LOCUS       NM_019230               3502 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 22 member 3 (Slc22a3),
            mRNA.
ACCESSION   NM_019230
VERSION     NM_019230.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3502)
  AUTHORS   He,Q., Wang,Q., Yuan,C. and Wang,Y.
  TITLE     Downregulation of miR-7116-5p in microglia by MPP+ sensitizes
            TNF-alpha production to induce dopaminergic neuron damage
  JOURNAL   Glia 65 (8), 1251-1263 (2017)
   PUBMED   28543680
REFERENCE   2  (bases 1 to 3502)
  AUTHORS   Gasser,P.J., Hurley,M.M., Chan,J. and Pickel,V.M.
  TITLE     Organic cation transporter 3 (OCT3) is localized to intracellular
            and surface membranes in select glial and neuronal cells within the
            basolateral amygdaloid complex of both rats and mice
  JOURNAL   Brain Struct Funct 222 (4), 1913-1928 (2017)
   PUBMED   27659446
  REMARK    GeneRIF: Study is the first to examine the subcellular localization
            of organic cation transporter 3 (OCT3) in any tissue, and the first
            to explore its spatial relationship to synaptic structures in the
            brain. Study suggests that OCT3 not only contributes to the
            clearance of extracellular monoamines, but also plays a role in
            their intracellular disposition and action.
REFERENCE   3  (bases 1 to 3502)
  AUTHORS   Sala-Rabanal,M., Li,D.C., Dake,G.R., Kurata,H.T., Inyushin,M.,
            Skatchkov,S.N. and Nichols,C.G.
  TITLE     Polyamine transport by the polyspecific organic cation transporters
            OCT1, OCT2, and OCT3
  JOURNAL   Mol Pharm 10 (4), 1450-1458 (2013)
   PUBMED   23458604
REFERENCE   4  (bases 1 to 3502)
  AUTHORS   Yang,J., Kalogerou,M., Gallacher,J., Sampson,J.R. and Shen,M.H.
  TITLE     Renal tumours in a Tsc1+/- mouse model show epigenetic suppression
            of organic cation transporters Slc22a1, Slc22a2 and Slc22a3, and do
            not respond to metformin
  JOURNAL   Eur J Cancer 49 (6), 1479-1490 (2013)
   PUBMED   23228442
REFERENCE   5  (bases 1 to 3502)
  AUTHORS   Gong,L., Goswami,S., Giacomini,K.M., Altman,R.B. and Klein,T.E.
  TITLE     Metformin pathways: pharmacokinetics and pharmacodynamics
  JOURNAL   Pharmacogenet Genomics 22 (11), 820-827 (2012)
   PUBMED   22722338
  REMARK    Review article
REFERENCE   6  (bases 1 to 3502)
  AUTHORS   Zwart,R., Verhaagh,S., Buitelaar,M., Popp-Snijders,C. and
            Barlow,D.P.
  TITLE     Impaired activity of the extraneuronal monoamine transporter system
            known as uptake-2 in Orct3/Slc22a3-deficient mice
  JOURNAL   Mol Cell Biol 21 (13), 4188-4196 (2001)
   PUBMED   11390648
REFERENCE   7  (bases 1 to 3502)
  AUTHORS   Verhey,K.J., Meyer,D., Deehan,R., Blenis,J., Schnapp,B.J.,
            Rapoport,T.A. and Margolis,B.
  TITLE     Cargo of kinesin identified as JIP scaffolding proteins and
            associated signaling molecules
  JOURNAL   J Cell Biol 152 (5), 959-970 (2001)
   PUBMED   11238452
REFERENCE   8  (bases 1 to 3502)
  AUTHORS   Wu,X., Huang,W., Ganapathy,M.E., Wang,H., Kekuda,R., Conway,S.J.,
            Leibach,F.H. and Ganapathy,V.
  TITLE     Structure, function, and regional distribution of the organic
            cation transporter OCT3 in the kidney
  JOURNAL   Am J Physiol Renal Physiol 279 (3), F449-F458 (2000)
   PUBMED   10966924
REFERENCE   9  (bases 1 to 3502)
  AUTHORS   Wu,X., Kekuda,R., Huang,W., Fei,Y.J., Leibach,F.H., Chen,J.,
            Conway,S.J. and Ganapathy,V.
  TITLE     Identity of the organic cation transporter OCT3 as the
            extraneuronal monoamine transporter (uptake2) and evidence for the
            expression of the transporter in the brain
  JOURNAL   J Biol Chem 273 (49), 32776-32786 (1998)
   PUBMED   9830022
REFERENCE   10 (bases 1 to 3502)
  AUTHORS   Kekuda,R., Prasad,P.D., Wu,X., Wang,H., Fei,Y.J., Leibach,F.H. and
            Ganapathy,V.
