LOCUS       NM_022270               2254 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Rattus norvegicus solute carrier family 22 member 4 (Slc22a4),
            mRNA.
ACCESSION   NM_022270
VERSION     NM_022270.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2254)
  AUTHORS   Shaheen,A., Alam,S.M., Azam,F., Saleem,S.A., Khan,M., Hasan,S.S.
            and Liaquat,A.
  TITLE     Lack of impact of OCTN1 gene polymorphisms on clinical outcomes of
            gabapentinoids in Pakistani patients with neuropathic pain
  JOURNAL   PLoS One 17 (5), e0266559 (2022)
   PUBMED   35559956
  REMARK    GeneRIF: Lack of impact of OCTN1 gene polymorphisms on clinical
            outcomes of gabapentinoids in Pakistani patients with neuropathic
            pain.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2254)
  AUTHORS   Vo,D.K., Nguyen,T.T. and Maeng,H.J.
  TITLE     Effects of 1alpha,25-dihydroxyvitamin D3 on the pharmacokinetics
            and biodistribution of ergothioneine, an endogenous organic
            cation/carnitine transporter 1 substrate, in rats
  JOURNAL   J Pharm Investig 52 (3), 341-351 (2022)
   PUBMED   35291466
REFERENCE   3  (bases 1 to 2254)
  AUTHORS   Yi,Y., Li,L., Song,F., Li,P., Chen,M., Ni,S., Zhang,H., Zhou,H.,
            Zeng,S. and Jiang,H.
  TITLE     L-tetrahydropalmatine reduces oxaliplatin accumulation in the
            dorsal root ganglion and mitochondria through selectively
            inhibiting the transporter-mediated uptake thereby attenuates
            peripheral neurotoxicity
  JOURNAL   Toxicology 459, 152853 (2021)
   PUBMED   34252480
REFERENCE   4  (bases 1 to 2254)
  AUTHORS   Qi,C., Zhou,J., Wang,Z., Fang,X., Li,D., Jin,Y. and Song,J.
  TITLE     Cigarette smoke extract combined with lipopolysaccharide reduces
            OCTN1/2 expression in human alveolar epithelial cells in vitro and
            rat lung in vivo under inflammatory conditions
  JOURNAL   Int Immunopharmacol 87, 106812 (2020)
   PUBMED   32707498
REFERENCE   5  (bases 1 to 2254)
  AUTHORS   Oppedisano,F., Muscoli,C., Musolino,V., Carresi,C., Macri,R.,
            Giancotta,C., Bosco,F., Maiuolo,J., Scarano,F., Paone,S.,
            Nucera,S., Zito,M.C., Scicchitano,M., Ruga,S., Ragusa,M., Palma,E.,
            Tavernese,A., Mollace,R., Bombardelli,E. and Mollace,V.
  TITLE     The Protective Effect of Cynara Cardunculus Extract in Diet-Induced
            NAFLD: Involvement of OCTN1 and OCTN2 Transporter Subfamily
  JOURNAL   Nutrients 12 (5), 1435 (2020)
   PUBMED   32429274
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2254)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 2254)
  AUTHORS   Tamai,I., Ohashi,R., Nezu,J.I., Sai,Y., Kobayashi,D., Oku,A.,
            Shimane,M. and Tsuji,A.
  TITLE     Molecular and functional characterization of organic
            cation/carnitine transporter family in mice
  JOURNAL   J Biol Chem 275 (51), 40064-40072 (2000)
   PUBMED   11010964
REFERENCE   8  (bases 1 to 2254)
  AUTHORS   Wu,X., George,R.L., Huang,W., Wang,H., Conway,S.J., Leibach,F.H.
            and Ganapathy,V.
  TITLE     Structural and functional characteristics and tissue distribution
            pattern of rat OCTN1, an organic cation transporter, cloned from
            placenta
  JOURNAL   Biochim Biophys Acta 1466 (1-2), 315-327 (2000)
   PUBMED   10825452
REFERENCE   9  (bases 1 to 2254)
  AUTHORS   Zhu,Y., Jong,M.C., Frazer,K.A., Gong,E., Krauss,R.M., Cheng,J.F.,
            Boffelli,D. and Rubin,E.M.
