LOCUS       NM_175758               2570 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 1 member 5 (Slc1a5), mRNA.
ACCESSION   NM_175758 NM_153723
VERSION     NM_175758.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2570)
  AUTHORS   Chen,Z., Gao,Y., Huang,X., Yao,Y., Chen,K., Zeng,S. and Mao,W.
  TITLE     Tissue-based metabolomics reveals metabolic biomarkers and
            potential therapeutic targets for esophageal squamous cell
            carcinoma
  JOURNAL   J Pharm Biomed Anal 197, 113937 (2021)
   PUBMED   33609949
REFERENCE   2  (bases 1 to 2570)
  AUTHORS   Ndaru,E., Garibsingh,R.A., Zielewicz,L., Schlessinger,A. and
            Grewer,C.
  TITLE     Interaction of the neutral amino acid transporter ASCT2 with basic
            amino acids
  JOURNAL   Biochem J 477 (8), 1443-1457 (2020)
   PUBMED   32242892
  REMARK    GeneRIF: Interaction of the neutral amino acid transporter ASCT2
            with basic amino acids.
REFERENCE   3  (bases 1 to 2570)
  AUTHORS   Garaeva,A.A., Oostergetel,G.T., Gati,C., Guskov,A., Paulino,C. and
            Slotboom,D.J.
  TITLE     Cryo-EM structure of the human neutral amino acid transporter ASCT2
  JOURNAL   Nat Struct Mol Biol 25 (6), 515-521 (2018)
   PUBMED   29872227
REFERENCE   4  (bases 1 to 2570)
  AUTHORS   Foster,A.C., Farnsworth,J., Lind,G.E., Li,Y.X., Yang,J.Y., Dang,V.,
            Penjwini,M., Viswanath,V., Staubli,U. and Kavanaugh,M.P.
  TITLE     D-Serine Is a Substrate for Neutral Amino Acid Transporters
            ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes
            in Rat Hippocampal Astrocyte Cultures
  JOURNAL   PLoS One 11 (6), e0156551 (2016)
   PUBMED   27272177
  REMARK    GeneRIF: the selectivity profile of D-serine uptake in cultured rat
            hippocampal astrocytes is consistent with uptake mediated by both
            ASCT1 and ASCT2. Together these data suggest that SLC1A4 (ASCT1)
            may represent an important route of Na-dependent D-serine flux in
            the brain that has the ability to regulate extracellular D-serine
            and thereby NMDA receptor activity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2570)
  AUTHORS   Honjo,H., Kaira,K., Miyazaki,T., Yokobori,T., Kanai,Y.,
            Nagamori,S., Oyama,T., Asao,T. and Kuwano,H.
  TITLE     Clinicopathological significance of LAT1 and ASCT2 in patients with
            surgically resected esophageal squamous cell carcinoma
  JOURNAL   J Surg Oncol 113 (4), 381-389 (2016)
   PUBMED   26936531
REFERENCE   6  (bases 1 to 2570)
  AUTHORS   Yamamoto,T., Nishizaki,I., Furuya,S., Hirabayashi,Y., Takahashi,K.,
            Okuyama,S. and Yamamoto,H.
  TITLE     Characterization of rapid and high-affinity uptake of L-serine in
            neurons and astrocytes in primary culture
  JOURNAL   FEBS Lett 548 (1-3), 69-73 (2003)
   PUBMED   12885409
REFERENCE   7  (bases 1 to 2570)
  AUTHORS   Pollard,M., Meredith,D. and McGivan,J.D.
  TITLE     Identification of a plasma membrane glutamine transporter from the
            rat hepatoma cell line H4-IIE-C3
  JOURNAL   Biochem J 368 (Pt 1), 371-375 (2002)
   PUBMED   12171599
REFERENCE   8  (bases 1 to 2570)
  AUTHORS   Marin,M., Tailor,C.S., Nouri,A. and Kabat,D.
  TITLE     Sodium-dependent neutral amino acid transporter type 1 is an
            auxiliary receptor for baboon endogenous retrovirus
  JOURNAL   J Virol 74 (17), 8085-8093 (2000)
   PUBMED   10933718
REFERENCE   9  (bases 1 to 2570)
  AUTHORS   Broer,A., Wagner,C., Lang,F. and Broer,S.
