LOCUS       NM_017302               2178 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus solute carrier family 16 member 7 (Slc16a7),
            mRNA.
ACCESSION   NM_017302 XM_346793
VERSION     NM_017302.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2178)
  AUTHORS   Chen,K., Cheng,P., Wang,H., Gao,S., Li,X., Deng,Z., Liu,J. and
            Sun,X.
  TITLE     Lactate transport facilitates neurite outgrowth
  JOURNAL   Biosci Rep 38 (5) (2018)
   PUBMED   30143583
  REMARK    GeneRIF: Monocarboxylate transporter-2-knockout, which blocked the
            lactate shuttle in neurons, showed a remarkable decrease in the
            length of axons and dendrites. We further demonstrated that Akt
            activity was decreased while glycogen synthase kinase 3beta
            (GSK3beta) activity was increased after astrocytic glycogen
            phosphorylase blockade. Additionally, GSK3betaSer9 mutation
            reversed neurite growth failure caused by DAB and isofag...
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2178)
  AUTHORS   Mazuel,L., Blanc,J., Repond,C., Bouchaud,V., Raffard,G., Deglon,N.,
            Bonvento,G., Pellerin,L. and Bouzier-Sore,A.K.
  TITLE     A neuronal MCT2 knockdown in the rat somatosensory cortex reduces
            both the NMR lactate signal and the BOLD response during whisker
            stimulation
  JOURNAL   PLoS One 12 (4), e0174990 (2017)
   PUBMED   28388627
  REMARK    GeneRIF: data not only demonstrate that glucose-derived lactate is
            locally produced following neuronal activation but also suggest
            that its use by neurons via MCT2 is probably essential to maintain
            synaptic activity within the barrel cortex
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2178)
  AUTHORS   Nancolas,B., Guo,L., Zhou,R., Nath,K., Nelson,D.S., Leeper,D.B.,
            Blair,I.A., Glickson,J.D. and Halestrap,A.P.
  TITLE     The anti-tumour agent lonidamine is a potent inhibitor of the
            mitochondrial pyruvate carrier and plasma membrane monocarboxylate
            transporters
  JOURNAL   Biochem J 473 (7), 929-936 (2016)
   PUBMED   26831515
  REMARK    GeneRIF: MPC inhibition is the most sensitive anti-tumour target
            for LND, with additional inhibitory effects on MCT-mediated
            L-lactic acid efflux and glutamine/glutamate oxidation.
REFERENCE   4  (bases 1 to 2178)
  AUTHORS   Gao,C., Zhou,L., Zhu,W., Wang,H., Wang,R., He,Y. and Li,Z.
  TITLE     Monocarboxylate transporter-dependent mechanism confers resistance
            to oxygen- and glucose-deprivation injury in astrocyte-neuron
            co-cultures
  JOURNAL   Neurosci Lett 594, 99-104 (2015)
   PUBMED   25827488
  REMARK    GeneRIF: resistance to oxygen- and glucose-deprivation injury in
            astrocyte-neuron co-cultures occurs via an MCT-dependent mechanism.
REFERENCE   5  (bases 1 to 2178)
  AUTHORS   Takimoto,M. and Hamada,T.
  TITLE     Acute exercise increases brain region-specific expression of MCT1,
            MCT2, MCT4, GLUT1, and COX IV proteins
  JOURNAL   J Appl Physiol (1985) 116 (9), 1238-1250 (2014)
   PUBMED   24610532
  REMARK    GeneRIF: MCT2 increased in the hippocampus immediately after
            exercise and in the cortex and hypothalamus 5-24 h postexercise.
REFERENCE   6  (bases 1 to 2178)
  AUTHORS   Baud,O., Fayol,L., Gressens,P., Pellerin,L., Magistretti,P.,
            Evrard,P. and Verney,C.
  TITLE     Perinatal and early postnatal changes in the expression of
            monocarboxylate transporters MCT1 and MCT2 in the rat forebrain
  JOURNAL   J Comp Neurol 465 (3), 445-454 (2003)
   PUBMED   12966567
  REMARK    GeneRIF: Monocarboxylate transporter Slc16a7/MCT2-like
            immunoreactivity is expressed along the medial and ventral border
            of the ventricle in the medial septum and habenula before birth.
REFERENCE   7  (bases 1 to 2178)
  AUTHORS   Broer,S., Broer,A., Schneider,H.P., Stegen,C., Halestrap,A.P. and
            Deitmer,J.W.