  TITLE     Genomic interval engineering of mice identifies a novel modulator
            of triglyceride production
  JOURNAL   Proc Natl Acad Sci U S A 97 (3), 1137-1142 (2000)
   PUBMED   10655497
REFERENCE   10 (bases 1 to 2254)
  AUTHORS   Tamai,I., Yabuuchi,H., Nezu,J., Sai,Y., Oku,A., Shimane,M. and
            Tsuji,A.
  TITLE     Cloning and characterization of a novel human pH-dependent organic
            cation transporter, OCTN1
  JOURNAL   FEBS Lett 419 (1), 107-111 (1997)
   PUBMED   9426230
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 27, 2020 this sequence version replaced NM_022270.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF169831.1, SRR26643286.30297.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-464               JAXUCZ010000010.1  38679457-38679920   c
            465-568             JAXUCZ010000010.1  38659521-38659624   c
            569-723             JAXUCZ010000010.1  38657291-38657445   c
            724-895             JAXUCZ010000010.1  38649163-38649334   c
            896-1022            JAXUCZ010000010.1  38647803-38647929   c
            1023-1123           JAXUCZ010000010.1  38643894-38643994   c
            1124-1338           JAXUCZ010000010.1  38642090-38642304   c
            1339-1521           JAXUCZ010000010.1  38640233-38640415   c
            1522-1657           JAXUCZ010000010.1  38637790-38637925   c
            1658-2254           JAXUCZ010000010.1  38634098-38634694   c
FEATURES             Location/Qualifiers
     source          1..2254
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..2254
                     /gene="Slc22a4"
                     /gene_synonym="Octn1"
                     /note="solute carrier family 22 member 4"
                     /db_xref="GeneID:64037"
                     /db_xref="RGD:621149"
     exon            1..464
                     /gene="Slc22a4"
                     /gene_synonym="Octn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1733
                     /gene="Slc22a4"
                     /gene_synonym="Octn1"
                     /note="organic cation/carnitine transporter 1; organic
                     cation transporter OCTN1; solute carrier family 22
                     (organic cation/zwitterion transporter), member 4; solute
                     carrier family 22 (organic cation transporter), member 4"
                     /codon_start=1
                     /product="solute carrier family 22 member 4"
                     /protein_id="NP_071606.1"
                     /db_xref="GeneID:64037"
                     /db_xref="RGD:621149"
                     /translation="MRDYDEVIAFLGDWGPFQRLIFFLLSASIIPNGFNGMSVVFLAG
                     TPEHRCLVPHTVNLSSAWRNHSIPLETKDGRQVPQSCRRYRLATIANFSALGLEPGLD
                     VDLEQLEQESCLDGWEYSKDVFLSTIVTEWNLVCEDDWKTPLTTSLFFVGVLCGSFVS
                     GQLSDRFGRKKVLFATMAVQTGFSFVQIFSTNWEMFTVLFAIVGMGQISNYVVAFILG
                     TEILSKSVRILFSTLGVCTFFAIGYMVLPLFAYFIRDWRMLLLALTLPGLFCVPLWWF
                     IPESPRWLISQRRFEEAEQIIQKAAKMNGIMAPAVIFDPLELQELNSLKQQKVFILDL
                     FKTRNIATITVMSVMLWMLTSVGYFALSLNVPNLHGDVYLNCFLSGLIEVPAYFTAWL
                     LLRTLPRRYIIAGVLFWGGGVLLLVQVVPEDYNFVSIGLVMLGKFGVTSAFSMLYVFT
                     AELYPTLVRNMAVGITSMASRVGSIIAPYFVYLGAYNRLLPYILMGSLTVLIGIITLF
                     FPESFGVTLPENLEQMQKVRGFRCGKKSTVSMDREENPKVLITAF"
     exon            465..568
                     /gene="Slc22a4"
                     /gene_synonym="Octn1"
                     /inference="alignment:Splign:2.1.0"
     exon            569..723
                     /gene="Slc22a4"
                     /gene_synonym="Octn1"
                     /inference="alignment:Splign:2.1.0"
     exon            724..895
