LOCUS       NM_019269               3033 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Rattus norvegicus solute carrier family 22 member 5 (Slc22a5),
            mRNA.
ACCESSION   NM_019269
VERSION     NM_019269.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3033)
  AUTHORS   Qi,C., Zhou,J., Wang,Z., Fang,X., Li,D., Jin,Y. and Song,J.
  TITLE     Cigarette smoke extract combined with lipopolysaccharide reduces
            OCTN1/2 expression in human alveolar epithelial cells in vitro and
            rat lung in vivo under inflammatory conditions
  JOURNAL   Int Immunopharmacol 87, 106812 (2020)
   PUBMED   32707498
REFERENCE   2  (bases 1 to 3033)
  AUTHORS   Oppedisano,F., Muscoli,C., Musolino,V., Carresi,C., Macri,R.,
            Giancotta,C., Bosco,F., Maiuolo,J., Scarano,F., Paone,S.,
            Nucera,S., Zito,M.C., Scicchitano,M., Ruga,S., Ragusa,M., Palma,E.,
            Tavernese,A., Mollace,R., Bombardelli,E. and Mollace,V.
  TITLE     The Protective Effect of Cynara Cardunculus Extract in Diet-Induced
            NAFLD: Involvement of OCTN1 and OCTN2 Transporter Subfamily
  JOURNAL   Nutrients 12 (5), 1435 (2020)
   PUBMED   32429274
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3033)
  AUTHORS   Li,D., Liu,J., Du,W., Liu,H., Xiao,W., Song,X., Fan,Z., Ke,C.,
            Yu,Q., Qin,W., Tang,Y. and Pu,X.
  TITLE     Carnitine/organic cation transporter 2 (OCTN2) contributes to rat
            epididymal epithelial cell growth and proliferation
  JOURNAL   Biomed Pharmacother 93, 444-450 (2017)
   PUBMED   28666211
  REMARK    GeneRIF: OCTN2 plays a positive role in epididymal epithelial
            cells, and might be useful in the clinical treatment of male
            infertility by serving as a key regulatory factor.
            Erratum:[Biomed Pharmacother. 2018 Aug;104:854. doi:
            10.1016/j.biopha.2018.04.029.. PMID: 29753602]
REFERENCE   4  (bases 1 to 3033)
  AUTHORS   Jurkiewicz,D., Michalec,K., Skowronek,K. and Nalecz,K.A.
  TITLE     Tight junction protein ZO-1 controls organic cation/carnitine
            transporter OCTN2 (SLC22A5) in a protein kinase C-dependent way
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1864 (5), 797-805 (2017)
   PUBMED   28257821
REFERENCE   5  (bases 1 to 3033)
  AUTHORS   Czeredys,M., Samluk,L., Michalec,K., Tulodziecka,K., Skowronek,K.
            and Nalecz,K.A.
  TITLE     Caveolin-1--a novel interacting partner of organic cation/carnitine
            transporter (Octn2): effect of protein kinase C on this interaction
            in rat astrocytes
  JOURNAL   PLoS One 8 (12), e82105 (2013)
   PUBMED   24349196
  REMARK    GeneRIF: PKC activation resulted in an augmented Octn2 presence in
            cholesterol/sphingolipid-rich microdomains of plasma membrane
            (rafts) and increased co-precipitation of Octn2 with raft-proteins,
            caveolin-1 and flotillin-1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3033)
  AUTHORS   Miyagawa,J., Kuwajima,M., Hanafusa,T., Ozaki,K., Fujimura,H.,
            Ono,A., Uenaka,R., Narama,I., Oue,T., Yamamoto,K. et al.
  TITLE     Mitochondrial abnormalities of muscle tissue in mice with juvenile
            visceral steatosis associated with systemic carnitine deficiency
  JOURNAL   Virchows Arch 426 (3), 271-279 (1995)
   PUBMED   7773507
REFERENCE   7  (bases 1 to 3033)
  AUTHORS   Tomomura,M., Imamura,Y., Tomomura,A., Horiuchi,M. and Saheki,T.
