LOCUS       NM_133554               1848 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 17 member 1 (Slc17a1),
            mRNA.
ACCESSION   NM_133554
VERSION     NM_133554.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1848)
  AUTHORS   Sakiyama,M., Matsuo,H., Nagamori,S., Ling,W., Kawamura,Y.,
            Nakayama,A., Higashino,T., Chiba,T., Ichida,K., Kanai,Y. and
            Shinomiya,N.
  TITLE     Expression of a human NPT1/SLC17A1 missense variant which increases
            urate export
  JOURNAL   Nucleosides Nucleotides Nucleic Acids 35 (10-12), 536-542 (2016)
   PUBMED   27906618
REFERENCE   2  (bases 1 to 1848)
  AUTHORS   Kolz,M., Johnson,T., Sanna,S., Teumer,A., Vitart,V., Perola,M.,
            Mangino,M., Albrecht,E., Wallace,C., Farrall,M., Johansson,A.,
            Nyholt,D.R., Aulchenko,Y., Beckmann,J.S., Bergmann,S., Bochud,M.,
            Brown,M., Campbell,H., Connell,J., Dominiczak,A., Homuth,G.,
            Lamina,C., McCarthy,M.I., Meitinger,T., Mooser,V., Munroe,P.,
            Nauck,M., Peden,J., Prokisch,H., Salo,P., Salomaa,V., Samani,N.J.,
            Schlessinger,D., Uda,M., Volker,U., Waeber,G., Waterworth,D.,
            Wang-Sattler,R., Wright,A.F., Adamski,J., Whitfield,J.B.,
            Gyllensten,U., Wilson,J.F., Rudan,I., Pramstaller,P., Watkins,H.,
            Doering,A., Wichmann,H.E., Spector,T.D., Peltonen,L., Volzke,H.,
            Nagaraja,R., Vollenweider,P., Caulfield,M., Illig,T. and Gieger,C.
  CONSRTM   EUROSPAN Consortium; ENGAGE Consortium; PROCARDIS Consortium; KORA
            Study; WTCCC
  TITLE     Meta-analysis of 28,141 individuals identifies common variants
            within five new loci that influence uric acid concentrations
  JOURNAL   PLoS Genet 5 (6), e1000504 (2009)
   PUBMED   19503597
REFERENCE   3  (bases 1 to 1848)
  AUTHORS   Hinojos,C.A., Boerwinkle,E., Fornage,M. and Doris,P.A.
  TITLE     Combined genealogical, mapping, and expression approaches to
            identify spontaneously hypertensive rat hypertension candidate
            genes
  JOURNAL   Hypertension 45 (4), 698-704 (2005)
   PUBMED   15710778
REFERENCE   4  (bases 1 to 1848)
  AUTHORS   Alvarez,F.J., Villalba,R.M., Zerda,R. and Schneider,S.P.
  TITLE     Vesicular glutamate transporters in the spinal cord, with special
            reference to sensory primary afferent synapses
  JOURNAL   J Comp Neurol 472 (3), 257-280 (2004)
   PUBMED   15065123
  REMARK    GeneRIF: VGLUT1 localization (most abundant in LIII/LIV and medial
            LV of sponal cord) is consistent with an origin from cutaneous and
            muscle mechanoreceptors and disappeared after rhizotomy.
REFERENCE   5  (bases 1 to 1848)
  AUTHORS   Landry,M., Bouali-Benazzouz,R., El Mestikawy,S., Ravassard,P. and
            Nagy,F.
  TITLE     Expression of vesicular glutamate transporters in rat lumbar spinal
            cord, with a note on dorsal root ganglia
  JOURNAL   J Comp Neurol 468 (3), 380-394 (2004)
   PUBMED   14681932
  REMARK    GeneRIF: VGLUT1 and VGLUT2 transcripts are colocalized in most
            sensory neurons of the dorsal root ganglia, as well as in motor
            neurons of the ventral horn.
REFERENCE   6  (bases 1 to 1848)
  AUTHORS   Li,J.L., Xiong,K.H., Dong,Y.L., Fujiyama,F., Kaneko,T. and
            Mizuno,N.
  TITLE     Vesicular glutamate transporters, VGluT1 and VGluT2, in the
            trigeminal ganglion neurons of the rat, with special reference to
            coexpression
  JOURNAL   J Comp Neurol 463 (2), 212-220 (2003)
   PUBMED   12815758
  REMARK    GeneRIF: More than 80% of trigeminal ganglion neurons express
            vesicular glutamate transporter (VGluT)1 and VGluT2. VGluT1 is
            coexpressed with VGluT2 in the cell bodies and axon terminals in
            most trigeminal ganglion neurons.
REFERENCE   7  (bases 1 to 1848)
  AUTHORS   Li,J.L., Fujiyama,F., Kaneko,T. and Mizuno,N.
