LOCUS       NM_012697               1882 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 22 member 1 (Slc22a1),
            mRNA.
ACCESSION   NM_012697
VERSION     NM_012697.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1882)
  AUTHORS   Floerl,S., Kuehne,A. and Hagos,Y.
  TITLE     Functional and Pharmacological Comparison of Human, Mouse, and Rat
            Organic Cation Transporter 1 toward Drug and Pesticide Interaction
  JOURNAL   Int J Mol Sci 21 (18), 6871 (2020)
   PUBMED   32961667
  REMARK    GeneRIF: Functional and Pharmacological Comparison of Human, Mouse,
            and Rat Organic Cation Transporter 1 toward Drug and Pesticide
            Interaction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1882)
  AUTHORS   Minocha,E., Chaturvedi,C.P. and Nityanand,S.
  TITLE     Renogenic characterization and in vitro differentiation of rat
            amniotic fluid stem cells into renal proximal tubular- and
            juxtaglomerular-like cells
  JOURNAL   In Vitro Cell Dev Biol Anim 55 (2), 138-147 (2019)
   PUBMED   30645697
REFERENCE   3  (bases 1 to 1882)
  AUTHORS   Keller,T., Gorboulev,V., Mueller,T.D., Dotsch,V., Bernhard,F. and
            Koepsell,H.
  TITLE     Rat Organic Cation Transporter 1 Contains Three Binding Sites for
            Substrate 1-Methyl-4-phenylpyridinium per Monomer
  JOURNAL   Mol Pharmacol 95 (2), 169-182 (2019)
   PUBMED   30409791
  REMARK    GeneRIF: The binding and transport of model substrate
            1-methyl-4-phenylpyridinium(+) (MPP(+)) by cell-free-expressed
            fusion proteins of rOCT1.
REFERENCE   4  (bases 1 to 1882)
  AUTHORS   Yang,J., Kalogerou,M., Gallacher,J., Sampson,J.R. and Shen,M.H.
  TITLE     Renal tumours in a Tsc1+/- mouse model show epigenetic suppression
            of organic cation transporters Slc22a1, Slc22a2 and Slc22a3, and do
            not respond to metformin
  JOURNAL   Eur J Cancer 49 (6), 1479-1490 (2013)
   PUBMED   23228442
REFERENCE   5  (bases 1 to 1882)
  AUTHORS   Komazawa,H., Yamaguchi,H., Hidaka,K., Ogura,J., Kobayashi,M. and
            Iseki,K.
  TITLE     Renal uptake of substrates for organic anion transporters Oat1 and
            Oat3 and organic cation transporters Oct1 and Oct2 is altered in
            rats with adenine-induced chronic renal failure
  JOURNAL   J Pharm Sci 102 (3), 1086-1094 (2013)
   PUBMED   23280877
  REMARK    GeneRIF: Protein and mRNA expression levels of Oat1, Oat3, Oct1,
            and Oct2 were significantly decreased in adenine-induced chronic
            renal failure rats.
REFERENCE   6  (bases 1 to 1882)
  AUTHORS   Breidert,T., Spitzenberger,F., Grundemann,D. and Schomig,E.
  TITLE     Catecholamine transport by the organic cation transporter type 1
            (OCT1)
  JOURNAL   Br J Pharmacol 125 (1), 218-224 (1998)
   PUBMED   9776363
REFERENCE   7  (bases 1 to 1882)
  AUTHORS   Meyer-Wentrup,F., Karbach,U., Gorboulev,V., Arndt,P. and
            Koepsell,H.
  TITLE     Membrane localization of the electrogenic cation transporter rOCT1
            in rat liver
  JOURNAL   Biochem Biophys Res Commun 248 (3), 673-678 (1998)
   PUBMED   9703985
REFERENCE   8  (bases 1 to 1882)
  AUTHORS   Zhang,L., Dresser,M.J., Chun,J.K., Babbitt,P.C. and Giacomini,K.M.