  TITLE     Abnormal gene expression and regulation in the liver of jvs mice
            with systemic carnitine deficiency
  JOURNAL   Biochim Biophys Acta 1226 (3), 307-314 (1994)
   PUBMED   7914432
REFERENCE   8  (bases 1 to 3033)
  AUTHORS   Horiuchi,M., Kobayashi,K., Yamaguchi,S., Shimizu,N., Koizumi,T.,
            Nikaido,H., Hayakawa,J., Kuwajima,M. and Saheki,T.
  TITLE     Primary defect of juvenile visceral steatosis (jvs) mouse with
            systemic carnitine deficiency is probably in renal carnitine
            transport system
  JOURNAL   Biochim Biophys Acta 1226 (1), 25-30 (1994)
   PUBMED   8155735
REFERENCE   9  (bases 1 to 3033)
  AUTHORS   Kuwajima,M., Kono,N., Horiuchi,M., Imamura,Y., Ono,A., Inui,Y.,
            Kawata,S., Koizumi,T., Hayakawa,J., Saheki,T. et al.
  TITLE     Animal model of systemic carnitine deficiency: analysis in C3H-H-2
            degrees strain of mouse associated with juvenile visceral steatosis
  JOURNAL   Biochem Biophys Res Commun 174 (3), 1090-1094 (1991)
   PUBMED   1996978
REFERENCE   10 (bases 1 to 3033)
  AUTHORS   Matsuishi,T., Hirata,K., Terasawa,K., Kato,H., Yoshino,M.,
            Ohtaki,E., Hirose,F., Nonaka,I., Sugiyama,N. and Ohta,K.
  TITLE     Successful carnitine treatment in two siblings having lipid storage
            myopathy with hypertrophic cardiomyopathy
  JOURNAL   Neuropediatrics 16 (1), 6-12 (1985)
   PUBMED   3974805
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Apr 13, 2023 this sequence version replaced NM_019269.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB017260.1, AF110416.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-501               JAXUCZ010000010.1  38535572-38536072   c
            502-605             JAXUCZ010000010.1  38528236-38528339   c
            606-760             JAXUCZ010000010.1  38520301-38520455   c
            761-932             JAXUCZ010000010.1  38519247-38519418   c
            933-1059            JAXUCZ010000010.1  38517999-38518125   c
            1060-1160           JAXUCZ010000010.1  38515835-38515935   c
            1161-1375           JAXUCZ010000010.1  38513894-38514108   c
            1376-1558           JAXUCZ010000010.1  38512095-38512277   c
            1559-1694           JAXUCZ010000010.1  38510756-38510891   c
            1695-3033           JAXUCZ010000010.1  38509072-38510410   c
FEATURES             Location/Qualifiers
     source          1..3033
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..3033
                     /gene="Slc22a5"
                     /gene_synonym="CT1; OCTN2; UST2r"
                     /note="solute carrier family 22 member 5"
                     /db_xref="GeneID:29726"
                     /db_xref="RGD:3702"
     exon            1..501
                     /gene="Slc22a5"
                     /gene_synonym="CT1; OCTN2; UST2r"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1782
                     /gene="Slc22a5"
                     /gene_synonym="CT1; OCTN2; UST2r"
                     /note="high-affinity sodium-dependent carnitine
                     cotransporter; solute carrier family 22 (organic cation
                     transporter), member 5; high-affinity carnitine
