LOCUS       NM_017215              10891 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus solute carrier family 1 member 2 (Slc1a2),
            transcript variant 1, mRNA.
ACCESSION   NM_017215
VERSION     NM_017215.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10891)
  AUTHORS   Liang,T., Hu,X., Zeng,L., Zhou,Z., Zhang,J., Xu,Z., Zeng,J. and
            Xu,P.
  TITLE     HSP90beta regulates EAAT2 expression and participates in
            ischemia-reperfusion injury in rats
  JOURNAL   Mol Med Rep 29 (1) (2024)
   PUBMED   37975223
  REMARK    GeneRIF: HSP90beta regulates EAAT2 expression and participates in
            ischemia-reperfusion injury in rats.
REFERENCE   2  (bases 1 to 10891)
  AUTHORS   Arasteh,A., Karimpour,M., Fallah,F., Kiani,S. and Kakavan,M.
  TITLE     Activity of Citrus aurantium and Lavandula angustifolia in
            Alzheimer's Disease Symptoms in Male Wistar Rats
  JOURNAL   Avicenna J Med Biotechnol 15 (4), 223-231 (2023)
   PUBMED   38078339
REFERENCE   3  (bases 1 to 10891)
  AUTHORS   Zhuang,Z., Liu,M., Dai,Z., Luo,J., Zhang,B., Yu,H., Xue,J. and
            Xu,H.
  TITLE     Bone marrow stromal cells-derived exosomes reduce neurological
            damage in traumatic brain injury through the miR-124-3p/p38
            MAPK/GLT-1 axis
  JOURNAL   Exp Neurol 365, 114408 (2023)
   PUBMED   37061176
  REMARK    GeneRIF: Bone marrow stromal cells-derived exosomes reduce
            neurological damage in traumatic brain injury through the
            miR-124-3p/p38 MAPK/GLT-1 axis.
REFERENCE   4  (bases 1 to 10891)
  AUTHORS   Cheng,S., Xu,J., Wang,W., Wang,R., Li,H., Jiang,Z., Liu,D. and
            Pan,F.
  TITLE     Inhibition of mGluR5 alters BDNF/TrkB and GLT-1 expression in the
            prefrontal cortex and hippocampus and ameliorates PTSD-like
            behavior in rats
  JOURNAL   Psychopharmacology (Berl) 240 (4), 837-851 (2023)
   PUBMED   36725696
  REMARK    GeneRIF: Inhibition of mGluR5 alters BDNF/TrkB and GLT-1 expression
            in the prefrontal cortex and hippocampus and ameliorates PTSD-like
            behavior in rats.
            Erratum:[Psychopharmacology (Berl). 2023 Jun;240(6):1391. doi:
            10.1007/s00213-023-06368-w. PMID: 37145309]
REFERENCE   5  (bases 1 to 10891)
  AUTHORS   Li,S., Zhang,L., Lin,J., Su,A., Liu,X., Zhang,J., Xian,X., Hu,Y.,
            Li,W., Sun,S. and Zhang,M.
  TITLE     LncRNA BIRF Promotes Brain Ischemic Tolerance Induced By Cerebral
            Ischemic Preconditioning Through Upregulating GLT-1 via Sponging
            miR-330-5p
  JOURNAL   Mol Neurobiol 59 (7), 3996-4014 (2022)
   PUBMED   35451738
  REMARK    GeneRIF: LncRNA BIRF Promotes Brain Ischemic Tolerance Induced By
            Cerebral Ischemic Preconditioning Through Upregulating GLT-1 via
            Sponging miR-330-5p.
REFERENCE   6  (bases 1 to 10891)
  AUTHORS   Kirschner,M.A., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and
            Amara,S.G.
  TITLE     Mouse excitatory amino acid transporter EAAT2: isolation,
            characterization, and proximity to neuroexcitability loci on mouse
            chromosome 2
  JOURNAL   Genomics 24 (2), 218-224 (1994)
   PUBMED   7698742
REFERENCE   7  (bases 1 to 10891)
  AUTHORS   Arriza,J.L., Fairman,W.A., Wadiche,J.I., Murdoch,G.H.,
            Kavanaugh,M.P. and Amara,S.G.
