LOCUS       NM_053427               3982 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus solute carrier family 17 member 6 (Slc17a6),
            mRNA.
ACCESSION   NM_053427
VERSION     NM_053427.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3982)
  AUTHORS   Anfimova,P.A., Pankrasheva,L.G., Emanuilov,A.I., Moiseev,K.Y. and
            Maslyukov,P.M.
  TITLE     Expression of GAD65/67 and VGLUT2 in Mediobasal Nuclei of Rat
            Hypothalamus during Aging
  JOURNAL   Bull Exp Biol Med 176 (2), 232-234 (2023)
   PUBMED   38194067
  REMARK    GeneRIF: Expression of GAD65/67 and VGLUT2 in Mediobasal Nuclei of
            Rat Hypothalamus during Aging.
REFERENCE   2  (bases 1 to 3982)
  AUTHORS   Reyes-Mendez,M.E., Herrera-Zamora,J.M., Osuna-Lopez,F.,
            Aguilar-Martinez,I.S., Gongora-Alfaro,J.L., Navarro-Polanco,R.A.,
            Sanchez-Pastor,E., Moreno-Galindo,E.G. and Alamilla,J.
  TITLE     Developmental light deprivation transiently reduces the expression
            of vGluT2 and GluN2B in the rat ventral suprachiasmatic nucleus
  JOURNAL   Synapse 77 (1), e22250 (2023)
   PUBMED   36085433
  REMARK    GeneRIF: Developmental light deprivation transiently reduces the
            expression of vGluT2 and GluN2B in the rat ventral suprachiasmatic
            nucleus.
REFERENCE   3  (bases 1 to 3982)
  AUTHORS   Zhang,J., Da,Y., Lu,J., Sun,Y., Wang,H., Wang,K., Wang,W., Qin,L.
            and Jia,J.
  TITLE     Changes in vesicular glutamate transporter 2 (Vglut2) and vesicular
            GABA transporter 1 (Vgat1) in the orofacial pain and temperature
            perception pathway under low estrogen conditions
  JOURNAL   Neuro Endocrinol Lett 43 (2), 88-98 (2022)
   PUBMED   35933616
  REMARK    GeneRIF: Changes in vesicular glutamate transporter 2 (Vglut2) and
            vesicular GABA transporter 1 (Vgat1) in the orofacial pain and
            temperature perception pathway under low estrogen conditions.
REFERENCE   4  (bases 1 to 3982)
  AUTHORS   Vrettou,M., Yan,L., Nilsson,K.W., Wallen-Mackenzie,A., Nylander,I.
            and Comasco,E.
  TITLE     DNA methylation of Vesicular Glutamate Transporters in the
            mesocorticolimbic brain following early-life stress and adult
            ethanol exposure-an explorative study
  JOURNAL   Sci Rep 11 (1), 15322 (2021)
   PUBMED   34321562
  REMARK    GeneRIF: DNA methylation of Vesicular Glutamate Transporters in the
            mesocorticolimbic brain following early-life stress and adult
            ethanol exposure-an explorative study.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3982)
  AUTHORS   Yokoyama,T., Yamamoto,Y., Hirakawa,M. and Saino,T.
  TITLE     GluN2A- and GluN2B-immunoreactive type I cells attached to
            vesicular glutamate transporter 2-immunoreactive afferent nerve
            terminals of the rat carotid body
  JOURNAL   Histochem Cell Biol 155 (6), 719-726 (2021)
   PUBMED   33550485
  REMARK    GeneRIF: GluN2A- and GluN2B-immunoreactive type I cells attached to
            vesicular glutamate transporter 2-immunoreactive afferent nerve
            terminals of the rat carotid body.
REFERENCE   6  (bases 1 to 3982)
  AUTHORS   Hayashi,M., Otsuka,M., Morimoto,R., Hirota,S., Yatsushiro,S.,
            Takeda,J., Yamamoto,A. and Moriyama,Y.