                     /gene="Slc22a4"
                     /gene_synonym="Octn1"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1022
                     /gene="Slc22a4"
                     /gene_synonym="Octn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1123
                     /gene="Slc22a4"
                     /gene_synonym="Octn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1338
                     /gene="Slc22a4"
                     /gene_synonym="Octn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1521
                     /gene="Slc22a4"
                     /gene_synonym="Octn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1657
                     /gene="Slc22a4"
                     /gene_synonym="Octn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..2254
                     /gene="Slc22a4"
                     /gene_synonym="Octn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gactcctgca atcgccggac ccctttctcc caacccacct ccctcgtgca agttgaggag
       61 aggcgggaag catgagggac tatgacgagg tgatagcctt cctgggcgat tgggggccct
      121 tccagcgcct tatcttcttc ctgctcagcg ccagcatcat ccccaatggc ttcaatggta
      181 tgtcagtcgt gttcctggcg gggaccccgg agcatcgttg ccttgtgcct cacaccgtga
      241 acttgagcag cgcgtggcgc aaccacagca tccccttgga aacgaaggac ggacgacagg
      301 tgcctcaaag ctgccgccgc taccgactgg ccaccatcgc caacttctct gcgctggggc
      361 tggagcccgg actggatgta gatctggagc agctggagca agagagctgc ctggatggct
      421 gggagtacag caaggacgtc ttcctgtcca ccatcgtgac agagtggaat ctggtgtgtg
      481 aggatgactg gaagacaccc ctcaccacct ccctgttctt cgtaggcgtt ctctgtggct
      541 ccttcgtgtc tgggcagctg tcagacaggt tcggcaggaa gaaagtcctc tttgccacca
      601 tggctgtgca gactggattc agcttcgtgc agattttctc aaccaactgg gagatgttta
      661 ctgtgttatt tgccatcgtg ggcatgggcc aaatctccaa ctatgtggtg gccttcatac
      721 tcgggaccga aatcctgagc aagtcggttc gcatcctctt ctccacgttg ggagtctgta
      781 cattttttgc catcggctac atggtgctgc cgctgtttgc atacttcatc cgagactgga
      841 ggatgctgct gctggcactg acactgcctg ggctgttctg tgtccccctg tggtggttta
      901 ttccagagtc tccccggtgg ctgatatccc agaggagatt tgaagaggca gaacagatca
      961 tccagaaagc cgcaaagatg aatggcatca tggcaccagc ggtgatattc gatcctctgg
     1021 agctacagga gctaaactcc ttgaagcagc agaaagtctt cattctggac ctgttcaaga
     1081 ctcggaacat tgccacaata acagtgatgt ctgtgatgct gtggatgcta acctcagtgg
     1141 gttactttgc tctgtctctc aatgttccta atttgcacgg agatgtctac ctgaactgct
     1201 tcctctctgg cctgattgaa gttccagctt atttcacagc ctggctgcta ctgcgaaccc
     1261 tgcctcggag atatattata gctggggtgc tgttctgggg aggtggtgtg cttctcttgg
     1321 tccaagtggt acctgaagat tacaactttg tgtccattgg cctggtgatg ctggggaaat
     1381 ttggggtcac ctctgccttc tccatgctgt acgtcttcac agcggagctc tacccaaccc
     1441 tggtcaggaa catggctgtg ggcatcacct ccatggcctc gagggtgggc agcatcattg
     1501 ccccctattt cgtgtacctg ggtgcttata accgactcct gccctacatc ctcatgggca
     1561 gtctgactgt cctcattgga atcatcacac tttttttccc tgagagtttt ggagtgactc
     1621 taccagagaa cttggagcag atgcagaaag tcagagggtt cagatgtggg aaaaaatcaa
     1681 cagtctccat ggacagagaa gaaaacccca aggttctaat aactgcattc tgacaaggtt
     1741 tccaaggcac gtggcaaact gaaaaacagg tggggtacaa tgagcagggt gtgctggagc
     1801 cagcctgaaa gcctgccctc ttggtatggg gacaggagga tcgagaagtc aaggtcatca
     1861 ttgactatgt caggagtgtg agaccagcct gtctcaccac aagcagccct gtctgaacaa
     1921 aacaaaacaa aacaaaacaa aacaaaacaa aacaaaacaa aacaaaacaa aagcctttcc
     1981 gctgaaaggt actaatagaa acaatgagca ccaaactgga cttgtggaga aatacacaat
     2041 atctcataaa ttctgggcca ctcttccaga tggtcttgtt tttaagaacc aacgtttcta
     2101 aacagtcttg actgctaact attccatgaa atagatttgt aagaattttt tttttgaaaa
     2161 tgtgttagtc aaggactggc aaaatccata tgaagatgat cacacatttt caaacgtata
     2221 aatgctgtcc aaataaaatt cattgtatta tgac
//
