LOCUS       NM_053537               1636 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 22 member 7 (Slc22a7),
            mRNA.
ACCESSION   NM_053537
VERSION     NM_053537.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1636)
  AUTHORS   Pellicer,M., Garcia-Gonzalez,X., Garcia,M.I., Robles,L.,
            Gravalos,C., Garcia-Alfonso,P., Pachon,V., Longo,F., Martinez,V.,
            Blanco,C., Iglesias,I., Sanjurjo,M. and Lopez-Fernandez,L.A.
  TITLE     Identification of new SNPs associated with severe toxicity to
            capecitabine
  JOURNAL   Pharmacol Res 120, 133-137 (2017)
   PUBMED   28347776
REFERENCE   2  (bases 1 to 1636)
  AUTHORS   Breljak,D., Ljubojevic,M., Hagos,Y., Micek,V., Balen Eror,D.,
            Vrhovac Madunic,I., Brzica,H., Karaica,D., Radovic,N., Kraus,O.,
            Anzai,N., Koepsell,H., Burckhardt,G., Burckhardt,B.C. and
            Sabolic,I.
  TITLE     Distribution of organic anion transporters NaDC3 and OAT1-3 along
            the human nephron
  JOURNAL   Am J Physiol Renal Physiol 311 (1), F227-F238 (2016)
   PUBMED   27053689
REFERENCE   3  (bases 1 to 1636)
  AUTHORS   Shen,H., Liu,T., Morse,B.L., Zhao,Y., Zhang,Y., Qiu,X., Chen,C.,
            Lewin,A.C., Wang,X.T., Liu,G., Christopher,L.J., Marathe,P. and
            Lai,Y.
  TITLE     Characterization of Organic Anion Transporter 2 (SLC22A7): A Highly
            Efficient Transporter for Creatinine and Species-Dependent Renal
            Tubular Expression
  JOURNAL   Drug Metab Dispos 43 (7), 984-993 (2015)
   PUBMED   25904762
  REMARK    GeneRIF: the findings revealed the important role of OAT2 in renal
            secretion and possible reabsorption of creatinine and suggested a
            molecular basis for potential species difference in the transporter
            handling of creatinine
REFERENCE   4  (bases 1 to 1636)
  AUTHORS   Babelova,A., Burckhardt,B.C., Wegner,W., Burckhardt,G. and
            Henjakovic,M.
  TITLE     Sex-differences in renal expression of selected transporters and
            transcription factors in lean and obese Zucker spontaneously
            hypertensive fatty rats
  JOURNAL   J Diabetes Res 2015, 483238 (2015)
   PUBMED   25710042
  REMARK    GeneRIF: strongly decreased expression of Oat2 and other
            transporters in female diabetic ZSF1 rats could possibly impair
            renal drug excretion, for example, of furosemide
REFERENCE   5  (bases 1 to 1636)
  AUTHORS   Fork,C., Bauer,T., Golz,S., Geerts,A., Weiland,J., Del Turco,D.,
            Schomig,E. and Grundemann,D.
  TITLE     OAT2 catalyses efflux of glutamate and uptake of orotic acid
  JOURNAL   Biochem J 436 (2), 305-312 (2011)
   PUBMED   21446918
  REMARK    GeneRIF: Expression of rat OAT2 in HEK (human embryonic kidney)-293
            cells stimulates accumulation of the zwitterion trigonelline;
            subsequently, orotic acid is identified as an excellent and
            specific substrate of OAT2 from rat.
REFERENCE   6  (bases 1 to 1636)
  AUTHORS   Kobayashi,Y., Hirokawa,N., Ohshiro,N., Sekine,T., Sasaki,T.,
            Tokuyama,S., Endou,H. and Yamamoto,T.
  TITLE     Differential gene expression of organic anion transporters in male
            and female rats
  JOURNAL   Biochem Biophys Res Commun 290 (1), 482-487 (2002)
   PUBMED   11779196
REFERENCE   7  (bases 1 to 1636)
  AUTHORS   Morita,N., Kusuhara,H., Sekine,T., Endou,H. and Sugiyama,Y.
