LOCUS       NM_173302               1995 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Rattus norvegicus solute carrier family 22, member 19 (Slc22a19),
            mRNA.
ACCESSION   NM_173302 XM_001072873 XM_342011
VERSION     NM_173302.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1995)
  AUTHORS   Campagno,R.V., Nosetto,E.C., Brandoni,A. and Torres,A.M.
  TITLE     Utility of urinary organic anion transporter 5 as an early
            biomarker of obstructive nephropathy
  JOURNAL   Clin Exp Pharmacol Physiol 47 (10), 1674-1681 (2020)
   PUBMED   32497308
  REMARK    GeneRIF: Utility of urinary organic anion transporter 5 as an early
            biomarker of obstructive nephropathy.
REFERENCE   2  (bases 1 to 1995)
  AUTHORS   Brandoni,A. and Torres,A.M.
  TITLE     Expression of renal Oat5 and NaDC1 transporters in rats with acute
            biliary obstruction
  JOURNAL   World J Gastroenterol 21 (29), 8817-8825 (2015)
   PUBMED   26269671
  REMARK    GeneRIF: Cholestasis induced by common bile duct ligation in the
            rat induces upregulation of Oat5 in kidneys.
REFERENCE   3  (bases 1 to 1995)
  AUTHORS   Hazelhoff,M.H., Bulacio,R.P. and Torres,A.M.
  TITLE     Organic anion transporter 5 renal expression and urinary excretion
            in rats with vascular calcification
  JOURNAL   Biomed Res Int 2013, 283429 (2013)
   PUBMED   24199190
  REMARK    GeneRIF: An increased expression of Oat5 in renal homogenates, in
            apical membranes, and in its urinary excretion was observed in rats
            with vascular calcification.
REFERENCE   4  (bases 1 to 1995)
  AUTHORS   Breljak,D., Ljubojevic,M., Balen,D., Zlender,V., Brzica,H.,
            Micek,V., Kusan,M., Anzai,N. and Sabolic,I.
  TITLE     Renal expression of organic anion transporter Oat5 in rats and mice
            exhibits the female-dominant sex differences
  JOURNAL   Histol Histopathol 25 (11), 1385-1402 (2010)
   PUBMED   20865662
  REMARK    GeneRIF: renal expression of Oat5 in rats (and mice) exhibits zonal
            and sex differences
REFERENCE   5  (bases 1 to 1995)
  AUTHORS   Zlender,V., Breljak,D., Ljubojevic,M., Flajs,D., Balen,D.,
            Brzica,H., Domijan,A.M., Peraica,M., Fuchs,R., Anzai,N. and
            Sabolic,I.
  TITLE     Low doses of ochratoxin A upregulate the protein expression of
            organic anion transporters Oat1, Oat2, Oat3 and Oat5 in rat kidney
            cortex
  JOURNAL   Toxicol Appl Pharmacol 239 (3), 284-296 (2009)
   PUBMED   19538982
REFERENCE   6  (bases 1 to 1995)
  AUTHORS   Di Giusto,G., Anzai,N., Endou,H. and Torres,A.M.
  TITLE     Oat5 and NaDC1 protein abundance in kidney and urine after renal
            ischemic reperfusion injury
  JOURNAL   J Histochem Cytochem 57 (1), 17-27 (2009)
   PUBMED   18796410
  REMARK    GeneRIF: Urinary excretion of Oat5 might be an early indicator of
            renal dysfunction
REFERENCE   7  (bases 1 to 1995)
  AUTHORS   Anzai,N., Jutabha,P., Enomoto,A., Yokoyama,H., Nonoguchi,H.,
            Hirata,T., Shiraya,K., He,X., Cha,S.H., Takeda,M., Miyazaki,H.,
            Sakata,T., Tomita,K., Igarashi,T., Kanai,Y. and Endou,H.
  TITLE     Functional characterization of rat organic anion transporter 5
            (Slc22a19) at the apical membrane of renal proximal tubules
  JOURNAL   J Pharmacol Exp Ther 315 (2), 534-544 (2005)
   PUBMED   16079298
  REMARK    GeneRIF: rOat5 is renal organic anion/dicarboxylates exchanger and,
            under physiological conditions, may function as an apical
            reabsorptive pathway
REFERENCE   8  (bases 1 to 1995)
  AUTHORS   Youngblood,G.L. and Sweet,D.H.