  TITLE     Functional comparisons of three glutamate transporter subtypes
            cloned from human motor cortex
  JOURNAL   J Neurosci 14 (9), 5559-5569 (1994)
   PUBMED   7521911
REFERENCE   8  (bases 1 to 10891)
  AUTHORS   Zhang,Y., Pines,G. and Kanner,B.I.
  TITLE     Histidine 326 is critical for the function of GLT-1, a (Na+ +
            K+)-coupled glutamate transporter from rat brain
  JOURNAL   J Biol Chem 269 (30), 19573-19577 (1994)
   PUBMED   7913472
REFERENCE   9  (bases 1 to 10891)
  AUTHORS   Kanner,B.I.
  TITLE     Glutamate transporters from brain. A novel neurotransmitter
            transporter family
  JOURNAL   FEBS Lett 325 (1-2), 95-99 (1993)
   PUBMED   8099882
  REMARK    Review article
REFERENCE   10 (bases 1 to 10891)
  AUTHORS   Pines,G., Danbolt,N.C., Bjoras,M., Zhang,Y., Bendahan,A., Eide,L.,
            Koepsell,H., Storm-Mathisen,J., Seeberg,E. and Kanner,B.I.
  TITLE     Cloning and expression of a rat brain L-glutamate transporter
  JOURNAL   Nature 360 (6403), 464-467 (1992)
   PUBMED   1448170
  REMARK    Erratum:[Nature 1992 Dec 24-31;360(6406):768]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Feb 26, 2021 this sequence version replaced NM_017215.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.143339.1,
                                           SRR26360176.990803.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               JAXUCZ010000003.1  109460109-109460236
            129-268             JAXUCZ010000003.1  109536475-109536614
            269-421             JAXUCZ010000003.1  109538241-109538393
            422-672             JAXUCZ010000003.1  109540111-109540361
            673-838             JAXUCZ010000003.1  109544220-109544385
            839-965             JAXUCZ010000003.1  109548829-109548955
            966-1199            JAXUCZ010000003.1  109556509-109556742
            1200-1394           JAXUCZ010000003.1  109561593-109561787
            1395-1529           JAXUCZ010000003.1  109567455-109567589
            1530-1761           JAXUCZ010000003.1  109577264-109577495
            1762-10891          JAXUCZ010000003.1  109581316-109590445
FEATURES             Location/Qualifiers
     source          1..10891
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q32"
     gene            1..10891
                     /gene="Slc1a2"
                     /gene_synonym="Eaat2; Glt; Glt-1"
                     /note="solute carrier family 1 member 2"
                     /db_xref="GeneID:29482"
                     /db_xref="RGD:3697"
     exon            1..128
                     /gene="Slc1a2"
                     /gene_synonym="Eaat2; Glt; Glt-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1833
                     /gene="Slc1a2"
                     /gene_synonym="Eaat2; Glt; Glt-1"
                     /note="isoform a is encoded by transcript variant 1;
                     excitatory amino acid transporter 2; glutamate transporter
                     1; solute carrier family 1 (glial high affinity glutamate
                     transporter), member 2; sodium-dependent
                     glutamate/aspartate transporter 2; high affinity glucose
                     transporter; glial glutamate transporter GLT1/V3; glial
                     glutamate transporter GLT1/V4; glial glutamate transporter
