LOCUS       NM_013032               1821 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 1 member 1 (Slc1a1), mRNA.
ACCESSION   NM_013032 XM_346583
VERSION     NM_013032.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1821)
  AUTHORS   Wang,J., Zielewicz,L., Dong,Y. and Grewer,C.
  TITLE     Pre-Steady-State Kinetics and Reverse Transport in Rat Glutamate
            Transporter EAAC1 with an Immobilized Transport Domain
  JOURNAL   Neurochem Res 47 (1), 148-162 (2022)
   PUBMED   33550531
  REMARK    GeneRIF: Pre-Steady-State Kinetics and Reverse Transport in Rat
            Glutamate Transporter EAAC1 with an Immobilized Transport Domain.
REFERENCE   2  (bases 1 to 1821)
  AUTHORS   Magi,S., Piccirillo,S., Maiolino,M., Lariccia,V. and Amoroso,S.
  TITLE     NCX1 and EAAC1 transporters are involved in the protective action
            of glutamate in an in vitro Alzheimer's disease-like model
  JOURNAL   Cell Calcium 91, 102268 (2020)
   PUBMED   32827867
  REMARK    GeneRIF: NCX1 and EAAC1 transporters are involved in the protective
            action of glutamate in an in vitro Alzheimer's disease-like model.
REFERENCE   3  (bases 1 to 1821)
  AUTHORS   Malik,A.R., Szydlowska,K., Nizinska,K., Asaro,A., van Vliet,E.A.,
            Popp,O., Dittmar,G., Fritsche-Guenther,R., Kirwan,J.A., Nykjaer,A.,
            Lukasiuk,K., Aronica,E. and Willnow,T.E.
  TITLE     SorCS2 Controls Functional Expression of Amino Acid Transporter
            EAAT3 and Protects Neurons from Oxidative Stress and
            Epilepsy-Induced Pathology
  JOURNAL   Cell Rep 26 (10), 2792-2804 (2019)
   PUBMED   30840898
REFERENCE   4  (bases 1 to 1821)
  AUTHORS   Ottestad-Hansen,S., Hu,Q.X., Follin-Arbelet,V.V., Bentea,E.,
            Sato,H., Massie,A., Zhou,Y. and Danbolt,N.C.
  TITLE     The cystine-glutamate exchanger (xCT, Slc7a11) is expressed in
            significant concentrations in a subpopulation of astrocytes in the
            mouse brain
  JOURNAL   Glia 66 (5), 951-970 (2018)
   PUBMED   29350434
REFERENCE   5  (bases 1 to 1821)
  AUTHORS   Wei,Y.B., Melas,P.A., Villaescusa,J.C., Liu,J.J., Xu,N.,
            Christiansen,S.H., Elbrond-Bek,H., Woldbye,D.P., Wegener,G.,
            Mathe,A.A. and Lavebratt,C.
  TITLE     MicroRNA 101b Is Downregulated in the Prefrontal Cortex of a
            Genetic Model of Depression and Targets the Glutamate Transporter
            SLC1A1 (EAAT3) in Vitro
  JOURNAL   Int J Neuropsychopharmacol 19 (12) (2016)
   PUBMED   27507301
  REMARK    GeneRIF: miR-101b targets the neuronal glutamate transporter
            SLC1A1.  Both mRNA and protein levels of SLC1A1 were found to be
            upregulated in the prefrontal cortex of rats genetically
            predisposed to develop major depressive disorder.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1821)
  AUTHORS   Palos,T.P., Ramachandran,B., Boado,R. and Howard,B.D.
  TITLE     Rat C6 and human astrocytic tumor cells express a neuronal type of
            glutamate transporter
  JOURNAL   Brain Res Mol Brain Res 37 (1-2), 297-303 (1996)
   PUBMED   8738164
REFERENCE   7  (bases 1 to 1821)
  AUTHORS   Kiryu,S., Yao,G.L., Morita,N., Kato,H. and Kiyama,H.
  TITLE     Nerve injury enhances rat neuronal glutamate transporter
            expression: identification by differential display PCR
  JOURNAL   J Neurosci 15 (12), 7872-7878 (1995)
   PUBMED   8613726
REFERENCE   8  (bases 1 to 1821)
  AUTHORS   Kanai,Y., Bhide,P.G., DiFiglia,M. and Hediger,M.A.
  TITLE     Neuronal high-affinity glutamate transport in the rat central
            nervous system
  JOURNAL   Neuroreport 6 (17), 2357-2362 (1995)
   PUBMED   8747153
REFERENCE   9  (bases 1 to 1821)
  AUTHORS   Arriza,J.L., Fairman,W.A., Wadiche,J.I., Murdoch,G.H.,
            Kavanaugh,M.P. and Amara,S.G.
  TITLE     Functional comparisons of three glutamate transporter subtypes
            cloned from human motor cortex
  JOURNAL   J Neurosci 14 (9), 5559-5569 (1994)
   PUBMED   7521911
REFERENCE   10 (bases 1 to 1821)
  AUTHORS   Kanai,Y., Stelzner,M., Nussberger,S., Khawaja,S., Hebert,S.C.,
            Smith,C.P. and Hediger,M.A.
  TITLE     The neuronal and epithelial human high affinity glutamate
            transporter. Insights into structure and mechanism of transport
  JOURNAL   J Biol Chem 269 (32), 20599-20606 (1994)
   PUBMED   7914198
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061743.1.
