LOCUS       NM_017223               3655 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 20 member 2 (Slc20a2),
            mRNA.
ACCESSION   NM_017223
VERSION     NM_017223.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3655)
  AUTHORS   Prie,D., Torres,P.U. and Friedlander,G.
  TITLE     Phosphate handling: new genes, new molecules
  JOURNAL   Horm Res Paediatr 76 Suppl 1, 71-75 (2011)
   PUBMED   21778753
  REMARK    Review article
REFERENCE   2  (bases 1 to 3655)
  AUTHORS   Picard,N., Capuano,P., Stange,G., Mihailova,M., Kaissling,B.,
            Murer,H., Biber,J. and Wagner,C.A.
  TITLE     Acute parathyroid hormone differentially regulates renal brush
            border membrane phosphate cotransporters
  JOURNAL   Pflugers Arch 460 (3), 677-687 (2010)
   PUBMED   20526720
  REMARK    GeneRIF: expression in renal brush border reduced by parathyroid
            hormone
REFERENCE   3  (bases 1 to 3655)
  AUTHORS   Villa-Bellosta,R. and Sorribas,V.
  TITLE     Compensatory regulation of the sodium/phosphate cotransporters
            NaPi-IIc (SCL34A3) and Pit-2 (SLC20A2) during Pi deprivation and
            acidosis
  JOURNAL   Pflugers Arch 459 (3), 499-508 (2010)
   PUBMED   19841935
  REMARK    GeneRIF: Results describe the regulation of the sodium/phosphate
            cotransporters SCL34A3 and SLC20A2 during phosphate deprivation and
            acidosis in rat kidney.
REFERENCE   4  (bases 1 to 3655)
  AUTHORS   Breusegem,S.Y., Takahashi,H., Giral-Arnal,H., Wang,X., Jiang,T.,
            Verlander,J.W., Wilson,P., Miyazaki-Anzai,S., Sutherland,E.,
            Caldas,Y., Blaine,J.T., Segawa,H., Miyamoto,K., Barry,N.P. and
            Levi,M.
  TITLE     Differential regulation of the renal sodium-phosphate
            cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium
            deficiency
  JOURNAL   Am J Physiol Renal Physiol 297 (2), F350-F361 (2009)
   PUBMED   19493963
  REMARK    GeneRIF: Differential regulation of the renal sodium-phosphate
            cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium
            deficiency.
REFERENCE   5  (bases 1 to 3655)
  AUTHORS   Villa-Bellosta,R., Bogaert,Y.E., Levi,M. and Sorribas,V.
  TITLE     Characterization of phosphate transport in rat vascular smooth
            muscle cells: implications for vascular calcification
  JOURNAL   Arterioscler Thromb Vasc Biol 27 (5), 1030-1036 (2007)
   PUBMED   17322102
  REMARK    GeneRIF: We have used RNA interference to demonstrate that Pit1 and
            Pit2 are the transporters responsible for Na-dependent Pi transport
            in VSMCs.
REFERENCE   6  (bases 1 to 3655)
  AUTHORS   Frei,P., Gao,B., Hagenbuch,B., Mate,A., Biber,J., Murer,H.,
            Meier,P.J. and Stieger,B.
  TITLE     Identification and localization of sodium-phosphate cotransporters
            in hepatocytes and cholangiocytes of rat liver
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 288 (4), G771-G778 (2005)
   PUBMED   15564340
  REMARK    GeneRIF: PiT-1 (Slc20a1) and PiT-2 (Slc20a2) were detected at the
            basolateral membrane of hepatocytes.
REFERENCE   7  (bases 1 to 3655)
  AUTHORS   Wada,K., Mizuno,M., Komori,T. and Tamura,M.
  TITLE     Extracellular inorganic phosphate regulates gibbon ape leukemia
            virus receptor-2/phosphate transporter mRNA expression in rat bone
            marrow stromal cells
  JOURNAL   J Cell Physiol 198 (1), 40-47 (2004)
   PUBMED   14584042
  REMARK    GeneRIF: mRNA expression level of Glvr-2 was increased by the
            addition of inorganic phosphate (Pi) in bone marrow stromal cells
REFERENCE   8  (bases 1 to 3655)
  AUTHORS   Miller,D.G. and Miller,A.D.
