-coupled ascorbic acid transporter 2;
                     sodium-dependent vitamin C transporter 2; Na(+)/L-ascorbic
                     acid transporter 2; solute carrier family 23 (nucleobase
                     transporters), member 2; solute carrier family 23
                     (ascorbic acid transporter), member 2"
                     /codon_start=1
                     /product="solute carrier family 23 member 2"
                     /protein_id="NP_059012.2"
                     /db_xref="GeneID:50622"
                     /db_xref="RGD:619876"
                     /translation="MMGVGKNTSKSVEVGGSTEGKYEEEAKRPDFFTLPVVINGGATS
                     SGEQDNEDTELMAIYTTENGIAEKSSLAETLDSTGSLDPQRSDMIYTIEDVPPWYLCI
                     FLGLQHYLTCFSGTIAVPFLLADAMCVGDDQWATSQLIGTIFFCVGITTLLQTTFGCR
                     LPLFQASAFAFLAPARAILSLDKWKCNTTEITVANGTAELLEHIWHPRIQEIQGAIIM
                     SSLIEVVIGLLGLPGALLRYIGPLTITPTVALIGLSGFQAAGERAGKHWGIAMLTIFL
                     VLLFSQYARNVKFPLPIYKSKKGWTAYKLQLFKMFPIILAILVSWLLCFIFTVTDVFP
                     SNSTDYGYYARTDARKGVLLVAPWFKVPYPFQWGMPTVSAAGVIGMLSAVVASIIESI
                     GDYYACARLSCAPPPPIHAINRGIFVEGLSCVLDGVFGTGNGSTSSSPNIGVLGITKV
                     GSRRVIQYGAALMLGLGMIGKFSALFASLPDPVLGALFCTLFGMITAVGLSNLQFIDL
                     NSSRNLFVLGFSIFFGLVLPSYLRQNPLVTGITGIDQVLNVLLTTAMFVGGCVAFILD
                     NTIPGTPEERGIKKWKKGVSKGNKSLDGMESYNLPFGMNIIKKYRCFSYLPISPTFAG
                     YTWKGFGKSENRRSSDKDSQATV"
     exon            316..414
                     /gene="Slc23a2"
                     /gene_synonym="SVCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            415..531
                     /gene="Slc23a2"
                     /gene_synonym="SVCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            532..689
                     /gene="Slc23a2"
                     /gene_synonym="SVCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            690..778
                     /gene="Slc23a2"
                     /gene_synonym="SVCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            779..843
                     /gene="Slc23a2"
                     /gene_synonym="SVCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1025
                     /gene="Slc23a2"
                     /gene_synonym="SVCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1146
                     /gene="Slc23a2"
                     /gene_synonym="SVCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1303
                     /gene="Slc23a2"
                     /gene_synonym="SVCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1451
                     /gene="Slc23a2"
                     /gene_synonym="SVCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1557
                     /gene="Slc23a2"
                     /gene_synonym="SVCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1687
                     /gene="Slc23a2"
                     /gene_synonym="SVCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1825
                     /gene="Slc23a2"
                     /gene_synonym="SVCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1921
                     /gene="Slc23a2"
                     /gene_synonym="SVCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..6298
                     /gene="Slc23a2"
                     /gene_synonym="SVCT2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcggcagg cactgcggcg cgagcggtgc gatcggcggg acgcgagccc agcgagctgc
       61 aggcaggtga taagcgatga cagtaatctg cgtctgagga tccagtgttc caggtgctaa
      121 aagctgcctc tggtcttaga cccctgcctt gcatacgcct tccctgcaag cactccaggc
      181 cacagtttgt aggctgctca gcctgccttg atgatgggtg tcggcaagaa cacatcaaag
      241 tcggtggagg ttgggggctc cacagaaggc aaatatgaag aggaggccaa gcgccccgat