            
            On Jun 10, 2007 this sequence version replaced NM_013032.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061743.1, U39555.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1821
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..1821
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /note="solute carrier family 1 member 1"
                     /db_xref="GeneID:25550"
                     /db_xref="RGD:3696"
     exon            1..180
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1661
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /note="excitatory amino-acid carrier 1; sodium-dependent
                     glutamate/aspartate transporter 3; Solute carrier family 1
                     A1 (brain glutamate transporter); solute carrier family 1
                     (neuronal/epithelial high affinity glutamate transporter,
                     system Xag), member 1"
                     /codon_start=1
                     /product="excitatory amino acid transporter 3"
                     /protein_id="NP_037164.3"
                     /db_xref="GeneID:25550"
                     /db_xref="RGD:3696"
                     /translation="MGKPTSSGCDWRRFLRNHWLLLSTVAAVVLGIVVGVLVRGHSEL
                     SNLDKFYFAFPGEILMRMLKLVILPLIISSMITGVAALDSNVSGKIGLRAVVYYFSTT
                     VIAVILGIVLVVSIKPGVTQKVNEINRTGKTPEVSTVDAMLDLIRNMFPENLVQACFQ
                     QYKTKREEVKPASDPGGNQTEVSVTTAMTTMSENKTKEYKIVGLYSDGINVLGLIIFC
                     LVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPIGILFLIAGKIIEVEDWE
                     IFRKLGLYMATVLSGLAIHSLVVLPLIYFIVVRKNPFRFALGMAQALLTALMISSSSA
                     TLPVTFRCAEEKNHVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNGMDLSIGQ
                     IITISITATAASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVN
                     VLGDAFGTGIVEKLSKKELEQVDVSSEVNIVNPFALEPTILDNEDSDTKKSYVNGGFS
                     VDKSDTISFTQTSQF"
     exon            181..321
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            322..414
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            415..529
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            530..572
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            573..668
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            669..853
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            854..961
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1084
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1279
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1414
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1805
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcccgtgcg ctgtgtctcc accgtgccct gcatccctca tcccacatcc gccgcgctcc
       61 ccgattcctc acaaacgccg gtgcccatca tggggaagcc cacgagctcg ggatgcgact
      121 ggcgccgctt cctgcggaat cactggctgc tgctctccac cgtggccgcc gtggtactgg
      181 gcatcgtggt aggagtcttg gttcgaggac acagtgagct ctcgaatctg gataaattct
      241 actttgcgtt tcctggagaa attctgatgc ggatgctgaa gctcgtcatt ctgccactga
      301 ttatatccag catgatcaca ggtgtcgctg cactggattc caacgtatct ggaaaaattg
      361 gtcttcgtgc tgtagtatat tatttctcca ccaccgtcat tgctgtaatc ctaggtattg
      421 tgttagttgt gagcatcaag cctggtgtca ctcagaaagt gaatgaaatc aacaggacag
      481 gcaaaacccc tgaagtcagc actgtggacg ccatgttgga tctgatcagg aacatgttcc
      541 ctgagaacct ggtccaagcc tgttttcagc agtacaaaac caagcgtgaa gaagtgaagc
      601 ctgccagtga tcctgggggg aaccagacag aggtgtctgt caccacggcc atgacaacaa
      661 tgtctgagaa caagacaaag gaatacaaaa tcgtgggcct gtactcagac ggcatcaacg
      721 tcctgggcct gattatcttc tgcctcgtct ttggacttgt cattggaaaa atgggagaaa
      781 aagggcagat tctggtggat ttcttcaatg cgttgagtga cgccaccatg aaaatcgttc
      841 agatcatcat gtgttacatg ccgatcggta ttttgttcct aatcgctggg aagatcatag
      901 aagttgaaga ctgggaaata ttccgcaagt tgggccttta tatggccact gtcctgagtg
      961 ggcttgcaat ccactccctc gtagtgctgc cactgatcta tttcatagtc gtgcggaaga
     1021 accctttccg ctttgccttg ggcatggcgc aggctctcct gacagctctc atgatctcat
     1081 ctagctcggc aacccttcca gttacattcc gctgtgcgga agaaaagaac cacgtggaca
     1141 agaggatcac aagatttgtg ctgcccgtcg gcgccaccat caacatggac ggcactgcgc
     1201 tctatgaagc cgtggcagct gtgttcattg cgcagctgaa cggcatggac ctgagcattg
     1261 ggcagatcat cacgatcagc atcacagcca ccgctgctag cattggagct gccggtgtgc
     1321 cccaggctgg cctggtgacc atggtgatcg tgttgagtgc cgtggggctg cctgctgagg
     1381 acgtcaccct catcattgcc gtcgactggc tcctggaccg gttcaggacc atggtgaacg
     1441 ttctgggtga tgcgtttggg acgggcatcg tggagaagct gtccaagaag gagctggagc
     1501 aggtggatgt ctcctctgaa gtcaacattg tgaacccctt tgccttggag cccacaatcc
     1561 tggataatga agactcagat acgaagaagt cttacgtcaa tgggggcttc tcggtagaca
     1621 aatctgacac catctcgttc actcagacct cgcagttcta gatgcctggc cttagatgcc
     1681 tgggactgtg aagggcatct ccgagggagc catctcttag ccaactccag cgttaaggag
     1741 cgagaaggac acaaagaatc aactgtacat ttagtttgat aaacagacct ccagattatt
     1801 ttctaaaaaa aaaaaaaaaa a
//
