LOCUS       NM_031148               2851 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus solute carrier family 20 member 1 (Slc20a1),
            mRNA.
ACCESSION   NM_031148
VERSION     NM_031148.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2851)
  AUTHORS   Sonou,T., Ohya,M., Yashiro,M., Masumoto,A., Nakashima,Y., Ito,T.,
            Mima,T., Negi,S., Kimura-Suda,H. and Shigematsu,T.
  TITLE     Magnesium prevents phosphate-induced vascular calcification via
            TRPM7 and Pit-1 in an aortic tissue culture model
  JOURNAL   Hypertens Res 40 (6), 562-567 (2017)
   PUBMED   28123180
  REMARK    GeneRIF: mechanism involving TRPM7 and Pit-1 underpins the
            magnesium-mediated reversal of high-phosphate-associated vascular
            calcification
REFERENCE   2  (bases 1 to 2851)
  AUTHORS   Masuda,M., Miyazaki-Anzai,S., Keenan,A.L., Shiozaki,Y., Okamura,K.,
            Chick,W.S., Williams,K., Zhao,X., Rahman,S.M., Tintut,Y.,
            Adams,C.M. and Miyazaki,M.
  TITLE     Activating transcription factor-4 promotes mineralization in
            vascular smooth muscle cells
  JOURNAL   JCI Insight 1 (18), e88646 (2016)
   PUBMED   27812542
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2851)
  AUTHORS   Zhang,C., Shi,L.M., Li,Y., Zhu,Q.G., Jin,C.L., Wang,H.P., Zhou,L.,
            Hu,X.P., Zhang,L., Wang,H., Yuan,G.J., Xu,L., Zhao,Y.K. and Chou,Y.
  TITLE     Effect of hyperphosphatemia on gene expression of the Na-Pi
            cotransporter in rats
  JOURNAL   Genet Mol Res 14 (4), 19404-19410 (2016)
   PUBMED   26782594
  REMARK    GeneRIF: NaPi-III mRNA expression is affected by hyperphosphatemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2851)
  AUTHORS   Han,X., Wang,L.Y., Diao,Z.L. and Liu,W.H.
  TITLE     Apelin: A novel inhibitor of vascular calcification in chronic
            kidney disease
  JOURNAL   Atherosclerosis 244, 1-8 (2016)
   PUBMED   26581047
  REMARK    GeneRIF: Apelin ameliorates VC by suppressing osteoblastic
            differentiation of VSMCs through downregulation of Pit-1.
REFERENCE   5  (bases 1 to 2851)
  AUTHORS   Prie,D., Torres,P.U. and Friedlander,G.
  TITLE     Phosphate handling: new genes, new molecules
  JOURNAL   Horm Res Paediatr 76 Suppl 1, 71-75 (2011)
   PUBMED   21778753
  REMARK    Review article
REFERENCE   6  (bases 1 to 2851)
  AUTHORS   Frei,P., Gao,B., Hagenbuch,B., Mate,A., Biber,J., Murer,H.,
            Meier,P.J. and Stieger,B.
  TITLE     Identification and localization of sodium-phosphate cotransporters
            in hepatocytes and cholangiocytes of rat liver
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 288 (4), G771-G778 (2005)
   PUBMED   15564340
  REMARK    GeneRIF: PiT-1 and PiT-2 were detected at the basolateral membrane
            of hepatocytes.
REFERENCE   7  (bases 1 to 2851)
  AUTHORS   Abraham,K.A., Brault,J.J. and Terjung,R.L.
  TITLE     Phosphate uptake and PiT-1 protein expression in rat skeletal
            muscle
  JOURNAL   Am J Physiol Cell Physiol 287 (1), C73-C78 (2004)
   PUBMED   14985238
  REMARK    GeneRIF: Sodium-phosphate cotransporter (PiT-1) soleus and red
            gastrocnemius was similar and seven- to eightfold greater than
            PiT-1 expression in white gastrocnemius. PiT-1 expression did not
            match pattern of P(i) uptake across fiber types.
REFERENCE   8  (bases 1 to 2851)
  AUTHORS   Khadeer,M.A., Tang,Z., Tenenhouse,H.S., Eiden,M.V., Murer,H.,
            Hernando,N., Weinman,E.J., Chellaiah,M.A. and Gupta,A.
  TITLE     Na+-dependent phosphate transporters in the murine osteoclast:
            cellular distribution and protein interactions
  JOURNAL   Am J Physiol Cell Physiol 284 (6), C1633-C1644 (2003)
   PUBMED   12606316
REFERENCE   9  (bases 1 to 2851)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   10 (bases 1 to 2851)
  AUTHORS   Tatsumi,S., Segawa,H., Morita,K., Haga,H., Kouda,T., Yamamoto,H.,
            Inoue,Y., Nii,T., Katai,K., Taketani,Y., Miyamoto,K.I. and
            Takeda,E.