  TITLE     A family of retroviruses that utilize related phosphate
            transporters for cell entry
  JOURNAL   J Virol 68 (12), 8270-8276 (1994)
   PUBMED   7966619
REFERENCE   9  (bases 1 to 3655)
  AUTHORS   Kavanaugh,M.P., Miller,D.G., Zhang,W., Law,W., Kozak,S.L., Kabat,D.
            and Miller,A.D.
  TITLE     Cell-surface receptors for gibbon ape leukemia virus and
            amphotropic murine retrovirus are inducible sodium-dependent
            phosphate symporters
  JOURNAL   Proc Natl Acad Sci U S A 91 (15), 7071-7075 (1994)
   PUBMED   8041748
REFERENCE   10 (bases 1 to 3655)
  AUTHORS   Miller,D.G., Edwards,R.H. and Miller,A.D.
  TITLE     Cloning of the cellular receptor for amphotropic murine
            retroviruses reveals homology to that for gibbon ape leukemia virus
  JOURNAL   Proc Natl Acad Sci U S A 91 (1), 78-82 (1994)
   PUBMED   8278411
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC070908.1.
            
            On May 24, 2004 this sequence version replaced NM_017223.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070908.1, SRR8487227.268257.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3655
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..3655
                     /gene="Slc20a2"
                     /gene_synonym="Ab1-188; Glvr2; Pit-2; RAM-1; Ram1"
                     /note="solute carrier family 20 member 2"
                     /db_xref="GeneID:29502"
                     /db_xref="RGD:3699"
     exon            1..148
                     /gene="Slc20a2"
                     /gene_synonym="Ab1-188; Glvr2; Pit-2; RAM-1; Ram1"
                     /inference="alignment:Splign:2.1.0"
     exon            149..703
                     /gene="Slc20a2"
                     /gene_synonym="Ab1-188; Glvr2; Pit-2; RAM-1; Ram1"
                     /inference="alignment:Splign:2.1.0"
     CDS             415..2385
                     /gene="Slc20a2"
                     /gene_synonym="Ab1-188; Glvr2; Pit-2; RAM-1; Ram1"
                     /note="gibbon ape leukemia virus receptor 2; phosphate
                     transporter 2; receptor for amphitropic viruses 1;
                     receptor for amphotropic viruses 1; solute carrier family
                     20 (phosphate transporter), member 2"
                     /codon_start=1
                     /product="sodium-dependent phosphate transporter 2"
                     /protein_id="NP_058919.1"
                     /db_xref="GeneID:29502"
                     /db_xref="RGD:3699"
                     /translation="MAMDGYLWMVILGFIIAFILAFSVGANDVANSFGTAVGSGVVTL
                     RQACILASIFETTGSVLLGAKVGETIRKGIIDVNLYNETVETLMAGEVSAMVGSAVWQ
                     LIASFLRLPISGTHCIVGSTIGFSLVAIGPKGVQWMELVKIVASWFISPLLSGFMSGV
                     LFILIRMFILTKEDPVPNGLQALPLFYAATIAINVFSIMYTGAPVLGLSLPIWAIALI
                     SFGVALLFAFFVWLFVCPWMKRKIAGRLEKESALSRASDESLRKVQEAESPVFKELPG
                     AKASDDSAVPLTSLAGEAAGASEGTSAGNHPRASYGRALSMTHGSAKSPISNGTFGFE
                     GHMRNDGHVYHTVHKDSGLYKDLLHKIHVDKGPEEKPAQENNYRLLRRNNSYTCYTAA
                     ICGMPVHATFRASDTSSAPEDSEKLVGDTVSYSKKRLRYDSYSSYCNAVAEAEIEAEE
                     GGVEMRLASELTDPDQPHEDPAEDEKEEKDSAEVHLLFHFLQVLTACFGSFAHGGNDV