                     GLT1/V2; glial glutamate transporter GLT1/V1"
                     /codon_start=1
                     /product="excitatory amino acid transporter 2 isoform a"
                     /protein_id="NP_058911.2"
                     /db_xref="GeneID:29482"
                     /db_xref="RGD:3697"
                     /translation="MASTEGANNMPKQVEVRMHDSHLSSEEPKHRNLGMRMCDKLGKN
                     LLLSLTVFGVILGAVCGGLLRLAAPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLI
                     TGLSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKND
                     EVSSLDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPSEEANTTKAVISLLNETM
                     NEAPEETKIVIKKGLEFKDGMNVLGLIGFFIAFGIAMGKMGEQAKLMVEFFNILNEIV
                     MKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMITVIVGLIIHGGIFLPLI
                     YFVVTRKNPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEDNLGIDKRVTRFVLPVG
                     ATINMDGTALYEAVAAIFIAQMNGVILDGGQIVTVSLTATLASIGAASIPSAGLVTML
                     LILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIVYHLSKSELDTIDSQHR
                     MHEDIEMTKTQSIYDDTKNHRESNSNQCVYAAHNSVVIDECKVTLAANGKSADCSVEE
                     EPWKREK"
     exon            129..268
                     /gene="Slc1a2"
                     /gene_synonym="Eaat2; Glt; Glt-1"
                     /inference="alignment:Splign:2.1.0"
     exon            269..421
                     /gene="Slc1a2"
                     /gene_synonym="Eaat2; Glt; Glt-1"
                     /inference="alignment:Splign:2.1.0"
     exon            422..672
                     /gene="Slc1a2"
                     /gene_synonym="Eaat2; Glt; Glt-1"
                     /inference="alignment:Splign:2.1.0"
     exon            673..838
                     /gene="Slc1a2"
                     /gene_synonym="Eaat2; Glt; Glt-1"
                     /inference="alignment:Splign:2.1.0"
     exon            839..965
                     /gene="Slc1a2"
                     /gene_synonym="Eaat2; Glt; Glt-1"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1199
                     /gene="Slc1a2"
                     /gene_synonym="Eaat2; Glt; Glt-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1394
                     /gene="Slc1a2"
                     /gene_synonym="Eaat2; Glt; Glt-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1529
                     /gene="Slc1a2"
                     /gene_synonym="Eaat2; Glt; Glt-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1761
                     /gene="Slc1a2"
                     /gene_synonym="Eaat2; Glt; Glt-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..10891
                     /gene="Slc1a2"
                     /gene_synonym="Eaat2; Glt; Glt-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggagaga ggctgcccgt taaataccgc tccccgccgc actccgggct cacccagctc
       61 gtcgccactg tctccagacc gtgcccggga ggagggggcg ttccccacgc catggcatca
      121 accgagggtg ccaacaatat gcccaagcag gtggaagtgc gcatgcacga cagccacctc
      181 agctccgagg agccaaagca ccgaaacctg ggcatgcgca tgtgcgacaa gctggggaag
      241 aacctcctgc tctcactgac tgtgtttggt gtcatcctgg gagcagtatg tggcgggctg
      301 cttcgcttgg cggctcccat ccaccctgat gtggtcatgt tgatagcctt cccgggggac
