LOCUS       NM_031584               2149 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus solute carrier family 22 member 2 (Slc22a2),
            mRNA.
ACCESSION   NM_031584
VERSION     NM_031584.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2149)
  AUTHORS   Huang,K.M., Leblanc,A.F., Uddin,M.E., Kim,J.Y., Chen,M.,
            Eisenmann,E.D., Gibson,A.A., Li,Y., Hong,K.W., DiGiacomo,D.,
            Xia,S.H., Alberti,P., Chiorazzi,A., Housley,S.N., Cope,T.C.,
            Sprowl,J.A., Wang,J., Loprinzi,C.L., Noonan,A., Lustberg,M.B.,
            Cavaletti,G., Pabla,N., Hu,S. and Sparreboom,A.
  TITLE     Neuronal uptake transporters contribute to oxaliplatin
            neurotoxicity in mice
  JOURNAL   J Clin Invest 130 (9), 4601-4606 (2020)
   PUBMED   32484793
  REMARK    GeneRIF: Neuronal uptake transporters contribute to oxaliplatin
            neurotoxicity in mice.
REFERENCE   2  (bases 1 to 2149)
  AUTHORS   Nishizawa,K., Yoda,N., Morokado,F., Komori,H., Nakanishi,T. and
            Tamai,I.
  TITLE     Changes of drug pharmacokinetics mediated by downregulation of
            kidney organic cation transporters Mate1 and Oct2 in a rat model of
            hyperuricemia
  JOURNAL   PLoS One 14 (4), e0214862 (2019)
   PUBMED   30951542
  REMARK    GeneRIF: Although multiple factors may influence renal handling of
            drugs, these observations can be accounted for, at least in part,
            by downregulation of Mate1-mediated apical efflux from tubular
            cells and Oct2-mediated basolateral uptake. Our results suggest
            that hyperuricemia could alter the disposition of drugs that are
            substrates of Mate1 and/or Oct2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2149)
  AUTHORS   Qi,X., Zhu,L., Yang,B., Luo,H., Xu,W., He,X. and Huang,K.
  TITLE     Mitigation of cell apoptosis induced by ochratoxin A (OTA) is
            possibly through organic cation transport 2 (OCT2) knockout
  JOURNAL   Food Chem Toxicol 121, 15-23 (2018)
   PUBMED   30120945
  REMARK    GeneRIF: findings indicate that OCT2 knockout possibly mitigate
            OTA-induced apoptosis by preventing the increase of Caspase 3 and
            CDK1
REFERENCE   4  (bases 1 to 2149)
  AUTHORS   Huang,D., Wang,C., Duan,Y., Meng,Q., Liu,Z., Huo,X., Sun,H., Ma,X.
            and Liu,K.
  TITLE     Targeting Oct2 and P53: Formononetin prevents cisplatin-induced
            acute kidney injury
  JOURNAL   Toxicol Appl Pharmacol 326, 15-24 (2017)
   PUBMED   28414026
  REMARK    GeneRIF: Formononetin prevents cisplatin-induced acute kidney
            injury by targeting Oct2/TP53 in the kidney.
            Erratum:[Toxicol Appl Pharmacol. 2022 Sep 1;450:116133. doi:
            10.1016/j.taap.2022.116133.. PMID: 35716766]
REFERENCE   5  (bases 1 to 2149)
  AUTHORS   Berry,M.D., Hart,S., Pryor,A.R., Hunter,S. and Gardiner,D.
  TITLE     Pharmacological characterization of a high-affinity p-tyramine
            transporter in rat brain synaptosomes
  JOURNAL   Sci Rep 6, 38006 (2016)
   PUBMED   27901065
  REMARK    GeneRIF: These results provide the first identification of a high
            affinity neuronal transporter for p-tyramine, and also confirm the
            recently described localization of OCT2 in pre-synaptic terminals.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2149)
  AUTHORS   Budiman,T., Bamberg,E., Koepsell,H. and Nagel,G.
  TITLE     Mechanism of electrogenic cation transport by the cloned organic
            cation transporter 2 from rat
  JOURNAL   J Biol Chem 275 (38), 29413-29420 (2000)
   PUBMED   10889205
REFERENCE   7  (bases 1 to 2149)
  AUTHORS   Grundemann,D., Liebich,G., Kiefer,N., Koster,S. and Schomig,E.
