LOCUS       NM_017315               2309 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Rattus norvegicus solute carrier family 23 member 1 (Slc23a1),
            mRNA.
ACCESSION   NM_017315
VERSION     NM_017315.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2309)
  AUTHORS   Hierro,C., Monte,M.J., Lozano,E., Gonzalez-Sanchez,E., Marin,J.J.
            and Macias,R.I.
  TITLE     Liver metabolic/oxidative stress induces hepatic and extrahepatic
            changes in the expression of the vitamin C transporters SVCT1 and
            SVCT2
  JOURNAL   Eur J Nutr 53 (2), 401-412 (2014)
   PUBMED   23708151
  REMARK    GeneRIF: metabolic/oxidative stress in the liver induce different
            responses in the expression of ascorbic acid transporters SVCT1 and
            SVCT2 in intrahepatic and extrahepatic tissues, which may affect
            the overall bioavailability and cellular uptake of this vitamin
REFERENCE   2  (bases 1 to 2309)
  AUTHORS   Mardones,L., Zuniga,F.A., Villagran,M., Sotomayor,K., Mendoza,P.,
            Escobar,D., Gonzalez,M., Ormazabal,V., Maldonado,M., Onate,G.,
            Angulo,C., Concha,I.I., Reyes,A.M., Carcamo,J.G., Barra,V.,
            Vera,J.C. and Rivas,C.I.
  TITLE     Essential role of intracellular glutathione in controlling ascorbic
            acid transporter expression and function in rat hepatocytes and
            hepatoma cells
  JOURNAL   Free Radic Biol Med 52 (9), 1874-1887 (2012)
   PUBMED   22348976
  REMARK    GeneRIF: glutathione depletion failed to affect ascorbic acid
            transport, and SVCT1 and SVCT2 expression in hepatoma cells.
REFERENCE   3  (bases 1 to 2309)
  AUTHORS   Macias,R.I., Hierro,C., de Juan,S.C., Jimenez,F., Gonzalez-San
            Martin,F. and Marin,J.J.
  TITLE     Hepatic expression of sodium-dependent vitamin C transporters:
            ontogeny, subtissular distribution and effect of chronic liver
            diseases
  JOURNAL   Br J Nutr 106 (12), 1814-1825 (2011)
   PUBMED   21733302
  REMARK    GeneRIF: In adult rats, when obstructive cholestasis was maintained
            for 8 weeks, a significant up-regulation of Slc23a2 accompanied by
            a down-regulation of Slc23a1 was found.
REFERENCE   4  (bases 1 to 2309)
  AUTHORS   Varma,S., Sobey,K., Campbell,C.E. and Kuo,S.M.
  TITLE     Hierarchal contribution of N- and C-terminal sequences to the
            differential localization of homologous sodium-dependent vitamin C
            transporters, SVCT1 and SVCT2, in epithelial cells
  JOURNAL   Biochemistry 48 (13), 2969-2980 (2009)
   PUBMED   19216494
REFERENCE   5  (bases 1 to 2309)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 2309)
  AUTHORS   Song,J., Kwon,O., Chen,S., Daruwala,R., Eck,P., Park,J.B. and
            Levine,M.
  TITLE     Flavonoid inhibition of sodium-dependent vitamin C transporter 1
            (SVCT1) and glucose transporter isoform 2 (GLUT2), intestinal
            transporters for vitamin C and Glucose
  JOURNAL   J Biol Chem 277 (18), 15252-15260 (2002)
   PUBMED   11834736
  REMARK    GeneRIF: inhibited by flavonoids, an intestinal transporter for
            vitamin c
REFERENCE   7  (bases 1 to 2309)
  AUTHORS   Sotiriou,S., Gispert,S., Cheng,J., Wang,Y., Chen,A.,
            Hoogstraten-Miller,S., Miller,G.F., Kwon,O., Levine,M.,
            Guttentag,S.H. and Nussbaum,R.L.
  TITLE     Ascorbic-acid transporter Slc23a1 is essential for vitamin C
            transport into the brain and for perinatal survival
  JOURNAL   Nat Med 8 (5), 514-517 (2002)
   PUBMED   11984597
REFERENCE   8  (bases 1 to 2309)
  AUTHORS   MacDonald,L., Thumser,A.E. and Sharp,P.