  TITLE     Neutral amino acid transporter ASCT2 displays substrate-induced Na+
            exchange and a substrate-gated anion conductance
  JOURNAL   Biochem J 346 Pt 3 (Pt 3), 705-710 (2000)
   PUBMED   10698697
REFERENCE   10 (bases 1 to 2570)
  AUTHORS   Broer,A., Brookes,N., Ganapathy,V., Dimmer,K.S., Wagner,C.A.,
            Lang,F. and Broer,S.
  TITLE     The astroglial ASCT2 amino acid transporter as a mediator of
            glutamine efflux
  JOURNAL   J Neurochem 73 (5), 2184-2194 (1999)
   PUBMED   10537079
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC080242.1.
            
            On or before Oct 20, 2005 this sequence version replaced
            NM_153723.1, NM_175758.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC080242.1, AJ132846.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2570
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2570
                     /gene="Slc1a5"
                     /gene_synonym="Asct2; ATB(0); H4-ASCT2; Slc1a7"
                     /note="solute carrier family 1 member 5"
                     /db_xref="GeneID:292657"
                     /db_xref="RGD:708512"
     exon            1..957
                     /gene="Slc1a5"
                     /gene_synonym="Asct2; ATB(0); H4-ASCT2; Slc1a7"
                     /inference="alignment:Splign:2.1.0"
     CDS             392..2011
                     /gene="Slc1a5"
                     /gene_synonym="Asct2; ATB(0); H4-ASCT2; Slc1a7"
                     /note="H4-system ASC-like transporter; solute carrier
                     family 1, member 7; CAZ-associated structural protein;
                     sodium-dependent neutral amino acid transporter ASCT2;
                     solute carrier family 1 (neutral amino acid transporter),
                     member 5; insulin-activated amino acid transporter;
                     sodium-dependent neutral amino acid transporter type 2;
                     ASC-like Na(+)-dependent neutral amino acid transporter
                     ASCT2"
                     /codon_start=1
                     /product="neutral amino acid transporter B(0)"
                     /protein_id="NP_786934.1"
                     /db_xref="GeneID:292657"
                     /db_xref="RGD:708512"
                     /translation="MAVDPPKADPKGVVAVDPTANCGSGLKSREDQGAKAGGCCSSRD
                     QVCRCLRANLLVLLTVAAAVAGVVLGLGVSAAGGAEALGHARFTAFAFPGELLLRLLE
                     MIILPLVVCSLIGGAASLDPSALGRLGAWALLFFLVTTLLSSALGVALALALKPGAAF
                     AAINSSVVDSSVHRAPTKEVLDSFLELLRNMFPSNLVSASAAFRIPCGACPQRSNATM
                     DQPHCEMKMNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNDATMVLVSWIMWYAP
                     IGILFLVAGKIVEMKDIRQLFIGLGKYIVCCLLGHAIHGLLVLPLIYFLFTRKNPYRF
                     LWGIVTPLATAFGTSSSSATLPLMMKCVEEKNGVAKHISRFILPIGATVNMDGAALFQ
                     CVAAVFIAQLNGMSLDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAISLPVKD
                     ISLILAVDWLVDRSCTVLNVEGDAFGAGLLQSYVDRTKMPSSEPELIQVKNDVSLKPL
                     PLATEEGNPLLKQCREPSGDSSATCEKESVM"
     exon            958..1006
                     /gene="Slc1a5"
                     /gene_synonym="Asct2; ATB(0); H4-ASCT2; Slc1a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1051
                     /gene="Slc1a5"
                     /gene_synonym="Asct2; ATB(0); H4-ASCT2; Slc1a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1209
                     /gene="Slc1a5"
                     /gene_synonym="Asct2; ATB(0); H4-ASCT2; Slc1a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1443
                     /gene="Slc1a5"
                     /gene_synonym="Asct2; ATB(0); H4-ASCT2; Slc1a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1638
