LOCUS       NM_198763               1996 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus solute carrier family 1 member 4 (Slc1a4), mRNA.
ACCESSION   NM_198763 XM_223649
VERSION     NM_198763.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1996)
  AUTHORS   Foster AC, Farnsworth J, Lind GE, Li YX, Yang JY, Dang V, Penjwini
            M, Viswanath V, Staubli U and Kavanaugh MP.
  TITLE     D-Serine Is a Substrate for Neutral Amino Acid Transporters
            ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes
            in Rat Hippocampal Astrocyte Cultures
  JOURNAL   PLoS One 11 (6), e0156551 (2016)
   PUBMED   27272177
  REMARK    GeneRIF: the selectivity profile of D-serine uptake in cultured rat
            hippocampal astrocytes is consistent with uptake mediated by both
            ASCT1 and ASCT2. Together these data suggest that SLC1A4 (ASCT1)
            may represent an important route of Na-dependent D-serine flux in
            the brain that has the ability to regulate extracellular D-serine
            and thereby NMDA receptor activity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1996)
  AUTHORS   Damseh N, Simonin A, Jalas C, Picoraro JA, Shaag A, Cho MT, Yaacov
            B, Neidich J, Al-Ashhab M, Juusola J, Bale S, Telegrafi A, Retterer
            K, Pappas JG, Moran E, Cappell J, Anyane Yeboa K, Abu-Libdeh B,
            Hediger MA, Chung WK, Elpeleg O and Edvardson S.
  TITLE     Mutations in SLC1A4, encoding the brain serine transporter, are
            associated with developmental delay, microcephaly and
            hypomyelination
  JOURNAL   J Med Genet 52 (8), 541-547 (2015)
   PUBMED   26041762
REFERENCE   3  (bases 1 to 1996)
  AUTHORS   Arthur S and Sundaram U.
  TITLE     Protein kinase C-mediated phosphorylation of RKIP regulates
            inhibition of Na-alanine cotransport by leukotriene D(4) in
            intestinal epithelial cells
  JOURNAL   Am J Physiol Cell Physiol 307 (11), C1010-C1016 (2014)
   PUBMED   25231108
  REMARK    GeneRIF: LTD4 inhibits ASCT1 through PKC-mediated phosphorylation
            of RKIP, leading to the subsequent activation of PKA pathway,
            possibly through beta2-andrenergic receptor activation.
REFERENCE   4  (bases 1 to 1996)
  AUTHORS   Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M and
            Stoorvogel W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   5  (bases 1 to 1996)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 1996)
  AUTHORS   Weiss MD, Derazi S, Kilberg MS and Anderson KJ.
  TITLE     Ontogeny and localization of the neutral amino acid transporter
            ASCT1 in rat brain
  JOURNAL   Brain Res Dev Brain Res 130 (2), 183-190 (2001)
   PUBMED   11675121
REFERENCE   7  (bases 1 to 1996)
  AUTHORS   Marin M, Tailor CS, Nouri A and Kabat D.
  TITLE     Sodium-dependent neutral amino acid transporter type 1 is an
            auxiliary receptor for baboon endogenous retrovirus
  JOURNAL   J Virol 74 (17), 8085-8093 (2000)
   PUBMED   10933718
REFERENCE   8  (bases 1 to 1996)
  AUTHORS   Zerangue N and Kavanaugh MP.
  TITLE     ASCT-1 is a neutral amino acid exchanger with chloride channel
            activity
  JOURNAL   J Biol Chem 271 (45), 27991-27994 (1996)
   PUBMED   8910405
REFERENCE   9  (bases 1 to 1996)
  AUTHORS   Shafqat S, Tamarappoo BK, Kilberg MS, Puranam RS, McNamara JO,
            Guadano-Ferraz A and Fremeau RT Jr.
  TITLE     Cloning and expression of a novel Na(+)-dependent neutral amino
            acid transporter structurally related to mammalian Na+/glutamate
            cotransporters
  JOURNAL   J Biol Chem 268 (21), 15351-15355 (1993)
   PUBMED   8340364
REFERENCE   10 (bases 1 to 1996)
  AUTHORS   Arriza JL, Kavanaugh MP, Fairman WA, Wu YN, Murdoch GH, North RA
            and Amara SG.
  TITLE     Cloning and expression of a human neutral amino acid transporter
            with structural similarity to the glutamate transporter gene family
  JOURNAL   J Biol Chem 268 (21), 15329-15332 (1993)
   PUBMED   8101838
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB103401.1.
            
            [WARNING] On Mar 25, 2024 this sequence was replaced by
            NM_198763.2.
