LOCUS       NM_013152               2357 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 18 member A1 (Slc18a1),
            mRNA.
ACCESSION   NM_013152 XM_001072228
VERSION     NM_013152.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2357)
  AUTHORS   Kato,K., Yokoyama,T., Kusakabe,T., Hata,K., Fushuku,S., Nakamuta,N.
            and Yamamoto,Y.
  TITLE     Differences in the expression of catecholamine-synthesizing enzymes
            between vesicular monoamine transporter 1- and 2-immunoreactive
            glomus cells in the rat carotid body
  JOURNAL   Acta Histochem 122 (3), 151507 (2020)
   PUBMED   31955909
  REMARK    GeneRIF: Differences in the expression of
            catecholamine-synthesizing enzymes between vesicular monoamine
            transporter 1- and 2-immunoreactive glomus cells in the rat carotid
            body.
REFERENCE   2  (bases 1 to 2357)
  AUTHORS   Multani,P.K., Hodge,R., Estevez,M.A., Abel,T., Kung,H., Alter,M.,
            Brookshire,B., Lucki,I., Nall,A.H., Talbot,K., Doyle,G.A. and
            Lohoff,F.W.
  TITLE     VMAT1 deletion causes neuronal loss in the hippocampus and
            neurocognitive deficits in spatial discrimination
  JOURNAL   Neuroscience 232, 32-44 (2013)
   PUBMED   23201251
REFERENCE   3  (bases 1 to 2357)
  AUTHORS   Talaei,F., Schmidt,M. and Henning,R.H.
  TITLE     Induction of VMAT-1 and TPH-1 expression induces vesicular
            accumulation of serotonin and protects cells and tissue from
            cooling/rewarming injury
  JOURNAL   PLoS One 7 (1), e30400 (2012)
   PUBMED   22253933
  REMARK    GeneRIF: Transfection of VMAT-1 and TPH-1 induced vesicular storage
            of serotonin which is triggered release upon cooling and has
            protective effects against hypothermia.
REFERENCE   4  (bases 1 to 2357)
  AUTHORS   Cartier,E.A., Parra,L.A., Baust,T.B., Quiroz,M., Salazar,G.,
            Faundez,V., Egana,L. and Torres,G.E.
  TITLE     A biochemical and functional protein complex involving dopamine
            synthesis and transport into synaptic vesicles
  JOURNAL   J Biol Chem 285 (3), 1957-1966 (2010)
   PUBMED   19903816
REFERENCE   5  (bases 1 to 2357)
  AUTHORS   Brunk,I., Blex,C., Speidel,D., Brose,N. and Ahnert-Hilger,G.
  TITLE     Ca2+-dependent activator proteins of secretion promote vesicular
            monoamine uptake
  JOURNAL   J Biol Chem 284 (2), 1050-1056 (2009)
   PUBMED   19008227
REFERENCE   6  (bases 1 to 2357)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   7  (bases 1 to 2357)
  AUTHORS   Grumolato,L., Louiset,E., Alexandre,D., Ait-Ali,D., Turquier,V.,
            Fournier,A., Fasolo,A., Vaudry,H. and Anouar,Y.
  TITLE     PACAP and NGF regulate common and distinct traits of the
            sympathoadrenal lineage: effects on electrical properties, gene
            markers and transcription factors in differentiating PC12 cells
  JOURNAL   Eur J Neurosci 17 (1), 71-82 (2003)
   PUBMED   12534970
REFERENCE   8  (bases 1 to 2357)
  AUTHORS   Cordeiro,M.L., Umbach,J.A. and Gundersen,C.B.
  TITLE     Lithium ions Up-regulate mRNAs encoding dense-core vesicle proteins
            in nerve growth factor-differentiated PC12 cells
  JOURNAL   J Neurochem 75 (6), 2622-2625 (2000)
   PUBMED   11080216
REFERENCE   9  (bases 1 to 2357)
  AUTHORS   Peter,D., Jimenez,J., Liu,Y., Kim,J. and Edwards,R.H.
  TITLE     The chromaffin granule and synaptic vesicle amine transporters
            differ in substrate recognition and sensitivity to inhibitors
  JOURNAL   J Biol Chem 269 (10), 7231-7237 (1994)
   PUBMED   8125935
REFERENCE   10 (bases 1 to 2357)
  AUTHORS   Liu,Y., Peter,D., Roghani,A., Schuldiner,S., Prive,G.G.,
            Eisenberg,D., Brecha,N. and Edwards,R.H.
  TITLE     A cDNA that suppresses MPP+ toxicity encodes a vesicular amine
            transporter
  JOURNAL   Cell 70 (4), 539-551 (1992)
   PUBMED   1505023
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M97380.1 and JAXUCZ010000016.1.