      301 ttctttactc tcccggtggt gatcaatggt ggggccacgt ccagtggaga acaggacaat
      361 gaagacactg agctcatggc catctacacc acagagaatg gcattgcaga gaagagctct
      421 ctcgcagaga ccctggacag cactgggagc ctggatcccc agaggtcaga tatgatctac
      481 actatagaag acgttcctcc ctggtactta tgcatattcc tggggttgca gcactacctg
      541 acgtgtttca gtggcacaat cgcagtgccc tttttgctgg ctgatgccat gtgcgtgggg
      601 gatgaccagt gggccaccag ccagctcatc gggaccattt tcttctgcgt gggaatcact
      661 acattgctgc agacaacatt tggatgcagg ttacccctgt ttcaggccag tgcttttgca
      721 tttttggccc ctgctcgagc catcctgtct ttagataaat ggaaatgtaa caccacagag
      781 atcacagttg ccaacggaac ggcagagctg ttggaacaca tctggcaccc ccggatccaa
      841 gagatccagg gggctataat catgtcctca ctgatagaag tggtcattgg cctccttggc
      901 ctgcctgggg ctctgctgag gtatattgga cccttgacca tcacacccac cgtggccctc
      961 attggcctct ctggtttcca ggcagcagga gagcgagctg ggaagcactg gggcattgcc
     1021 atgctgacaa ttttcctagt gttactattc tcacaatatg ccagaaatgt taaatttcct
     1081 ctcccaatct acaaatccaa gaaaggatgg acggcctaca agttacaact tttcaaaatg
     1141 tttcctataa tcctggctat cctcgtgtcc tggctgctgt gcttcatctt cacggtgact
     1201 gacgtcttcc cttccaacag caccgactat ggctactatg cacgcacaga tgccaggaag
     1261 ggcgtacttc tggtagcccc atggtttaag gttccatacc catttcagtg ggggatgccc
     1321 accgtctctg cagctggcgt cattggcatg ctcagtgctg tcgtagccag tatcattgag
     1381 tccatcggcg actactatgc ctgcgccagg ctctcctgtg ccccaccacc tcctatacat
     1441 gcaataaaca ggggtatttt tgtggagggt ctttcttgtg ttctcgatgg cgtatttggt
     1501 accgggaatg gctctacctc ctccagtccc aatattggag ttttgggaat tacaaaggtt
     1561 ggcagccgcc gagtgatcca gtatggtgca gctctcatgc tgggcttggg catgattggc
     1621 aagttcagcg ccctcttcgc ctccctccca gaccctgtac tcggagccct cttctgcaca
     1681 ctctttggaa tgatcacagc tgttggcctc tctaacctgc agttcattga cttgaattct
     1741 tcccggaacc tatttgtgct tggattttcc atcttctttg ggcttgttct tccaagttac
     1801 ctcagacaaa accctctggt tacaggcata acaggcattg atcaagttct gaatgtcctt
     1861 ctcaccactg ctatgttcgt cggaggctgt gtggctttta ttttggacaa caccatccca
     1921 ggaaccccag aggaaagagg aatcaagaaa tggaagaagg gtgtgagcaa aggaaacaag
     1981 tctcttgacg gcatggagtc ctataatttg ccatttggca tgaacattat taaaaaatac
     2041 agatgcttca gctacctgcc tatcagccca acctttgcag gttacacatg gaaaggcttt
     2101 gggaagagtg agaacaggcg gagttcagac aaagactccc aggccacagt atagcctttg
     2161 ctgtgtcctg tggcctggcc acagtacggc atgcatctgt agttccttgc tgaataacaa
     2221 gaagatatat gtttgtatat ctatctacat ggcatcctgt acctcagagc taagacaggt
     2281 tgcatatcac tcttctgttg tgggtggtga ttatgtccaa tatggtgtct cacttgtgtc
     2341 cttattgatc ccttacccgt tttgtgtcca ttgctggcca tggtcactga acttgaaatc
     2401 acagtcctgc cattggagtg ggcatttgga atctatagtg ctcctgcctt caagtgctct
     2461 ctttcttaca agctgcttcg aggtctaggg gtttctgctt cttaaacact atgtcccagt
     2521 cttcccatgt gacctcagcc tgaaccctgt ggagacctcc tctggccagg ggccactggt
     2581 gtccttactt tgttgtgatt ctattatcct tgatagccca ggagcctact gacctgactg
     2641 agaataatga catgtctgtc ctgtgaccag atatgagtgt gcataaggtc ctgtatagct
     2701 gtgactgggg gagctctggt taggagattg acagggagta gaacgatcct gagtcagtgg
     2761 gattctcaac catgctcccc cctcgtcacc ctggacccat ctgggccagc acagttcata
     2821 ctagtctctt tctggccgag acaccctatt tggcattttc actgctggct ggtgtgatgg
     2881 gtgttagagt gcccacaggt agtctgtggg tgtcttggct ctgctgccct gtatttgcgt
     2941 gtgttttatt cctatttaat gttattgact atagcggatt tttgaaatca gtgttttccg
     3001 tgtgaacttc caaccttgca tcctgttcct tggcctgtac tctttactcc attgagaaaa
     3061 gaaccagcgt ctgtaaaagc tgtgggtgcc atcagggaag cttcttgtgt cggctgttga
     3121 aagccagtga cagttgttgt gggtgtgttt tgtactgctc tataccatga aagtgtaaat
     3181 actgtagtgt ctaatctatt tatcacaact gactactgga ccagggccca gaaacatggg
     3241 tcaagttaca cgtgaatttg tttggtgaag aagggaagct ggggcagcga cagcatcagc
