LOCUS       NM_153725               4690 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus solute carrier family 17 member 8 (Slc17a8),
            mRNA.
ACCESSION   NM_153725
VERSION     NM_153725.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4690)
  AUTHORS   Vrettou,M., Yan,L., Nilsson,K.W., Wallen-Mackenzie,A., Nylander,I.
            and Comasco,E.
  TITLE     DNA methylation of Vesicular Glutamate Transporters in the
            mesocorticolimbic brain following early-life stress and adult
            ethanol exposure-an explorative study
  JOURNAL   Sci Rep 11 (1), 15322 (2021)
   PUBMED   34321562
  REMARK    GeneRIF: DNA methylation of Vesicular Glutamate Transporters in the
            mesocorticolimbic brain following early-life stress and adult
            ethanol exposure-an explorative study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4690)
  AUTHORS   Graban,J., Hlavacova,N. and Jezova,D.
  TITLE     Increased gene expression of selected vesicular and glial glutamate
            transporters in the frontal cortex in rats exposed to voluntary
            wheel running
  JOURNAL   J Physiol Pharmacol 68 (5), 709-714 (2017)
   PUBMED   29375045
  REMARK    GeneRIF: Chronic voluntary wheel running results in increased gene
            expression of VGLUT3 (and GLT-1) in the frontal cortex without
            changes in other glutamate transporter subtypes.
REFERENCE   3  (bases 1 to 4690)
  AUTHORS   Vogl,C., Panou,I., Yamanbaeva,G., Wichmann,C., Mangosing,S.J.,
            Vilardi,F., Indzhykulian,A.A., Pangrsic,T., Santarelli,R.,
            Rodriguez-Ballesteros,M., Weber,T., Jung,S., Cardenas,E., Wu,X.,
            Wojcik,S.M., Kwan,K.Y., Del Castillo,I., Schwappach,B.,
            Strenzke,N., Corey,D.P., Lin,S.Y. and Moser,T.
  TITLE     Tryptophan-rich basic protein (WRB) mediates insertion of the
            tail-anchored protein otoferlin and is required for hair cell
            exocytosis and hearing
  JOURNAL   EMBO J 35 (23), 2536-2552 (2016)
   PUBMED   27458190
REFERENCE   4  (bases 1 to 4690)
  AUTHORS   Eriksen,J., Chang,R., McGregor,M., Silm,K., Suzuki,T. and
            Edwards,R.H.
  TITLE     Protons Regulate Vesicular Glutamate Transporters through an
            Allosteric Mechanism
  JOURNAL   Neuron 90 (4), 768-780 (2016)
   PUBMED   27133463
REFERENCE   5  (bases 1 to 4690)
  AUTHORS   Yang,C.Q., Duan,L.P., Qiao,P.T., Zhao,L. and Guo,L.L.
  TITLE     Increased VGLUT3 involved in visceral hyperalgesia in a rat model
            of irritable bowel syndrome
  JOURNAL   World J Gastroenterol 21 (10), 2959-2966 (2015)
   PUBMED   25780293
  REMARK    GeneRIF: VGLUT3 is involved in the pathogenesis of visceral
            hyperalgesia in a rat model of irritable bowel syndrome.
REFERENCE   6  (bases 1 to 4690)
  AUTHORS   Landry,M., Bouali-Benazzouz,R., El Mestikawy,S., Ravassard,P. and
            Nagy,F.
  TITLE     Expression of vesicular glutamate transporters in rat lumbar spinal
            cord, with a note on dorsal root ganglia
  JOURNAL   J Comp Neurol 468 (3), 380-394 (2004)
   PUBMED   14681932
  REMARK    GeneRIF: Weak expression of VGLUT3 mRNA is only detected in deep
            laminae of lumbar spinal cord.
REFERENCE   7  (bases 1 to 4690)
  AUTHORS   Haverkamp,S. and Wassle,H.
  TITLE     Characterization of an amacrine cell type of the mammalian retina
            immunoreactive for vesicular glutamate transporter 3
  JOURNAL   J Comp Neurol 468 (2), 251-263 (2004)
   PUBMED   14648683
  REMARK    GeneRIF: In the rat retina, the dendrites of vGluT3 amacrine cells
            form a dendritic tree that is bistratified in the inner plexiform
            layer. The vGluT3 cells have a dendritic overlap and form a regular
            mosaic, suggesting a single type of amacrine cell.
REFERENCE   8  (bases 1 to 4690)
  AUTHORS   Schafer,M.K., Varoqui,H., Defamie,N., Weihe,E. and Erickson,J.D.