      361 atcctcatga ggatgctgaa gatgctcatc ctccctctca tcatttccag tctcatcaca
      421 gggctgtcag ggctggatgc taaagccagc ggccgcctag gcacgagagc catggtatat
      481 tacatgtcca cgaccatcat tgccgctgtg ctgggggtca tcctggtgtt ggccatccac
      541 cctgggaatc ccaaactcaa gaagcagctg gggcctggga agaagaacga cgaggtgtcc
      601 agcctggatg ccttcctgga tctcattaga aatctcttcc cggagaacct ggtacaagcc
      661 tgtttccaac agattcagac tgtgacaaag aaagttctgg tggcacctcc atccgaggag
      721 gccaatacaa ccaaggcagt catctccctg ttgaatgaga ccatgaatga ggcccctgaa
      781 gaaactaaga tcgttatcaa gaagggcctg gagttcaagg acgggatgaa tgtcttaggt
      841 ctgattggat tctttattgc tttcggcatt gccatgggga agatgggtga gcaggccaag
      901 ctgatggtgg agttcttcaa cattctgaac gagattgtca tgaagttagt gatcatgatc
      961 atgtggtatt ccccgctggg tatcgcctgc ttgatctgtg ggaagatcat cgccatcaag
     1021 gacttagaag tggttgctag gcagctgggg atgtacatga tcacagtgat cgtgggcctc
     1081 atcattcatg ggggcatctt tctccccttg atttactttg tagtgaccag aaaaaaccca
     1141 ttctcctttt ttgctggcat tttccaagcc tggatcactg ccctgggaac cgcttccagt
     1201 gctggaactt tgcctgtcac cttccgttgc ttggaagata atctagggat tgacaagcgt
     1261 gtgaccagat tcgtcctccc agtcggagca accattaaca tggatggtac agccctttac
     1321 gaagccgtgg cagccatctt catagcccag atgaatgggg tcatcctgga tggaggtcag
     1381 atagtgactg taagccttac agcaactctg gcgagcattg gtgcagccag tattcccagc
     1441 gccgggttgg tcaccatgct cctcattctc acagctgtgg gcctgccgac agaggacatc
     1501 agtctgctgg tggcagtgga ctggctgctg gatagaatga gaacttcggt caatgtagtg
     1561 ggcgattctt ttggggctgg gattgtctat cacctttcca agtccgagct ggacaccatt
     1621 gactcccaac accgaatgca cgaagacatc gaaatgacca agacgcagtc catttatgac
     1681 gacacgaaga accacaggga aagcaactct aatcaatgtg tctatgccgc acacaactct
     1741 gtcgtaatag atgagtgcaa ggtaactctg gcggccaatg gaaagtcagc tgactgcagt
     1801 gttgaggaag aaccttggaa acgtgaaaaa taatgacccg attctcagcc aattcttgaa
     1861 taaactcccc agcgtatctt atggtaaaag atgctctaaa caggcttcct ttacaaaagg
     1921 aaaaatgcat atatttctat gtttacttaa tctgttagct gaggcgtaga ggagctgtgt
     1981 acacccatga tgataggcac cgtgccgtgt ctttgccaaa taatgcttca taaccatcta
     2041 attttcttac ttgtgttatt gtctgaatgg atgctgctgg agaaaccact ttgaatggaa
     2101 gacatgttct tgccagcttc ctgttgtctc agtgcaaaac tgtggatgct gtttttccaa
     2161 ggggatggga tgaaagcagt gcggtgccct ccggggactt gagacaccaa gcacacaagg
     2221 tgtccttaaa gtgtggctca ccttgttctg cacaaaagat tctgctggaa gcttttagaa
     2281 gtacctcccc tccagcctgt agagtcggca cctacattga ttgaaagcat ctgtcttggg
     2341 gaactctgag aacttacctt tttgtgcact gtctaagtaa aatgtttcag agtttcagtg
     2401 ggcacccata ttctgaaatg caggtgatca cagaggccac agctctgcct tcctgtggag
     2461 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtatgtgtg ttatcactgt
     2521 ataccttgag gaacatgaag gagcacagtc aacctgaatt ttagccagaa ttaaatattc
     2581 caatccactt gtttgaccta cactcgtaga gcatagtgaa ggcaagtgtg atgatccgag
     2641 ctgtactttt cgttccacct atagattctc acttgagttc ctcaccggaa gatatttttc
     2701 aacatccgaa tcatgtctaa cacttcttgt ctgcttacat ggctgagcat tttagcttcc
     2761 tcacagtaag aaacacacgt gggctatgac tcttttccta tcatcttggt agatagctat
     2821 tatgtagaaa gtgttttgtt atatcaaagc acgtgaaaac tctcaccaaa cacaaaagca
     2881 cccttcctct ttggtgagaa agcaaacaga aagcaaacat ctatataaaa tcctatgaag
     2941 gttcctatga cagagtccag gcagctccaa accatcaaat ggagaccaag aatggctcta
