LOCUS       NM_001004260            1495 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Rattus norvegicus solute carrier family 22, member 18 (Slc22a18),
            mRNA.
ACCESSION   NM_001004260 XM_219507
VERSION     NM_001004260.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1495)
  AUTHORS   Noguera-Ucles,J.F., Boyero,L., Salinas,A., Cordero Varela,J.A.,
            Benedetti,J.C., Bernabe-Caro,R., Sanchez-Gastaldo,A., Alonso,M.,
            Paz-Ares,L. and Molina-Pinelo,S.
  TITLE     The Roles of Imprinted SLC22A18 and SLC22A18AS Gene Overexpression
            Caused by Promoter CpG Island Hypomethylation as Diagnostic and
            Prognostic Biomarkers for Non-Small Cell Lung Cancer Patients
  JOURNAL   Cancers (Basel) 12 (8), 2075 (2020)
   PUBMED   32726996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1495)
  AUTHORS   Jung,Y., Jun,Y., Lee,H.Y., Kim,S., Jung,Y., Keum,J., Lee,Y.S.,
            Cho,Y.B., Lee,S. and Kim,J.
  TITLE     Characterization of SLC22A18 as a tumor suppressor and novel
            biomarker in colorectal cancer
  JOURNAL   Oncotarget 6 (28), 25368-25380 (2015)
   PUBMED   26196590
REFERENCE   3  (bases 1 to 1495)
  AUTHORS   Zhang,B., Liu,T., Wu,T., Wang,Z., Rao,Z. and Gao,J.
  TITLE     microRNA-137 functions as a tumor suppressor in human non-small
            cell lung cancer by targeting SLC22A18
  JOURNAL   Int J Biol Macromol 74, 111-118 (2015)
   PUBMED   25498886
REFERENCE   4  (bases 1 to 1495)
  AUTHORS   Yamamoto,T., Izumi-Yamamoto,K., Iizuka,Y., Shirota,M., Nagase,M.,
            Fujita,T. and Gotoda,T.
  TITLE     A novel link between Slc22a18 and fat accumulation revealed by a
            mutation in the spontaneously hypertensive rat
  JOURNAL   Biochem Biophys Res Commun 440 (4), 521-526 (2013)
   PUBMED   24099777
  REMARK    GeneRIF: These results reveal a novel link between Slc22a18 and fat
            accumulation and suggest that this gene could be a new therapeutic
            target in obesity.
REFERENCE   5  (bases 1 to 1495)
  AUTHORS   Alvi,M.A., Liu,X., O'Donovan,M., Newton,R., Wernisch,L.,
            Shannon,N.B., Shariff,K., di Pietro,M., Bergman,J.J., Ragunath,K.
            and Fitzgerald,R.C.
  TITLE     DNA methylation as an adjunct to histopathology to detect
            prevalent, inconspicuous dysplasia and early-stage neoplasia in
            Barrett's esophagus
  JOURNAL   Clin Cancer Res 19 (4), 878-888 (2013)
   PUBMED   23243219
REFERENCE   6  (bases 1 to 1495)
  AUTHORS   Lei,M., Cheng,Q., Zhao,Y., Liu,T., Wang,X., Deng,Y., Yang,J. and
            Zhang,Z.
  TITLE     [Expression and its clinical significance of SLC22A18 in non-small
            cell lung cancer]
  JOURNAL   Zhongguo Fei Ai Za Zhi 15 (1), 17-20 (2012)
   PUBMED   22237119
REFERENCE   7  (bases 1 to 1495)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 1495)
  AUTHORS   Yamada,H.Y. and Gorbsky,G.J.
  TITLE     Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel
            ubiquitin ligase RING105
  JOURNAL   Oncogene 25 (9), 1330-1339 (2006)
   PUBMED   16314844
REFERENCE   9  (bases 1 to 1495)
  AUTHORS   Tzortzaki,E.G., Yang,M., Glass,D., Deng,L., Evan,A.P.,
            Bledsoe,S.B., Stambrook,P.J., Sahota,A. and Tischfield,J.A.
  TITLE     Impaired expression of an organic cation transporter, IMPT1, in a
            knockout mouse model for kidney stone disease
  JOURNAL   Urol Res 31 (4), 257-261 (2003)
   PUBMED   12856169
REFERENCE   10 (bases 1 to 1495)
  AUTHORS   Reece,M., Prawitt,D., Landers,J., Kast,C., Gros,P., Housman,D.,
            Zabel,B.U. and Pelletier,J.
  TITLE     Functional characterization of ORCTL2--an organic cation
            transporter expressed in the renal proximal tubules
  JOURNAL   FEBS Lett 433 (3), 245-250 (1998)
   PUBMED   9744804
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079159.1.