  TITLE     Functional characterization of rat organic anion transporter 2 in
            LLC-PK1 cells
  JOURNAL   J Pharmacol Exp Ther 298 (3), 1179-1184 (2001)
   PUBMED   11504818
REFERENCE   8  (bases 1 to 1636)
  AUTHORS   Sekine,T., Cha,S.H., Tsuda,M., Apiwattanakul,N., Nakajima,N.,
            Kanai,Y. and Endou,H.
  TITLE     Identification of multispecific organic anion transporter 2
            expressed predominantly in the liver
  JOURNAL   FEBS Lett 429 (2), 179-182 (1998)
   PUBMED   9650585
REFERENCE   9  (bases 1 to 1636)
  AUTHORS   Simonson,G.D. and Iwanij,V.
  TITLE     Genomic organization and promoter sequence of a gene encoding a rat
            liver-specific type-I transport protein
  JOURNAL   Gene 154 (2), 243-247 (1995)
   PUBMED   7890171
REFERENCE   10 (bases 1 to 1636)
  AUTHORS   Simonson,G.D., Vincent,A.C., Roberg,K.J., Huang,Y. and Iwanij,V.
  TITLE     Molecular cloning and characterization of a novel liver-specific
            transport protein
  JOURNAL   J Cell Sci 107 (Pt 4), 1065-1072 (1994)
   PUBMED   8056831
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY816233.1.
            
            On Jun 10, 2007 this sequence version replaced NM_053537.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY816233.1, L27651.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1636
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..1636
                     /gene="Slc22a7"
                     /gene_synonym="Livtr; Oat2; rOAT2"
                     /note="solute carrier family 22 member 7"
                     /db_xref="GeneID:89776"
                     /db_xref="RGD:621699"
     exon            1..406
                     /gene="Slc22a7"
                     /gene_synonym="Livtr; Oat2; rOAT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1621
                     /gene="Slc22a7"
                     /gene_synonym="Livtr; Oat2; rOAT2"
                     /note="organic anion transporter 2; novel liver
                     transporter; solute carrier family 22 (organic anion
                     transporter), member 7; Liver-specific transporter"
                     /codon_start=1
                     /product="solute carrier family 22 member 7"
                     /protein_id="NP_445989.2"
                     /db_xref="GeneID:89776"
                     /db_xref="RGD:621699"
                     /translation="MGFEDLLDKVGGFGPFQLRNLVLMALPRMLLPMHFLLPVFMAAV
                     PAHHCALPGAPANLSHQDLWLEAHLPRETDGSFSSCLRFAYPQTVPNVTLGTEVSNSG
                     EPEGEPLTVPCSQGWEYDRSEFSSTIATEWDLVCQQRGLNKITSTCFFIGVLVGAVVY
                     GYLSDRFGRRRLLLVAYVSSLVLGLMSAASINYIMFVVTRTLTGSALAGFTIIVLPLE
                     LEWLDVEHRTVAGVISTVFWSGGVLLLALVGYLIRSWRWLLLAATLPCVPGIISIWWV
                     PESARWLLTQGRVEEAKKYLLSCAKLNGRPVGEGSLSQEALNNVVTMERALQRPSYLD
                     LFRTSQLRHISLCCMMVWFGVNFSYYGLTLDVSGLGLNVYQTQLLFGAVELPSKIMVY
                     FLVRRLGRRLTEAGMLLGAALTFGTSLLVSLETKSWITALVVVGKAFSEAAFTTAYLF
                     TSELYPTVLRQTGLGLTALMGRLGASLAPLAALLDGVWLLLPKVAYGGIALVAACTAL
                     LLPETKKAQLPETIQDVERKSTQEEDV"
     exon            407..510
                     /gene="Slc22a7"
                     /gene_synonym="Livtr; Oat2; rOAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            511..665
