LOCUS       NM_017224               2025 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 22 member 6 (Slc22a6),
            mRNA.
ACCESSION   NM_017224
VERSION     NM_017224.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2025)
  AUTHORS   Taniguchi,T., Omura,K., Motoki,K., Sakai,M., Chikamatsu,N.,
            Ashizawa,N., Takada,T. and Iwanaga,T.
  TITLE     Hypouricemic agents reduce indoxyl sulfate excretion by inhibiting
            the renal transporters OAT1/3 and ABCG2
  JOURNAL   Sci Rep 11 (1), 7232 (2021)
   PUBMED   33790363
  REMARK    GeneRIF: Hypouricemic agents reduce indoxyl sulfate excretion by
            inhibiting the renal transporters OAT1/3 and ABCG2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2025)
  AUTHORS   Nosetto,E.C., Campagno,R.V., Torres,A.M. and Brandoni,A.
  TITLE     Distribution of the organic anion transporters Oat1 and Oat3
            between renal membrane microdomains in obstructive jaundice
  JOURNAL   Pflugers Arch 472 (6), 711-719 (2020)
   PUBMED   32451678
  REMARK    GeneRIF: Distribution of the organic anion transporters Oat1 and
            Oat3 between renal membrane microdomains in obstructive jaundice.
REFERENCE   3  (bases 1 to 2025)
  AUTHORS   Bush,K.T., Singh,P. and Nigam,S.K.
  TITLE     Gut-derived uremic toxin handling in vivo requires OAT-mediated
            tubular secretion in chronic kidney disease
  JOURNAL   JCI Insight 5 (7), 133817 (2020)
   PUBMED   32271169
  REMARK    GeneRIF: Gut-derived uremic toxin handling in vivo requires
            OAT-mediated tubular secretion in chronic kidney disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2025)
  AUTHORS   Minocha,E., Chaturvedi,C.P. and Nityanand,S.
  TITLE     Renogenic characterization and in vitro differentiation of rat
            amniotic fluid stem cells into renal proximal tubular- and
            juxtaglomerular-like cells
  JOURNAL   In Vitro Cell Dev Biol Anim 55 (2), 138-147 (2019)
   PUBMED   30645697
REFERENCE   5  (bases 1 to 2025)
  AUTHORS   Zhang,Z., Tachikawa,M., Uchida,Y. and Terasaki,T.
  TITLE     Drug Clearance from Cerebrospinal Fluid Mediated by Organic Anion
            Transporters 1 (Slc22a6) and 3 (Slc22a8) at Arachnoid Membrane of
            Rats
  JOURNAL   Mol Pharm 15 (3), 911-922 (2018)
   PUBMED   29436232
  REMARK    GeneRIF: Study results indicate that Oat1 and Oat3 at the
            blood-arachnoid barrier provide a distinct clearance pathway of
            organic anion drugs from cerebrospinal fluid independently of
            choroid plexus.
REFERENCE   6  (bases 1 to 2025)
  AUTHORS   Race,J.E., Grassl,S.M., Williams,W.J. and Holtzman,E.J.
  TITLE     Molecular cloning and characterization of two novel human renal
            organic anion transporters (hOAT1 and hOAT3)
  JOURNAL   Biochem Biophys Res Commun 255 (2), 508-514 (1999)
   PUBMED   10049739
REFERENCE   7  (bases 1 to 2025)
  AUTHORS   Lu,R., Chan,B.S. and Schuster,V.L.
  TITLE     Cloning of the human kidney PAH transporter: narrow substrate
            specificity and regulation by protein kinase C
  JOURNAL   Am J Physiol 276 (2), F295-F303 (1999)
   PUBMED   9950961
REFERENCE   8  (bases 1 to 2025)
  AUTHORS   Hosoyamada,M., Sekine,T., Kanai,Y. and Endou,H.
  TITLE     Molecular cloning and functional expression of a multispecific
            organic anion transporter from human kidney
  JOURNAL   Am J Physiol 276 (1), F122-F128 (1999)
   PUBMED   9887087
REFERENCE   9  (bases 1 to 2025)
  AUTHORS   Sweet,D.H., Wolff,N.A. and Pritchard,J.B.
  TITLE     Expression cloning and characterization of ROAT1. The basolateral
            organic anion transporter in rat kidney
  JOURNAL   J Biol Chem 272 (48), 30088-30095 (1997)
   PUBMED   9374486
REFERENCE   10 (bases 1 to 2025)
  AUTHORS   Sekine,T., Watanabe,N., Hosoyamada,M., Kanai,Y. and Endou,H.
  TITLE     Expression cloning and characterization of a novel multispecific
            organic anion transporter
  JOURNAL   J Biol Chem 272 (30), 18526-18529 (1997)
   PUBMED   9228014
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC104692.1.