  TITLE     Identification and functional assessment of the novel murine
            organic anion transporter Oat5 (Slc22a19) expressed in kidney
  JOURNAL   Am J Physiol Renal Physiol 287 (2), F236-F244 (2004)
   PUBMED   15068970
  REMARK    GeneRIF: Highly expressed in kidney. Motive forces behind Oat5
            function, which provide insight into its membrane localization,
            need to be further resolved.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB051836.1.
            
            On or before Aug 28, 2008 this sequence version replaced
            XM_001072873.1, XM_342011.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB051836.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1995
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1995
                     /gene="Slc22a19"
                     /gene_synonym="Oat5; rOat5; Slc22a24; Slc22a9"
                     /note="solute carrier family 22, member 19"
                     /db_xref="GeneID:286961"
                     /db_xref="RGD:628885"
     exon            1..522
                     /gene="Slc22a19"
                     /gene_synonym="Oat5; rOat5; Slc22a24; Slc22a9"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1776
                     /gene="Slc22a19"
                     /gene_synonym="Oat5; rOat5; Slc22a24; Slc22a9"
                     /note="solute carrier family 22 (organic anion/cation
                     transporter), member 9; solute carrier family 22 (organic
                     anion transporter), member 19; organic anion transporter
                     5; solute carrier family 22 member 10; solute carrier
                     family 22 (organic anion transporter), member 9; solute
                     carrier family 22, member 24"
                     /codon_start=1
                     /product="steroid transmembrane transporter SLC22A24"
                     /protein_id="NP_775424.1"
                     /db_xref="GeneID:286961"
                     /db_xref="RGD:628885"
                     /translation="MAFQDLITQIGCLGRFQILHLIFVLICFILVVPHTVLENFTAAI
                     PSHRCWVPILDNNTMSDNNSRILSQDDLLRISIPMDSNLRPEKCRRYIQPQWDLLHLN
                     GTFSTVTEPDTEPCVDGWVYDQSTFLSTTVTQWDLVCGSQTLNSVAKFIYMTGIFIGH
                     LMGGHLSDKFGRKFIVTCGLLTLAVTETSVAFAPTFLIYCSLRFLTGISSSCIRTNSA
                     LLILEWTSPKFQAMVMALIFSAGGIGQVLLGVLAFGIRNWQHLQLAMSVPVFFLLIPT
                     RWLSESARWLIITNKPQEGLKELIKVAHINGIKNSRDVLTLEVVKTTMKDELEAAETK
                     PSPLVLFRTPNLRKRICLLSFVRCVSLISTVGLLINLQYLSNKVFLLQCLYGVVCTPA
                     NLLGNFSMNYMGRRTTQIIFMSVMGISILSITFLTQEMQIPRLVLASLGGAISSASLT
                     STAVLSNELVPTVIRATALGVIGIFGSAGAALSPLLMILMTYSASLPWIIYGVLPILS
                     SLVVLLLPETRNQPLPDSIQDVENKRKSSREVKKDAVAKVTPF"
     exon            523..626
                     /gene="Slc22a19"
                     /gene_synonym="Oat5; rOat5; Slc22a24; Slc22a9"
                     /inference="alignment:Splign:2.1.0"
     exon            627..781
                     /gene="Slc22a19"
                     /gene_synonym="Oat5; rOat5; Slc22a24; Slc22a9"
                     /inference="alignment:Splign:2.1.0"
     exon            782..950
                     /gene="Slc22a19"
                     /gene_synonym="Oat5; rOat5; Slc22a24; Slc22a9"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1074
                     /gene="Slc22a19"