     3001 caaaactttc cagatagaat cctttccaga gactgtgaaa gtctgaagga ataaataata
     3061 taattggcag agcctgatgg tttgcctgtg gtaggcagcc aacgaatcct taatgatggg
     3121 ttatgcaagc taaaattgtg aatgtctcta ttattatctt ctggtgaaga atgcacagta
     3181 ttttcctaag atcctgggtt taacggttag ctgggaactc gaaccactga gaagcaaaac
     3241 aaattcaact tgaaggagtg atggaacctg agctatcagt caggacatgc gcatcctctg
     3301 agtcaggcag agctgaggag acattcataa gcagtaatag ggcccagtgt ctccgaggaa
     3361 gggtgctgag tcagcacctc tcctgttagt ctctctgtgt gacctctctc cttcaaatca
     3421 gaaagcttgg aaacatacaa aagacaagag attcctgttg ctttatctca taaatcccaa
     3481 ctatttttaa acaaggatca ctattgagca gtattaaatg aattattttg ttctgtttca
     3541 ggctttgact tttgaaacaa ggtcatgctg tgtagcccag aatagcttca aactctcaga
     3601 cctactgttc agcctcagtt ttaagatcgc aggtgggcac ccctcattgc ctggcagaac
     3661 actgtttatt ttcactttct tctgggggac agtgaacagg gtagcagtga ccagcaatga
     3721 atccctgata gaagataaga ctggctgagg ggattccatt tagatgtaga aaatattcta
     3781 gatagtctgt aagtggtacc caagggcttt cctatgctaa gtagatatat ctaggcaagg
     3841 catccagaag catgccgggt tttgctatgt gggggagggt aaggccattc catccaatgg
     3901 gtctccccat acaagaagat acaaggccac ctgggtactt gagcattgac tttctctcaa
     3961 aagcactcgc agggtgactg tgtctgtcat ctctgattct gtttgaaaat ctttctagtt
     4021 ggccttatct tcagctctcc cctaggagtc ctgttagcct atgtgacaga acgttcagga
     4081 gaacaaaggc acactacttc acaagtcagg ttttgctgac tacatacatt gtctgaagag
     4141 aatatgctaa ggaaatcaca tttatctgaa aatttaataa atttttttaa aactaaataa
     4201 tttatcaaat tggagaccac cctaaaaatc taggatgtgg tggaatttag gtagtactgt
     4261 gtcttgcttt tgtaaggctg cattaaccct tcccatgcca tgcccactga ggattccttt
     4321 gcctagaaaa ggagcgggaa gccgaaaaga tgatcaagaa tgtgttctag tagccatagt
     4381 ctatatagat tgcctgtcac tgtgcgtgtc tgtattaata gagttatcgt agatctgaat
     4441 gcccataatg attaatcttt tatgtgtagt gctttctctc tctctctctc tctctctata
     4501 tatatatata tatatatata tatatatata tatatatata tatatatatc tgcgcgcgcg
     4561 cgcacacaca cacacacaca cacacacaca cacacacaca cacagggtgt atgtcacata
     4621 cactaactcc aggtaccagg gagacttgta tattggggct ttggcagtac tatttcctta
     4681 atggattcag ttaatatttt caaggaatca aaatcatttc agaagaaacc aagtgagtag
     4741 acattcatgc ttccctttct catcctttcc ctacgagaag caagacaaat catcatttaa
     4801 atgttgagta aatttcaaca aagtcaattc actgtaggct tctgagggtg gcaggacacc
     4861 aaagagtcca ggtagccata ggatctaagc acacaaaacc tcagtaaagg cctgtaggtg
     4921 attttaggac catgagatca ttaccagatt tggttttcta cttcctgttc ggtgtagcaa
     4981 aagcctgtgt ggccccattg cctaaggaag attttattct ccataaaaga caaatattca
     5041 cttctcctca ctagtcacta gttagtttag acattcacag agtaaagaaa gggtgccaaa
     5101 atgcccccgg atgaaaatga gaaaagcaga gaactgggta ggaggaagtc agtccctgct
     5161 cggggatgct gggatctcaa tagtttgctg ataaggagct cagttaattt ccaactatgg
     5221 ctgcaaaatc atggcacatg gaagtgccaa aggtccttgg aagtagttag aggcccttga
     5281 gagagagctg agatgcctct gaagaaaacc caaccttgtc ttgctgttgc aagtaatcct
     5341 ccctttgttc tccaaagtag aatcttacta taattttcac ttttgtcaga atctaggctc
     5401 ttgcctacac attattttcc tcatgcaaca gagcaataaa ccaaataggt gttcacatgc
     5461 ttctggctcc agataaacaa ggctgagcag ctctggcctc ttttgatgac taaaatggca
     5521 gcggttacac cccagagggc aacctaccct gtttgctgct ctctactagg accaatctgt
     5581 ctgccctgaa ttgttgttgt tgctgctgct gctgctgcta ctgttgttgt tttccttatt