                     transporter; integral membrane transport protein; solute
                     carrier family 22 (organic cation/carnitine transporter),
                     member 5"
                     /codon_start=1
                     /product="organic cation/carnitine transporter 2"
                     /protein_id="NP_062142.1"
                     /db_xref="GeneID:29726"
                     /db_xref="RGD:3702"
                     /translation="MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFNGMSIVFLAG
                     TPEHRCLVPHTVNLSSAWRNHSIPLETKDGRQVPQSCRRYRLATIANFSALGLEPGRD
                     VDLEQLEQENCLDGWEYNKDVFLSTIVTEWDLVCKDDWKAPLTTSLFFVGVLMGSFIS
                     GQLSDRFGRKNVLFLTMGMQTGFSFLQLFSVNFEMFTVLFVLVGMGQISNYVAAFVLG
                     TEILSKSIRIIFATLGVCIFYAFGFMVLPLFAYFIRDWRMLLLALTVPGVLCGALWWF
                     IPESPRWLISQGRVKEAEVIIRKAAKFNGIVAPSTIFDPSELQDLNSKKPQSHHIYDL
                     VRTRNIRIITIMSIILWLTISVGYFGLSLDTPNLHGDIYVNCFLLAAVEVPAYVLAWL
                     LLQHLPRRYSISAALFLGGSVLLFIQLVPSELFYLSTALVMVGKFGITSAYSMVYVYT
                     AELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLF
                     FPESFGAPLPDTIDQMLRVKGIKQWQIQSQTRTQKDGGESPTVLKSTAF"
     exon            502..605
                     /gene="Slc22a5"
                     /gene_synonym="CT1; OCTN2; UST2r"
                     /inference="alignment:Splign:2.1.0"
     exon            606..760
                     /gene="Slc22a5"
                     /gene_synonym="CT1; OCTN2; UST2r"
                     /inference="alignment:Splign:2.1.0"
     exon            761..932
                     /gene="Slc22a5"
                     /gene_synonym="CT1; OCTN2; UST2r"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1059
                     /gene="Slc22a5"
                     /gene_synonym="CT1; OCTN2; UST2r"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1160
                     /gene="Slc22a5"
                     /gene_synonym="CT1; OCTN2; UST2r"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1375
                     /gene="Slc22a5"
                     /gene_synonym="CT1; OCTN2; UST2r"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1558
                     /gene="Slc22a5"
                     /gene_synonym="CT1; OCTN2; UST2r"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1694
                     /gene="Slc22a5"
                     /gene_synonym="CT1; OCTN2; UST2r"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..3033
                     /gene="Slc22a5"
                     /gene_synonym="CT1; OCTN2; UST2r"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcggtggga actcacgagc ctcgcacgca gaggccctca gcgccccgtt tcccgctctg
       61 cggtatcccc agatccccgg acgggtgctg tgggaggctg aggacggcat gcgggactac
      121 gacgaggtga ccgccttcct gggcgagtgg gggcccttcc agcgcctcat tttcttcctg
      181 ctcagcgcca gcatcatccc caatggcttc aatggtatgt ctatcgtgtt cctggcgggg
      241 accccggagc accgttgcct tgtgcctcac accgtgaact tgagcagcgc gtggcgcaac
      301 cacagtatcc cgttggagac gaaggacgga cgacaggtgc ctcagagctg ccgccgctac
      361 cgactggcca ccatcgccaa cttctctgcg ctggggctgg agccgggacg ggacgtggac
      421 ctggagcagc tggagcaaga gaactgcctg gatggctggg agtacaacaa ggacgtcttc
