LOCUS       NM_001400828            2460 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 18 member B1 (Slc18b1),
            mRNA.
ACCESSION   NM_001400828 XM_006227717
VERSION     NM_001400828.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2460)
  AUTHORS   Takeuchi,T., Harada,Y., Moriyama,S., Furuta,K., Tanaka,S.,
            Miyaji,T., Omote,H., Moriyama,Y. and Hiasa,M.
  TITLE     Vesicular Polyamine Transporter Mediates Vesicular Storage and
            Release of Polyamine from Mast Cells
  JOURNAL   J Biol Chem 292 (9), 3909-3918 (2017)
   PUBMED   28082679
  REMARK    GeneRIF: VPAT is expressed and is responsible for vesicular storage
            of spermine and spermidine in novel secretory granules that differ
            from histamine- and serotonin-containing granules and is involved
            in vesicular release of these polyamines from mast cells
REFERENCE   2  (bases 1 to 2460)
  AUTHORS   Hiasa,M., Miyaji,T., Haruna,Y., Takeuchi,T., Harada,Y.,
            Moriyama,S., Yamamoto,A., Omote,H. and Moriyama,Y.
  TITLE     Identification of a mammalian vesicular polyamine transporter
  JOURNAL   Sci Rep 4, 6836 (2014)
   PUBMED   25355561
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 27, 2022 this sequence version replaced XM_006227717.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.194.1, SRR26643293.322.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               JAXUCZ010000001.1  23489724-23489918   c
            196-335             JAXUCZ010000001.1  23488447-23488586   c
            336-431             JAXUCZ010000001.1  23480100-23480195   c
            432-505             JAXUCZ010000001.1  23478975-23479048   c
            506-653             JAXUCZ010000001.1  23477096-23477243   c
            654-810             JAXUCZ010000001.1  23466562-23466718   c
            811-947             JAXUCZ010000001.1  23459810-23459946   c
            948-1049            JAXUCZ010000001.1  23458070-23458171   c
            1050-1141           JAXUCZ010000001.1  23455915-23456006   c
            1142-1237           JAXUCZ010000001.1  23451514-23451609   c
            1238-1312           JAXUCZ010000001.1  23450168-23450242   c
            1313-1406           JAXUCZ010000001.1  23448984-23449077   c
            1407-1456           JAXUCZ010000001.1  23448842-23448891   c
            1457-2460           JAXUCZ010000001.1  23447462-23448465   c
FEATURES             Location/Qualifiers
     source          1..2460
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..2460
                     /gene="Slc18b1"
                     /gene_synonym="RGD1306962; VPAT"
                     /note="solute carrier family 18 member B1"
                     /db_xref="GeneID:309570"
                     /db_xref="RGD:1306962"
     exon            1..195
                     /gene="Slc18b1"
                     /gene_synonym="RGD1306962; VPAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1523
                     /gene="Slc18b1"
                     /gene_synonym="RGD1306962; VPAT"
                     /note="solute carrier family 18, subfamily B, member 1;
                     vesicular polyamine transporter"
                     /codon_start=1
                     /product="MFS-type transporter SLC18B1"
                     /protein_id="NP_001387757.1"
                     /db_xref="GeneID:309570"
                     /db_xref="RGD:1306962"
                     /translation="MDTAGPPAPAGTEGDGPGGSTGETSRRLSKEQIFVLVSAASMNL
                     GCMMTYSILGPFFPKEAEKKGASNTTIGMIFGCYALFELLASLVFGKYLVHIGAKFMF
                     IAGMFVSGGVTILFGVLDQLPEGPIFIAMCFLVRIVDAIGFGAAITASSSILAKAFPN
                     NVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLNLCILPSY
                     ESDAGKQSFWKLVTLPKIGLIAFVIISLSSCFGFLDPTLSLFVMKKFSLSTGYVGLVF
                     LGLSLSYAISSPLFGLLSDKMPNLRKWFLVFGNLITAGCYMLLGPIPLLHIKSQLWLL
                     VLVLVINGVSAGMSIIPTFPEMLSCAYANGFEDGISTLGLVSGLFGAMWSVGAFMGPI
                     LGGFLCEKIGFEWAAAIQGLWTLLSGVAMALFYLWEDSTMRRSKAQNILGTEEEQAAL
                     LPNDT"
     exon            196..335
                     /gene="Slc18b1"
                     /gene_synonym="RGD1306962; VPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            336..431
                     /gene="Slc18b1"
                     /gene_synonym="RGD1306962; VPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            432..505
                     /gene="Slc18b1"
                     /gene_synonym="RGD1306962; VPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            506..653