  TITLE     Cloning and functional characterization of a potential-sensitive,
            polyspecific organic cation transporter (OCT3) most abundantly
            expressed in placenta
  JOURNAL   J Biol Chem 273 (26), 15971-15979 (1998)
   PUBMED   9632645
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF055286.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF055286.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680426
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3502
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..3502
                     /gene="Slc22a3"
                     /gene_synonym="EMT; OCT3"
                     /note="solute carrier family 22 member 3"
                     /db_xref="GeneID:29504"
                     /db_xref="RGD:3701"
     exon            1..805
                     /gene="Slc22a3"
                     /gene_synonym="EMT; OCT3"
                     /inference="alignment:Splign:2.1.0"
     CDS             392..2047
                     /gene="Slc22a3"
                     /gene_synonym="EMT; OCT3"
                     /note="organic cation transporter 3; solute carrier family
                     22 (extraneuronal monoamine transporter), member 3; solute
                     carrier family 22 (organic cation transporter), member 3"
                     /codon_start=1
                     /product="solute carrier family 22 member 3"
                     /protein_id="NP_062103.1"
                     /db_xref="GeneID:29504"
                     /db_xref="RGD:3701"
                     /translation="MPTFDQALRKAGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGS
                     QPDYYWCRGPRATALAERCAWSPEEEWNLTTPELHVPAERRGQGHCHRYLLEDTNTSS
                     ELSCDPLAAFPNRSAPLVPCSGDWRYVETHSTIVSQFDLVCGNAWMLDLTQAILNLGF
                     LAGAFTLGYAADRYGRLIVYLISCFGVGITGVVVAFAPNFSVFVIFRFLQGVFGKGAW
                     MTCFVIVTEIVGSKQRRIVGIVIQMFFTLGIIILPGIAYFTPSWQGIQLAISLPSFLF
                     LLYYWVVPESPRWLITRKQGEKALQILRRVAKCNGKHLSSNYSEITVTDEEVSNPSCL
                     DLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGLIGGNLYMDFFISGLVELPGALLI
                     LLTIERLGRRLPFAASNIVAGVSCLVTAFLPEGIPWLRTTVATLGRLGITMAFEIVYL
                     VNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAIWLELPLIIFGILASVCGGL
                     VMLLPETKGIALPETVEDVEKLGSSQLHQCGRKKKTQVSTSNV"
     exon            806..909
                     /gene="Slc22a3"
                     /gene_synonym="EMT; OCT3"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1064
                     /gene="Slc22a3"
                     /gene_synonym="EMT; OCT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1233
                     /gene="Slc22a3"
                     /gene_synonym="EMT; OCT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1351
                     /gene="Slc22a3"
                     /gene_synonym="EMT; OCT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1449
                     /gene="Slc22a3"
                     /gene_synonym="EMT; OCT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1664
                     /gene="Slc22a3"
                     /gene_synonym="EMT; OCT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1773
                     /gene="Slc22a3"
                     /gene_synonym="EMT; OCT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1886
                     /gene="Slc22a3"
                     /gene_synonym="EMT; OCT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..1986
                     /gene="Slc22a3"
                     /gene_synonym="EMT; OCT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..3491
                     /gene="Slc22a3"
                     /gene_synonym="EMT; OCT3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcacagcgg cttggacccc tgcagcctaa gagcactgga ggctattcct gcaatcagca
       61 gagtcctgag tctggcgagt ctgggtgatc ctagaactca gtgaactcca acttggagtg
      121 accctttagg gcaggctata agtctgggtc cttggtgcac ggtgacactg ctgtgaaacc
      181 accccaatcc gctctccggg tttacgccgg tcccgggcgc atacgggcag gaggccggga