     3301 acgtgggatg tgccgttgtc taagccgctc cttcctcctg ttgcacgtca ttgctgacag
     3361 agctgactta atgactgtgt gggttgtcag gtcacatatc cactggatgt agattcttac
     3421 agagggaaga tttgacccct tagtcaaata gcctatggga tttgttacag atgatagcag
     3481 aaaagcagcc tttgggtgcc ctctgtgaaa gagttctaac ttggaaaaca aactcccaca
     3541 gacaaatgac ttgtactgaa tctggttttg gtttccaagc caagggcaaa gctgaagaca
     3601 tgagaatgcc cttgcttctt gaggttgtac ctcttaagtg gctgtggacc tggctgaact
     3661 gtgggtggca gtgggcatcc ccgtcaccct tagcaaggtg tggttggttc tcagtgcctg
     3721 tccatggtat gtgtttctgt gcccaggata gctcagtgtc cccatgttac caggtctttg
     3781 tgtttctgca gccctcacga cccttgagag ttttgggttg cagtcacacc tcagagccac
     3841 tgcattgttt tgccaaaatc ttactccaga ttaagttcgg gacttggttt ctaactgtat
     3901 ttagttttga tggtttatat tcagacaatt agtgctttgg aagcacattg ttgagtagcc
     3961 ttttgtccct ccttcttagc aagcccattt ggctgacagc tctcctgctc tgcgttcact
     4021 ctgtgcctcc atttgcattt tgcttagttg acccagtttc tctgacaagg tagaaaactg
     4081 gcaagcatct cagatctgta gtattgtggt gctgtggtgg gcaggagcag gagtccatcc
     4141 agaagcgtga gaacgaacgg gctgtaatcc aggccgtgcc ctgccactta tgctgtactg
     4201 ccgagtgcca cccgaggctt ctattggctg tagtttgctc tggggctttc acagttgaat
     4261 cctggagcct gggctcagca ggtatctgtg tggccaagga agtgctatgc caacatcttc
     4321 cattagaatc agggtttccc cttcttgctt catcagagcc aacttttgat attcttggaa
     4381 ggggacagga ggtaggaaca aagagagaag tagcctacgc gtgcaccccc agggtggggt
     4441 actgtccaca gtgccctggg tgactagtac cttgtaacca ctggtaaggt ttgtccttga
     4501 agcttgtggt cctcccaaca tatagggaat gtgtgtttat gtaccagatg ggaattttta
     4561 ggggacatgg tgactgtgtg atctctttgt ccagtgttgg ccctcggtac tagaacttgg
     4621 agttgctctg tttggttacc agtggactgt ttttcagatg tgagcatctt acagggcatt
     4681 ctatcctaat tctcacaatg aacacccctc cccccgcccc aaatcctgag agcaagcatt
     4741 tgtgccagcc acaggaagca gaagtattaa gggaagaggt gctggcagct accttgcggg
     4801 gagactccag taggaaagtc acaggcaatg acaccagtct tcatgacttt cattctcatt
     4861 tataagttgg acttcgagtc agtagaacat ttatgctcag aatctttctt aagacagttt
     4921 ccagtatttc tttgattgga attaatccag gcaaaagaag aggctttatc agagagcggg
     4981 agtgaagtat cgtgggtcct gcccgtatcc cattttcaca gtaacaaatt cacatgcagg
     5041 atttacttta tactgtagaa tactgacttt catgatgaca acttgattta tgcatgaata
     5101 tcaacagtat ttccatatag taaaataaca tttctgccca ggataatagt cacagttttc
     5161 cagggaggga atgatataat tttcatgaca atgtcatgtg ctgatagaat ttctccattg
     5221 atgaacctct agtatgtgtg tatactttat ttacccctgt gtatatttta tgatcatgat
     5281 ctaagctgtt aattctttca ttcatgtccc cgctaagaca ctgatattag caacttagag
     5341 ttggtgagtt ttatcttcag tcataccagt tccacagaga tgaggcctca gtccagaacc
     5401 catcttcaca gaaaagcagc agtagcctgc aggtggctat gcttggagcg acatttggct
     5461 gccagtagca ggcctggcat ggtgtgacgt gaggggccta attacctagc tgttgctgga
     5521 caccagctgt gcatacctga gcatgcccag tgtattgggt tcatgcacag tcctggaccc
     5581 gagctttcac aagctctgtc ctcaagggaa ctgtgtcctt ctccgtccca ttaagatttg
     5641 gacacagata agacatcttc cacttcattc ttcctggtca taagccagta aggcaagaag
     5701 gcccccacgt ggcagcattc agctctcatc catggagccc agagcgcagc agtgctgggc
     5761 tctccttttc agcagcctca cagcctcccc atccttccag gatgtcgacc gccatgtcac
     5821 cactctgatg cccagcattc tcgggttgct gcatgagtgt tgagaacact cctaaccaac
     5881 attgctgtct gctgccgtct ggcagtccag tgagcccttt tctgtccgtt cctaacaact
     5941 ttgattggac acattgaaaa ttttctgact gtccttaaga cagcagagac gcctctgttt
     6001 tatttgggtt ttgtgactga ctttgcctat gtatcttcct ggggttttgt ttgtgtttaa
     6061 tttttatttt gcatactgag ggtattgggg tggggttgtt ttttgagatg tgtaattctt
     6121 tcatggagtt tttaaaaaga attttcatat tgtttttcta acatggcttc attaaacgtt
     6181 taagtatttt aaaactatgt aatatttgga ccagatgttg tgaataacag tagagaaaag
     6241 ctattttatt ctgtattttt aaaactgttc cgtacaaata aaagctctcc tggatgtaaa
     6301 aaaaaaaaaa aaaa
//