                     /gene="Slc1a5"
                     /gene_synonym="Asct2; ATB(0); H4-ASCT2; Slc1a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1773
                     /gene="Slc1a5"
                     /gene_synonym="Asct2; ATB(0); H4-ASCT2; Slc1a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..2541
                     /gene="Slc1a5"
                     /gene_synonym="Asct2; ATB(0); H4-ASCT2; Slc1a7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caagaatccg agtcaggcag cctagacctg ggatcacgga tcttgggttc ccggagccag
       61 acatcccgga tctacaccac ctgagcgtcc ttaatccttc agggaatcaa agaccgctac
      121 gtcctgatct gaagaactgt tcgccacccc aacaaaaaga aaagaaaagc tacaaaggct
      181 ctctcaactc ccagttttcg gaaattcgac atcaccgggg aaaaaaggga tctccgcgcc
      241 cagctcagga agcttaggac cctccagtct cagaaatcca gtggacgcac aacttcaggg
      301 accgttgcaa agtttcagcc tcctctctcc gtcctaagga cctcacatcc agtctctagg
      361 cgcacaagga acccctccgt tgcggctcaa catggcagtg gatcctccta aggctgaccc
      421 caaaggggtg gtggcggtgg atcccaccgc gaactgtggc tcggggctga agtccagaga
      481 ggaccaggga gcgaaagcag gtggatgctg cagttcccgg gaccaagtgt gccgctgcct
      541 tcgcgccaac ctgctggttc tgctcaccgt ggcggcggcg gtggctggcg tggtgctagg
      601 tctgggggtc tcggcggcgg gcggtgctga ggcgctgggc cacgcgcgct ttaccgcttt
      661 cgccttcccg ggagagctgc tgttgcgtct gctggagatg atcatcctgc cgctggtggt
      721 gtgcagcctg atcggaggtg cagccagtct ggaccctagc gcgctcggcc gtttgggcgc
      781 ctgggccctg ctctttttcc tggtcaccac actgctctct tcggctctcg gcgtggcctt
      841 ggccctggcg ctgaagccgg gcgccgcgtt tgctgccatc aactcctctg ttgtagactc
      901 cagtgtccac agagcaccca ccaaagaggt gctggattcc tttctggaac tcctgaggaa
      961 tatgttcccc tccaatctgg tgtctgcttc tgctgccttc cgcattccat gtggtgcctg
     1021 tccacagagg agcaatgcaa ccatggacca gcctcactgt gagatgaaga tgaacattct
     1081 gggcttggtc gtgttcgcta tagtctttgg cgtggctctg aggaagctgg ggcccgaggg
     1141 tgagctgctc atccgattct tcaactcctt caatgatgcc accatggtcc tggtctcctg
     1201 gattatgtgg tacgccccca ttggcatctt gttcctggtg gccggcaaga ttgtggagat
     1261 gaaagacatc cgccagctct tcatcggcct cggcaaatac atcgtgtgct gcctgctggg
     1321 ccacgccatc cacgggctcc tggttctgcc tctcatctac ttcctcttta cccgcaaaaa
     1381 cccttatcga ttcctgtggg gcatcgtgac acccctggct acagctttcg ggacctcttc
     1441 tagctctgcc acattgcccc tgatgatgaa gtgtgtagag gagaagaatg gtgtggccaa
     1501 acacatcagc cggttcatcc tgcccatcgg cgccaccgtc aatatggacg gggcagcgtt
     1561 gttccagtgc gtggcggcag tgttcattgc acaactaaat gggatgtccc tggacttcgt
     1621 gaagatcatc accatcctgg tcacagctac tgcatccagt gtcggggccg caggtatccc
     1681 tgcagggggc gtcctcactc ttgccatcat tctagaagca atcagcctcc ctgtcaagga
     1741 catctccttg atcttggccg tggactggct agtggacagg tcctgtacgg tcctcaacgt
     1801 ggagggtgat gcttttgggg ccggattgct ccagagttac gtggatcgca ccaagatgcc
     1861 gagctcagag cctgaactga tccaggtgaa gaacgacgtg tctctgaaac cattgcccct
     1921 cgccacagag gaggggaacc cccttctgaa acagtgccgg gaaccctccg gggactccag
     1981 tgccacatgc gaaaaggaat ctgtcatgtg aatgtttgga gggcttctat gccctggtga
     2041 cctcactttg gaaattgggc tcttgagagc tggagaaatg gactgggtgt gggcctgagg
     2101 ggaggctgtt tacagactcc ggcaacctgg gggtcctcat ctcctttctg gagaggttat
     2161 tcagagcctt cttgctgggg cgcatgtggt tatatatgaa tgtgtcccta aatcttcccc
     2221 catcctgtcc cctattcaag gagatggcat ttctctgtct cccagagcca tcctgcatac
     2281 ctgtctcagg gaatgggttg ctctgtagag gtctccaccc tttgaaggca aaatattgtg
     2341 atgaaatatt ttcttattat ccctagctgt ggtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     2401 tgtgtgtgtg cgcgcgcact tgctataacc ttccctgtag ctcctccatg acaacaaaca
     2461 ttcccatgag tcctgagaga aagccaaaaa taaatgtcac tccaaatcac attttttagc
     2521 aataaaatgg tgtcaaatgt aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
