LOCUS       NM_001034943            2180 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus solute carrier family 22 member 12 (Slc22a12),
            mRNA.
ACCESSION   NM_001034943 XM_344985
VERSION     NM_001034943.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2180)
  AUTHORS   Arakawa,H., Amezawa,N., Kawakatsu,Y. and Tamai,I.
  TITLE     Renal Reabsorptive Transport of Uric Acid Precursor Xanthine by
            URAT1 and GLUT9
  JOURNAL   Biol Pharm Bull 43 (11), 1792-1798 (2020)
   PUBMED   33132325
  REMARK    GeneRIF: Renal Reabsorptive Transport of Uric Acid Precursor
            Xanthine by URAT1 and GLUT9.
REFERENCE   2  (bases 1 to 2180)
  AUTHORS   Lee,C.T., Chang,L.C., Liu,C.W. and Wu,P.F.
  TITLE     Negative correlation between serum uric acid and kidney URAT1 mRNA
            expression caused by resveratrol in rats
  JOURNAL   Mol Nutr Food Res 61 (10) (2017)
   PUBMED   28499081
  REMARK    GeneRIF: Resveratrol reduced URAT1 mRNA expression under high uric
            acid levels, thereby reducing uric acid reabsorption in renal
            cells.
REFERENCE   3  (bases 1 to 2180)
  AUTHORS   Toyoki,D., Shibata,S., Kuribayashi-Okuma,E., Xu,N., Ishizawa,K.,
            Hosoyamada,M. and Uchida,S.
  TITLE     Insulin stimulates uric acid reabsorption via regulating urate
            transporter 1 and ATP-binding cassette subfamily G member 2
  JOURNAL   Am J Physiol Renal Physiol 313 (3), F826-F834 (2017)
   PUBMED   28679589
  REMARK    GeneRIF: Insulin significantly increased URAT1 and decreased ABCG2
            levels, resulting in increased kidney tubule uric acid reabsorption
            in streptozotocin-diabetic rats.
REFERENCE   4  (bases 1 to 2180)
  AUTHORS   Wu,X., Zhang,J., Liu,T., Yan,M., Liu,H., Xie,H., Zhang,S., Sun,B.,
            Ke,B. and Zhou,H.
  TITLE     Uric acid crystal could inhibit Numb-induced URAT1 lysosome
            degradation in uric acid nephropathy
  JOURNAL   J Physiol Biochem 71 (2), 217-226 (2015)
   PUBMED   25773064
  REMARK    GeneRIF: URAT1 lysosome degradation is affected by uric acid in
            uric acid nephropathy.
REFERENCE   5  (bases 1 to 2180)
  AUTHORS   Sato,M., Wakayama,T., Mamada,H., Shirasaka,Y., Nakanishi,T. and
            Tamai,I.
  TITLE     Identification and functional characterization of uric acid
            transporter Urat1 (Slc22a12) in rats
  JOURNAL   Biochim Biophys Acta 1808 (6), 1441-1447 (2011)
   PUBMED   21074513
  REMARK    GeneRIF: Data show that Urat1 (Slc22a12) is involved in uric acid
            reabsorption in rats in the same manner as URAT1 in humans,
            suggesting a useful model to study issues related to the role of
            human URAT1.
REFERENCE   6  (bases 1 to 2180)
  AUTHORS   Anzai,N., Miyazaki,H., Noshiro,R., Khamdang,S., Chairoungdua,A.,
            Shin,H.J., Enomoto,A., Sakamoto,S., Hirata,T., Tomita,K., Kanai,Y.
            and Endou,H.
  TITLE     The multivalent PDZ domain-containing protein PDZK1 regulates
            transport activity of renal urate-anion exchanger URAT1 via its C
            terminus
  JOURNAL   J Biol Chem 279 (44), 45942-45950 (2004)
   PUBMED   15304510
REFERENCE   7  (bases 1 to 2180)
  AUTHORS   Hosoyamada,M., Ichida,K., Enomoto,A., Hosoya,T. and Endou,H.
  TITLE     Function and localization of urate transporter 1 in mouse kidney
  JOURNAL   J Am Soc Nephrol 15 (2), 261-268 (2004)
   PUBMED   14747372
REFERENCE   8  (bases 1 to 2180)
  AUTHORS   Ichida,K., Hosoyamada,M., Hisatome,I., Enomoto,A., Hikita,M.,
            Endou,H. and Hosoya,T.