            
            On Jun 3, 2007 this sequence version replaced NM_017224.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC104692.1, AF008221.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2025
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2025
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /note="solute carrier family 22 member 6"
                     /db_xref="GeneID:29509"
                     /db_xref="RGD:69338"
     exon            1..414
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1701
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /note="organic cationic transporter-like 1; rROAT1;
                     organic anion transporter 1; renal organic anion
                     transporter 1; solute carrier family 22 (organic anion
                     transporter), member 6"
                     /codon_start=1
                     /product="solute carrier family 22 member 6"
                     /protein_id="NP_058920.1"
                     /db_xref="GeneID:29509"
                     /db_xref="RGD:69338"
                     /translation="MAFNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAI
                     PPHHCRPPANANLSKDGGLEAWLPLDKQGQPESCLRFTSPQWGPPFYNGTEANGTRVT
                     EPCIDGWVYDNSTFPSTIVTEWNLVCSHRAFRQLAQSLYMVGVLLGAMVFGYLADRLG
                     RRKVLILNYLQTAVSGTCAAYAPNYTVYCVFRLLSGMSLASIAINCMTLNVEWMPIHT
                     RAYVGTLIGYVYSLGQFLLAGIAYAVPHWRHLQLVVSVPFFIAFIYSWFFIESARWYS
                     SSGRLDLTLRALQRVARINGKQEEGAKLSIEVLRTSLQKELTLSKGQASAMELLRCPT
                     LRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYLIQVIFGAVDLPAKFVCFLVINSM
                     GRRPAQMASLLLAGICILVNGIIPKSHTIIRTSLAVLGKGCLASSFNCIFLYTGELYP
                     TVIRQTGLGMGSTMARVGSIVSPLVSMTAEFYPSMPLFIFGAVPVVASAVTALLPETL
                     GQPLPDTVQDLKSRSRGKQNQQQQEQQKQMMPLQASTQEKNGL"
     exon            415..518
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /inference="alignment:Splign:2.1.0"
     exon            519..673
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /inference="alignment:Splign:2.1.0"
     exon            674..842
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /inference="alignment:Splign:2.1.0"
     exon            843..966
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1082
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1297
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1406
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1610
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1997
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gactggaggt cctcagtcat tgaccactca gcctggccca gccccatggc cttcaatgac
       61 ctcctgaaac aggtgggggg cgtcggacgc ttccagttga tccaggtcac catggtggtt
      121 gctcccctac tgctgatggc ttcccacaac accttgcaga acttcactgc cgctatcccc
      181 cctcatcact gccgcccacc tgccaatgcc aatctcagca aagatggagg tctggaggcc
      241 tggctgcccc tggacaagca aggacaaccc gaatcttgcc tccgctttac ttccccccag
      301 tggggaccac ccttttacaa tggcacagaa gccaatggca ccagagtcac agagccctgc
      361 attgatggct gggtctatga caacagcacc ttcccttcaa ccatcgtgac tgagtggaac
      421 cttgtgtgct ctcatcgggc tttccgccag ctggcccagt ccctgtacat ggtgggagtg
      481 ctgctgggag ccatggtgtt tggctacctg gcggacaggc tgggccgccg gaaggtgctg
      541 atcttgaact acctgcagac agctgtgtcg ggaacctgtg cagcctatgc acccaactat
      601 actgtctact gcgttttccg gctcctctcg ggcatgtctt tggctagcat tgcaatcaac
      661 tgcatgacac taaatgtgga atggatgcct atccacaccc gtgcctatgt gggcaccttg
      721 attggctatg tctacagcct gggccagttc ctcctggctg gcatcgccta tgctgtgccc
      781 cactggcgcc acctgcagct tgtggtctct gtgccttttt tcattgcctt catctactct
      841 tggttcttca ttgagtcagc ccgctggtac tcctcctcag gaaggctgga cctcaccctc
      901 cgagccctgc agagagtggc ccggatcaat gggaaacaag aagaaggggc taagctaagt
      961 atagaggtgc tccggaccag cctgcagaag gaactgactc taagcaaagg ccaagcctca
     1021 gccatggagc tgctgcgctg ccccaccctt cgacacctct tcctctgtct ctccatgctg
     1081 tggtttgcca ctagctttgc ctactacggg ctggtcatgg acctgcaggg ctttggggtc
     1141 agcatgtacc ttatccaggt gattttcggt gccgtggacc tgcctgccaa gtttgtatgc
     1201 ttcctagtca tcaactccat ggggcgccgg cctgcacaga tggcctccct gctgctggca
     1261 ggcatctgca tcctggtgaa tggcataata ccgaagagcc atacgatcat tcgcacctcc
     1321 ctggctgtgc tagggaaggg ctgcctggct tcctctttca actgcatctt cctgtacacc
     1381 ggagagctgt accccacagt gattcggcag acaggcctgg gcatgggcag caccatggcc
     1441 cgggtgggca gcattgtgag cccgctggtg agtatgactg cagagttcta cccctccatg
     1501 cctctcttca tcttcggcgc tgtccctgtg gtcgccagtg ctgtcactgc cctgctgcca
     1561 gagaccttgg gccagccgct gccagataca gtgcaggacc tgaagagcag gagcagagga
     1621 aagcagaatc aacagcagca ggaacagcag aagcagatga tgccgctcca ggcctcaaca
     1681 caagagaaga atggactttg agaacggaag ggcttcacac agcactaaag ggagtggagt
     1741 tctacaggtc ctgccgtcta catgaggagg gggagtgagt agagggactg gaccatccaa
     1801 atgtggaggc tgccattcag agaaatccct ccccaaaggt catgtcagta gacccactag
     1861 gaacaaaagc tctgactatg tgcagcttct taagcagaat gttctcggca ccggccatct
     1921 tcctgctcat ggtcactccg ccacctccag gaccttgcaa agaatctcag acaattaaat
     1981 gaatctcttc taccttgaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