  TITLE     Cloning and functional characterization of a rat renal organic
            cation transporter isoform (rOCT1A)
  JOURNAL   J Biol Chem 272 (26), 16548-16554 (1997)
   PUBMED   9195965
REFERENCE   9  (bases 1 to 1882)
  AUTHORS   Busch,A.E., Quester,S., Ulzheimer,J.C., Waldegger,S., Gorboulev,V.,
            Arndt,P., Lang,F. and Koepsell,H.
  TITLE     Electrogenic properties and substrate specificity of the
            polyspecific rat cation transporter rOCT1
  JOURNAL   J Biol Chem 271 (51), 32599-32604 (1996)
   PUBMED   8955087
REFERENCE   10 (bases 1 to 1882)
  AUTHORS   Grundemann,D., Gorboulev,V., Gambaryan,S., Veyhl,M. and Koepsell,H.
  TITLE     Drug excretion mediated by a new prototype of polyspecific
            transporter
  JOURNAL   Nature 372 (6506), 549-552 (1994)
   PUBMED   7990927
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X78855.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X78855.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1882
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..1882
                     /gene="Slc22a1"
                     /gene_synonym="Oct1; Orct1; Roct1"
                     /note="solute carrier family 22 member 1"
                     /db_xref="GeneID:24904"
                     /db_xref="RGD:3224"
     exon            1..451
                     /gene="Slc22a1"
                     /gene_synonym="Oct1; Orct1; Roct1"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1708
                     /gene="Slc22a1"
                     /gene_synonym="Oct1; Orct1; Roct1"
                     /note="organic cation transporter 1; solute carrier family
                     22 (organic cation transporter), member 1"
                     /codon_start=1
                     /product="solute carrier family 22 member 1"
                     /protein_id="NP_036829.1"
                     /db_xref="GeneID:24904"
                     /db_xref="RGD:3224"
                     /translation="MPTVDDVLEQVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGF
                     TPGHYCQNPGVAELSQRCGWSQAEELNYTVPGLGPSDEASFLSQCMRYEVDWNQSTLD
                     CVDPLSSLVANRSQLPLGPCEHGWVYDTPGSSIVTEFNLVCGDAWKVDLFQSCVNLGF
                     FLGSLVVGYIADRFGRKLCLLVTTLVTSVSGVLTAVAPDYTSMLLFRLLQGMVSKGSW
                     VSGYTLITEFVGSGYRRTTAILYQMAFTVGLVGLAGVAYAIPDWRWLQLAVSLPTFLF
                     LLYYWFVPESPRWLLSQKRTTRAVRIMEQIAQKNGKVPPADLKMLCLEEDASEKRSPS
                     FADLFRTPNLRKHTVILMYLWFSCAVLYQGLIMHVGATGANLYLDFFYSSLVEFPAAF
                     IILVTIDRIGRIYPIAASNLVTGAACLLMIFIPHELHWLNVTLACLGRMGATIVLQMV
                     CLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQALPLILFGVLGLTAG
                     AMTLLLPETKGVALPETIEEAENLGRRKSKAKENTIYLQVQTGKSSST"
     exon            452..555
                     /gene="Slc22a1"
                     /gene_synonym="Oct1; Orct1; Roct1"
                     /inference="alignment:Splign:2.1.0"
     exon            556..710
                     /gene="Slc22a1"
                     /gene_synonym="Oct1; Orct1; Roct1"
                     /inference="alignment:Splign:2.1.0"
     exon            711..879
                     /gene="Slc22a1"
                     /gene_synonym="Oct1; Orct1; Roct1"
                     /inference="alignment:Splign:2.1.0"
     exon            880..994
                     /gene="Slc22a1"
                     /gene_synonym="Oct1; Orct1; Roct1"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1101