            
            On Oct 24, 2007 this sequence version replaced NM_013152.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M97380.1, SRR26643288.55484.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16418971, SAMN16418986
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               M97380.1           30-181
            153-91443060        JAXUCZ010000016.1  1-91442908
            91443061-91443408   M97380.1           183-530
            91443409-182886316  JAXUCZ010000016.1  1-91442908
            182886317-182886389 M97380.1           532-604
            182886390-274329297 JAXUCZ010000016.1  1-91442908
            274329298-274329654 M97380.1           606-962
            274329655-365772562 JAXUCZ010000016.1  1-91442908
            365772563-365772684 M97380.1           964-1085
            365772685-457215592 JAXUCZ010000016.1  1-91442908
            457215593-457215631 M97380.1           1087-1125
            457215632-548658539 JAXUCZ010000016.1  1-91442908
            548658540-548658609 M97380.1           1127-1196
            548658610-640101517 JAXUCZ010000016.1  1-91442908
            640101518-640102044 M97380.1           1198-1724
            640102045-731544952 JAXUCZ010000016.1  1-91442908
            731544953-731544988 M97380.1           1726-1761
            731544989-822987896 JAXUCZ010000016.1  1-91442908
            822987897-822987914 M97380.1           1763-1780
            822987915-914430822 JAXUCZ010000016.1  1-91442908
            914430823-914430887 M97380.1           1782-1846
            914430888-1005873795JAXUCZ010000016.1  1-91442908
            1005873796-100587407M97380.1           1848-2128
            1005874077-109731698JAXUCZ010000016.1  1-91442908
            1097316985-109731704M97380.1           2130-2190
            1097317046-109731724M97380.1           2194-2389
FEATURES             Location/Qualifiers
     source          1..2357
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..2357
                     /gene="Slc18a1"
                     /gene_synonym="CGAT; VMAT-1"
                     /note="solute carrier family 18 member A1"
                     /db_xref="GeneID:25693"
                     /db_xref="RGD:3693"
     exon            1..90
                     /gene="Slc18a1"
                     /gene_synonym="CGAT; VMAT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            91..356
                     /gene="Slc18a1"
                     /gene_synonym="CGAT; VMAT-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..1798
                     /gene="Slc18a1"
                     /gene_synonym="CGAT; VMAT-1"
                     /note="solute carrier family18 (vesicular monoamine)
                     member 1 (chromaffin granule amine transporter); vesicular
                     monoamine transporter 1; VAT1; vesicular amine transporter
                     1; VMAT1; solute carrier family 18 (vesicular monoamine),
                     member 1; solute carrier family 18 (vesicular monoamine
                     transporter), member 1; solute carrier family 18 member 1"
                     /codon_start=1
                     /product="chromaffin granule amine transporter"
                     /protein_id="NP_037284.2"
                     /db_xref="GeneID:25693"
                     /db_xref="RGD:3693"
                     /translation="MLQVVLGAPQRLLKEGRQSRKLVLVVVFVALLLDNMLLTVVVPI
                     VPTFLYATEFKDSNSSLHRGPSVSSQQALTSPAFSTIFSFFDNTTTTVEEHVPFRVTW
                     TNGTIPPPVTEATSVPKNNCLQGIEFLEEENVRIGILFASKALMQLLVNPFVGPLTNR
                     IGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASVYTD
                     NYERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQLCILW
                     PSKVSPESAMGTPLLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQ
                     LGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGISLLCVPLAHNIFGLIGP
                     NAGLGFAIGMVDSSLMPIMGYLVDLRHTSVYGSVYAIADVAFCVGFAIGPSTGGVIVQ
                     VIGFPWLMVIIGTINIIYAPLCCFLQNPPAKEEKRAILSQECPTETQMYTVQKPTKEF
                     PLGENSDDPSSGE"
     exon            357..711
                     /gene="Slc18a1"
                     /gene_synonym="CGAT; VMAT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            712..770
                     /gene="Slc18a1"
                     /gene_synonym="CGAT; VMAT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..854
                     /gene="Slc18a1"
                     /gene_synonym="CGAT; VMAT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            855..947
