LOCUS       NM_053859               2899 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus solute carrier family 17 member 7 (Slc17a7),
            mRNA.
ACCESSION   NM_053859
VERSION     NM_053859.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2899)
  AUTHORS   Vrettou,M., Yan,L., Nilsson,K.W., Wallen-Mackenzie,A., Nylander,I.
            and Comasco,E.
  TITLE     DNA methylation of Vesicular Glutamate Transporters in the
            mesocorticolimbic brain following early-life stress and adult
            ethanol exposure-an explorative study
  JOURNAL   Sci Rep 11 (1), 15322 (2021)
   PUBMED   34321562
  REMARK    GeneRIF: DNA methylation of Vesicular Glutamate Transporters in the
            mesocorticolimbic brain following early-life stress and adult
            ethanol exposure-an explorative study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2899)
  AUTHORS   Cheret,C., Ganzella,M., Preobraschenski,J., Jahn,R. and
            Ahnert-Hilger,G.
  TITLE     Vesicular Glutamate Transporters (SLCA17 A6, 7, 8) Control Synaptic
            Phosphate Levels
  JOURNAL   Cell Rep 34 (2), 108623 (2021)
   PUBMED   33440152
REFERENCE   3  (bases 1 to 2899)
  AUTHORS   Li,Z.H., Zhang,C.K., Qiao,Y., Ge,S.N., Zhang,T. and Li,J.L.
  TITLE     Coexpression of VGLUT1 and VGLUT2 in precerebellar neurons in the
            lateral reticular nucleus of the rat
  JOURNAL   Brain Res Bull 162, 94-106 (2020)
   PUBMED   32562720
  REMARK    GeneRIF: Coexpression of VGLUT1 and VGLUT2 in precerebellar neurons
            in the lateral reticular nucleus of the rat.
REFERENCE   4  (bases 1 to 2899)
  AUTHORS   Ortiz-Perez,A., Limon-Morales,O., Rojas-Castaneda,J.C., Cerbon,M.
            and Picazo,O.
  TITLE     Prolactin prevents the kainic acid-induced neuronal loss in the rat
            hippocampus by inducing prolactin receptor and putatively
            increasing the VGLUT1 overexpression
  JOURNAL   Neurosci Lett 694, 116-123 (2019)
   PUBMED   30500398
  REMARK    GeneRIF: Study indicates that chronic prolactin administration
            before kainic acid induced damage induces hippocampal
            neuroprotection associated with prolactin receptor and VGLUT1
            overexpression.
REFERENCE   5  (bases 1 to 2899)
  AUTHORS   Zhang,C.K., Li,Z.H., Qiao,Y., Zhang,T., Lu,Y.C., Chen,T.,
            Dong,Y.L., Li,Y.Q. and Li,J.L.
  TITLE     VGLUT1 or VGLUT2 mRNA-positive neurons in spinal trigeminal nucleus
            provide collateral projections to both the thalamus and the
            parabrachial nucleus in rats
  JOURNAL   Mol Brain 11 (1), 22 (2018)
   PUBMED   29650024
  REMARK    GeneRIF: dual retrograde tract tracing was used in combination with
            fluorescence in situ hybridization (FISH) for VGLUT1 or VGLUT2 mRNA
            to identify the existence of VGLUT1 or VGLUT2 mRNA neurons that
            send collateral projections to both the thalamus and the
            parabrachial nucleus.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2899)
  AUTHORS   Montana,V., Ni,Y., Sunjara,V., Hua,X. and Parpura,V.
  TITLE     Vesicular glutamate transporter-dependent glutamate release from
            astrocytes
  JOURNAL   J Neurosci 24 (11), 2633-2642 (2004)
   PUBMED   15028755
  REMARK    GeneRIF: data indicate that VGLUTs play a functional role in
            exocytotic glutamate release from astrocytes
REFERENCE   7  (bases 1 to 2899)
  AUTHORS   Gleason,K.K., Dondeti,V.R., Hsia,H.L., Cochran,E.R.,
            Gumulak-Smith,J. and Saha,M.S.
  TITLE     The vesicular glutamate transporter 1 (xVGlut1) is expressed in
            discrete regions of the developing Xenopus laevis nervous system
  JOURNAL   Gene Expr Patterns 3 (4), 503-507 (2003)
   PUBMED   12915319
REFERENCE   8  (bases 1 to 2899)
  AUTHORS   Bellocchio,E.E., Reimer,R.J., Fremeau,R.T. Jr. and Edwards,R.H.
  TITLE     Uptake of glutamate into synaptic vesicles by an inorganic
            phosphate transporter
  JOURNAL   Science 289 (5481), 957-960 (2000)
   PUBMED   10938000
REFERENCE   9  (bases 1 to 2899)
  AUTHORS   Aihara,Y., Mashima,H., Onda,H., Hisano,S., Kasuya,H., Hori,T.,
            Yamada,S., Tomura,H., Yamada,Y., Inoue,I., Kojima,I. and Takeda,J.