      481 ctgtccacca tcgtgacaga gtgggacctg gtgtgtaagg atgactggaa agccccactc
      541 accacctcct tgtttttcgt gggtgtgctg atgggctcct tcatttcggg acagctctca
      601 gacaggtttg gtcgcaagaa tgtgctgttt ttgaccatgg gcatgcagac tggcttcagc
      661 ttcctgcagc tcttctctgt gaacttcgag atgtttacag tgctttttgt ccttgttggc
      721 atgggtcaga tctccaacta cgtggcagca tttgtcctgg gaacagaaat tctttccaag
      781 tcaattcgaa ttatattcgc caccttagga gtttgcatat tttatgcatt tggcttcatg
      841 gtgctgcctc tgtttgcata cttcatcaga gactggagga tgctgctgct tgcgctcact
      901 gtaccagggg tgctgtgtgg ggctctctgg tggttcatcc ctgagtcccc ccgatggctc
      961 atctctcaag gccgagttaa agaggcagag gtgatcatcc gcaaagctgc caaattcaat
     1021 gggattgttg cgccttccac tatcttcgat cccagtgagt tacaagactt aaattccaag
     1081 aagcctcagt cgcaccacat ttatgatctg gtccgaacac gaaatatcag gatcatcacc
     1141 atcatgtcca taatcctgtg gctgaccata tcagtgggct acttcggact ttctcttgac
     1201 actcctaact tgcatgggga catctatgtg aactgcttcc tactggcagc tgttgaagtc
     1261 cccgcctatg tgttggcctg gctgttgcta cagcacctgc cccggcggta ttctatctct
     1321 gctgccctct tcctgggtgg cagtgtcctt ctcttcatac agctggtgcc ttcagaattg
     1381 ttttacttgt ccactgccct ggtgatggtg ggcaagtttg gaatcacctc tgcctattcc
     1441 atggtctatg tgtacacggc cgagctgtac cccactgtgg tcagaaacat gggtgtgggg
     1501 gtcagctcca cagcatcccg ccttggcagc atcctgtctc cctactttgt ctaccttggt
     1561 gcctatgatc gcttcctgcc ttatatcctc atgggaagtc tgaccatcct gacagctatc
     1621 ctcaccttgt tcttcccaga gagctttggt gcccctctcc ccgacaccat tgaccagatg
     1681 ctcagggtca aaggaataaa acaatggcaa atccaaagcc aaacaaggac gcaaaaagat
     1741 ggtggagaaa gcccaacggt cctaaagagc acagccttct aacaccctgt ccagaaggtg
     1801 aaaaactgaa aggaaacctg cgtgtagtca gaaatgctct caatcactga gggctttctg
     1861 ttctgttgac cttgtgtctc acatgctcac ggatggggca tctgtcctga agagccacct
     1921 tcctccaggg ccaccaaggc taaccacaca cagcttgcac atcccatcac agtgtggact
     1981 ggggcctccc agagaagtta ctgagtctct tgaagcagtg ggacttggaa gactgagaaa
     2041 catctgctag acatgctttg ttatcctgta agacctgata gtcacagaca gaacagcagg
     2101 tctgtttccc ctcctttccc taactgaaga acttacagga aaggaataaa agtgactcag
     2161 tggtggtgtg cttgtctagg atgcaccaga aggaaacaaa aatttctttt cagaaaataa
     2221 gtgattccat ggggagtttg atttctcatc ttacctaagt taaccaaaat cctgtgatca
     2281 ttttaaccca caacagaaga acacaagacc aagggaaccc taaaggaaac tgaggtgagg
     2341 ctggtacata aagcagacag tgtgtggact gtggctgctc tgcccctcag ccagctgtac
     2401 tgtgtgtgtc tggtcagggt cctgccttgc ccagaccctg tgagaaacct actgttgagg
     2461 ccaggcttgg cctccactgc tgtgtaaatc agaactcagg ctgccagaca cttggctgtg
     2521 tcttgaggga aatgtatgga taacagagtg ttccttcctt cttccagcac tgtcatggga
     2581 gtttgtcatc tgctgttgta tctcaagcta tttgtccttt agcagaaact tgggaactgc
     2641 ctgtgtttcc cagctcaggg ttaccctggc tggtgtgcag ttgccaatat aaatggcctt
     2701 cacagtctta gccactagag cggctctgag tgccaaaaat actaacacca tgcttcttcc
     2761 ttttacgatg tgtaatcatg aggaaaatca caagaaagaa atgtaaattg tgttcacagt
     2821 ctctcagagt cgctggctgc agtcacatcg gtggggattt cgtgttcagt gattgtcttc
     2881 tcttctgatt atgttgccat ggtgctccga aagcacacgc ttcacgctct taaaatgcaa
     2941 aacaaacaca gaaacccgta ttttgtgaaa gctactgaag tgccttgggc aaggatatgg
     3001 ttttaataaa ctgatttttt tttttaaata ata
//