            
            On Sep 10, 2004 this sequence version replaced XM_219507.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079159.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132303, SAMD00132304
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1495
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42"
     gene            1..1495
                     /gene="Slc22a18"
                     /note="solute carrier family 22, member 18"
                     /db_xref="GeneID:309131"
                     /db_xref="RGD:1303323"
     exon            1..43
                     /gene="Slc22a18"
                     /inference="alignment:Splign:2.1.0"
     exon            44..297
                     /gene="Slc22a18"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..1416
                     /gene="Slc22a18"
                     /note="ORCTL-2; organic cation transporter-like protein 2;
                     tumor suppressing subtransferable candidate 5; solute
                     carrier family 22 (organic cation transporter), member 18"
                     /codon_start=1
                     /product="solute carrier family 22 member 18"
                     /protein_id="NP_001004260.1"
                     /db_xref="GeneID:309131"
                     /db_xref="RGD:1303323"
                     /translation="MSGQLPSSMVALPRQGIIILTYVLAALELTCLFMQFSIIPYLSR
                     TLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAASALYLLLVASC
                     SPALPGVFLLFASRLPAALMHTLPAAQMVITDLTAPTKRPTALSRLGLCFGIGVIFGS
                     LLGGTLSTAYGIQCPAFLAFVVTLLGAVLSFTCIPVTTKEASVQSAHQGGTSVFDLKA
                     ISRLLLLPRVLPVFLVKVISGFPSGLFMVMFSIISMDFFQLEAAQAGYLMSFFGILQM
                     MIQGLVIGRLSTRFPEEALLRSSVLVFAVVGLGMALMSNVFHFCLLLPGLVFSLCALN
                     IVTDSMLTKAVSASDTGTMLGLCASVHPLTRTVGPTLGGLLYRSYGVSILGHVQLMVN
                     LLVLLVLWKKPLSQKGDKAR"
     exon            298..395
                     /gene="Slc22a18"
                     /inference="alignment:Splign:2.1.0"
     exon            396..556
                     /gene="Slc22a18"
                     /inference="alignment:Splign:2.1.0"
     exon            557..689
                     /gene="Slc22a18"
                     /inference="alignment:Splign:2.1.0"
     exon            690..802
                     /gene="Slc22a18"
                     /inference="alignment:Splign:2.1.0"
     exon            803..904
                     /gene="Slc22a18"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1005
                     /gene="Slc22a18"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1107
                     /gene="Slc22a18"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1228
                     /gene="Slc22a18"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1468
                     /gene="Slc22a18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacccacccg gaacacaggc ccactttctc ccgtcaaaag caggcacagg ccactccttc
       61 caacctggtg agtcagcatc cagccagaat caacaggact tttgcccctt gcctactgca
      121 aggcttgctc tcctctagtt ccggtccctc cgggactctg gatacctcct gcccaggatg
      181 tctggccagc tccccagcag catggttgct ctgccccggc aggggatcat catactcacc
      241 tatgtgctgg cggccctgga gctaacatgt ctcttcatgc agttctccat cataccatat
      301 ctgtctcgga cactgggcct ggattctgtc tcctttggtt acctacagac gaccttcggg
      361 gtgcttcagc tgctgggtgg gcctgtgttt ggcaggttcg cagaccagcg gggagccaga
      421 gcagcactca cactctcctt cctggcggcc tctgctctgt acctgctcct ggtggcctcc
      481 tgtagcccag ccctgcctgg tgtcttcctg ctcttcgcct cgcgtctacc tgccgcactc
      541 atgcacacac ttccagctgc ccagatggtc atcactgatc tgacggcgcc cacaaagcgg
      601 cccacagcac tgagccggct gggcctctgc tttggcattg gagttatctt cggctccctg
      661 cttggtggga cccttagcac cgcatacggg atccagtgtc ctgccttcct ggcttttgtg
      721 gtcaccctct taggagctgt cctcagcttt acctgtatcc ctgttaccac caaggaggcc
      781 agtgtccagt cagcccatca gggtggaacc agtgtatttg acctgaaggc catctcccgc
      841 ctgctgctgc tgcccagagt gctgcccgta ttcctggtca aggtaatctc tggcttccct
      901 tcaggactct tcatggtgat gttctccatc atctccatgg acttcttcca gctggaggct
      961 gcacaggctg gctacctcat gtccttcttt gggatcctcc agatgatgat ccaaggcctg
     1021 gttattggga gactaagcac ccgttttcca gaggaagccc tgctgagatc cagtgtacta
     1081 gtctttgctg ttgtgggcct gggcatggca ctgatgtcca atgtgttcca cttctgcctt
     1141 ttgttgcctg gactcgtatt cagtctctgt gctctcaaca tagtcacaga cagcatgctg
     1201 accaaggctg tatctgcttc agacacaggg accatgttgg gcctctgtgc atctgtgcat
     1261 ccattgaccc gtactgtagg acccaccctg ggtggcctgc tgtaccggag ctatggtgtc
     1321 tccatcttgg gccatgtgca actcatggtg aacttgcttg tcctattggt cctctggaag
     1381 aaaccattgt cccagaaggg agacaaagcc cggtgaccac aaaacccaac gacctggccc
     1441 agtcaagcaa taaacttaag aacctcttaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