                     SNAIGPLVALWLIYKQGGVTQEAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKDLTP
                     ITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWIRSRKAVDWRLFRNIF
                     IAWFVTVPVAGLFSAAIMALLMYICGFVSSSR"
     exon            704..844
                     /gene="Slc20a2"
                     /gene_synonym="Ab1-188; Glvr2; Pit-2; RAM-1; Ram1"
                     /inference="alignment:Splign:2.1.0"
     exon            845..930
                     /gene="Slc20a2"
                     /gene_synonym="Ab1-188; Glvr2; Pit-2; RAM-1; Ram1"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1027
                     /gene="Slc20a2"
                     /gene_synonym="Ab1-188; Glvr2; Pit-2; RAM-1; Ram1"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1144
                     /gene="Slc20a2"
                     /gene_synonym="Ab1-188; Glvr2; Pit-2; RAM-1; Ram1"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1348
                     /gene="Slc20a2"
                     /gene_synonym="Ab1-188; Glvr2; Pit-2; RAM-1; Ram1"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1940
                     /gene="Slc20a2"
                     /gene_synonym="Ab1-188; Glvr2; Pit-2; RAM-1; Ram1"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2126
                     /gene="Slc20a2"
                     /gene_synonym="Ab1-188; Glvr2; Pit-2; RAM-1; Ram1"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2211
                     /gene="Slc20a2"
                     /gene_synonym="Ab1-188; Glvr2; Pit-2; RAM-1; Ram1"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..3630
                     /gene="Slc20a2"
                     /gene_synonym="Ab1-188; Glvr2; Pit-2; RAM-1; Ram1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggaggccg ccgcgccgcg ccggtccgct ccgctcggac tgttccggga gtcgggcggg
       61 gagcgcaggc cgagacccag cggaccggac gacctctcct tcgtcacttc ctgccggccc
      121 gcggtttccg gagggaacga gaagccagaa agaaagatca cagctttccc agactgggag
      181 aaaaaatatg gaatgtggtg taccactgac tgaccataac caaatgaact gtagtgacag
      241 tagtctaaaa gccagcggtt aacaatttct tcagacttca acactatcca tcgctttcca
      301 gagcagactc gctgtttaca agaactcttg gcctcccgaa gatagcaacc tcaaattttg
      361 tttatttaaa atatttctgc aaaaggaaaa gtaccccaga gcccattttc caaaatggcc
      421 atggatgggt atctgtggat ggtcattttg ggtttcatta ttgctttcat cctggcattt
      481 tcagttggtg ccaatgatgt tgccaactcc tttggaaccg cggtgggctc tggcgtggtg
      541 accctgagac aggcatgcat tctggcttcg atatttgaaa ccaccggctc tgtgcttttg
      601 ggagcgaaag tgggagagac tatccggaag ggcatcattg acgtgaacct ctacaatgag
      661 actgtggaaa cgctcatggc tggggaagtg agtgcaatgg tcggctcagc ggtctggcag
      721 ttgatcgcgt ccttcctgag actcccaatc tcagggacac actgcatcgt gggctctacc
      781 attggcttct cgctcgtggc catcggccca aagggagtgc agtggatgga actcgtcaag
      841 atcgttgcct cctggttcat atccccactt ctgtctggct tcatgtctgg tgtgctgttc
      901 atcctgatca gaatgttcat cctaaccaag gaggaccctg ttccaaacgg tctccaggca
      961 cttcctctgt tttatgctgc cactatagca ataaacgtct tctccatcat gtacacagga
     1021 gcaccagtgc tgggcctgtc gctccccatc tgggcaatag cgctcatctc cttcggcgtt
     1081 gccctgctgt tcgccttctt cgtgtggctg ttcgtgtgtc cgtggatgaa gaggaaaata