                     /gene="Slc22a1"
                     /gene_synonym="Oct1; Orct1; Roct1"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1316
                     /gene="Slc22a1"
                     /gene_synonym="Oct1; Orct1; Roct1"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1425
                     /gene="Slc22a1"
                     /gene_synonym="Oct1; Orct1; Roct1"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1538
                     /gene="Slc22a1"
                     /gene_synonym="Oct1; Orct1; Roct1"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1641
                     /gene="Slc22a1"
                     /gene_synonym="Oct1; Orct1; Roct1"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1858
                     /gene="Slc22a1"
                     /gene_synonym="Oct1; Orct1; Roct1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1857
                     /gene="Slc22a1"
                     /gene_synonym="Oct1; Orct1; Roct1"
ORIGIN      
        1 gcaggcctgg ctaaactggt gagggcccta cccagccatg cccaccgtgg atgatgtcct
       61 ggagcaagtt ggagagtttg gctggttcca gaaacaagcc ttcctgttgc tatgcctgat
      121 ctcagcttct ttagctccca tctatgtggg catcgtcttc ctgggcttca cccctggaca
      181 ttattgccag aatcctgggg tggctgagct gagccagcgg tgtggctgga gccaggcaga
      241 ggagctgaac tacactgtgc cgggcctggg accttcggac gaggcctcct tcctcagcca
      301 gtgcatgagg tatgaggtgg actggaacca gagcaccctt gactgtgtgg acccactgtc
      361 cagcctggtt gccaacagga gtcagttgcc attgggcccc tgcgagcatg gctgggtata
      421 cgacactccc ggctcctcca tcgtcactga gtttaacctg gtgtgtggag acgcctggaa
      481 agtggacctt tttcagtcct gtgtgaactt gggcttcttc ctgggctccc tggttgtggg
      541 ttacattgca gacaggtttg gccgtaagct ctgtctcttg gtgaccacgc tggtcacatc
      601 tgtgtccggt gtgctaacag cggtggcccc agactataca tccatgttgc tctttcgcct
      661 gctgcagggc atggtcagca agggcagctg ggtgtccggc tataccttga tcacagagtt
      721 tgtcggctct ggctacagga gaacgacggc cattttgtac cagatggcct tcacagtggg
      781 gctagtgggg cttgccgggg tggcctatgc cattccagac tggcgctggc tccagctagc
      841 tgtgtccctg cctaccttcc tcttcctgct gtattactgg tttgtcccag aatccccccg
      901 gtggctgttg tcccagaaga gaaccacgcg agctgtcagg ataatggagc aaattgcaca
      961 gaagaacggg aaggtgcctc ctgctgacct gaagatgctc tgccttgagg aggatgcctc
     1021 agaaaagcga agtccttcgt ttgccgacct gttccgcact cccaacctga ggaagcacac
     1081 cgtcatcctg atgtatctat ggttctcttg tgctgtgctg taccagggtc tcatcatgca
     1141 cgtgggagcc acaggggcca acctctacct ggacttcttt tattcttctc tggtggaatt
     1201 ccccgcggcc ttcatcatcc tggtcaccat tgaccgcatt ggccgcatct acccaatagc
     1261 ggcctcgaat ctggtgacgg gggcagcctg cctcctcatg atctttatcc cgcatgagct
     1321 gcactggttg aacgttaccc tcgcctgtct tggccgtatg ggggccacca ttgtgctgca
     1381 gatggtctgc ctggtgaacg ctgagctgta ccctacattc atcaggaatc ttgggatgat
     1441 ggtatgctct gccctgtgtg acctgggtgg gatcttcacc cccttcatgg tgttcaggct
     1501 gatggaagtt tggcaagccc tgcccctcat tttgtttggg gttttgggcc tgactgctgg
     1561 ggccatgact cttcttctcc cagagaccaa gggtgtggct ttgcctgaga ctattgaaga
     1621 agcagagaac ctggggagga ggaaatcaaa ggccaaagaa aacacgattt accttcaggt
     1681 ccaaacaggc aagtcctcaa gtacctgaca gggatgctgt gccaggagct gagtggcaga
     1741 gagaaaggag gacttgccac ttggaggatt cccagaagcc tttgcctttc cagactcttg
     1801 tatatatgca ccaggttcca aatgaactac caaccttaaa gacttttctg aaagcccaaa
     1861 aaaaaaaaaa aaaaaaaaaa aa
//