  TITLE     Clinical and molecular analysis of patients with renal hypouricemia
            in Japan-influence of URAT1 gene on urinary urate excretion
  JOURNAL   J Am Soc Nephrol 15 (1), 164-173 (2004)
   PUBMED   14694169
REFERENCE   9  (bases 1 to 2180)
  AUTHORS   Enomoto,A., Kimura,H., Chairoungdua,A., Shigeta,Y., Jutabha,P.,
            Cha,S.H., Hosoyamada,M., Takeda,M., Sekine,T., Igarashi,T.,
            Matsuo,H., Kikuchi,Y., Oda,T., Ichida,K., Hosoya,T., Shimokata,K.,
            Niwa,T., Kanai,Y. and Endou,H.
  TITLE     Molecular identification of a renal urate anion exchanger that
            regulates blood urate levels
  JOURNAL   Nature 417 (6887), 447-452 (2002)
   PUBMED   12024214
REFERENCE   10 (bases 1 to 2180)
  AUTHORS   Hu,E., Chen,Z., Fredrickson,T.A., Spurr,N., Gentle,S., Sims,M.,
            Zhu,Y., Halsey,W., Van Horn,S., Mao,J., Sathe,G.M. and Brooks,D.P.
  TITLE     Rapid isolation of tissue-specific genes from rat kidney
  JOURNAL   Exp Nephrol 9 (2), 156-164 (2001)
   PUBMED   11150865
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC103638.1.
            
            On Oct 21, 2005 this sequence version replaced XM_344985.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC103638.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2180
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2180
                     /gene="Slc22a12"
                     /gene_synonym="Rst; Slc22al2; URAT1"
                     /note="solute carrier family 22 member 12"
                     /db_xref="GeneID:365398"
                     /db_xref="RGD:621628"
     exon            1..659
                     /gene="Slc22a12"
                     /gene_synonym="Rst; Slc22al2; URAT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..1919
                     /gene="Slc22a12"
                     /gene_synonym="Rst; Slc22al2; URAT1"
                     /note="solute carrier family 22 (organic cation
                     transporter)-like 2; solute carrier family 22 (organic
                     anion/cation transporter), member 12; urate anion
                     exchanger 1; solute carrier family 22 (organic anion/urate
                     transporter), member 12; urate:anion antiporter SLC22A12"
                     /codon_start=1
                     /product="solute carrier family 22 member 12"
                     /protein_id="NP_001030115.1"
                     /db_xref="GeneID:365398"
                     /db_xref="RGD:621628"
                     /translation="MAFPELLDRVGGRGRFQLLQAVALVTPILWVTTQNMLENFSAAV
                     PHHRCWVPLLDNSTSQASIPGDFGRDVLLAVSIPPGPDQRPHQCLRFRQPQWQLIESN
                     TTATNWSDADTEPCEDGWVYDHSTFRSTIVTTWDLVCDSQALRPMAQSIFLAGILVGA
                     AVCGHASDRFGRRRVLTWSYLLVSVSGTIAALMPTFPLYCLFRFLVASAVAGVMMNTA
                     SLLMEWTSAQAGPLMMTLNALGFSFGQVLTGSVAYGVRSWRMLQLAVSAPFFLFFVYS
                     WWLPESARWLITVGRLDQSLRELQRVAAVNRRKAEADTLTVEVLRSAMQEEPNGNQAG
                     ARLGTLLHTPGLRLRTFISMLCWFAFGFTFYGLALDLQALGSNIFLLQALIGIVDLPV
                     KMGSLLLLSRLGRRLCQASSLVLPGLCILANILVPREMGILRSSLAVLGLGSLGAAFT
                     CVTIFSSELFPTVIRMTAVGLGQVAARGGAMLGPLVRLLGVYGSWLPLLVYGVVPVLS
                     GLAALLLPETKNLPLPDTIQDIQKQSVKKVTHDIAGGSVLKSARL"
     exon            660..763
                     /gene="Slc22a12"
                     /gene_synonym="Rst; Slc22al2; URAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..918
                     /gene="Slc22a12"
                     /gene_synonym="Rst; Slc22al2; URAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1087
                     /gene="Slc22a12"
