LOCUS       NM_177421               2365 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus solute carrier family 22, member 17 (Slc22a17),
            mRNA.
ACCESSION   NM_177421
VERSION     NM_177421.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2365)
  AUTHORS   De La Chesnaye,E., Manuel-Apolinar,L., Damasio,L., Castrejon,E.,
            Lopez-Ballesteros,R., Revilla-Monsalve,M.C. and Mendez,J.P.
  TITLE     The gonadal expression pattern of lipocalin-2 and 24p3 receptor is
            modified in the gonads of the offspring of obese rats
  JOURNAL   Mol Med Rep 22 (2), 1409-1419 (2020)
   PUBMED   32627017
  REMARK    GeneRIF: The gonadal expression pattern of lipocalin2 and 24p3
            receptor is modified in the gonads of the offspring of obese rats.
REFERENCE   2  (bases 1 to 2365)
  AUTHORS   Arakawa,Y., Ushijima,K., Tsuchiya,H., Morishige,J.I., Mii,A.,
            Ando,H., Tsuruoka,S.I. and Fujimura,A.
  TITLE     Influence of renal ischaemia-reperfusion injury on renal neutrophil
            gelatinase-associated lipocalin receptor (24p3R) in rats
  JOURNAL   Clin Exp Pharmacol Physiol 46 (12), 1166-1173 (2019)
   PUBMED   31211866
  REMARK    GeneRIF: Influence of renal ischaemia-reperfusion injury on renal
            neutrophil gelatinase-associated lipocalin receptor (24p3R) in
            rats.
REFERENCE   3  (bases 1 to 2365)
  AUTHORS   Betten,R., Scharner,B., Probst,S., Edemir,B., Wolff,N.A.,
            Langelueddecke,C., Lee,W.K. and Thevenod,F.
  TITLE     Tonicity inversely modulates lipocalin-2 (Lcn2/24p3/NGAL) receptor
            (SLC22A17) and Lcn2 expression via Wnt/beta-catenin signaling in
            renal inner medullary collecting duct cells: implications for cell
            fate and bacterial infection
  JOURNAL   Cell Commun Signal 16 (1), 74 (2018)
   PUBMED   30404645
  REMARK    GeneRIF: Lcn2-R upregulation and Lcn2 downregulation via
            Wnt/beta-catenin may promote adaptive osmotolerant survival of IMCD
            cells
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2365)
  AUTHORS   Langelueddecke,C., Roussa,E., Fenton,R.A., Wolff,N.A., Lee,W.K. and
            Thevenod,F.
  TITLE     Lipocalin-2 (24p3/neutrophil gelatinase-associated lipocalin
            (NGAL)) receptor is expressed in distal nephron and mediates
            protein endocytosis
  JOURNAL   J Biol Chem 287 (1), 159-169 (2012)
   PUBMED   22084236
  REMARK    GeneRIF: 24p3R binds proteins filtered by the kidney with high
            affinity and may contribute to receptor-mediated endocy of proteins
REFERENCE   5  (bases 1 to 2365)
  AUTHORS   Bennett,K.M., Liu,J., Hoelting,C. and Stoll,J.
  TITLE     Expression and analysis of two novel rat organic cation transporter
            homologs, SLC22A17 and SLC22A23
  JOURNAL   Mol Cell Biochem 352 (1-2), 143-154 (2011)
   PUBMED   21359964
  REMARK    GeneRIF: These novel family members have a nonconserved amino
            terminus, relative to other organic cation transporters, that may
            preclude typical SLC22 transport function
REFERENCE   6  (bases 1 to 2365)
  AUTHORS   Fang,W.K., Xu,L.Y., Lu,X.F., Liao,L.D., Cai,W.J., Shen,Z.Y. and
            Li,E.M.
  TITLE     A novel alternative spliced variant of neutrophil
            gelatinase-associated lipocalin receptor in oesophageal carcinoma
            cells
  JOURNAL   Biochem J 403 (2), 297-303 (2007)
   PUBMED   17253959
REFERENCE   7  (bases 1 to 2365)
  AUTHORS   Devireddy,L.R., Gazin,C., Zhu,X. and Green,M.R.