                     /gene="Slc18b1"
                     /gene_synonym="RGD1306962; VPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            654..810
                     /gene="Slc18b1"
                     /gene_synonym="RGD1306962; VPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            811..947
                     /gene="Slc18b1"
                     /gene_synonym="RGD1306962; VPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1049
                     /gene="Slc18b1"
                     /gene_synonym="RGD1306962; VPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1141
                     /gene="Slc18b1"
                     /gene_synonym="RGD1306962; VPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1237
                     /gene="Slc18b1"
                     /gene_synonym="RGD1306962; VPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1312
                     /gene="Slc18b1"
                     /gene_synonym="RGD1306962; VPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1406
                     /gene="Slc18b1"
                     /gene_synonym="RGD1306962; VPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1456
                     /gene="Slc18b1"
                     /gene_synonym="RGD1306962; VPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..2460
                     /gene="Slc18b1"
                     /gene_synonym="RGD1306962; VPAT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgggtcccc ggttccaggg atcagcgagg tttcttgtcc cggctccgat ttccacctct
       61 ggactggaat gcagagtcgg atccccgcag ctcgcccgca gccatcgcat cccgcccgct
      121 gatcccggag cgccggagga ccaggagagc agctcatgga cacggcgggc ccccctgctc
      181 ctgcggggac agaaggtgac ggccctggag gaagcacagg agagacatct agacgactgt
      241 caaaagaaca gatttttgtc ctcgtatcag cagcttccat gaacttgggt tgtatgatga
      301 cctactccat ccttggacca ttcttcccca aggaggcaga gaagaaggga gccagcaaca
      361 cgacgatagg aatgattttc ggatgctacg cgttgtttga attgctggca tcattggtgt
      421 ttggaaaata tcttgtacac attggagcca aatttatgtt catagcagga atgtttgtct
      481 caggaggagt gacaattctc tttggtgtct tggatcagct tccagaaggg ccgatattta
      541 ttgccatgtg tttcctggtg agaatagtag acgccatagg ctttggtgca gccataacag
      601 cttcgtcttc catcctggca aaggctttcc cgaacaatgt ggctacagtc atgggaagtc
      661 ttgaggtttt ctctggactg ggactggtag caggtcctcc tttgggtggc cttttgtatc
      721 aatcctttgg ctacgaggtg ccctttattt ttctggggtg catagttctg ctgatgatac
      781 cactcaacct atgcattttg cctagctatg agtccgatgc agggaaacag tccttctgga
      841 aacttgtcac cttacccaag atcggtctta tagccttcgt gatcatctct ctcagctcct
      901 gcttcggctt cctcgacccg accctgtctc tctttgtcat gaagaagttc agtttgtcga
      961 ctggatacgt gggactggtc ttcctgggtc tgtctctatc ctacgccatc tcttcgccgc
     1021 tgtttggtct actcagtgat aagatgccta atctaaggaa atggtttctg gtttttggaa
     1081 acttaatcac agctggctgc tacatgctct taggacctat accccttctg cacattaaaa
     1141 gtcagctctg gcttctcgtg ctggtgttag ttataaacgg ggtctccgct ggcatgagca
     1201 tcatcccaac cttcccagag atgctcagtt gtgcatacgc aaatgggttt gaagacggaa
     1261 taagtacgct gggacttgta tctggtcttt ttggtgccat gtggtcagtt ggtgctttca
     1321 tgggacctat cctgggtgga tttctgtgtg agaaaatcgg tttcgagtgg gcagcagcta
     1381 tacaaggtct atggactctg ctaagtggtg ttgcgatggc cttgttttat ctctgggagg
     1441 actcaacgat gagaagatct aaagctcaga acatcctcgg cacagaggag gaacaagctg
     1501 ctctcttgcc caatgacacc tagccttgca agcagtggat tgatccagac caagagacag
     1561 gtgcagtgtc caggatcaca gcctggagga gcttcctgtg tgccacgcag agatccatac
     1621 ttcctgcact cacacacagc gatgtcaagc tgcttttacg tgacctggag ccaggctgtg
     1681 cttcgtgtag ttctggaaag ctggtttgcc aaggcagcct tttggaacat ctatgagaaa
     1741 gggcaaacca acaaaagccg gggtttctaa aggacccacc ttgcccattg gggtgttttt
     1801 attgactgtc tgtgttttct gattcttgtg ttcccttttc actccaagtt cacagatgct
     1861 gtgactgtac ctcttaaaat caataagtga aaagaaaaaa gaagctattt aattttcgtt
     1921 gaacatataa aatagagaga atggttttat gaaattagtt ttgaaagatg gcctttttct
     1981 gcactgaagt ttgtactcat cggaaaggca aaattcctgc ctgccattta aaaactccag
     2041 agcatatctt ggctttcagt ttttctaaaa atggttgcat ggtgggtcca agcaaaatga
     2101 tgcatgcgct tgggtcctgc gatgtttccg gccgtgatct gggcttatac acattatttg
     2161 cataacattg tttctgatct tagcacatct gtgtgttggt cccataattt gtttgcttat
     2221 tgtgtttacg actcctcata ctcctgggaa atgtgtgcca tcaggaggca gggcaacacc
     2281 tgcctctgcc cagccgagcg agagccctgt gctccacctt ggagaaatac tgcctctaac
     2341 ttcacagaaa atccttgctg ctacttgaag ttagaatgtc aactttgtac ctcctgattc
     2401 gttttcatat tgtagtagct acatttcctt tctaagagaa taataaatga ttcttgtcta
//