  TITLE     Molecular cloning and functional identification of mouse vesicular
            glutamate transporter 3 and its expression in subsets of novel
            excitatory neurons
  JOURNAL   J Biol Chem 277 (52), 50734-50748 (2002)
   PUBMED   12384506
REFERENCE   9  (bases 1 to 4690)
  AUTHORS   Fremeau,R.T. Jr., Burman,J., Qureshi,T., Tran,C.H., Proctor,J.,
            Johnson,J., Zhang,H., Sulzer,D., Copenhagen,D.R.,
            Storm-Mathisen,J., Reimer,R.J., Chaudhry,F.A. and Edwards,R.H.
  TITLE     The identification of vesicular glutamate transporter 3 suggests
            novel modes of signaling by glutamate
  JOURNAL   Proc Natl Acad Sci U S A 99 (22), 14488-14493 (2002)
   PUBMED   12388773
  REMARK    GeneRIF: dendritic expression of VGLUT3 by particular neurons also
            indicates the potential for retrograde synaptic signaling
REFERENCE   10 (bases 1 to 4690)
  AUTHORS   Gras,C., Herzog,E., Bellenchi,G.C., Bernard,V., Ravassard,P.,
            Pohl,M., Gasnier,B., Giros,B. and El Mestikawy,S.
  TITLE     A third vesicular glutamate transporter expressed by cholinergic
            and serotoninergic neurons
  JOURNAL   J Neurosci 22 (13), 5442-5451 (2002)
   PUBMED   12097496
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 24, 2020 this sequence version replaced NM_153725.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ491795.1, AY117026.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-701               JAXUCZ010000007.1  25934710-25935410   c
            702-954             JAXUCZ010000007.1  25918828-25919080   c
            955-1073            JAXUCZ010000007.1  25912015-25912133   c
            1074-1188           JAXUCZ010000007.1  25909419-25909533   c
            1189-1276           JAXUCZ010000007.1  25908228-25908315   c
            1277-1363           JAXUCZ010000007.1  25900879-25900965   c
            1364-1503           JAXUCZ010000007.1  25900064-25900203   c
            1504-1653           JAXUCZ010000007.1  25899211-25899360   c
            1654-1786           JAXUCZ010000007.1  25897535-25897667   c
            1787-1897           JAXUCZ010000007.1  25889679-25889789   c
            1898-2025           JAXUCZ010000007.1  25885136-25885263   c
            2026-4690           JAXUCZ010000007.1  25881557-25884221   c
FEATURES             Location/Qualifiers
     source          1..4690
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..4690
                     /gene="Slc17a8"
                     /gene_synonym="Vglut3"
                     /note="solute carrier family 17 member 8"
                     /db_xref="GeneID:266767"
                     /db_xref="RGD:628870"
     exon            1..701
                     /gene="Slc17a8"
                     /gene_synonym="Vglut3"
                     /inference="alignment:Splign:2.1.0"
     CDS             601..2367
                     /gene="Slc17a8"
                     /gene_synonym="Vglut3"
                     /note="solute carrier family 17 (sodium-dependent
                     inorganic phosphate cotransporter), member 8; solute
                     carrier family 17 (vesicular glutamate transporter),
                     member 8"
                     /codon_start=1
                     /product="vesicular glutamate transporter 3"
                     /protein_id="NP_714947.1"
                     /db_xref="GeneID:266767"
                     /db_xref="RGD:628870"
                     /translation="MPFNAFDTFKEKILKPGKEGVKNAVGDSLGILQRKLDGTNEEGD
                     AIELSEEGRPVQTSRARAPVCDCSCCGIPKRYIIAVMSGLGFCISFGIRCNLGVAIVE
                     MVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVF
                     GAAIFLTSTLNMFIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSR
                     LATTSFCGSYAGAVVAMPLAGVLVQYIGWASVFYIYGMFGIIWYMFWLLQAYECPAVH
                     PTISNEERTYIETSIGEGANLASLSKFNTPWRRFFTSLPVYAIIVANFCRSWTFYLLL