  TITLE     Expression of vesicular glutamate transporters, VGluT1 and VGluT2,
            in axon terminals of nociceptive primary afferent fibers in the
            superficial layers of the medullary and spinal dorsal horns of the
            rat
  JOURNAL   J Comp Neurol 457 (3), 236-249 (2003)
   PUBMED   12541308
  REMARK    GeneRIF: Both VGluT1 and VGluT2 were expressed in axon terminals of
            primary afferent fibers, including SP-containing nociceptive fibers
            and that VGluT in unmyelinated primary afferent fibers terminating
            in lamina II was primarily VGluT2.
REFERENCE   8  (bases 1 to 1848)
  AUTHORS   Minelli,A., Edwards,R.H., Manzoni,T. and Conti,F.
  TITLE     Postnatal development of the glutamate vesicular transporter VGLUT1
            in rat cerebral cortex
  JOURNAL   Brain Res Dev Brain Res 140 (2), 309-314 (2003)
   PUBMED   12586437
  REMARK    GeneRIF: VGLUT is localized to puncta coexpressing synaptophysin.
            Faint at birth, increases in subplate during first postnatal week,
            invades supragranular layers in second week and reaches adult
            pattern at P20-P30.
REFERENCE   9  (bases 1 to 1848)
  AUTHORS   Hioki,H., Fujiyama,F., Taki,K., Tomioka,R., Furuta,T., Tamamaki,N.
            and Kaneko,T.
  TITLE     Differential distribution of vesicular glutamate transporters in
            the rat cerebellar cortex
  JOURNAL   Neuroscience 117 (1), 1-6 (2003)
   PUBMED   12605886
  REMARK    GeneRIF: In the cerebellar granular layer, vesicular glutamate
            transporter 1 (Slc17a1) immunoreactivity is found in mossy fiber
            terminals and in single-axon terminals and in most brainstem
            precerebellar nuclei sending mossy fibers.
REFERENCE   10 (bases 1 to 1848)
  AUTHORS   Li,H. and Xie,Z.
  TITLE     Molecular cloning of two rat Na+/Pi cotransporters: evidence for
            differential tissue expression of transcripts
  JOURNAL   Cell Mol Biol Res 41 (5), 451-460 (1995)
   PUBMED   8867793
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078748.1.
            
            On Aug 8, 2004 this sequence version replaced NM_133554.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078748.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1848
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p11"
     gene            1..1848
                     /gene="Slc17a1"
                     /gene_synonym="Napi-1"
                     /note="solute carrier family 17 member 1"
                     /db_xref="GeneID:171080"
                     /db_xref="RGD:620099"
     exon            1..103
                     /gene="Slc17a1"
                     /gene_synonym="Napi-1"
                     /inference="alignment:Splign:2.1.0"
     exon            104..172
                     /gene="Slc17a1"
                     /gene_synonym="Napi-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1542
                     /gene="Slc17a1"
                     /gene_synonym="Napi-1"
                     /note="solute carrier family 17 vesicular glutamate
                     transporter), member 1; sodium/phosphate cotransporter 1;
                     renal sodium-phosphate transport protein 1; renal
                     Na(+)-dependent phosphate cotransporter 1; solute carrier
                     family 17 (sodium phosphate), member 1; renal
                     sodium-dependent phosphate transport protein 1; Na(+)/PI
                     cotransporter 1; solute carrier family 17 (organic anion
                     transporter), member 1"
                     /codon_start=1
                     /product="sodium-dependent phosphate transport protein 1"
                     /protein_id="NP_598238.2"
                     /db_xref="GeneID:171080"
                     /db_xref="RGD:620099"
                     /translation="MENRCLPKKVPGFCSFRYGLAILLHFCNIVIMAQRVCLNLTMVA
                     MVNKTEPPHLSNKSVAEMLDNVKNPVHSWSLDIQGLILSSVFLGMVVIQVPVGYLSGA
                     YPMKKIIGSSLFLSSVLSLLIPPAAQVGAALVIVCRVLQGIAQGAVSTGQHGIWVKWA
                     PPLERGRLTSMTLSGFVMGPFIALLVSGFICDLLGWPMVFYIFGIVGCVLSLFWFILF
                     FDDPNNHPYMSSSEKDYITSSLMQQVHSGRQSLPIKAMLKSLPLWAIILNSFAFIWSN