     1141 gcgggcaggt tagagaagga gagtgctctg tcccgcgcgt ctgacgaaag cctcaggaag
     1201 gtacaggaag ctgagtcccc tgtctttaag gagcttcctg gtgccaaagc cagtgatgac
     1261 agcgctgtcc ccctcaccag tctggctggg gaggctgcgg gggcctcaga aggcacgtca
     1321 gcagggaacc acccccgggc ttcctacggc cgagcacttt ccatgactca cggctctgca
     1381 aagtcaccca tctccaatgg aacctttggc ttcgaaggcc acatgaggaa tgacggtcac
     1441 gtttatcata ctgtacacaa agactcggga ctctacaaag acttgctgca caaaatccat
     1501 gtagacaagg gccccgagga gaaaccagct caggaaaaca actacaggct gctccggagg
     1561 aacaacagct acacgtgcta cacggcagcc atctgcggca tgccggtgca cgccaccttc
     1621 agggcctcgg acacctcctc cgcccccgag gatagcgaga agctggtggg tgacaccgtg
     1681 tcctattcca agaagaggct ccgctacgac agctactcca gctactgcaa cgcggtggcc
     1741 gaggcggaga tcgaggccga agagggcggc gtggaaatga ggctggcctc tgagctgacc
     1801 gatcctgacc agcctcacga ggatcctgcg gaagacgaga aggaggagaa ggactccgca
     1861 gaggtccacc tgctcttcca cttcctgcaa gtcctcactg cctgctttgg gtcctttgct
     1921 cacggtggca acgatgtgag caatgctatc ggtccccttg tggccctgtg gctgatatat
     1981 aaacaaggcg gagttacaca agaagctgct actccagtct ggctgctgtt ttatgggggc
     2041 gttggcatct gcacaggtct ctgggtttgg ggcagaagag tgatccagac catggggaag
     2101 gatctcacac ccatcacacc gtccagtggc ttcactattg agctggcctc tgccttcacc
     2161 gtggtgatcg cctccaacat tgggcttccc gtcagcacca cacactgcaa ggtgggctca
     2221 gtggtagccg tgggctggat ccgctcccgg aaggctgtgg actggcgcct cttccggaac
     2281 atatttattg cctggttcgt gaccgtgccg gtggccggac ttttcagtgc tgctatcatg
     2341 gctctcctca tgtatatatg tggttttgtt tcttccagtc ggtaaatggc cacagggatg
     2401 ctctgacacg gatatggtcc tcacacctcc cacccctgct ttctctgaca cttgcacacc
     2461 ccttccacac accttcctga tggtgtcata tcacccctgc ttacccaggc cacagttcat
     2521 cttccagaat taacctacct gctgtacata gtagtctaca tcaagctgat gtcgtgatga
     2581 cacaatgtgg tgcggttact tatatgaaat atatattgtg tacctagaac aggtagcatt
     2641 tatttcaaac aaactcagaa tgaacgtgga gggtattgcc tagaatgcaa tattctgtta
     2701 actgtacata atgatttcag tggcagtaag cgtagagtat caaatccttt tttaaataca
     2761 ctgtatatag cgggatacag tatacttcat acaaacccgg gcaggcgggt gggcgggtga
     2821 gttccggccc ttgtgtgatt gcccagtgct gggacaggtt ttcacaagtg ctttctctga
     2881 agagtgtgtt cgtgagcgga gtccgagtta ctgtgtaatg taccacgatt gcttctgtaa
     2941 atactttcaa ctgtaatttt aatgctaagc ttccctcata cttttttgat cggagaattt
     3001 tggaaagtac caaagaacga gaggataact cgccagtgtt acaccttccc actgcttgtc
     3061 tcccttccca ccggccctga cagtggacct ggttacttca gccaggcgag cttagaactc
     3121 agccacccac cagcagcagc caggaggctg ccacaccaga tactggaaag cttgttcagt
     3181 ggcctttcac tgtcaccagc gcggatgaca tacagcagtg ggggtgtaga attaaacact
     3241 acatacatat caagtccaac tccagggtcc ctccccgtcg cacccagtgg cctgaaaagc
     3301 aggaatctcg ttgcagacat taaagccagt gaggctcttg atgggctcgg atgctgccaa
     3361 ctcagggctt agccggaagt atgggcgggg acactgggct tggggatctt tgaggccttt
     3421 tctgtggaga acatccgagg ttctcctgtg gagccgctgt tctcttctga tggcggcggg
     3481 agagcgtcgg tgtcactaaa atgttaagag cctgaaacca tggaaacgct gctaatattt
     3541 ttatattgac atacattttc acggtacttc attgtaattt tttcattaat caagcatatt
     3601 aaatttataa taaaaaagtg cccctcaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