  TITLE     Decreased expression of the vitamin C transporter SVCT1 by ascorbic
            acid in a human intestinal epithelial cell line
  JOURNAL   Br J Nutr 87 (2), 97-100 (2002)
   PUBMED   11895172
REFERENCE   9  (bases 1 to 2309)
  AUTHORS   Wang,Y., Mackenzie,B., Tsukaguchi,H., Weremowicz,S., Morton,C.C.
            and Hediger,M.A.
  TITLE     Human vitamin C (L-ascorbic acid) transporter SVCT1
  JOURNAL   Biochem Biophys Res Commun 267 (2), 488-494 (2000)
   PUBMED   10631088
REFERENCE   10 (bases 1 to 2309)
  AUTHORS   Tsukaguchi,H., Tokui,T., Mackenzie,B., Berger,U.V., Chen,X.Z.,
            Wang,Y., Brubaker,R.F. and Hediger,M.A.
  TITLE     A family of mammalian Na+-dependent L-ascorbic acid transporters
  JOURNAL   Nature 399 (6731), 70-75 (1999)
   PUBMED   10331392
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078851.1.
            
            On Jun 10, 2007 this sequence version replaced NM_017315.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078851.1, AF080452.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132281,
                                           SAMD00132295 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2309
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..2309
                     /gene="Slc23a1"
                     /gene_synonym="SVCT1"
                     /note="solute carrier family 23 member 1"
                     /db_xref="GeneID:50621"
                     /db_xref="RGD:619875"
     exon            1..41
                     /gene="Slc23a1"
                     /gene_synonym="SVCT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..1820
                     /gene="Slc23a1"
                     /gene_synonym="SVCT1"
                     /note="sodium-coupled ascorbic acid transporter 1; solute
                     carrier family 23 (nucleobase transporters), member 1;
                     sodium-dependent vitamin C transporter 1; Na(+)/L-ascorbic
                     acid transporter 1; solute carrier family 23 (ascorbic
                     acid transporter), member 1"
                     /codon_start=1
                     /product="solute carrier family 23 member 1"
                     /protein_id="NP_059011.1"
                     /db_xref="GeneID:50621"
                     /db_xref="RGD:619875"
                     /translation="MKAQEDPGSSKQHECPDSAGTSTRDQQAPLPAEPKFDMLYKIED
                     VPPWYLCILLGFQHYLTCFSGTIAVPFLLAEALCVGRDQHMISQLIGTIFTCVGITTL
                     IQTTVGIRLPLFQASAFAFLVPAKAILALERWKCPPEEEIYGNWSMPLNTSHIWHPRI
                     REVQGAIMVSSVVEVVIGLLGLPGALLSYIGPLTVTPTVSLIGLSVFQAAGDRAGSHW
                     GISACSILLIVLFSQYLRNLTFLLPVYRWGKGLTLFRIQIFKMFPIVLAIMTVWLLCY
                     VLTLTDVLPADPTVYGFQARTDARGDIMAISPWIRIPYPCQWGLPTVTVAAVLGMFSA
                     TLAGIIESIGDYYACARLAGAPPPPVHAINRGIFTEGVCCIIAGLLGTGNGSTSSSPN
                     IGVLGITKVGSRRVVQYGAGIMLILGAIGKFTALFASLPDPILGGMFCTLFGMITAVG
                     LSNLQFVDMNSSRNLFVLGFSMFFGLTLPNYLDSNPGAINTGVPEVDQILTVLLTTEM
                     FVGGCLAFILDNTVPGSPEERGLIQWKAGAHANSETLASLKSYDFPFGMGMVKRTTFF
                     RYIPICPVFRGFSKTENQPAVLEDAPDNTETGSVCTKV"
     exon            42..176
                     /gene="Slc23a1"
                     /gene_synonym="SVCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            177..334
                     /gene="Slc23a1"
                     /gene_synonym="SVCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            335..423
                     /gene="Slc23a1"
                     /gene_synonym="SVCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            424..491
                     /gene="Slc23a1"
                     /gene_synonym="SVCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            492..673
                     /gene="Slc23a1"
                     /gene_synonym="SVCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            674..794
                     /gene="Slc23a1"
                     /gene_synonym="SVCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            795..951