  TITLE     Molecular cloning and hormonal regulation of PiT-1, a
            sodium-dependent phosphate cotransporter from rat parathyroid
            glands
  JOURNAL   Endocrinology 139 (4), 1692-1699 (1998)
   PUBMED   9528951
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            [WARNING] On Jul 16, 2024 this sequence was replaced by
            NM_031148.3.
            
            On Nov 27, 2020 this sequence version replaced NM_031148.1.
            
            Sequence Note: This sequence has been modified as follows: removed
            40 bp suspected to be vector contamination from the 5' end.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB000489.1, SRR26643292.14488.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-397               JAXUCZ010000003.1  136881171-136881567
            398-538             JAXUCZ010000003.1  136881697-136881837
            539-624             JAXUCZ010000003.1  136882147-136882232
            625-721             JAXUCZ010000003.1  136886012-136886108
            722-841             JAXUCZ010000003.1  136889071-136889190
            842-1105            JAXUCZ010000003.1  136890416-136890679
            1106-1664           JAXUCZ010000003.1  136890784-136891342
            1665-1850           JAXUCZ010000003.1  136891827-136892012
            1851-1935           JAXUCZ010000003.1  136892561-136892645
            1936-2851           JAXUCZ010000003.1  136893329-136894244
FEATURES             Location/Qualifiers
     source          1..2851
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..2851
                     /gene="Slc20a1"
                     /gene_synonym="PiT-1"
                     /note="solute carrier family 20 member 1"
                     /db_xref="GeneID:81826"
                     /db_xref="RGD:621079"
     exon            1..397
                     /gene="Slc20a1"
                     /gene_synonym="PiT-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..2097
                     /gene="Slc20a1"
                     /gene_synonym="PiT-1"
                     /note="RPHO-1; phosphate transporter 1; solute carrier
                     family 20 (phosphate transporter), member 1"
                     /codon_start=1
                     /product="sodium-dependent phosphate transporter 1"
                     /protein_id="NP_112410.1"
                     /db_xref="GeneID:81826"
                     /db_xref="RGD:621079"
                     /translation="MASTLAPITSTLAAVTASAPPKYDNLWMLILGFIIAFVLAFSVG
                     ANDVANSFGTAVGSGVVTLKQACILASIFETVGSALLGAKVSETIRKGLIDVEKYNAT
                     QDLLMAGSVSAMFGSAVWQLVASFLKLPISGTHCIVGATIGFSLVAKGQEGIKWSELI
                     KIVMSWFVSPLLSGIMSGILFFLVRAFILRKADPVPNGLRALPIFYACTIGINLFSIM
                     YTGAPLLGFDKLPLWGTILISVGCAVFCALIVWFFVCPRMKRKIEREVKSSPSESPLM
                     EKKNNLKDHEETKMAPGDVENRNPVSEVVCATGPLRAVVEERTVSFKLGDLEEAPERE
                     RLPMDLKEETNIDGTINGAVQLPNGNLVQFSQTVSNQINSSGHYQYHTVHKDSGLYKE
                     LLHKLHLAKVGDCMGDSGDKPLRRNNSYTSYTMAICGMPLDSFRAKEGEQKGDEMETL
                     TWPNADTKKRIRMDSYTSYCNAVSDLHSESEMDMSVKAEMGLGDRKGSSGSLEEWYDQ
                     DKPEVSLLFQFLQILTACFGSFAHGGNDVSNAIGPLVALYLVYETRDVTTKEATPIWL
                     LLYGGVGICMGLWVWGRRVIQTMGKDLTPITPSSGFSIELASAFTVVVASNIGLPIST
                     THCKVGSVVSVGWLRSKKAVDWRLFRNIFMAWFVTVPISGVISAAIMAVFKHIILPV"
     exon            398..538
                     /gene="Slc20a1"
                     /gene_synonym="PiT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            539..624
                     /gene="Slc20a1"
                     /gene_synonym="PiT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            625..721
                     /gene="Slc20a1"
                     /gene_synonym="PiT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            722..841
                     /gene="Slc20a1"
                     /gene_synonym="PiT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1105
                     /gene="Slc20a1"
                     /gene_synonym="PiT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1664