  TITLE     Differentiation-associated Na+-dependent inorganic phosphate
            cotransporter (DNPI) is a vesicular glutamate transporter in
            endocrine glutamatergic systems
  JOURNAL   J Biol Chem 276 (46), 43400-43406 (2001)
   PUBMED   11551935
REFERENCE   7  (bases 1 to 3982)
  AUTHORS   Takamori,S., Rhee,J.S., Rosenmund,C. and Jahn,R.
  TITLE     Identification of differentiation-associated brain-specific
            phosphate transporter as a second vesicular glutamate transporter
            (VGLUT2)
  JOURNAL   J Neurosci 21 (22), RC182 (2001)
   PUBMED   11698620
REFERENCE   8  (bases 1 to 3982)
  AUTHORS   Herzog,E., Bellenchi,G.C., Gras,C., Bernard,V., Ravassard,P.,
            Bedet,C., Gasnier,B., Giros,B. and El Mestikawy,S.
  TITLE     The existence of a second vesicular glutamate transporter specifies
            subpopulations of glutamatergic neurons
  JOURNAL   J Neurosci 21 (22), RC181 (2001)
   PUBMED   11698619
REFERENCE   9  (bases 1 to 3982)
  AUTHORS   Bai,L., Xu,H., Collins,J.F. and Ghishan,F.K.
  TITLE     Molecular and functional analysis of a novel neuronal vesicular
            glutamate transporter
  JOURNAL   J Biol Chem 276 (39), 36764-36769 (2001)
   PUBMED   11432869
REFERENCE   10 (bases 1 to 3982)
  AUTHORS   Fremeau,R.T. Jr., Troyer,M.D., Pahner,I., Nygaard,G.O., Tran,C.H.,
            Reimer,R.J., Bellocchio,E.E., Fortin,D., Storm-Mathisen,J. and
            Edwards,R.H.
  TITLE     The expression of vesicular glutamate transporters defines two
            classes of excitatory synapse
  JOURNAL   Neuron 31 (2), 247-260 (2001)
   PUBMED   11502256
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF271235.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF271235.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN12840105
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3982
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..3982
                     /gene="Slc17a6"
                     /gene_synonym="Dnpi; Vglut2"
                     /note="solute carrier family 17 member 6"
                     /db_xref="GeneID:84487"
                     /db_xref="RGD:620531"
     exon            1..548
                     /gene="Slc17a6"
                     /gene_synonym="Dnpi; Vglut2"
                     /inference="alignment:Splign:2.1.0"
     CDS             463..2211
                     /gene="Slc17a6"
                     /gene_synonym="Dnpi; Vglut2"
                     /note="differentiation-associated BNPI;
                     differentiation-associated Na(+)-dependent inorganic
                     phosphate cotransporter; differentation-associated
                     Na-dependent inorganic phosphate cotransporter; solute
                     carrier family 17 (sodium-dependent inorganic phosphate
                     cotransporter), member 6; solute carrier family 17
                     (vesicular glutamate transporter), member 6"
                     /codon_start=1
                     /product="vesicular glutamate transporter 2"
                     /protein_id="NP_445879.1"
                     /db_xref="GeneID:84487"
                     /db_xref="RGD:620531"
                     /translation="MESVKQRILAPGKEGIKNFAGKSLGQIYRVLEKKQDNRETIELT
                     EDGKPLEVPEKKAPLCDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNS
                     TIHRGGKVIKEKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAIL
                     LTSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTS
                     FCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITD
                     EERRYIEESIGESANLLGAMEKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQP
                     AYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVRKIMNCGG
                     FGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISN
                     GVGTLSGMVCPIIVGAMTKNKSREEWQYVFLIAALVHYGGVIFYALFASGEKQPWADP
                     EETSEEKCGFIHEDELDEETGDITQNYINYGTTKSYGATSQENGGWPNGWEKKEEFVQ
                     ESAQDAYSYKDRDDYS"
     exon            549..801
                     /gene="Slc17a6"
                     /gene_synonym="Dnpi; Vglut2"
                     /inference="alignment:Splign:2.1.0"
     exon            802..920
                     /gene="Slc17a6"
                     /gene_synonym="Dnpi; Vglut2"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1035
                     /gene="Slc17a6"
                     /gene_synonym="Dnpi; Vglut2"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1123
                     /gene="Slc17a6"
                     /gene_synonym="Dnpi; Vglut2"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1210
                     /gene="Slc17a6"
                     /gene_synonym="Dnpi; Vglut2"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1353
                     /gene="Slc17a6"
                     /gene_synonym="Dnpi; Vglut2"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1503
                     /gene="Slc17a6"
                     /gene_synonym="Dnpi; Vglut2"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1636
                     /gene="Slc17a6"
                     /gene_synonym="Dnpi; Vglut2"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1747
                     /gene="Slc17a6"
                     /gene_synonym="Dnpi; Vglut2"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1875
                     /gene="Slc17a6"
                     /gene_synonym="Dnpi; Vglut2"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..3970
                     /gene="Slc17a6"
                     /gene_synonym="Dnpi; Vglut2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacagtaag gttcttttgc ttttttccct tacacaagga ttcgatgacg tttttggtca
       61 atctgattaa aagacagcgg atttggttgc gttaagactt caaaaccggg aatttacgtt
      121 gtttttcggt gaggtgactt ccagaacggg gactcatcag cacccgccca aataccacgg
      181 cactgcgcgc gccctcggcc accggatcct ccccttccaa tgagactttg tgactgtgtg
      241 taccaattct cctattagga aacccgtggg ctgaatgcag ctattccgtt gtactctctt
      301 tctcgctctc cctcccctct ccaactcaca gccttgctga aaagctcatc tctgctgaga
      361 agaaaacgtt ctaccttaac ctattaagac tatgcgcaga actcgccttt catagccatc
      421 acaatttaaa tctggtaagg ctggacacga gtctttacaa gaatggagtc ggtaaaacaa
      481 aggattttgg ccccggggaa agaggggata aagaattttg ctggaaaatc cctcggacag
      541 atctacaggg tgctggagaa gaagcaggat aaccgagaga ccatcgagct gacagaggac
      601 ggcaagcccc tggaggtgcc tgagaagaag gctccgctat gcgactgtac gtgcttcggc
      661 ctgccgcgcc gctacatcat agccatcatg agcggcctcg gcttctgcat ctcctttggt
      721 atccgctgta acctgggtgt ggccattgtg gacatggtca acaacagcac catccaccgg
      781 ggtggcaaag ttatcaagga gaaagccaag tttaactggg accccgagac tgtggggatg
      841 attcacgggt cgttcttctg gggctatatc atcacgcaga ttccgggcgg atacatcgca
      901 tcgcgactgg ctgctaaccg ggtctttggg gctgccatac tgcttacctc taccctcaat
      961 atgctgatcc catctgcagc cagagtgcat tatggatgcg tcatctttgt tagaatattg
     1021 caaggacttg tggagggcgt cacctaccca gcctgtcacg ggatatggag caagtgggcc
     1081 cctcctttgg agaggagtag gttggctacc acctccttct gtggttccta tgctggagca
