LOCUS       NM_001030024            3458 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 19 member 2 (Slc19a2),
            mRNA.
ACCESSION   NM_001030024 XM_222832
VERSION     NM_001030024.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3458)
  AUTHORS   Nabokina,S.M., Senthilkumar,S.R. and Said,H.M.
  TITLE     Tspan-1 interacts with the thiamine transporter-1 in human
            intestinal epithelial cells and modulates its stability
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 301 (5), G808-G813 (2011)
   PUBMED   21836059
REFERENCE   2  (bases 1 to 3458)
  AUTHORS   Bukhari,F.J., Moradi,H., Gollapudi,P., Ju Kim,H., Vaziri,N.D. and
            Said,H.M.
  TITLE     Effect of chronic kidney disease on the expression of thiamin and
            folic acid transporters
  JOURNAL   Nephrol Dial Transplant 26 (7), 2137-2144 (2011)
   PUBMED   21149507
REFERENCE   3  (bases 1 to 3458)
  AUTHORS   Reidling,J.C., Lambrecht,N., Kassir,M. and Said,H.M.
  TITLE     Impaired intestinal vitamin B1 (thiamin) uptake in thiamin
            transporter-2-deficient mice
  JOURNAL   Gastroenterology 138 (5), 1802-1809 (2010)
   PUBMED   19879271
REFERENCE   4  (bases 1 to 3458)
  AUTHORS   Hosoya,K., Fujita,K. and Tachikawa,M.
  TITLE     Involvement of reduced folate carrier 1 in the inner blood-retinal
            barrier transport of methyltetrahydrofolate
  JOURNAL   Drug Metab Pharmacokinet 23 (4), 285-292 (2008)
   PUBMED   18762716
  REMARK    GeneRIF: involvement of RFC1 in the inner BRB transport of
            methyltetrahydrofolate.
REFERENCE   5  (bases 1 to 3458)
  AUTHORS   Lo,P.K., Chen,J.Y., Tang,P.P., Lin,J., Lin,C.H., Su,L.T., Wu,C.H.,
            Chen,T.L., Yang,Y. and Wang,F.F.
  TITLE     Identification of a mouse thiamine transporter gene as a direct
            transcriptional target for p53
  JOURNAL   J Biol Chem 276 (40), 37186-37193 (2001)
   PUBMED   11481326
REFERENCE   6  (bases 1 to 3458)
  AUTHORS   Labay,V., Raz,T., Baron,D., Mandel,H., Williams,H., Barrett,T.,
            Szargel,R., McDonald,L., Shalata,A., Nosaka,K., Gregory,S. and
            Cohen,N.
  TITLE     Mutations in SLC19A2 cause thiamine-responsive megaloblastic
            anaemia associated with diabetes mellitus and deafness
  JOURNAL   Nat Genet 22 (3), 300-304 (1999)
   PUBMED   10391221
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001030024.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099811.1, SRR26643429.44968.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-361               JAXUCZ010000013.1  79135118-79135478
            362-964             JAXUCZ010000013.1  79141954-79142556
            965-1190            JAXUCZ010000013.1  79144697-79144922
            1191-1383           JAXUCZ010000013.1  79145971-79146163
            1384-1525           JAXUCZ010000013.1  79146512-79146653
            1526-3458           JAXUCZ010000013.1  79147382-79149314
FEATURES             Location/Qualifiers
     source          1..3458
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q23"
     gene            1..3458
                     /gene="Slc19a2"