     5641 ctgcagctga actctttatc agccaagaag aaggaccaaa tgggattttc cagtattgga
     5701 atacttgcag ggctccaggg cccaagggcc agaagaagat aaggttagag tctgaagcaa
     5761 gggtttttta aactaagttg tcactgaaga ttcatggtct cggtatctgt agtagcctct
     5821 ggctaaaccc aaaagaagga ttactgggtg ccaacccagc caggtggcaa ctgtgacagc
     5881 tagttttcca tgggtggagt gagataggat ctcatcaaga acaccaacca gcttaggatt
     5941 ttccctaaaa ctcttcccag tttactgccc tctcctcccc ttcccttcct gctgtttcat
     6001 tgctcaatag actgcttagt aaatggccaa atagttatga gggggttggc ttggaagcag
     6061 ataacaggag atcttaactg aataatagtc ttatagctta acaccataat caggcaacaa
     6121 cacagagatg cttaaaaaca acgtggcttg ggagaggaaa catttgatta agacactccc
     6181 cacttgtagc cactgtgtgc ccaggtttct tatgcttctg tctgagatga gaagggattg
     6241 gaccaaatgc cctgctttac ttttgtccat ctgactgctc tcaaacattg cttatttata
     6301 ttttaagtta gaaagacaca aaataatgaa taatcagttt agatgtttcc tcatccattt
     6361 tggaaaaact ccaactcaag cttccactca ttccatactt tacaacaagc ttgaagagtg
     6421 gccacagtaa cccaccattt gcggcagttt cgagacatcc gtaaatatcc tttggttaaa
     6481 atccctattc cctaaacgca ttgtcctcac ggaagcagtg attctgctcg gggacatgtt
     6541 cagcatcacc gtgagggacc aggtacctcg tgtctgcatt ttgagttctt gcatcatacc
     6601 tgctgtagca acagagccca ctccaaatac tcagcccaca taattttccc caaacagtcc
     6661 taattgccaa ccctgtgtgg gaaattgagg gcctctggca aacaagcttg aacactcctg
     6721 acatttggtg caagatttgc acaacaacag caactgtctc cacacatgca ggtagacaag
     6781 cacattcatt ctgagacaac cctcacacca tcagggatgt gcagatggag ctgactgatt
     6841 tcagtagaaa gttttcctct ttatcaagag gaaacatgca taagggacat catcataggg
     6901 agagatgctg tcacttacaa gattggagtt agttttcccg tttgcccctg cccttcccat
     6961 gttaacacag tgtctaagtc atcacagcgg tgagaggtgg ctgtacctta ctctctctgg
     7021 ttctgttaca aaaggccata gtttgcattt tggctgtctg accaaatctc agccagaatt
     7081 aaattgctgt atttagtttt cagcccttca aatgtggggg agcaacacag acagccaggt
     7141 cagaaagggt taatttttgt tgatggtgat gatggttggg tttttctctc ctttcaaggt
     7201 gacagaagat ctaaagggag agcagaaaga tgtttcttaa ctgatccact taaggtcact
     7261 gcagaaaagc aggagaagtc cagaaggtcc tggggcatta ggctcacact aacactctga
     7321 atcattcatt tctcatcatt ttttttcctc tgctgagtct tgttttatcc tgtgatccat
     7381 ttatccattt tggtattttt aagtctttct gattgtattt tgaggaactt ttaggctgag
     7441 aataaaatct actattggga cagacctgtg ctctgcagag gcatcaggtg acccagacaa
     7501 cgggtggcag aatatctggg ttcctctaga gacaccccca atccctgggt gagctttgga
     7561 acctaacaac tgattgttat ccttatcacc atcctctggg acatggggat gatgcagtca
     7621 gacagagact tgctacttct tggctctgtt tctccccatg gcaaccattt agcctgcctg
     7681 gaagtggcct gctgccttag gtaggggaca gagacactca tagaccaagg aagtggtcaa
     7741 accgatcact aatttttctc catgctacat caaattccct aacacacaca actagaaact
     7801 cagctcctgg gtgtcttagt acccacaaag tcactttcct gttataattg ccttcggtat
     7861 ccagattctt ctacaaacca actccacccc aactctttcc tctttcttcc ctcctcccta
     7921 aaatctcagc atcccatccc caccttgcac aacacaacac agaccagatc agctggtcac
     7981 tatagagatt tgtatatatt aaaacaaacc tactttttgg agaatttttt gtatattctt
     8041 tttctatttg ttttctacag attgaggaga gagctggcaa actgtgaatc taattttatc
     8101 ttgatgccag cagatatatt ttggcttccc ggtctgaatc tgtgttacta gggacggcat
     8161 atcgccctct gatcagtatt gcatctccag tctacaaagt tactttggcc caatcttaca
     8221 ttctttcttc cacaaatccc caaatttctt tgttattatt tatacagaga aatatttata