                     ISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTTTAVRKIM
                     NCGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILM
                     GISNGVGTLSGMVCPLIVGAMTKHKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQD
                     WADPENLSEEKCGIIDQDELAEETELNHEAFVSPRKKMSYGATTQNCEVQKTDRRQQR
                     ESAFEGEEPLSYQNEEDFSETS"
     exon            702..954
                     /gene="Slc17a8"
                     /gene_synonym="Vglut3"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1073
                     /gene="Slc17a8"
                     /gene_synonym="Vglut3"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1188
                     /gene="Slc17a8"
                     /gene_synonym="Vglut3"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1276
                     /gene="Slc17a8"
                     /gene_synonym="Vglut3"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1363
                     /gene="Slc17a8"
                     /gene_synonym="Vglut3"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1503
                     /gene="Slc17a8"
                     /gene_synonym="Vglut3"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1653
                     /gene="Slc17a8"
                     /gene_synonym="Vglut3"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1786
                     /gene="Slc17a8"
                     /gene_synonym="Vglut3"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1897
                     /gene="Slc17a8"
                     /gene_synonym="Vglut3"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2025
                     /gene="Slc17a8"
                     /gene_synonym="Vglut3"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..4690
                     /gene="Slc17a8"
                     /gene_synonym="Vglut3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaaaagcag gagacttgta aatgtttcat aaacttcact ctgggctccg gccctggctg
       61 ggagcccatt cataagccca ggctgcagag gggcaggtgt tcttggtttc tatagcatcg
      121 ccccagggag aagctgacag cgccacctgc aagctgaagg aagcaggagg ggccagggct
      181 ggcttcagaa actgctgctg gtctcaggac ccctcataca ctggagctca ctttagcttc
      241 tccagccggc cacagccagg gatacaggct gtgctcagtc tgagcgtggc tgcccgagac
      301 agctgtcaca ggctgctgct cagccggtag cttttgcaag ggactggatt cctagccagc
      361 aattcctcaa ccagctttgt tgactctgaa tcgagaggag agggtttttc tcttcttaga
      421 acatccgagc tggggttccc ctcctttctg attttaagta gttccctcca tgagaactaa
      481 atttcaagtg ttcctcaagg gcaaacgcag cgcccctggg ctggaggttc gagaggatga
      541 cagcttctga ggtcgcctgc taagggctct gaggtgcctc tcctattgcc cccattcaaa
      601 atgccattta acgcatttga taccttcaaa gaaaaaattt tgaaacccgg gaaggaagga
      661 gtgaagaatg ccgtgggaga ttcgctgggg atcttacaaa gaaaactcga tgggaccaac
      721 gaggagggag atgccattga gctgagtgag gaaggaaggc ctgtgcagac atccagagcc
      781 cgagcccctg tgtgcgactg cagctgctgt ggcatcccca agcggtacat catcgctgtc
      841 atgagtggcc tgggattctg catttccttt gggattcggt gcaaccttgg agtggccatt
      901 gtggaaatgg tcaacaatag cactgtgtat gtggatggga aaccggaaat ccagacagca
      961 cagtttaact gggatccaga gacggtgggt cttatccatg gatctttttt ctggggttat
     1021 attgtgacac aaattcccgg tggcttcatt tcaaacaagt ttgctgctaa cagggtcttt
     1081 ggagctgcca tcttcttgac gtcaaccctg aacatgttca tcccttccgc ggccagggtg
     1141 cattacggct gtgtcatgtg tgtgaggatt ttgcagggtc tggtggaggg tgtgacctac
     1201 ccagcctgcc acgggatgtg gagtaagtgg gcacctcccc tggagagaag tcgtctagcc
     1261 acaacctctt tttgtggttc ctatgccggg gcagtcgttg ctatgcccct tgcaggagta
     1321 ttggtgcagt acattggctg ggcctctgtc ttttatattt acgggatgtt tggaattatt
     1381 tggtacatgt tttggctgct gcaggcttat gagtgtccag cagttcaccc aacaatatcc
     1441 aatgaagaac ggacctacat agagacaagt ataggagaag gcgccaactt ggccagtctg
     1501 agcaaattca acacaccatg gagaaggttt ttcacatcct tgcctgtcta tgccattatt
     1561 gtggcaaact tttgtagaag ctggaccttc tatttgctct taataagtca gcctgcttac