                     /gene="Slc20a1"
                     /gene_synonym="PiT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1850
                     /gene="Slc20a1"
                     /gene_synonym="PiT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1935
                     /gene="Slc20a1"
                     /gene_synonym="PiT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2851
                     /gene="Slc20a1"
                     /gene_synonym="PiT-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaagccgct cagtaattct cgtattattt aaagaaccac tacactacag gatggcatct
       61 accctggccc cgattactag tactctagct gctgttactg cttctgctcc accgaagtat
      121 gacaatctgt ggatgctcat cctgggcttc atcattgcat ttgtcttggc attctccgtg
      181 ggagccaatg atgtagcaaa ttcatttggt acagctgtag gctcaggtgt agtgaccctg
      241 aagcaagcct gcatcctagc tagcatcttc gaaactgtgg gctccgcctt gctgggggcc
      301 aaagtgagtg aaaccatccg gaagggcttg atagatgtgg agaagtacaa cgcaactcaa
      361 gatctgctca tggctggctc tgtcagtgct atgtttggtt ctgctgtgtg gcaactagtg
      421 gcttcgtttt tgaagcttcc tatttctggg acccattgta ttgtcggtgc aaccattggt
      481 ttctcccttg tggcaaaggg acaagagggt atcaaatggt ccgaactgat aaaaattgtg
      541 atgtcttggt tcgtctctcc actgctttct ggtattatgt ctggaatttt attcttcctt
      601 gttcgtgcat tcatcctccg taaggcagat ccagttccta atggcttacg agctttaccc
      661 attttttatg cctgcacaat tggaatcaac ctcttttcca ttatgtatac tggagcacca
      721 ttgctgggct ttgacaaact tcctctgtgg ggtaccatcc tcatctcggt gggatgtgca
      781 gttttctgtg cccttatcgt ctggttcttt gtatgtccca ggatgaagag gaaaattgaa
      841 cgagaagtaa agtctagtcc ctctgaaagt cccttaatgg aaaagaagaa caacttaaaa
      901 gaccatgaag aaacaaagat ggctcctggc gatgttgaga ataggaatcc tgtgtctgag
      961 gtagtatgtg ccactggccc actacgggct gtggtggagg agagaacggt gtcatttaaa
     1021 ctcggtgacc tggaggaagc tccggagcga gagcggcttc ccatggacct gaaggaggag
     1081 accaacatag atggtactat caatggtgca gtgcagttgc ctaatgggaa ccttgttcag
     1141 ttcagtcaaa ccgtcagcaa ccagatcaac tccagtggcc actatcagta tcacaccgtg
     1201 cacaaggatt ctggcttgta caaagagctg ctccataagc tacatctggc caaggtggga
     1261 gactgcatgg gagactctgg ggacaagccc ttgagacgca acaacagcta cacatcctac
     1321 accatggcaa tatgtggcat gcccctggat tccttccgtg ccaaagaagg ggaacaaaag
     1381 ggagacgaaa tggaaacgct gacttggcct aatgcagata ccaagaagcg gattcggatg
     1441 gacagttaca ccagttactg caatgctgtg tctgaccttc actcagagtc tgagatggac
     1501 atgagtgtta aggcagagat gggtctgggt gacagaaaag gaagcagtgg ctctcttgaa
     1561 gaatggtatg atcaggataa gcctgaagtg tcccttctct tccagtttct gcagatcctt
     1621 acagcctgct ttgggtcctt tgcccatggt ggcaatgacg tcagcaatgc catcggccct
     1681 ctggttgctt tgtatcttgt ttatgaaacg agagatgtca ctacaaaaga ggcaacaccc
     1741 atatggcttc tgctttatgg tggtgttggc atttgcatgg ggctatgggt ttggggaaga
     1801 agagttatcc agactatggg gaaggacctg acaccaatca caccctccag tggtttcagt
     1861 attgaactgg catctgcctt cactgtggtc gtcgcatcaa acattggcct tcccatcagc
     1921 acaacacatt gtaaggtggg ctctgtggtg tctgttggct ggctccgatc caagaaggct
     1981 gttgactggc gactgtttcg aaacattttt atggcctggt ttgtcaccgt ccctatttct
     2041 ggggttatca gtgctgctat catggcagtg ttcaagcaca tcattctgcc ggtgtgaagc
     2101 tgagctcaga attgtgtcag tgtctgggac catcgcacac acccctgttc ctaaagaatg
     2161 ctcagtgttg ctgaagatag gccagggttt taaagtgggg gagctgtggg aaggaagtgt
     2221 aatttatact ataattgctt ttgtgctaaa tatgacttat ctcaaaatta gctgtgtaaa
     2281 atagccaggt ttccattgat tcattctaag gtcccttttc tcctgggcta tgacttcctg
     2341 tacatatttc tctacttttg tatcaggcat caattccatt atgttttaat gtcgtctgtg
     2401 agataactta atgtggattc tttttaaaca gccaagcaga gccatttgat ggcatatact
     2461 gctttgttgg cctcaccagc ttcttcccca gcgtgcacag ggatttaaca aacatgtaac
     2521 tgaagcttcc cttgtagtct ctcatagaaa tagtcacggc actctgctcc ctgtcactag
     2581 tggcaggttc tgttgacatg tgacaacttc ttagagggcc gagaatcttt ggcacagtga
     2641 aaatttaagt ttgtagtaac ttctttgcaa acagttcgtg gacgtgttgc taagaagtag
     2701 gaagacaaag cctggtggtt gtggttattc ttttgagatt tctggcagtg tgggatgggt
     2761 gaatgaagtg gaatgggaac tttgggcaaa ttcaatggga cagccttcca tgttcatctg
     2821 tctacctctt aactgaataa aaagcctaca g
//