     8281 gtcctggata tcacaagttt aatgttaatt taacttttaa taatgttaca catttatatc
     8341 tattcttcaa aaatcataaa gactcagagt aggctgatat agtctctttg gtatctgcaa
     8401 ttttttcaga cagatatttt cttatgatat tttctataca accacataga tagaagtata
     8461 gctaattaga gcacatgttt ctatagcaat ttggggtatc aactgttttc tgagcataca
     8521 gacacatttg agaaattttg gaactcagtc cttaatgatg caattcgacc aaactcagaa
     8581 caaggaattg cttaagcccc ttaggtagtt agggtatatg catctgaaca gttaatcctt
     8641 caacatcaag gaatggtgct gactgctttt ttccaacacc agtccttgtt ttcccaactg
     8701 accttcctaa tttttctgtc tcataaaatg aataaaggct ggtgctaata gcaggactgc
     8761 ttctctatca gaatctccat gcattactag atgtttatgt gaaaattggc ctaataaaat
     8821 gtagagtagc aacagctgag gatggctggt aaggaaagaa ttcaggtcag ttttggtgca
     8881 gttatgtctt gccaagaaaa aatgatagca aaacctcaca ttgttatatg aattgaacat
     8941 atatttttaa gaagaaatta aagacaacat atttttagta cccattcaga atccatgctg
     9001 tatcactggg gcgctggagc tgggagttag aatcatactg ggattattta gaattaaacc
     9061 ccaatagttt atcctcaggt aggcaacaga ctgatgtgac cttcccacaa agtaaaccag
     9121 tagtcacgga aaacacaagg tgtcttttct ccaccaaaca cactctctgc aatggtgggg
     9181 agactggtat tttactgtgc ttgaaagaat aaatagcctg ttatatagat gacatattag
     9241 gatgtattca agcctgctcc tcattaagcg aacagattag atgtgccatc aactggctaa
     9301 gattgtatct gttttcacag ctagctatca gagcatgact ttcttgtgtg tatacgttga
     9361 tacttggttc acgcatgaag acagtgccta tgcactttgt gtagctataa tgtaggtatt
     9421 tgtgtgtaat ttcagtgaag cagtgtattg atgtaattta atttaactgt ttttcttggc
     9481 tgtttatcta aatgcaatag atatgaccat gaccatttgg aaacctttct ttgcagtctt
     9541 aggtatcaac taagagttat ttcttaatgt gatctgagtg aagagcttac ctatgaaacc
     9601 tctgtactga tgactgtttg aaaatctcta gtctagcacc tttgtaaata cagccctgag
     9661 ctgggatggg gttgaatgtg tttcctgtta ctcagtgaag tgtcatctta tgcctgcatc
     9721 attcctattc aatgtacgtg tggaacttgt ggttaccaag tctgagggag gttcagaatg
     9781 aagatgctca tctctcctcc ctcacagtgg actgggctta aaaaatgtcc atttcctcct
     9841 catactcaaa tcatgtcttt ggggaagtgt caacttctca ggttgtcata tcttcaccat
     9901 gatgaccatg gcctaagatt ataaagaact ttgctaccct taactttctg agttagagta
     9961 caagaatgca tttactgatt agcaaccatg caggtgagac accccctcct gaaagcacag
    10021 tctggcagca aattgcacac ttgtgagaga atgacagagt actagaagca caccgagacc
    10081 tggagccagc aacagccagg ggccagcaat ggtcaaggac cagcaaaggc caacggccaa
    10141 ccttggcacc ggaggaggac caacctctga tgcactgatc ctgagtatgt gacaggaggc
    10201 tggtctcctc tacccagtaa tgctctgttt gcgtgaatga gattaacaat ggcaattaga
    10261 tgtgatctcc caaaccacat tctcactaat taccatactg ggagctttgt agttcctata
    10321 agccctttct tccccacaaa gaagaaacaa cattgtgctg gagagtaccc ctcccttttc
    10381 tcacagatca tggagatgtg aagcaagcac actcattttc aggggcttct ccagatgtgt
    10441 ggagtgaggg gatgtggtgg ctgtatcctt caaattatga atgaaaacaa agtacagaaa
    10501 ggaaaggaga ctttaggcag gattattttt gaatgaaaga taagactaat ggtttctctc
    10561 ccattcccag tccccattgg tctgatgtca tgtagcatag tacatctata gcacatggta
    10621 tttaaagact aatgaatgca aagagactaa tttgggggct gtttcttata tatggtacta
    10681 ggaaatgcct tgttggcaaa gcacaccttg ggtagttgag atctcctatg tttgtattta
    10741 gcttttcttg tgactgtaac atttcatgtg taaaataact ggatattctt catatgatgg
    10801 aaataacctg tgaattcaat ctttcatcga gtgttttaac tcccgtgtac atatatatct
    10861 catcaataaa tgtggattcc aatttctctt t
//