     1621 tttgaagagg tctttgggtt tgcaataagt aaggtgggtc tcttgtcagc tgtcccacac
     1681 atggtgatga caatcgtggt acccattgga ggacaactgg ctgattattt aagaagccga
     1741 aagattttga ccacaactgc tgtcagaaag atcatgaatt gtggaggctt tggcatggag
     1801 gcaaccttgc tcctggtggt tgggttttcc cataccaaag gagtggctat ctccttcctg
     1861 gtgcttgctg taggatttag tggctttgca atttcaggtt tcaatgtcaa ccacctggac
     1921 attgctccac gatatgccag catcctcatg gggatctcaa atggcgtggg aaccctctct
     1981 ggaatggttt gtcccctcat tgttggtgca atgaccaagc acaagacccg ggaagaatgg
     2041 cagaatgtgt tcctcatagc agccctggtg cactacagtg gagtcatctt ctacggggtc
     2101 tttgcttctg gggaaaaaca ggactgggct gatccagaga atctctctga ggagaaatgt
     2161 ggaatcattg accaagatga attagccgag gaaacagaac tcaaccacga ggctttcgta
     2221 agtcccagaa agaagatgtc ttatggagcc accacccaga attgtgaggt ccagaagacg
     2281 gatcggagac aacagagaga atccgccttc gagggggagg agccattatc ctaccagaat
     2341 gaagaggact tttcagaaac atcttaacgt gcatcttccc ctcagcttac aaccagaagt
     2401 ctccacaccc attgcttttc ccataccttg gccttccagg gggccaaatc acaggaaagg
     2461 gggagactaa atcaacaaca gagaagaaaa atgccttctt acaaagatgg gcgtatggat
     2521 cttggtctca gttaattaga tagttgatca tatttttttg ggggggggca attgggcatt
     2581 ggctgttgag ccttctctca aaagaacaat ttattcagga agaaatggct agaagaataa
     2641 ggagtggctt gttgctcaaa taaacactga agaaatccct ctttggtctg gagaagagta
     2701 catggtggtt gccaccccat ctccaaggat atccatgtag aggacaatct ctgcaaccta
     2761 atgaagggaa tcactcacgg gggcccttgg ttgtgccagg tgctttatga acattcttat
     2821 ttaactccca caccctaata tagttattgt acccatttta caactaagaa cattaaatga
     2881 ctaggttggc ccacccaagg ttgtcctctc agagccaaag ctgagactgg cagatgacca
     2941 ggagttttag gaaggaagga aggaaggaag gaaggaagga aggaaggaag gaagaaggaa
     3001 ggaaggaagg gttcagttga gtgtagggtc attttcaatg acaaatacaa aaactgaaat
     3061 cagttggttt gtgggtaatt ccatgtttgg tcaagggtgt gtgcatgcaa acgtgtatgt
     3121 gcgtgtgtgt gtgtttgtgt gtttgtgtgt atgtgtgtgt aactatttag actagtgtgg
     3181 cagagggaat tcaaatatat gaaattctag aatcaaagac ccttaaggta ctatattatc
     3241 tgttggacca aacaatttgg taaattgatg ggaatttttt tcttcaaaag tcacagacta
     3301 gtgaaacaca taaaactcag gctccaggaa tggttgaaaa taagtatatg aaagattggt
     3361 cattaattta aaccctctac agcatcagga aattggttaa gtaatgtctc aagtcgacta
     3421 taagccccta agatatttaa taaccaaagg agcaggtcca ggggagacta tttgggtaat
     3481 agtctcttga aagaattttg ttcaaacaaa agtgtgccac cagctttctt ggaaagtgtg
     3541 gtcagatgat ataaaactat gcccaaaaga ttcataatga ctctgtctgt aatgttcata
     3601 gaaaacaaaa gcataacagc aggtttatag agaaatactg cagtcaaaat atccgaaaga
     3661 agctataatt agtattgaag aattcatctg tgatcatgta gggcaataac atggatacta
     3721 catgggtact ctctaaatac atttaaaagg taatgttagc atgtaagcac atattagaaa
     3781 ataaaattat tttcctgctc cttagttttg aaaattttat ttatatgtta aggaggaaaa
     3841 tttaatatga tgatgaaata aagatttatt tgcataatat ttattttcta ggtttttcca
     3901 ttttatttta tttctggacc cttgctatac tcaaggagtt ataatacact ttatagaaag
     3961 actaaccagg gatggagaga tggctcagtg gttaagaacc ctgcctattc ttccagaggt
     4021 cctgggttca attcccagca accacgtggt agctcacaac catctgtaat aggatccatg
     4081 ccctcttctg gtgtgtctga agacaggtac agtgtactca tataaataaa gtaaaattta
     4141 aaaaaagaga gactttaaaa aataaataaa ataaaaagac atcatagatt ttaaaaagga
     4201 agagcggtct tcccactgaa tgatattctt tatatcattt gtagatgctt tgtgttatca
     4261 gatgcggtta aatcccccta ttgtgtgaat ccatgtaagt cccctagagc agttttgagc
     4321 ataaagaagc cctcaagaaa tagatgccac atcagcattg tccttaactc ctgtgtgact
     4381 atgtcatctg tgaagaaaga gtgtcatgtc atttcatgca ttggccacag agtttattat
     4441 ggaaattgta cttgttttct tagtaaaaaa aaattaggaa aaaatagtgc ttatttcttt
     4501 gtgtgttaat aaggcataat aattataagt atgaaaaaca cctcatgacg accatgaagg
     4561 taatgcagat tatgacacaa tctattgttc gcgttgactt catgcagaaa taccacactt
     4621 tgcttttcac ttgcgtgtac gattgttttt aatggtgggc tgatcgtggc attaaacgct
     4681 gtaaagcatg
//