  TITLE     Selective substrates for non-neuronal monoamine transporters
  JOURNAL   Mol Pharmacol 56 (1), 1-10 (1999)
   PUBMED   10385678
REFERENCE   8  (bases 1 to 2149)
  AUTHORS   Grundemann,D., Koster,S., Kiefer,N., Breidert,T., Engelhardt,M.,
            Spitzenberger,F., Obermuller,N. and Schomig,E.
  TITLE     Transport of monoamine transmitters by the organic cation
            transporter type 2, OCT2
  JOURNAL   J Biol Chem 273 (47), 30915-30920 (1998)
   PUBMED   9812985
REFERENCE   9  (bases 1 to 2149)
  AUTHORS   Urakami,Y., Okuda,M., Masuda,S., Saito,H. and Inui,K.I.
  TITLE     Functional characteristics and membrane localization of rat
            multispecific organic cation transporters, OCT1 and OCT2, mediating
            tubular secretion of cationic drugs
  JOURNAL   J Pharmacol Exp Ther 287 (2), 800-805 (1998)
   PUBMED   9808712
REFERENCE   10 (bases 1 to 2149)
  AUTHORS   Okuda,M., Saito,H., Urakami,Y., Takano,M. and Inui,K.
  TITLE     cDNA cloning and functional expression of a novel rat kidney
            organic cation transporter, OCT2
  JOURNAL   Biochem Biophys Res Commun 224 (2), 500-507 (1996)
   PUBMED   8702418
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D83044.1.
            
            On Aug 30, 2012 this sequence version replaced NM_031584.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D83044.1, X98334.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760384 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2149              D83044.1           4-2152
FEATURES             Location/Qualifiers
     source          1..2149
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..2149
                     /gene="Slc22a2"
                     /gene_synonym="OCT2; OCT2r; rOCT2"
                     /note="solute carrier family 22 member 2"
                     /db_xref="GeneID:29503"
                     /db_xref="RGD:61936"
     exon            1..502
                     /gene="Slc22a2"
                     /gene_synonym="OCT2; OCT2r; rOCT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1870
                     /gene="Slc22a2"
                     /gene_synonym="OCT2; OCT2r; rOCT2"
                     /note="organic cation transporter 2; solute carrier family
                     22 (organic cation transporter), member 2"
                     /codon_start=1
                     /product="solute carrier family 22 member 2"
                     /protein_id="NP_113772.1"
                     /db_xref="GeneID:29503"
                     /db_xref="RGD:61936"
                     /translation="MSTVDDILEHIGEFHLFQKQTFFLLALLSGAFTPIYVGIVFLGF
                     TPDHHCWSPGAAKLSQRCGWSQAEELNYTVPGLGPSDEASFLSQCMRYEVDWNQSTLD
                     CVDPLSSLAADRNQLPLGPCEHGWVYNTPGSSIVTEFNLVCAHSWMLDLFQSVVNVGF
                     FIGAMMIGYLADRFGRKFCLLVTILINAISGALMAISPNYAWMLVFRFLQGLVSKAGW
                     LIGYILITEFVGLGYRRMVGICYQIAFTVGLLILAGVAYVIPNWRWLQFAVTLPNFCF
                     LLYFWCIPESPRWLISQNKIVKAMKIIKHIAKKNGKSVPVSLQNLTPDEDAGKKLKPS
                     ILDLVRTPQIRKHTLILMYNWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAF
                     IIILTIDRVGRRYPWAVSNMVAGAACLASVFIPDDLQWLKITIACLGRMGITMAYEMV
                     CLVNAELYPTYIRNLGVLVCSSMCDIGGIITPFLVYRLTDIWMEFPLVVFAVVGLVAG
                     ALVLLLPETKGKALPETIEDAENMQRPRKKERKENLPPSQASRPSAKLKRKGIIAAGA
                     DFALSEARDGASLSPPPKPTQTNLTYP"
     exon            503..606
                     /gene="Slc22a2"
                     /gene_synonym="OCT2; OCT2r; rOCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            607..761
                     /gene="Slc22a2"
                     /gene_synonym="OCT2; OCT2r; rOCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            762..930
                     /gene="Slc22a2"