  TITLE     Molecular cloning of a novel brain-type Na(+)-dependent inorganic
            phosphate cotransporter
  JOURNAL   J Neurochem 74 (6), 2622-2625 (2000)
   PUBMED   10820226
REFERENCE   10 (bases 1 to 2899)
  AUTHORS   Ni,B., Rosteck,P.R. Jr., Nadi,N.S. and Paul,S.M.
  TITLE     Cloning and expression of a cDNA encoding a brain-specific
            Na(+)-dependent inorganic phosphate cotransporter
  JOURNAL   Proc Natl Acad Sci U S A 91 (12), 5607-5611 (1994)
   PUBMED   8202535
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000033.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_053859.5.
            
            On Feb 10, 2021 this sequence version replaced NM_053859.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ211811.1, U07609.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               JACYVU010000033.1  19526699-19526893
            196-448             JACYVU010000033.1  19531477-19531729
            449-567             JACYVU010000033.1  19532583-19532701
            568-682             JACYVU010000033.1  19532974-19533088
            683-770             JACYVU010000033.1  19533165-19533252
            771-857             JACYVU010000033.1  19533394-19533480
            858-1000            JACYVU010000033.1  19533576-19533718
            1001-1150           JACYVU010000033.1  19534508-19534657
            1151-1283           JACYVU010000033.1  19534784-19534916
            1284-1394           JACYVU010000033.1  19535591-19535701
            1395-1522           JACYVU010000033.1  19536065-19536192
            1523-2899           JACYVU010000033.1  19537169-19538545
FEATURES             Location/Qualifiers
     source          1..2899
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2899
                     /gene="Slc17a7"
                     /gene_synonym="BNPI; Vglut1"
                     /note="solute carrier family 17 member 7"
                     /db_xref="GeneID:116638"
                     /db_xref="RGD:620101"
     exon            1..195
                     /gene="Slc17a7"
                     /gene_synonym="BNPI; Vglut1"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1816
                     /gene="Slc17a7"
                     /gene_synonym="BNPI; Vglut1"
                     /note="brain-specific Na(+)-dependent inorganic phosphate
                     cotransporter; brain-specific Na-dependent inorganic
                     phosphate cotransporter; solute carrier family 17
                     (sodium-dependent inorganic phosphate cotransporter),
                     member 7; solute carrier family 17 (vesicular glutamate
                     transporter), member 7"
                     /codon_start=1
                     /product="vesicular glutamate transporter 1"
                     /protein_id="NP_446311.1"
                     /db_xref="GeneID:116638"
                     /db_xref="RGD:620101"
                     /translation="MEFRQEEFRKLAGRALGRLHRLLEKRQEGAETLELSADGRPVTT
                     HTRDPPVVDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVSMVNNSTTHRGGHV
                     VVQKAQFNWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLNML
                     IPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGA
                     VVAMPLAGVLVQYSGWSSVFYVYGSFGIFWYLFWLLVSYESPALHPSISEEERKYIED
                     AIGESAKLMNPVTKFNTPWRRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFG
                     FEISKVGLVSALPHLVMTIIVPIGGQIADFLRSRHIMSTTNVRKLMNCGGFGMEATLL
                     LVVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGM
                     VCPIIVGAMTKHKTREEWQYVFLIASLVHYGGVIFYGVFASGEKQPWAEPEEMSEEKC
                     GFVGHDQLAGSDESEMEDEVEPPGAPPAPPPSYGATHSTVQPPRPPPPVRDY"
     exon            196..448
                     /gene="Slc17a7"
                     /gene_synonym="BNPI; Vglut1"
                     /inference="alignment:Splign:2.1.0"
     exon            449..567
                     /gene="Slc17a7"
                     /gene_synonym="BNPI; Vglut1"
                     /inference="alignment:Splign:2.1.0"
     exon            568..682
                     /gene="Slc17a7"
                     /gene_synonym="BNPI; Vglut1"
                     /inference="alignment:Splign:2.1.0"
     exon            683..770
                     /gene="Slc17a7"
                     /gene_synonym="BNPI; Vglut1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..857
                     /gene="Slc17a7"
                     /gene_synonym="BNPI; Vglut1"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1000