      241 gcttggagca ggaggagcag cccggggcgg gctgccaggg cgagcaagcg agcgaggcgg
      301 gggcggcggg tgcagaactg cgggcggcgg cgcccgcggg tcactctcag gccgggcagc
      361 agcgacaggg cgcagggtgg tggggcgcac catgcccacg ttcgaccagg cgctgaggaa
      421 ggcgggcgag ttcgggcgct tccagcggcg cgtgttcctg ctgctgtgcc tgacgggtgt
      481 caccttcgcc ttcctcttcg ttggtgtggt cttcctgggc agccagcccg actactattg
      541 gtgtcgcggg ccccgcgcca ccgcgctggc cgagcgctgc gcctggagcc ctgaggagga
      601 gtggaacctc accacgccgg agcttcacgt cccagctgag cgccgtggcc aaggccactg
      661 tcaccgctac ctgctggaag acaccaatac cagctcagag ctcagctgcg acccactcgc
      721 tgccttcccc aaccgctccg ctcctctggt gccctgcagc ggcgactggc gctatgtgga
      781 gacccactcc accatcgtca gccagtttga ccttgtctgc ggcaacgcct ggatgttgga
      841 cctcacccaa gccatcttga accttggctt cctggctggg gcttttacct tgggctatgc
      901 agcggacaga tacggcaggc tcatcgttta cttaatatcc tgtttcggcg ttggcatcac
      961 gggagttgtg gtggcgtttg caccgaattt ttctgtgttt gtgatcttcc gcttcctgca
     1021 aggggtgttt ggaaaggggg cctggatgac ttgctttgtg attgtgacag aaatagttgg
     1081 ttcgaaacag aggaggattg tgggaatagt gatccagatg ttcttcaccc tcggaatcat
     1141 cattctgccc ggaattgcct acttcacccc cagctggcag ggcatccagc tagccatatc
     1201 gctgcctagc tttctcttcc tcctttatta ctgggtggtc cctgagtctc cccgctggct
     1261 gatcacccgg aagcagggag agaaagcctt gcagatcctg aggcgtgtgg ctaagtgcaa
     1321 tgggaaacac ctctcgtcaa attactcaga gatcacagtt acagatgaag aggtcagtaa
     1381 cccatcctgt ttagaccttg tgaggactcc ccaaatgagg aagtgcacac tcattctcat
     1441 gtttgcttgg ttcacaagtg ccgtggtgta tcaaggactt gtcatgcgcc tgggactcat
     1501 cggaggcaac ctctacatgg acttctttat ctcggggctc gtggagctgc ccggagctct
     1561 cttgatcctt ctgaccattg agcgccttgg acgacgcctt ccctttgccg caagcaatat
     1621 agtggcaggg gtgtcgtgtc tggtcactgc ctttttacca gaagggatac cgtggctgag
     1681 gaccacagtc gctaccttgg gaagactagg aataaccatg gcctttgaaa ttgtttattt
     1741 ggtaaattca gagttgtacc caacgacatt acggaacttt ggggtttcac tctgctcagg
     1801 cctgtgtgac tttgggggga tcatagcccc atttctgctc tttcgactag cagccatatg
     1861 gctagaactg cctctgatca tctttgggat cctggcatct gtctgtggtg gccttgtgat
     1921 gcttttgcct gaaactaagg gcatcgcctt gccggagacg gtggaagatg tggaaaagct
     1981 tggcagttca cagttgcacc agtgtggcag aaaaaagaaa acccaggttt ctacttctaa
     2041 tgtctgaggc ccctgagtct gcctggaaga ccacagaagc tgagcttgga atatgccttg
     2101 cagtgtgctt cacctcctct aggtggcgcc gttccaagga accgtaaaga ttccagagta
     2161 ttttatatgg aataagataa agatttatca tgctacccaa gcttctggga acacataacc
     2221 tttgacctct ttagcaaaga tccagtaggt acacagattc tgcctaggtt ctctttcatt
     2281 gggaccaatg tctctgaccc actggggagg agatatgaga aggtcccaac cagttctcca
     2341 gttctcagga cagtcccatc caggaagcag gatgaacata tcaaggcctg gcagtgaacg
     2401 gaagtgtact cagctgatct gatcaagact gagcagtgag gagtgttctg aagagtctga
     2461 gaactgctat ttctgattcg cttaagctcc gaatacatgc cttcagagag ccgacatgcc
     2521 tggtgcccct ccccttctgt ccccaaagcc actgaggttc caggccccag gttaggcaca
     2581 gttccctaaa tgcaacacat ccaaggaccc agctacatta ttgtgaaatc acactgcagt
     2641 ccccacaccc caatattttg tctcctcctt cagtggaccg ctataatcac agattcttaa
     2701 ttgaggaaga aaaaaaaaac atggattttg atttcccggg ccttagaatt tgaaaaataa
     2761 aggggtaatt atgtcatatt tgtgaattcc gtttcagtgg tgcctgtggc tgagagtcca
     2821 aagaatagac tttcttcatg ccatctgggc acttccgact tatcttggga gaaaaacaaa
     2881 acaccaaaaa caaatacaaa tacagttgtt gtcacttcat gataaaagtc aattgtattc
     2941 atactttaaa ggattggcga cccatttata agggatgtag gagatactaa tgagggactg
     3001 aatttttttt ttattagatc aagactcctc aagcaaagac tcaaatgtaa acacggtatt
     3061 ctacgtggtg tgcagttctt gataaatttt cggactcagt gtgtatgtta gactgaaagt
     3121 ttcttaaact tcaaactcag tgtggacagg caaaagtagc ctcaaaggga aaccttaccg
     3181 atgtggaaga aagaaatgca tatgtggaga acataagaca tgtgtgccac cccagagaag
     3241 atgtgcgtgt gactgtaaaa catcgtttca ccctgacgca tgtgagaacc gaatgtgagt
     3301 gttcagactc ttgacagcct tttgggtatt cattgccaca cccactgtgc gtgcccggca
     3361 tctgtggcct ggttccctgt gtgtttcatg gctgtagcgc ggctcttgtc cactctgctg
     3421 cctttggatt gcatttcaag ttggaagttc tgtttcataa caataaacaa tttttaaact
     3481 gtttttaaaa aaaaaaaaaa aa
//