                     /gene_synonym="Oat5; rOat5; Slc22a24; Slc22a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1190
                     /gene="Slc22a19"
                     /gene_synonym="Oat5; rOat5; Slc22a24; Slc22a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1405
                     /gene="Slc22a19"
                     /gene_synonym="Oat5; rOat5; Slc22a24; Slc22a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1514
                     /gene="Slc22a19"
                     /gene_synonym="Oat5; rOat5; Slc22a24; Slc22a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1718
                     /gene="Slc22a19"
                     /gene_synonym="Oat5; rOat5; Slc22a24; Slc22a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1973
                     /gene="Slc22a19"
                     /gene_synonym="Oat5; rOat5; Slc22a24; Slc22a9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagggactta ctaagtacag ctctggatca gccctattta gtgtgtcttg gtaaaaaaaa
       61 atcttttaga aacctagata tagtcatctt gcctcccact agagatagag atcaaccaag
      121 atggcctttc aggaccttat aactcaaatt ggctgcctgg ggaggttcca gatccttcac
      181 ttgatttttg tactgatctg ctttatcctg gtagttcctc acactgtttt ggagaacttc
      241 actgcagcca ttcctagtca tcgctgttgg gtccccatcc tcgacaataa cactatgtct
      301 gataataaca gtaggatcct gagccaagat gacctcctaa ggatctccat cccaatggac
      361 tccaacctga ggccagagaa atgccgtcgc tatatccaac cacagtggga tctccttcat
      421 ctgaatggca ccttctccac tgtaacagag ccagacacag agccctgtgt ggatggttgg
      481 gtgtatgacc aaagcacctt cctctccacc acagtgaccc agtgggacct ggtgtgtgga
      541 tctcaaacac tgaattcagt ggctaaattt atctacatga ctggtatctt tatagggcat
      601 ctcatgggtg gccatttatc agacaagttt gggaggaagt tcattgtgac atgtggttta
      661 ctgacactgg ctgtcactga aacttctgtc gcttttgctc ccaccttcct catctactgc
      721 tcacttcgat tcctcacagg gatttcttcc tcatgcatta ggacaaacag tgctttgctc
      781 atattagaat ggacaagtcc taaattccaa gctatggtaa tggcactgat attttctgct
      841 gggggaattg gacaggttct actgggagtc ctggcttttg gtattcggaa ctggcaacac
      901 ctccagctgg cgatgtctgt accagtgttc ttcctcctta ttcccacaag gtggttgtca
      961 gagtcagctc gatggctgat tataaccaac aaaccccagg agggcttaaa ggaacttata
     1021 aaagttgcac acataaatgg aataaagaat tcaagagatg tcctaacctt ggaggttgtg
     1081 aaaactacca tgaaggatga actggaggca gcagagacaa aaccctcccc actggtgctg
     1141 ttccgtacac ccaaccttcg caagcggatc tgtcttctat cctttgtgag atgtgtgtca
     1201 ttgatatcaa ctgtaggcct gcttatcaac ctccaatatc tgagcaataa agtgttcctg
     1261 ctgcagtgtc tctatggtgt ggtgtgcact ccagccaatc ttcttggaaa tttttcaatg
     1321 aattacatgg gccgcagaac aacccaaatc attttcatgt ctgtgatggg aatctccatt
     1381 ctgtctatca catttttgac tcaagaaatg cagatcccgc gtttagtttt ggcatcatta
     1441 ggaggagcaa tttcttctgc ctctttgaca agtactgctg tgctttcaaa tgagctagtc
     1501 cccactgtaa tcagggcaac tgctttagga gtcattggaa tttttggtag tgctggagca
     1561 gccctgtctc ctctgttgat gattctcatg acatattctg cttccttgcc ctggatcatc
     1621 tatggggttc ttcccatcct tagtagcctt gttgtccttc ttcttcctga gacgaggaat
     1681 cagcctctgc ctgactccat ccaagatgta gaaaataaga ggaaaagctc aagagaggta
     1741 aagaaagatg cggttgccaa agtgacacca ttttaaagaa ttccaactga gctctgatca
     1801 aggagaaaga taaaaagtac atattgttca gaatatggtg gtccagaatc atacctacat
     1861 gttagcagaa tttttccata taagtgatat gtgtaaataa agttaaatta aaattatacc
     1921 agtttgccat gtataaaata actataataa agaaatttga agaaaatcac aaaaaaaaaa
     1981 aaaaaaaaaa aaaaa
//