                     /gene="Slc17a7"
                     /gene_synonym="BNPI; Vglut1"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1150
                     /gene="Slc17a7"
                     /gene_synonym="BNPI; Vglut1"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1283
                     /gene="Slc17a7"
                     /gene_synonym="BNPI; Vglut1"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1394
                     /gene="Slc17a7"
                     /gene_synonym="BNPI; Vglut1"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1522
                     /gene="Slc17a7"
                     /gene_synonym="BNPI; Vglut1"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..2899
                     /gene="Slc17a7"
                     /gene_synonym="BNPI; Vglut1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcgcagcc tggttccccc cgagcggagc tgcggggccg ggccgggccg gggcggaccc
       61 cgggatcccg gacgcggccg cccgggcccg cgggcggggg gattggcagg ggacccgcgt
      121 gggcacagcc accatggagt tccggcagga ggagtttcgg aagctggcgg ggcgcgccct
      181 ggggaggctg caccggttac tggagaagcg gcaggaaggc gcggagacat tggagctgag
      241 cgccgacggg cgcccagtga ccacacacac gcgggacccg ccggtggtgg actgcacttg
      301 ctttggcctc cctcgccgct acatcatcgc gatcatgagc ggtctgggtt tctgcatcag
      361 ctttggcatc cgctgcaacc tgggcgtggc catcgtatcc atggtcaaca acagtacaac
      421 ccaccgtggg ggccacgtgg tggtgcagaa agcccagttc aactgggatc cagagactgt
      481 cggcctcata catggctcct ttttctgggg gtacattgtc actcagattc ctggaggatt
      541 tatctgccaa aaattcgcag ccaacagggt ctttggcttt gccattgtgg ctacctccac
      601 cctaaatatg ttgatccctt cagcagcccg tgttcactat ggctgtgtca tcttcgtgag
      661 gatccttcag ggattggtgg agggggtcac ataccctgct tgccatggca tctggagcaa
      721 atgggcccct cccttagaac ggagtcggct ggcgacgaca gccttttgcg gttcctatgc
      781 cggggcagtg gttgccatgc ctctggctgg ggtcctggta cagtattcag gatggagttc
      841 tgtcttctat gtctatggca gcttcgggat cttttggtac ctgttctggt tgcttgtctc
      901 ctacgagtca cctgcactac accccagcat ctccgaggag gagcgcaaat acattgagga
      961 tgccatcgga gaaagcgcca agctcatgaa ccctgttacg aagtttaaca caccctggag
     1021 gcgcttcttt acctccatgc cggtctatgc catcattgtc gccaactttt gccgcagctg
     1081 gactttctac ctgctcctca tctcccagcc cgcctacttt gaagaagtgt tcggctttga
     1141 gatcagcaag gtgggactgg tgtcggcact gcctcacctt gtcatgacta tcatcgtacc
     1201 catcggaggc cagatcgccg acttcctgcg cagtcgtcat ataatgtcca cgaccaatgt
     1261 gcgaaagctg atgaactgcg ggggtttcgg gatggaagct acgctgctgc tggtggtcgg
     1321 atactcacac tccaagggcg tggccatctc cttcctggtc ctggctgtgg gcttcagtgg
     1381 ctttgctatc tctgggttta acgtgaacca cttggacatc gcccctcgat atgccagcat
     1441 cttgatgggc atttccaatg gcgtgggcac actgtctggg atggtgtgcc ccatcatcgt
     1501 gggtgcaatg accaagcaca agacgcggga ggagtggcag tacgtgttcc tcatagcctc
     1561 cctggtgcac tatggaggtg tcatcttcta tggggtcttt gcttcgggag agaaacagcc
     1621 gtgggcagag ccggaggaga tgagcgagga gaagtgtggc tttgttggcc acgaccagct
     1681 ggctggcagt gacgaaagtg aaatggaaga cgaggttgag cccccggggg caccccccgc
     1741 acctccgcct tcctacgggg ccacacacag cacagttcag cctccaaggc ccccaccccc
     1801 tgtccgggac tactgaccac gtgcctccca ctggtgggca gtttccagga cctccactcg
     1861 atacacctct agcctaaacg gcagtgtcga ggaaccccac tcctctcctg cctcaggctt
     1921 aagatgcaag tcttcccttg tgcccagtgc tgtccgacca gccctctctc cttctcaact
     1981 gcctcttgca ggggtgaagc tgcacactag cagtttcaag gatacccaaa cacccctgag
     2041 agttgttctc cccttgttcc gcctgtgtgg tttgaaatct cccctttcag ggctttattt
     2101 ggatggacag ttcaacctct ttcttgtggt tttgaggttt cacccccttt tcccaagacc
     2161 ccagggattc tcaggctacc ccgagattat tcaggtggtc cccaactcag aaaaattcat
     2221 ggtcgtcctc tatgagttcc aaggctcgcc taaccattct gcattttcca agttggttca
     2281 accaaccatc aacgccgcca ttcccaggac tgattctcac cagcgtttct gagggaaaat
     2341 ggcggtttca agtccccccc cccccccagt cttttctttt ctcatcccct caccagcaca
     2401 ctttgccggg ccttgtcctt agcttagtac aatcaatgtc cagggaaatg gtcgaaatgg
     2461 ctctgctcac cctgtgctct ttttctgact cagttttcag gtctaaatag tggctgctca
     2521 aagctattaa ttcagtggct ctaggccacc tcttcctccc tgtggtggtt tcaggatctc
     2581 cctttcttcc ccaaacccgt gcactttatt ctcctgggtg gctttagact gccctcggtt
     2641 tctcagtggc catttgttgt gtccctcagg ggctaaatga ttccaaatct ggggtgcttc
     2701 ccttcacaga cacccctttt tcaacgtaga aatctgggga gggggggtat gtgagagaag
     2761 ttacagaatc ccaggaaagg gagcggggct gggagtagag ggttgttcct ggggcagggt
     2821 tgtgtcttgg tgtctgtctc tgtgaccgta aatcctgccc tgccccaccc cactcccaat
     2881 aaatgctttg gtgtacaga
//
