LOCUS       NM_001009713            2715 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 17 member 5 (Slc17a5),
            mRNA.
ACCESSION   NM_001009713 XM_343436
VERSION     NM_001009713.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2715)
  AUTHORS   Wang,B., Li,Z., Li,J., Shao,Q. and Qin,L.
  TITLE     Sialin mediates submandibular gland regeneration ability by
            affecting polysialic acid synthesis
  JOURNAL   Oral Dis 29 (5), 2096-2106 (2023)
   PUBMED   35593110
  REMARK    GeneRIF: Sialin mediates submandibular gland regeneration ability
            by affecting polysialic acid synthesis.
REFERENCE   2  (bases 1 to 2715)
  AUTHORS   Morland,C., Nordengen,K., Larsson,M., Prolo,L.M., Farzampour,Z.,
            Reimer,R.J. and Gundersen,V.
  TITLE     Vesicular uptake and exocytosis of L-aspartate is independent of
            sialin
  JOURNAL   FASEB J 27 (3), 1264-1274 (2013)
   PUBMED   23221336
  REMARK    GeneRIF: l-aspartate is exocytotically released from nerve
            terminals after vesicular accumulation by a transporter other than
            sialin.
REFERENCE   3  (bases 1 to 2715)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   4  (bases 1 to 2715)
  AUTHORS   Courville,P., Quick,M. and Reimer,R.J.
  TITLE     Structure-function studies of the SLC17 transporter sialin identify
            crucial residues and substrate-induced conformational changes
  JOURNAL   J Biol Chem 285 (25), 19316-19323 (2010)
   PUBMED   20424173
  REMARK    GeneRIF: analysis of crucial residues and substrate-induced
            conformational changes in SLC17 transporter sialin
REFERENCE   5  (bases 1 to 2715)
  AUTHORS   Miyaji,T., Echigo,N., Hiasa,M., Senoh,S., Omote,H. and Moriyama,Y.
  TITLE     Identification of a vesicular aspartate transporter
  JOURNAL   Proc Natl Acad Sci U S A 105 (33), 11720-11724 (2008)
   PUBMED   18695252
  REMARK    GeneRIF: sialin possesses dual physiological functions and acts as
            a vesicular aspartate/glutamate transporter
REFERENCE   6  (bases 1 to 2715)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   7  (bases 1 to 2715)
  AUTHORS   Wreden,C.C., Wlizla,M. and Reimer,R.J.
  TITLE     Varied mechanisms underlie the free sialic acid storage disorders
  JOURNAL   J Biol Chem 280 (2), 1408-1416 (2005)
   PUBMED   15516337
REFERENCE   8  (bases 1 to 2715)
  AUTHORS   Aula,N., Kopra,O., Jalanko,A. and Peltonen,L.
  TITLE     Sialin expression in the CNS implicates extralysosomal function in
            neurons
  JOURNAL   Neurobiol Dis 15 (2), 251-261 (2004)
   PUBMED   15006695
REFERENCE   9  (bases 1 to 2715)
  AUTHORS   Verheijen,F.W., Verbeek,E., Aula,N., Beerens,C.E., Havelaar,A.C.,
            Joosse,M., Peltonen,L., Aula,P., Galjaard,H., van der Spek,P.J. and
            Mancini,G.M.
  TITLE     A new gene, encoding an anion transporter, is mutated in sialic
            acid storage diseases
  JOURNAL   Nat Genet 23 (4), 462-465 (1999)
   PUBMED   10581036
REFERENCE   10 (bases 1 to 2715)
  AUTHORS   Renlund,M., Tietze,F. and Gahl,W.A.
  TITLE     Defective sialic acid egress from isolated fibroblast lysosomes of
            patients with Salla disease
  JOURNAL   Science 232 (4751), 759-762 (1986)
   PUBMED   3961501
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097482.1.