                     /note="solute carrier family 19 member 2"
                     /db_xref="GeneID:289175"
                     /db_xref="RGD:1308611"
     exon            1..361
                     /gene="Slc19a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1654
                     /gene="Slc19a2"
                     /note="solute carrier family 19 (thiamine transporter),
                     member 2"
                     /codon_start=1
                     /product="thiamine transporter 1"
                     /protein_id="NP_001025195.1"
                     /db_xref="GeneID:289175"
                     /db_xref="RGD:1308611"
                     /translation="MDVPARVSRRAAAAAARMLLRTARVPRECWFLPTALLCAYGFFA
                     NLRPSEPFLTPYLLGPDKNLTERQVFNEIYPVWTYSYLLLLFPVFLATDYLRYKPVIL
                     LQGLSLIVTWFMLLYAQGLLAVQFLEFFYGIATATEIAYYSYIYTVVDLGMYQKVTSY
                     CRSATLVGFTVGSVLGQILVSVVGWSLFSLNVLSLTCVSVAFAVAWFLPMPQKSLFFH
                     HIPSSCHGVNGLKVQNGGITTDTPASNHLPGWEDIESKIPLNLDEPPVEEPEEPKPDR
                     LRVFKVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYAQGLWEKVMPSQNAVIYN
                     GGVEAVSTLLGASAVFAVGYIKLSWSTWGEVTLFLCSLLIAAAVYIMDTVENIWVCYA
                     SYVVFRIIYMVLITIATFQIAANLSMERYALVFGVNTFIALALQTLLTLIVVDARGLG
                     LCIITQFLIYASYFAAISVVFLANGIVSIVKKCRKQEDPNSSPQATTS"
     exon            362..964
                     /gene="Slc19a2"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1190
                     /gene="Slc19a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1383
                     /gene="Slc19a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1525
                     /gene="Slc19a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..3458
                     /gene="Slc19a2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggcggctgg cggctgggac tccaagcacc ttgaccctgg cgcgaggcgg cgtcgcgcac
       61 gcttacaggt gcccgcgcgg ggccgcggct cgggcgccct cccgttggcg gagaaggagg
      121 agggggccgt gttggcgtcc agcccctcac gcccaggatg gacgtgcccg cccgggtgtc
      181 ccgacgagct gcggcggcgg cggccaggat gctcctacgt actgcccgcg tccctcgcga
      241 gtgctggttc ctgccgaccg cgctgctctg cgcctacggt ttcttcgcaa acctccggcc
      301 gtcggagccg ttcctcactc cctacctgct ggggccggac aagaacttga ccgagagaca
      361 ggtcttcaat gaaatttatc cagtgtggac atactcttac ctgctgctac tcttccccgt
      421 gttccttgcc acagactacc tccgttacaa gcctgtcatt ctactgcagg gactcagcct
      481 tattgttaca tggttcatgc tgctctatgc ccaaggactg ctggctgttc agttcctgga
      541 attcttctat ggcattgcca cagccactga aatcgcctac tactcctata tctacactgt
      601 ggtcgacctg ggcatgtacc agaaagtcac aagttactgt agaagtgcca ccttggtggg
      661 ctttacagtg ggctctgtcc tagggcagat cctcgtctcc gtggtgggct ggtcactgtt
      721 cagcttgaac gtcctctccc tcacctgcgt ttctgtggcc tttgctgtgg cctggtttct
      781 gcctatgcca cagaagagcc tcttctttca ccacatccct tcctcctgtc acggagtgaa
      841 tggcctcaag gtacaaaatg gcggcatcac tactgatacc ccagcatcta accatcttcc
      901 tggatgggag gacattgagt caaaaatccc tctaaattta gatgagcctc cggtggagga
      961 accggaggag cccaagccag accggctgcg ggtgttcaaa gtcctgtgga atgacttcct