     1141 gtcattgcaa tgcccctagc tggtatcctg gtgcagtaca ctggatggtc ttcagtattt
     1201 tacgtatatg gaagctttgg tatggtctgg tatatgttct ggcttctggt gtcttacgag
     1261 agccccgcaa agcatccaac cataacagac gaagaacgta ggtacataga agagagcatc
     1321 ggggagagcg caaatctgtt aggagcaatg gagaaattca agaccccatg gaggaagttt
     1381 ttcacatcca tgcccgtcta tgcgataatt gttgcaaact tctgcaggag ttggactttt
     1441 tatttactgc tcatcagtca accagcttat ttcgaggagg tttttggatt tgaaatcagc
     1501 aaggttggca tgttgtctgc ggtcccacac ctggtcatga caatcattgt gcctatcggg
     1561 gggcaaattg cagactttct aaggagcaag caaattcttt caacaactac agtgcgaaag
     1621 atcatgaact gcgggggttt tggcatggaa gccacactgc ttctggttgt tggctactct
     1681 catactagag gggtggccat ctccttcttg gtgcttgcag tgggattcag tggatttgct
     1741 atctctggtt tcaatgtgaa ccacttggat attgccccga gatatgccag tatcttaatg
     1801 ggcatttcaa atggtgttgg cacgctgtcg ggaatggtct gcccgatcat tgttggtgca
     1861 atgacgaaga acaagtcccg tgaagaatgg cagtatgtct tcctcatcgc tgcactggtc
     1921 cactatggtg gagtcatatt ttatgcacta tttgcctcag gagagaagca accttgggca
     1981 gaccctgagg aaacaagcga agaaaagtgt ggcttcattc atgaagatga actggatgaa
     2041 gaaacggggg acatcactca gaattacata aattacggta ccaccaaatc ctacggcgcc
     2101 acctcacagg agaacggagg ctggcctaac ggctgggaga aaaaggaaga atttgtgcaa
     2161 gaaagtgcgc aagacgcgta ctcctataag gaccgagatg attattcata acgaagctag
     2221 ttgctggatt cctttgtagt gtttgtgatt aaattaattg tgattgcaca aaatcatttt
     2281 aagaaatgtg gtgtaaacat gtaaacacat caaccaagca agtcttgctg ttcaaaaaat
     2341 aataataata tgaattcaaa acagaccgtg agagtcccat caagtgcaat ctgtggcggc
     2401 agtcacgtga cgccatttcc attcaggcca ttcgtccttt tcgtttgtga tttaaaggtt
     2461 tcctgtagaa ataagtaggt attcgttgga tccatcacca cgttagagag tacaactaca
     2521 acagttggca catgtcatcc tacggaagtt aggaagccaa agctactgga ttatgtgaac
     2581 tgcatttatt tatttattac actggactgc aaaatatccc agggaaatcc tgtctagaga
     2641 catagtagaa ctggaaagat ggctagattg ggtactgacg ataatcattg tgtgtatatc
     2701 atggagtggc tatatctttt aattggagaa ctatattgta tagctagcaa aattgtactg
     2761 aattattact aggagtgcac agtgtgtgat attttgtgat cttccaaaag cttatcttgc
     2821 agtgttttgt gaaacgcttg ggcacaaaca cttattttta tgaacaagag cttgtaaagg
     2881 gaggagtatg ctccatgctc tcccattcac tacctgacag tatcaaacct tcacatttca
     2941 atgaaatcca acgtccatgt aacatatcac atgacttttt ttgcaaaaaa gaatataaga
     3001 agaaatagac ttcaatgtat tttttattac aactttgtac tggttgtaac ttgcattagg
     3061 aaaaatgatt aatatatgta taatcgtaaa gaatctaata aaaatttact atgaagatat
     3121 agcccttaaa atgcaatatt aacaacaaaa atatatagaa aatttagata atcttccttg
     3181 ataactagag actatatgga actcacacca caaagctata tataatatga aaagataaac
     3241 aatagagatt gtatatgtag acgattttat gacctaatgt cccatttaag aggtatttgt
     3301 cttgagtata tagtacaaag tatattaaaa ttatatctac atccctgtat atcttataca
     3361 tatccactca cacaaacata acaaatactt ttcacacaga accaaaaaca agcatacacc
     3421 taatgttggg tttggggatt gcaatttcta ctttcataga gtcatagaat tttagatggg
     3481 aaaaaaaaag gcattttgct cgtcatttct taatataatt aattcaacag gaactgcaac
     3541 atttgtgtac caagcaataa gtgcgaagca taaacctgct gtgtgtaaac tatccccata
     3601 ctgcttgtgg tagcactgat ttctttcttt taaagaactt aacatcggag ctctttacaa
     3661 tgttttgcgc tgataagaat gcacatccca atttaacgca aagtgtcacc tggtgtgttt
     3721 acctgtctgt tttgggtatt tggtctgttt ggtgtcctgt gctcttgact ggaggccctg
     3781 ctactgcgaa tataaaacgt gaagtttgtt tctaaatgca aaccactcct gaccttaaga
     3841 aactaaagtc cctctctgct ttgtgtctcc aagtactatc atgtgaccat aacccttgct
     3901 gtgctgagta aaaagatgtg aactgtcatt ttgttgctgc gaagcaagtg ttaataaaat
     3961 gttctattta aaaaaaaaaa aa
//