            
            On Jun 19, 2005 this sequence version replaced NM_001009713.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097482.1, AY800277.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2715
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..2715
                     /gene="Slc17a5"
                     /gene_synonym="AST; VEAT"
                     /note="solute carrier family 17 member 5"
                     /db_xref="GeneID:363103"
                     /db_xref="RGD:1311388"
     exon            1..139
                     /gene="Slc17a5"
                     /gene_synonym="AST; VEAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1533
                     /gene="Slc17a5"
                     /gene_synonym="AST; VEAT"
                     /note="proton-coupled sialic acid transporter; solute
                     carrier family 17 (anion/sugar transporter), member 5;
                     H(+)/nitrate cotransporter; H(+)/sialic acid
                     cotransporter; vesicular excitatory amino acid
                     transporter; solute carrier family 17 (acidic sugar
                     transporter), member 5"
                     /codon_start=1
                     /product="sialin"
                     /protein_id="NP_001009713.1"
                     /db_xref="GeneID:363103"
                     /db_xref="RGD:1311388"
                     /translation="MRPLLRGPAGNDDEESSDSTPLLPSARQIEAAPACCSARYNLAL
                     LAFCGFFVLYALRVNLSVALVDMVDSNSTLTDNRTSKECAEHSAPVKVHHNHTGKKYQ
                     WDAETQGWILGSFFYGYIVTQIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAADLG
                     VVALIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSG
                     IICYYMNWTYVFYLFGLVGIVWFILWMWIVSDTPETHKTISHYEKEYIVSSLKNQLSS
                     QKVVPWVSILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSALP
                     YFGCWLCMIVCGQAADYLRVKWNFSTISVRRIFSLIGMVGPAVFLVAAGFIGCDYSLA
                     VAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMIGPIIAKSLTPD
                     NTIKEWQTVFCIAAAINVFGAIFFTLFAKGEVQNWALSDHHGHGN"
     exon            140..336
                     /gene="Slc17a5"
                     /gene_synonym="AST; VEAT"
                     /inference="alignment:Splign:2.1.0"
     exon            337..570
                     /gene="Slc17a5"
                     /gene_synonym="AST; VEAT"
                     /inference="alignment:Splign:2.1.0"
     exon            571..658
                     /gene="Slc17a5"
                     /gene_synonym="AST; VEAT"
                     /inference="alignment:Splign:2.1.0"
     exon            659..745
                     /gene="Slc17a5"
                     /gene_synonym="AST; VEAT"
                     /inference="alignment:Splign:2.1.0"
     exon            746..864
                     /gene="Slc17a5"
                     /gene_synonym="AST; VEAT"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1023
                     /gene="Slc17a5"
                     /gene_synonym="AST; VEAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1156
                     /gene="Slc17a5"
                     /gene_synonym="AST; VEAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1304
                     /gene="Slc17a5"
                     /gene_synonym="AST; VEAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1395
                     /gene="Slc17a5"
                     /gene_synonym="AST; VEAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..2707