  TITLE     A cell-surface receptor for lipocalin 24p3 selectively mediates
            apoptosis and iron uptake
  JOURNAL   Cell 123 (7), 1293-1305 (2005)
   PUBMED   16377569
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099072.1.
            
            [WARNING] On Jan 22, 2025 this sequence was replaced by
            NM_177421.4.
            
            On Dec 7, 2007 this sequence version replaced NM_177421.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099072.1, AB040056.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2365
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..2365
                     /gene="Slc22a17"
                     /gene_synonym="24p3R; Boct; rBOCT"
                     /note="solute carrier family 22, member 17"
                     /db_xref="GeneID:305886"
                     /db_xref="RGD:631405"
     exon            1..232
                     /gene="Slc22a17"
                     /gene_synonym="24p3R; Boct; rBOCT"
                     /inference="alignment:Splign:2.1.0"
     exon            233..724
                     /gene="Slc22a17"
                     /gene_synonym="24p3R; Boct; rBOCT"
                     /inference="alignment:Splign:2.1.0"
     CDS             458..2020
                     /gene="Slc22a17"
                     /gene_synonym="24p3R; Boct; rBOCT"
                     /note="brain-type organic cation transporter; 24p3
                     receptor; lipocalin-2 receptor; solute carrier family 22
                     (organic cation transporter), member 17; brain-specific
                     organic ion transporter"
                     /codon_start=1
                     /product="solute carrier family 22 member 17"
                     /protein_id="NP_803156.2"
                     /db_xref="GeneID:305886"
                     /db_xref="RGD:631405"
                     /translation="MASDPIFTLAPPLHCHYGALPPNASGWEQPPNSSGVSVAGAALA
                     ASAASRVVTSTDPSCSGFAPPDFNHCLKDWDYNGLPVLTTNAIGQWDLVCDLGWQVIL
                     EQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGIMTLRFL
                     LGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQR
                     MITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERNRPHGQMLGEEAQE
                     ALQELENTCPLPTTSTFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCYQPVGGGGSP
                     SDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDYLNDA
                     AITTFSVLGLFSSQASAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSCPAQRLHM
                     GHGAFLQHVVLAACALLCILSIMLLPETKRKLLPEVLRDGELCRRPSLLRQPPPNRCD
                     HVPLLATPNPAL"
     exon            725..828
                     /gene="Slc22a17"
                     /gene_synonym="24p3R; Boct; rBOCT"
                     /inference="alignment:Splign:2.1.0"
     exon            829..983
                     /gene="Slc22a17"
                     /gene_synonym="24p3R; Boct; rBOCT"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1149
                     /gene="Slc22a17"
                     /gene_synonym="24p3R; Boct; rBOCT"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1295
                     /gene="Slc22a17"
                     /gene_synonym="24p3R; Boct; rBOCT"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1401
                     /gene="Slc22a17"
                     /gene_synonym="24p3R; Boct; rBOCT"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1619