                     /gene="Slc18a1"
                     /gene_synonym="CGAT; VMAT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1037
                     /gene="Slc18a1"
                     /gene_synonym="CGAT; VMAT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1081
                     /gene="Slc18a1"
                     /gene_synonym="CGAT; VMAT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1142
                     /gene="Slc18a1"
                     /gene_synonym="CGAT; VMAT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1238
                     /gene="Slc18a1"
                     /gene_synonym="CGAT; VMAT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1317
                     /gene="Slc18a1"
                     /gene_synonym="CGAT; VMAT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1369
                     /gene="Slc18a1"
                     /gene_synonym="CGAT; VMAT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1433
                     /gene="Slc18a1"
                     /gene_synonym="CGAT; VMAT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1553
                     /gene="Slc18a1"
                     /gene_synonym="CGAT; VMAT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1687
                     /gene="Slc18a1"
                     /gene_synonym="CGAT; VMAT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..2357
                     /gene="Slc18a1"
                     /gene_synonym="CGAT; VMAT-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacatccact ttcagagaac agagtctctg ctgtcttgcc aacggctgct ccttcctctc
       61 tgagtgcctc acatcaagat aagctagaag tgagcttcac tggaccaggc agacttcttc
      121 tcctataaag gtgacagaag accacatttg tcaaggggtc ttcctaagcc ctgggaggag
      181 aagcccccac catctcactc cctacccagc ccagcctcct gcagcccttg ccatgctcca
      241 ggttgttctg ggtgctcctc agcggttgct gaaggaagga aggcagtccc gcaagctggt
      301 gctggtggtg gtgttcgtgg ctctgcttct ggacaacatg ctgctcactg tggtggtgcc
      361 cattgtgccc accttcctgt acgcgacaga gttcaaagac agcaactctt ctctgcatag
      421 gggtccttct gtaagctccc agcaagctct cacctctcct gccttctcta ccatattctc
      481 cttctttgac aacaccacca caactgtaga agaacatgta cccttccgtg taacttggac
      541 aaatggcacc atccctcctc cagtcactga agccacctca gtaccaaaaa acaactgctt
      601 gcaagggata gagttcttag aagaagaaaa cgttcggatt gggattctat ttgcttcaaa
      661 agctttgatg caacttctgg tcaacccatt tgtaggacct cttactaaca ggattggcta
      721 tcacatcccc atgtttgttg gctttatgat catgtttctc tccacactaa tgtttgcttt
      781 ctctggcacc tatgccctgc tatttgtggc ccgaactctc caaggcattg gatcttcgtt
      841 ttcatctgtt gcaggacttg ggatgctggc cagtgtctat actgacaact atgagagagg
      901 gagagccatg ggaattgctt tggggggcct ggctttggga cttctggtgg gagcaccttt
      961 cggaagtgtg atgtatgaat ttgtgggcaa gtcctcacca ttcctcatct tggccttctt
     1021 ggcacttctg gatggagctc tccaactttg catcctgtgg ccttcgaaag tgtctcctga
     1081 gagtgccatg gggactccgc ttttgacgct tctcaaagac ccttacatcc tggtagcagc
     1141 aggttccatc tgcttggcca acatgggtgt cgccatacta gagcccacgc tgcccatctg
     1201 gatgatgcag accatgtgct cccccgagtg gcagctaggt ctggctttct tgcctgctag
     1261 tgtggcctac ctcattggca cgaacctctt tggtgtgttg gctaacaaga tgggtcggtg
     1321 gctgtgctcc cttgttggga tggtggcagt aggtatcagc ttgctctgtg tacctctggc
     1381 tcacaatatt tttggtctta ttggccccaa tgcaggcctt ggctttgcca taggaatggt
     1441 ggattcctct ctgatgccca tcatgggata cctggtggac ttacgccaca cctctgtgta
     1501 tgggagtgtc tatgccatcg ccgatgtggc cttttgtgtg ggctttgcta ttggcccatc
     1561 tactgggggt gttatcgtac aggtcattgg ctttccttgg ctcatggtca tcattggtac
     1621 catcaacatc atttatgctc ctctctgctg cttcctgcag aacccgccag ctaaggagga
     1681 gaagcgtgca attctgagcc aggaatgccc cacagagacc cagatgtaca cagtccagaa
     1741 gcccacaaag gagtttccac taggagagaa cagcgatgat cctagcagcg gggagtaact
     1801 gcggagggcg atatctgcgc ctcacatcta cagggaccag tctactacag attcaataat
     1861 tttcactttc ctctcctcca ggccactgcc ttcctccctt cttattgata cctttccttt
     1921 actcacctgt aagtgcaacc caccactctc cctctgtgct ttgacaccac ccatggccca
     1981 ctttttgtgg gaggacagtg ctatttcctg ccaggccaaa gcgaagctga ttaaagctga
     2041 gttgtgacaa gttctgcaag gggtgactca cttcctgcag gcaggactga acaatgtgcc
     2101 tgcgaaatca gggggacaaa tgacaagcct gcctttcttc tctgattgtt tttttttttt
     2161 tgacatatta ccaatatgtc ctaaaatttg acttgtgtcc tgtgaaatgc tttcccctta
     2221 ttttttccag tttagcttct atacatacgg gtttttgctt attttatgtg ctaaaattgt
     2281 ttaccttcat taagtgaggc cttcctactt tcttcatcgc ccaattgaga ggaaataaac
     2341 aactttctta ggcttga
//