                     NLLVTYTPTFISTTLHVNVRENGLLSSLPYLLAYICGIVAGQMSDFLLSRKIFSVVAV
                     RKLFTTLGIFCPVIFVVCLLYLSYNFYSTVIFLTLANSTLSFSFCGQLINALDIAPRY
                     YGFLKAVTALIGIFGGLISSTLAGLILNQDPEYAWHKNFFLMAGINVTCLAFYLLFAK
                     GDIQDWAKETKTTRL"
     exon            173..345
                     /gene="Slc17a1"
                     /gene_synonym="Napi-1"
                     /inference="alignment:Splign:2.1.0"
     exon            346..579
                     /gene="Slc17a1"
                     /gene_synonym="Napi-1"
                     /inference="alignment:Splign:2.1.0"
     exon            580..667
                     /gene="Slc17a1"
                     /gene_synonym="Napi-1"
                     /inference="alignment:Splign:2.1.0"
     exon            668..754
                     /gene="Slc17a1"
                     /gene_synonym="Napi-1"
                     /inference="alignment:Splign:2.1.0"
     exon            755..873
                     /gene="Slc17a1"
                     /gene_synonym="Napi-1"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1035
                     /gene="Slc17a1"
                     /gene_synonym="Napi-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1168
                     /gene="Slc17a1"
                     /gene_synonym="Napi-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1316
                     /gene="Slc17a1"
                     /gene_synonym="Napi-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1407
                     /gene="Slc17a1"
                     /gene_synonym="Napi-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1544
                     /gene="Slc17a1"
                     /gene_synonym="Napi-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1827
                     /gene="Slc17a1"
                     /gene_synonym="Napi-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcccggag ctgaaccagg agaagccaca ggacatgtca cggctttgag aggcaggccc
       61 taagaaaagg tgcagctttc tgagcacatc aaatgtcaaa gagtggatgg agaccaagtc
      121 catcaattag aagataagtc tcaaatggag aaccggtgcc tccccaagaa agttccaggt
      181 ttctgttcct ttcggtatgg actggctatc cttttgcact tctgtaacat tgtcatcatg
      241 gctcagcgag tgtgcctgaa cctcacaatg gtagccatgg tgaataaaac agagccaccc
      301 catttatcta acaagtctgt agcagagatg ctggataatg taaagaaccc tgtgcattcc
      361 tggagtcttg atattcaagg gcttattctc agttctgtct tcttgggtat ggttgtgatt
      421 caagttcctg ttgggtacct atctggagca tacccaatga agaaaataat tgggtcttca
      481 ttgttcctca gctctgtgct gtccctgctc atcccaccag ctgcacaagt cggagcagct
      541 ttggtcattg tatgccgagt actccaagga atagcccagg gagcagtgtc aacaggccag
      601 catggaatat gggtcaaatg ggcacctccc ttggaacgag gcagacttac ctctatgact
      661 ctatcagggt ttgtaatggg accatttatt gccctgcttg tgagtggctt catctgtgat
      721 cttctgggtt ggcccatggt tttctacatc tttggtattg ttgggtgtgt tctgagtctt
      781 ttctggttca tccttttctt tgatgacccc aacaaccacc catatatgag cagcagtgag
      841 aaggattaca tcacatcctc tctcatgcaa caggtgcact cgggcagaca atctctgcca
      901 atcaaagcta tgcttaagtc tcttccactc tgggccatta tcctcaatag ctttgctttc
      961 atatggtcga acaatcttct ggttacatac acgccaacat ttattagcac cacgcttcat
     1021 gttaatgtta gagagaatgg gctgctgtcc agcctcccct atctgcttgc ctacatctgt
     1081 ggtatcgtag caggtcagat gtcagacttc ctcctgtcaa ggaagatttt cagcgtagtt
     1141 gctgtccgga aactcttcac cacactaggg attttctgtc ctgtgatttt tgtcgtgtgc
     1201 ctgctctacc tgagctacaa cttctacagc accgtcattt tccttacact tgccaactcg
     1261 acacttagct tttccttctg tggacaactt atcaatgcct tggatattgc tcccagatat
     1321 tatggatttc taaaggcagt cacagcttta attggaatat ttgggggcct aatttcttca
     1381 actcttgctg ggttgatcct taatcaggat ccagaatatg cttggcataa aaacttcttc
     1441 ttgatggcag gcattaacgt gacatgcctg gctttctacc ttctgtttgc aaaaggagat
     1501 attcaggact gggctaaaga aacaaaaacc acacggctgt gaagttagta gaagagtgag
     1561 cacctgagaa gcatgaggtc agcatccata ttgaaaggaa gaggattctg tgtgggactg
     1621 cagtcatggg agtcatgaac acctgaagac cggtagcctg aagcttttaa gggagtcatt
     1681 gcctcccact ttagtctgag tgattctttt gcactgtgta ttgtgtgtaa caagttatac
     1741 ttctgacttt aaagaggaat ctgtctgtct tcctatgatc caataaacaa acataagcca
     1801 aaactttact ccactacttt atgaaaaaaa aaaaaaaaaa aaaaaaaa
//