                     /gene="Slc23a1"
                     /gene_synonym="SVCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1099
                     /gene="Slc23a1"
                     /gene_synonym="SVCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1205
                     /gene="Slc23a1"
                     /gene_synonym="SVCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1335
                     /gene="Slc23a1"
                     /gene_synonym="SVCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1479
                     /gene="Slc23a1"
                     /gene_synonym="SVCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1575
                     /gene="Slc23a1"
                     /gene_synonym="SVCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1837
                     /gene="Slc23a1"
                     /gene_synonym="SVCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..2278
                     /gene="Slc23a1"
                     /gene_synonym="SVCT1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagagatgaa agctcaggag gaccccggga gctcaaagca gcatgaatgc ccagattcag
       61 cagggacttc caccagggac cagcaggcac ctttgcccgc ggagcccaag tttgacatgt
      121 tgtacaagat tgaggacgtg ccaccatggt acctgtgtat cctgctgggc ttccagcatt
      181 acctgacatg cttcagtggt accattgctg tgcccttcct cctggctgag gcgctgtgtg
      241 tgggccgcga ccagcacatg atcagtcagc tcattggtac catcttcacc tgcgtgggta
      301 tcaccactct cattcagact acagtgggca tccggctgcc gctgttccag gccagtgcct
      361 ttgcgtttct ggttccagcc aaggctatcc tggccttgga gaggtggaag tgtcctccag
      421 aagaggagat ctacggtaac tggagtatgc ccctgaacac ctctcatatc tggcatcctc
      481 ggattcggga ggtccagggt gcaatcatgg tgtccagcgt ggtagaggtg gtgattgggc
      541 tgttggggct gcctggggcc ctgctcagct acattggacc tctcacagtc acccccactg
      601 tctcccttat cggtctctct gttttccaag ctgctggcga ccgagctggc tcccattggg
      661 gcatttcggc ttgctccatt ctactgatcg tcctgttctc ccagtatcta cgcaacctca
      721 ccttcctgtt gcctgtttac cgatggggca agggtcttac tctcttccgc atccagatct
      781 ttaagatgtt tccgatcgtg ctggccatca tgaccgtgtg gctactctgc tatgtgctga
      841 ctctgacaga cgtgctgccc gcagatccca cagtctacgg tttccaggct cgaactgatg
      901 cccgagggga catcatggct atctctccct ggatccggat cccctaccca tgtcaatggg
      961 gcctacccac agtgaccgtg gctgcagttc tgggaatgtt cagcgccaca ctggcgggca
     1021 tcatcgagtc catcggtgat tactatgcct gcgcccggtt ggctggagca ccaccccctc
     1081 cagtccatgc tatcaacagg gggattttca ccgaaggcgt ctgctgcatc atcgctgggc
     1141 tactgggcac aggcaacggg tccacctctt ccagccccaa catcggggtc ctagggatta
     1201 ccaaggtggg cagccgaaga gtcgtgcagt atggtgcagg tatcatgcta atcctggggg
     1261 ccattggcaa attcacagct ctcttcgcct cactgccgga ccccatcctg ggagggatgt
     1321 tctgcactct tttcggtatg atcaccgctg tgggactgtc caatctgcag tttgtggaca
     1381 tgaactcctc ccgcaacctc tttgtattgg gattctccat gttcttcggc ctcacgctac
     1441 ccaactacct ggattccaac ccaggtgcca tcaacacagg cgttcctgaa gtggatcaga
     1501 tcctaactgt gctgctgacc acagagatgt ttgttggtgg ctgtcttgct ttcatactgg
     1561 acaacacagt accagggagc ccagaggaaa gaggtctgat acagtggaaa gccggggcac
     1621 acgccaacag tgagacgctg gccagtctca agagctacga tttcccgttc gggatgggca
     1681 tggtaaaaag gaccaccttt tttagataca tccccatctg cccagtcttc agaggattct
     1741 ctaagacaga aaatcagcct gcagttctag aagacgctcc agacaacaca gaaactgggt
     1801 ctgtgtgtac caaggtctga aactacctct atgaaaggag gcacggtgtg tatcaggaaa
     1861 acaaactacc caggagacag aagacctgag ttggagatct cagctgtccc tattctaaat
     1921 tcccatggaa gactggacag atcaccctct ctttgactcc attttcgtga cagcccaagt
     1981 ctctaagtcc tcgggagacc tgtatttgca ctgctctgat tccttacttc cactttccta
     2041 agcatgcatg tcaaggagga agagctggag aaaaaaaagg aaacccagag agattctagg
     2101 gcttcatgta gacatgaaga tagggttaaa aacaaaccaa acaaaacccc ctgaattcca
     2161 atgctatgta ttttaagacc aaaacagtat taaataatat actggaccaa taatttagat
     2221 aagtttagat aagtattctc ccttcacaca gggaaaataa atctatactt tcagactaaa
     2281 aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