            
            On Dec 17, 2003 this sequence version replaced XM_223649.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB103401.1, FQ210448.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1996
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q22"
     gene            1..1996
                     /gene="Slc1a4"
                     /gene_synonym="ASCT1"
                     /note="solute carrier family 1 member 4"
                     /db_xref="GeneID:305540"
                     /db_xref="RGD:735146"
     exon            1..531
                     /gene="Slc1a4"
                     /gene_synonym="ASCT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1603
                     /gene="Slc1a4"
                     /gene_synonym="ASCT1"
                     /note="neutral amino acid transporter ASCT1; solute
                     carrier family 1 (glutamate/neutral amino acid
                     transporter), member 4"
                     /codon_start=1
                     /product="neutral amino acid transporter A"
                     /protein_id="NP_942058.1"
                     /db_xref="GeneID:305540"
                     /db_xref="RGD:735146"
                     /translation="MEETNGYLDGAQAQPAARPRTPETGTSKAQRCASFFRRNALVLL
                     TVSGVLAGAGMGAALRGLQLTRTQITYLAFPGEMLLRMLRMIILPLVVCSLVSGAASL
                     DASSLGRLGGIAVAYFGLTTLSASALAVALAFIIKPGVGAQTLHSSSLGLENSEPPPV
                     SKETVDSFLDLLRNLFPSNLVVAAFSTSATSYTVVVHNSSLGNVTKEKIPVVTDVKGM
                     NILGLVLFALMLGVALKKLGPEGDELIRFFNSFNEATMVLVSWIMWYVPIGIMFLIGS
                     KIVEMQDLIVLVTSLGKYIFASILGHVIHGGIVLPLVYFAFTRKNPFTFLLGLLTPFA
                     TAFATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQ
                     LNNVDLNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTNDLSLILAVDW
                     IVDRTTTVVNVEGDALGAGILNHLNQRTVKKGEQELQEVKVEAIPNSKSEEETSPLVT
                     HQNRAGPVAVAPELESKESVL"
     exon            532..574
                     /gene="Slc1a4"
                     /gene_synonym="ASCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            575..637
                     /gene="Slc1a4"
                     /gene_synonym="ASCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            638..804
                     /gene="Slc1a4"
                     /gene_synonym="ASCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            805..1038
                     /gene="Slc1a4"
                     /gene_synonym="ASCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1233
                     /gene="Slc1a4"
                     /gene_synonym="ASCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1368
                     /gene="Slc1a4"
                     /gene_synonym="ASCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1996
                     /gene="Slc1a4"
                     /gene_synonym="ASCT1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgggcagc gacatggagg agaccaacgg atacctcgac ggcgcccagg ctcagcctgc
       61 ggcccgtccc cgaacgcccg agacggggac gagcaaagcg cagcgctgtg ctagcttttt
      121 tcggcgcaac gcgctggtgc tgctcaccgt gtcgggggtg ttggcgggcg ccggcatggg
      181 cgcggcgctt cgcgggctgc agctcacccg cacgcaaatc acttacctgg ccttcccggg
      241 cgagatgctg ctccgtatgc tgcgcatgat catcctaccg ctggtggttt gcagtctggt
      301 gtcgggcgcc gcctccctgg acgccagctc cctcgggcgt ctgggtggca tcgctgttgc
      361 ttacttcggc ctcaccacgc tgagtgcctc tgcgctcgct gttgctctgg cgttcatcat
      421 caagccagga gtgggcgcgc agacccttca ttccagcagc ctggggctgg agaactcaga
      481 acctcctcca gtctccaaag agacagtgga ctctttcctg gatttactca gaaacctgtt
      541 cccttccaat cttgtggttg ccgcattctc tacgtctgca accagttaca cagtggtcgt
      601 ccataactcc agcttgggga acgtgaccaa agagaagatc cccgtcgtca ctgatgtgaa
      661 agggatgaac atcttaggac tggtcctttt tgccctgatg ttaggagtgg ctctaaagaa
      721 gctaggcccc gagggagacg agctcatccg attcttcaat tccttcaatg aggcaacaat
      781 ggtgttggtg tcgtggatca tgtggtacgt acctatcggc atcatgttcc tgatcggaag
      841 caagattgtg gaaatgcagg acctcatcgt gctcgtgact agcctcggga aatacatctt
      901 cgcctctata ctgggccatg ttatccatgg aggaattgtt ctgcctcttg tctattttgc
      961 ttttacgagg aaaaacccgt tcacgttcct cctgggcctc ctcaccccgt ttgcgacggc
     1021 ttttgcgacc tgttccagct cagcaaccct tccgtctatg atgaagtgca tcgaggaaaa
     1081 caatggcgtg gacaagagga tcagcaggtt catccttccc atcggggcca cagtcaacat
     1141 ggatggggcc gccatcttcc agtgtgtggc tgcagtgttc atcgcccagc tcaacaacgt
     1201 ggacctgaac gcgggacaga ttttcaccat tctggtgacc gccaccgcat ccagtgttgg
     1261 agcagcgggt gtgccggctg gaggggtcct caccattgcc atcatcctag aggccattgg
     1321 actgcccacg aacgacctct ctctgatcct ggctgtggac tggattgtgg acaggaccac
     1381 cactgtggtg aacgtggaag gggatgccct gggagctggg atcctcaacc acctgaatca
     1441 gaggacagtg aagaagggtg agcaggagct gcaagaagtg aaggtggaag ccattcccaa
     1501 ttccaagtct gaggaggaga cgtcgcccct ggtgacacac cagaaccggg caggccctgt
     1561 agccgttgct cctgaactcg aatccaagga gtcagtgctg tgattgggct gggtcttggg
     1621 ccatcctgct agtaccagcg acctaccctg gtagcctgcc ccactgacgt gggcatggcc
     1681 ctcacagact tttcgtctcc caaggaatgc gttggcccaa tcactaatct gagagtgacc
     1741 tctcagcaca gtcatggagc tcccaagcca ggactgctta ccgaggacta gaacactctg
     1801 acctttgtct tgatccatgt ctcaatggag ctgtggattc accttgactc tgtttgtgaa
     1861 cccccttgag ctgccagacc tcagggatcc caggttcatg gaggcctggg ataaaggtcc
     1921 gggttggggt gggggtgcgg atggattctt cagtgtctcc cgggagctct gcatctggtg
     1981 ctttctgggc gagcca
//