                     /gene_synonym="OCT2; OCT2r; rOCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1045
                     /gene="Slc22a2"
                     /gene_synonym="OCT2; OCT2r; rOCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1152
                     /gene="Slc22a2"
                     /gene_synonym="OCT2; OCT2r; rOCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1367
                     /gene="Slc22a2"
                     /gene_synonym="OCT2; OCT2r; rOCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1476
                     /gene="Slc22a2"
                     /gene_synonym="OCT2; OCT2r; rOCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1589
                     /gene="Slc22a2"
                     /gene_synonym="OCT2; OCT2r; rOCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1689
                     /gene="Slc22a2"
                     /gene_synonym="OCT2; OCT2r; rOCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..2149
                     /gene="Slc22a2"
                     /gene_synonym="OCT2; OCT2r; rOCT2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacgcgtccg cctgagctga gcgcgctgcc ttcagcagca tttggagccc tgtgggtgaa
       61 gcctcaggaa cagctgcctc cagggaccat gtcgaccgtg gatgatattc tagaacatat
      121 aggggaattc cacctttttc agaaacaaac atttttcctc ttagctctgc tgtctggtgc
      181 cttcaccccc atctacgtgg gcatcgtttt cctaggattt acccctgacc accactgctg
      241 gagtcctggg gcagccaagc tgagccagcg gtgtggctgg agccaggcag aggagctgaa
      301 ctacaccgtg ccgggtctgg gaccttcgga cgaggcctcc ttcctcagcc agtgcatgag
      361 gtatgaagtg gactggaacc agagcaccct tgactgtgtg gacccactgt ccagcctggc
      421 tgcggacagg aaccagttgc cattgggccc ctgcgagcat ggctgggtat acaacactcc
      481 cggctcctcc attgtcactg agtttaacct ggtgtgtgct cactcctgga tgctggacct
      541 gtttcagtca gtagtgaacg tggggttttt catcggtgct atgatgattg gctacctagc
      601 ggacaggttt ggccggaagt tctgcctctt ggtcaccatc ctcatcaatg ctatctctgg
      661 ggctctcatg gcgatttctc ccaactatgc ctggatgttg gtgtttcgct ttctccaggg
      721 actggtcagc aaagcaggct ggttaattgg ctacatcctg attacagaat ttgttgggct
      781 gggctatcgc agaatggtgg ggatttgcta tcaaatcgcc ttcaccgttg gcctcctgat
      841 cctggctgga gtggcctatg tgattcccaa ctggagatgg ctacaatttg ctgtgactct
      901 gcccaacttc tgcttcctgc tctatttctg gtgcataccg gaatctccaa gatggctgat
      961 ctcccagaac aaaatcgtaa aagccatgaa gataattaaa catattgcta agaaaaatgg
     1021 aaagtcggtg ccggtctctc ttcagaacct gacaccagat gaggacgctg gcaagaaatt
     1081 gaaaccttca atcctggact tggtcagaac ccctcagata aggaaacaca cgttgatctt
     1141 gatgtacaat tggttcacga gctctgttct ctaccagggc ctcatcatgc acatgggcct
     1201 tgcaggggac aacatctacc tggatttctt ctactccgcc ctggtggagt ttccagccgc
     1261 cttcatcatc atcctcacca tcgaccgggt tggtcgccgc tatccctggg ctgtgtcaaa
     1321 tatggtggca ggagcagcct gtctagcctc tgtttttatc cctgatgatc tacagtggct
     1381 gaaaattacc attgcatgct tgggtagaat gggcatcacc atggcctatg aaatggtctg
     1441 cctggtcaat gctgagctgt accccacata catcaggaat cttggtgtcc ttgtctgctc
     1501 ctccatgtgt gacattggcg gcatcatcac gcctttcctc gtctaccgtc tcacggacat
     1561 ctggatggag ttcccactgg ttgtatttgc tgtggttggc cttgtcgctg gggcacttgt
     1621 gctgttgcta cctgagacca aagggaaggc tctgcctgag accatcgagg atgccgagaa
     1681 tatgcagagg ccaagaaaaa aagaaagaaa agagaattta cctccaagtc aagcaagcag
     1741 accgtccgct aagctaaaaa gaaagggcat cattgctgct ggagctgact ttgctctctc
     1801 tgaggccaga gatggagctt ctctctcccc tccccccaaa cccacacaaa ccaacctcac
     1861 ttacccctga actccatcag caagagctgt agcttgcacg gtctgttgca ctgatgtgtc
     1921 aagctcttcc tcccagccag gattttccgc ctcactctgc tctcagcact cccaggaaat
     1981 gaccattgct ttactggatt cgttatggtt gttttttcat ctttacattc tttatttagt
     2041 ttccttctcc accacaacat caaaccaaaa tacccaaggg agctgtgggc caggacaacc
     2101 aactattaaa gaagtaagaa atctgaaaaa acaataaacg tgggagaag
//