                     /gene_synonym="Rst; Slc22al2; URAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1211
                     /gene="Slc22a12"
                     /gene_synonym="Rst; Slc22al2; URAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1327
                     /gene="Slc22a12"
                     /gene_synonym="Rst; Slc22al2; URAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1542
                     /gene="Slc22a12"
                     /gene_synonym="Rst; Slc22al2; URAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1651
                     /gene="Slc22a12"
                     /gene_synonym="Rst; Slc22al2; URAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1855
                     /gene="Slc22a12"
                     /gene_synonym="Rst; Slc22al2; URAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..2156
                     /gene="Slc22a12"
                     /gene_synonym="Rst; Slc22al2; URAT1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtctgctg tgtctctgag aggttcccat ggcctccaga ttactagaga gggttccagg
       61 tctcagggta acggccagca ggcagataca caagagcctt ggttggctgt gactcagcga
      121 ctcggctgtg tggcatgcat atgaagaggc tggtgtgggc agagtcgtgg gagaagcagg
      181 cgcatcacac agaccctgtg gtcctgggcc agcctctata aagtggaagc tgcgtgctgg
      241 tacccaggaa aaaatcaatg gcgtttcctg aactcctgga ccgagtaggg ggccggggca
      301 ggttccagct cctccaggca gtggctctgg tgacccccat tttgtgggtc accacccaga
      361 acatgctgga gaacttctca gccgcagttc cccaccaccg ctgttgggtg cctcttctgg
      421 acaacagcac ctcccaggcg agtatccctg gggactttgg acgagacgtt cttctggccg
      481 tctccatccc acctggtccg gatcagcgac cccaccagtg cctccgcttc cgacaacctc
      541 agtggcagct tatagagtcc aacaccacgg ccaccaactg gagcgacgct gacaccgagc
      601 catgtgagga tggctgggtt tacgaccaca gtaccttcag gtccacaatt gtgaccacgt
      661 gggacctggt atgtgattcc caggctctga gacccatggc ccagtccatc ttcctggctg
      721 gaatcctggt aggagccgca gtgtgcggcc atgcctcaga taggtttggg cgcagaaggg
      781 tgctgacctg gagctatctt ctggtgtctg tgtctggcac aatagctgcc ctcatgccca
      841 ccttccccct ctactgcctg ttccgtttcc tggtggcctc tgcagtggca ggtgtcatga
      901 tgaacacagc cagcctcttg atggagtgga catcagccca ggctggcccc ttgatgatga
      961 ccttgaacgc cttgggcttc agctttgggc aggtcctgac aggctctgtg gcctacggcg
     1021 tgcgcagctg gaggatgctg cagttggctg tctctgcccc cttcttcctc ttctttgttt
     1081 actcatggtg gctgccagaa tcagcacgct ggctcatcac agtgggcaga ctggaccaga
     1141 gcctgcggga actacagagg gtggctgctg tcaacaggag aaaggcagag gcagacacgt
     1201 tgactgtgga ggtcctgcgg tcagccatgc aggaggaacc gaacgggaac caagctggtg
     1261 cccgtttggg cactctactc cacacacctg ggctgcgcct ccgaaccttc atctccatgc
     1321 tgtgctggtt tgcctttggc ttcaccttct atggcctggc ccttgacctg caagccctag
     1381 gaagcaatat cttcctgctc caggcactca tcgggattgt ggacctcccg gtgaagatgg
     1441 gcagcctgct gctgctcagc cgcttgggcc ggcgcctctg ccaggccagc tccctggtgc
     1501 tgccgggact ctgcatcctg gccaacatac tggtgccccg tgagatgggg atccttcgct
     1561 catccttggc tgtgctgggg ctggggtccc tgggggctgc cttcacctgt gtcaccatat
     1621 tcagcagtga actcttcccc actgtgatca ggatgactgc agtgggcctg ggccaggtag
     1681 cagcccgagg aggagccatg ctagggcctt tggtgcggct gctgggtgtc tatggctcct
     1741 ggctgcctct gctggtgtat ggagtggtgc cagtgttaag cggcctagct gcattgctgc
     1801 tgcctgagac caagaacttg ccactgcctg acaccatcca agacatccag aaacagtcag
     1861 tgaagaaagt gacacatgac atagcaggcg gctccgtcct gaagtctgcc cggttgtaag
     1921 ctcctggaga aggatcacaa cctcaatgga aggaggagaa ggagagggag aggggaggga
     1981 aagggtaggg ttggcggtgg caggtaaagg ctcctgcctc tgggcctaac ggtctggaac
     2041 ccacatggtg gagggaaaga aatactccac aaagtagtcc tctgacctct gcatggaaca
     2101 tgcccctccc cacccccacc tctgatatac acacaaataa ataatttata aaagaaaaaa
     2161 aaaaaaaaaa aaaaaaaaaa
//