                     /gene="Slc17a5"
                     /gene_synonym="AST; VEAT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgtcagcca agcaacgata gtggcacatc tgctctccag gcgtcatgag gcccctgctt
       61 cggggtccgg cgggaaacga tgatgaggaa agctcggaca gcaccccgct cctgcctagc
      121 gcccggcaga tcgaagcggc tccagcatgc tgctctgctc ggtacaattt agcactgttg
      181 gcgttctgtg gtttcttcgt tctctatgct ttacgggtga acctgagtgt ggcgctagtg
      241 gacatggtag attccaacag cactctgact gataacagaa cttccaagga gtgtgcggaa
      301 cactctgccc ccgtaaaagt ccaccacaac cacacaggta aaaagtacca gtgggatgca
      361 gaaactcaag ggtggattct cggctccttt ttttacggct acatcgtcac acagatcccc
      421 ggggggtaca tggccagcag aatcggaggg aagctgctgc tgggcctggg catcttaggc
      481 accgccgtgt tcaccctgtt cacacccctg gccgctgacc tgggagtggt ggcgcttatc
      541 gtgctgagag cactggaagg actcggggag ggtgtcacgt ttccggctat gcatgccatg
      601 tggtcctcct gggctccccc tctggaaaga agcaagcttc tcaccatttc ttatgcagga
      661 gcacagcttg ggacagtaat ctcacttcct ctttccggaa taatttgcta ctatatgaat
      721 tggacttatg tcttctacct ttttggttta gttggaattg tctggtttat tttatggatg
      781 tggatagtca gtgatacacc agaaactcac aagacaatct cccactatga aaaggaatac
      841 attgtttcat cattaaaaaa tcagctttct tcacagaagg tagtgccatg ggtatccatc
      901 ttgaagtcac tgccactttg ggcaattgta gtagcacatt tttcctacaa ctggaccttt
      961 tacactctac tgacgttgtt gcctacatat atgaaagaaa tcctaaggtt caatgttcaa
     1021 gagaacgggt ttttatctgc attgccctat tttggctgtt ggttatgcat gattgtctgt
     1081 ggtcaagccg ctgattattt aagagtcaag tggaattttt caaccataag cgttcggaga
     1141 attttttccc tcataggaat ggttggccct gcagttttcc tagtcgcggc tggatttata
     1201 ggctgtgact attctttggc tgttgcattc ctaaccatat ccacgacgct gggaggcttc
     1261 gcctcttctg gatttagcat caaccatctg gatatcgccc cttcgtatgc cggcatcctc
     1321 ctgggcatca caaacacgtt tgccaccatt cccggaatga ttgggcccat cattgctaaa
     1381 agtctgaccc ctgataacac tattaaggaa tggcagactg tcttctgtat cgctgctgct
     1441 attaacgtgt tcggcgccat tttcttcaca ctgtttgcca aaggagaggt gcagaactgg
     1501 gctctcagtg accaccacgg acacggaaac tgaagacgac aataattaat atatttttat
     1561 ttatcatgga aactgaaagt gcctttgatt gcataataag cattctatgt gaggaaaaaa
     1621 tagtacttat atttgtaagg taatcatgaa atgttactgg ttccaagatc atttaaaatg
     1681 agctggtttt aattatcact aatatatctg ccagacctta cacttgggtt cacacaccag
     1741 gctgcaagta aggcagcata ataaaaaggt aagggcgtag gaaatgaagc tgaagtggaa
     1801 cacacacaca cacacacaca cacacacaca cacacttgtt taattaaatt agataaatcg
     1861 tctcagctct tgctaaatac ctgtttttgt ctacctccct tataaaaaat ggttgccaac
     1921 tctccctaac acatagatct caataacatc tccgtaaagc tgccagccac agtaagagtt
     1981 ggcctggtac ccgcactgaa ggccccgtgc ccaggcagct gccaagcacc ccctccctga
     2041 ccgcagggct ggaatgccca gcactcatgg ggtggcttcc aagtgcaggg ccagtgacag
     2101 catttggctg acactcttcc cccgtggctg ttaaagtgta gataaagccc taagtggact
     2161 ggagcggtgg gatccccagc tactgtcttg acactgccag ccagccttgg cagcacccag
     2221 gcctgctact ggaaggtgat ctacaaagca gaatcgtgat acccagtcaa tcacagagaa
     2281 catcctcgat aaaatgactg ctatgtgagt cagaataaat gttcacatgc aggtttttct
     2341 ggctacgtta gaacttattt aaatgtcttt ccctcagtct gtcttgattt atgcttctgg
     2401 tcacagttta aagtgacttt cagggccagg ggtttggctc agtggtagaa cacttacata
     2461 ggactgtggt ctgtccaaca gcaaaatgga ggtaaatgac tgggcaccca aagctggtaa
     2521 atcatgcagc ttcctctgac cagagtttcc tggttgttag gcatactgta agaggtccct
     2581 ggtctgtgtg gtggctcatg cctttaatcc cagaacttgg gaggcagggg caacttcaag
     2641 accagtctgg tctataaagg gagttccagg actgcccgag ctgttactca aaaaaaaaaa
     2701 aaaaaaaaaa aaaaa
//