                     /gene="Slc22a17"
                     /gene_synonym="24p3R; Boct; rBOCT"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1731
                     /gene="Slc22a17"
                     /gene_synonym="24p3R; Boct; rBOCT"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..2343
                     /gene="Slc22a17"
                     /gene_synonym="24p3R; Boct; rBOCT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggaggaggc gcccgcggct gcagagctgc agagcggggt ctcccggccc tcggcgtccc
       61 agccctttgc acatagctgg gccagacaac agctcattct ctcggcgcgg ccgtcagggc
      121 cccagcggtc ggcaagctgg ctccccgagt agccaccggg acccccgagc ccaatggcgg
      181 gggcggcaac aaaatcgaca gcaccgtgga gatcgccccc ggcgccaatg gacaggtcgg
      241 gagcctcgga gatgcggtcc cccccgagca gctgcagggt gagcgggagc gccggcggga
      301 gggggagggc gacgcgctgg gcagcagcct gtcgctggcc gcgcccccgg gccccctcag
      361 cttcgaggct ctactcgccc aggtgggggc cctgggtggc ggccagcagc tgcagctcgg
      421 cctgtgctgc ctgcccgtgc tcttcgtggc gctgggcatg gcctcagacc ccatcttcac
      481 gctggcgccc ccgctgcact gccactacgg cgccttgccc cccaacgctt cgggctggga
      541 gcagcccccc aactccagcg gcgtcagcgt cgccggcgca gccctagcag ccagcgccgc
      601 cagcagagtc gtcaccagta cggacccctc gtgcagtggc ttcgccccac cggatttcaa
      661 ccactgcctg aaggactggg actacaacgg actgcccgtg ctcaccacca atgccatcgg
      721 ccagtgggat ctggtgtgtg acctgggctg gcaggtgatc ctggagcaga tcctcttcat
      781 cttgggcttt gcctccggct acctgttcct cggttacccc gcggacaggt ttggccgtcg
      841 tgggattgta ctgctgacct tggggctcgt gggcccctgt ggagtgggag gagctgctgc
      901 gggctcctcc acgggcataa tgactcttcg attcctcctg ggcttcctgc tggctggcgt
      961 tgaccttggt gtctacctga tgcgcctgga gctgtgcgac ccaacccaga ggcttcgggt
     1021 ggccctggca ggggagttgg taggggtggg agggcacttc ctgttcctgg gcctggccct
     1081 tgtctctaag gactggcggt tcctgcagcg aatgatcacc gctccttgca tcctcttcct
     1141 gttttatggc tggcccggtc tgtttctgga gtccgcacgg tggctgatag tgaaacggca
     1201 gattgaggaa gcccagtctg tgctgaggat cctggctgag cgaaaccggc cccatggcca
     1261 gatgctggga gaagaggccc aggaagccct gcaggagctg gagaatacct gtcctctccc
     1321 cacaacgtcc accttttcct tcgcctccct cctcaactac cgaaacatct ggaaaaatct
     1381 gcttatcctg ggcttcacca actttatcgc ccatgccatt cgccactgct accagcctgt
     1441 gggaggagga gggagcccat cagacttcta cttgtgctct cttctggcca gcggcacagc
     1501 agccctggcc tgcgtcttcc tgggggtgac cgtggaccgt ttcggccgtc ggggcatcct
     1561 gcttctctca atgactctca cggggattgc atccctggtc ttgctgggcc tgtgggatta
     1621 tctgaacgat gctgccatca caaccttctc ggtcctcgga ctcttctcct cccaagcttc
     1681 tgctatcctc agtaccctcc ttgctgctga agtcatcccc accactgtcc ggggccgtgg
     1741 cctgggcctt atcatggcac ttggggcgct tggagggctg agctgtccag ctcagcgcct
     1801 ccacatgggc catggagctt tcctgcagca tgtggtactg gcggcctgtg ccctcctctg
     1861 catccttagc atcatgctgc tgccagagac caagcgcaag cttctgccag aggtactccg
     1921 ggatggggaa ctgtgccgtc ggccttccct gctgaggcag ccacctccta accgctgtga
     1981 ccatgtcccc ctgctagcca ctcctaatcc tgccctctaa gcagcctctg agcctggtgg
     2041 gaggctggcc atttagaaag gtgacggagg gctggctagc aagatagacg gagaggcaag
     2101 gccaccctgt acatacaaaa ggctccaagg cgcctcacgc catctaggag agctcagagt
     2161 gccattccca accccctctc ctccccgctg ctttctgttc acttcatcag caagagtcag
     2221 gacggggata gcatctcgct ataaccgtta ggtctgggat ccatcctatg cccaaagaca
     2281 ttttcccaga ccttgctctt tctcgctctt cattctgttt caataaaaga cattttgaat
     2341 aaaaaaaaaa aaaaaaaaaa aaaaa
//