                     /gene="Slc22a7"
                     /gene_synonym="Livtr; Oat2; rOAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            666..834
                     /gene="Slc22a7"
                     /gene_synonym="Livtr; Oat2; rOAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            835..958
                     /gene="Slc22a7"
                     /gene_synonym="Livtr; Oat2; rOAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1068
                     /gene="Slc22a7"
                     /gene_synonym="Livtr; Oat2; rOAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1283
                     /gene="Slc22a7"
                     /gene_synonym="Livtr; Oat2; rOAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1392
                     /gene="Slc22a7"
                     /gene_synonym="Livtr; Oat2; rOAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1599
                     /gene="Slc22a7"
                     /gene_synonym="Livtr; Oat2; rOAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1636
                     /gene="Slc22a7"
                     /gene_synonym="Livtr; Oat2; rOAT2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgggtgggt agcatgggct tcgaagacct gctggacaag gtgggcggct ttgggccctt
       61 ccaacttcgg aatctggttc tgatggccct gccccgaatg ctgctcccca tgcactttct
      121 cctgcccgtc ttcatggccg ctgtgcctgc ccaccattgt gccctgcccg gtgcccctgc
      181 caacctcagt caccaggact tatggctgga agcccatcta ccccgggaga ctgacggcag
      241 ctttagctcc tgcctccgat ttgcctatcc ccagactgtc cccaatgtca ctttggggac
      301 agaggtgtcc aactctgggg agcctgaggg tgagcccctc acggtgccct gctctcaggg
      361 ctgggagtac gaccgctcag aattctcctc caccattgca actgagtggg atcttgtgtg
      421 tcagcagaga ggactgaaca aaattacgtc cacctgcttc ttcattggtg tgctggtggg
      481 agccgtggtg tatggatact tgtctgacag gtttggcagg cgccggcttc tgctggtggc
      541 ctacgtgagc tccctggtgc tgggtctgat gtctgcagcc tccatcaact acatcatgtt
      601 cgtagtcacc cgtacactca ccggctcagc cctggctggc ttcaccatca ttgtgctccc
      661 actggagttg gagtggctgg atgtggagca ccgcactgtg gccggggtca tcagcaccgt
      721 cttctggtcg ggaggcgtgc tgctgctggc actggtgggc tacctgatcc ggagctggcg
      781 ctggcttctg ctggctgcca ccctgccgtg tgtcccaggc atcatcagca tctggtgggt
      841 tcctgagtct gcacggtggc ttctaaccca gggtcgtgtg gaggaggcaa aaaaatactt
      901 gctgagctgt gccaagctca atgggcggcc cgtgggtgag ggcagcctga gccaggaggc
      961 cctgaacaac gtggtcacca tggaaagggc gttgcaaaga ccctcatact tagacctgtt
     1021 ccgaacatct cagctccgac atatctcact gtgctgcatg atggtgtggt ttggagtgaa
     1081 cttttcctac tacggcctga ctctggacgt gtctgggctg gggctgaacg tgtaccagac
     1141 acagctgctg tttggggctg tggagctccc ctccaaaatt atggtctact tccttgtgcg
     1201 ccgtctggga cgccgtctca cggaggctgg gatgctgctg ggcgctgctc tgacctttgg
     1261 caccagcctg ctggtatcct tggagactaa gtcatggatc actgctctgg tggtggtggg
     1321 gaaagctttt tctgaagctg cttttactac ggcctacctg ttcacgtccg agttgtaccc
     1381 tactgtgctc agacagacag gattgggact tactgcactc atgggcaggc taggggcctc
     1441 tctggcccca ctggcggcct tgctggatgg agtgtggctg ttgctgccca aagttgctta
     1501 cggggggatt gccctggtgg ctgcctgcac tgcactcctg ctgcctgaga cgaagaaggc
     1561 acagctgcca gagaccatcc aggatgtgga gaggaagagt acccaggagg aagatgtgta
     1621 ggtccgggac tgagtt
//