     1021 gatgtgttac tcctcccgcc ctctgctctg ctggtccgtg tggtgggccc tctccacctg
     1081 cggttatttc caagtggtga actacgcaca gggattgtgg gagaaggtca tgccttctca
     1141 gaatgctgtc atctacaatg gcggtgtgga ggctgtttca accttgctgg gtgcaagtgc
     1201 tgtgtttgcg gttggttata taaaactatc ttggtcaact tggggagagg tgacgttatt
     1261 cctgtgttct cttctgattg ctgctgcagt gtacatcatg gacaccgtgg agaacatttg
     1321 ggtgtgctat gcatcctatg ttgtcttcag aatcatctac atggtactca tcaccatagc
     1381 aacttttcag attgctgcaa accttagcat ggagcgttac gcccttgtgt ttggagtgaa
     1441 caccttcatt gctctggcct tacagactct gctcactctg attgtggtag atgccagggg
     1501 ccttggcttg tgtattatta ctcagttcct gatttatgcg agttactttg cagccatctc
     1561 tgtggttttc ctggctaatg gcatagtcag tattgtaaag aaatgcagaa agcaggaaga
     1621 tcccaactcc agccctcaag caaccacttc ctaacgtgct cccggaatgc tgctgcttcc
     1681 aagcaaggac tctgcacagt aaccgcttgg atgtacttac actctctgtg gctcagataa
     1741 ctatttatga atgtgtatct catgccttca aagcagctac tcaactaaca ccttgtactc
     1801 ttggggttag tgcaatactg ttgagggagg ccagaactga agctgttttt catggcttgt
     1861 ttataagcag taatttaaga atgacttctt ctaattcata aaaccccaca aaacttgatt
     1921 ttggaaaacc gagtaatgaa gcagcacgtc tgctctctcc ttgattagca tgtgagtgtg
     1981 atgctttttg tcacatttgt cactcaccca gacctgtagc ctggtgggac cagggcttca
     2041 caagctgcag gatggtagac gtcacgatag acgtgcgttc tgtcagcact cgccccatcc
     2101 agcctcattt tgatttcagt gttacttgtg tgcacgtgta tgtccgcaga tggaaatcgt
     2161 ttcttactgg caatatctgc tcaggtttaa tgttctgtct tctaaggagt gttgtctaat
     2221 tttattttta aaattcattg tgtgaatgtt agtgcttccc attctgacca ttgtacattt
     2281 tggaaacttt ctttagaagt acatttgtgc actattcata tgcttcccgg agaagctcat
     2341 ttcattagaa aaggcacatt ttaaagcctg ctgatacctg aggaaggata gttaggtagg
     2401 cttgtttgtc tttaatactt cagtatgaag gactctcgat tgcaattaaa aaggtcattt
     2461 gtaggttaga gatacagaga gcccatttta tatttgcatc ccctttcctt tccaaaacaa
     2521 gatgaactct ttttttcttt gagtatcatt cccatatgcc tctcatcatc ttggctttct
     2581 tagccaagat caagatgtca gtaggaactg gattattcca caggcttttt tataaactga
     2641 gcctcttttt aatgatttta gtggggttgg aactaggata gaccttagac ctgcctttgt
     2701 tcctcagggt agatcatctt gagagttaaa gcatttcttc cttacttgaa agagtgatgt
     2761 tctgtgtgct gatatttgtg aggcatggaa actgtcgtct tgtcgtgcaa cagatccggg
     2821 taggtgcttt aatgagagtg ttgacttttt aagaccaacg tcactaaaca gtattattaa
     2881 tactgagatt gcaaaactgc agcttaatga atacatagaa gaccctgggt caactactag
     2941 cactgggaag accaaaccgc ataggaaaca tgaggatagc acaggtccgt gggtcttcct
     3001 ttgcagctcg ggagaggaga acactaagga gacggagaac taaggtcaga gtagccttac
     3061 atttaacgtc cgagcttaca ttttggtctc cctcctccca ccgtttcttg ttgctctgta
     3121 ggatgttggt tgcccagaaa caagaagaaa cgtgattgag aaattttatt ttgtttttta
     3181 aaataatatg tattatgata caatcaaatt gttcacatta ccaaagcaat atttccttgg
     3241 aatttagtta actatttgtg gcacttaatc tgatccttct tacctgtcta aatcaagact
     3301 atgttcatgt actactatgt ggccatgttt gtggaatgca aaacccaatg tgctgtactg
     3361 tttgcacttt tatgcagaag tggaaataat ctgttgcact ttttattcaa tctgtataga
     3421 ctataaaact atttttatta aataaatatt ttacagta
//