  TITLE     Characterization of the high-affinity monocarboxylate transporter
            MCT2 in Xenopus laevis oocytes
  JOURNAL   Biochem J 341 (Pt 3) (Pt 3), 529-535 (1999)
   PUBMED   10417314
REFERENCE   8  (bases 1 to 2178)
  AUTHORS   Lin,R.Y., Vera,J.C., Chaganti,R.S. and Golde,D.W.
  TITLE     Human monocarboxylate transporter 2 (MCT2) is a high affinity
            pyruvate transporter
  JOURNAL   J Biol Chem 273 (44), 28959-28965 (1998)
   PUBMED   9786900
REFERENCE   9  (bases 1 to 2178)
  AUTHORS   Gerhart,D.Z., Enerson,B.E., Zhdankina,O.Y., Leino,R.L. and
            Drewes,L.R.
  TITLE     Expression of the monocarboxylate transporter MCT2 by rat brain
            glia
  JOURNAL   Glia 22 (3), 272-281 (1998)
   PUBMED   9482213
REFERENCE   10 (bases 1 to 2178)
  AUTHORS   Jackson,V.N., Price,N.T., Carpenter,L. and Halestrap,A.P.
  TITLE     Cloning of the monocarboxylate transporter isoform MCT2 from rat
            testis provides evidence that expression in tissues is
            species-specific and may involve post-transcriptional regulation
  JOURNAL   Biochem J 324 (Pt 2) (Pt 2), 447-453 (1997)
   PUBMED   9182702
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081701.1.
            
            On Jun 10, 2007 this sequence version replaced NM_017302.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081701.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2178
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..2178
                     /gene="Slc16a7"
                     /gene_synonym="Mct2"
                     /note="solute carrier family 16 member 7"
                     /db_xref="GeneID:29735"
                     /db_xref="RGD:3691"
     exon            1..38
                     /gene="Slc16a7"
                     /gene_synonym="Mct2"
                     /inference="alignment:Splign:2.1.0"
     exon            39..303
                     /gene="Slc16a7"
                     /gene_synonym="Mct2"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1538
                     /gene="Slc16a7"
                     /gene_synonym="Mct2"
                     /note="MCT 2; solute carrier family 16 (monocarboxylic
                     acid transporters), member 7; solute carrier family 16,
                     member 7 (monocarboxylic acid transporter 2); solute
                     carrier family 16 (monocarboxylate transporter), member 7"
                     /codon_start=1
                     /product="monocarboxylate transporter 2"
                     /protein_id="NP_058998.2"
                     /db_xref="GeneID:29735"
                     /db_xref="RGD:3691"
                     /translation="MPSESSVKATAAPPPFPLPPDGGWGWVVVCASFISIGFSYAFPK
                     AVTVFFNDIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLC
                     CTGMILASFSSSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRKRPLANGFAMAGS
                     PVFLSTLAPFNQFLFNSYGWKGSFLILGAIFLHSCVAGCLMRPVGPSPRAAKSKSKVG
                     SRQDSSTKRLSKVSTAEKINRFLDFGLFTHRGFLIYLSGNVVLFLGMFAPIIFLAPYA
                     KDKGVDDYNSAFLLSVMAFTDMFARPSVGLIANTSLIRPRIQYLFSVAIMFTGICHLL
                     CPLAHSYTALVVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVECCPVLF
                     GPPLAGKLLDITGQYKYLYIASGIVVLSSGIYLLICNAINYRLLEKERKREKARRKKS
                     ASQASKEMEALSRSKQDDVTVKVSNTHNPPSDRDKESSI"
     exon            304..447
                     /gene="Slc16a7"
                     /gene_synonym="Mct2"
                     /inference="alignment:Splign:2.1.0"
     exon            448..1260
                     /gene="Slc16a7"
                     /gene_synonym="Mct2"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..2156
                     /gene="Slc16a7"
                     /gene_synonym="Mct2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caacaagtgg ctaatgcggc ttttctctcg ctctccaggt tgttttcgtc tccagtagaa
       61 gctcagaaat gccatcagag tcttcagtaa aggcaacggc ggcgccgcct ccattcccac
      121 ttcctccgga cggagggtgg ggctgggttg tagtctgcgc atccttcatc tccattgggt
      181 tctcctatgc cttccccaaa gccgtcacgg tattcttcaa tgacatcaag gacattttca
      241 agaccacctc cagtcagatc gcgtggatat cctccattat gctggctgtc atgtacgcag
      301 gaggtcccat cagtagtgtg ttggtgaata actatggcag ccggcctgtg gtgatagtag
      361 gaggattact gtgctgtact ggaatgatct tggcttcttt cagcagcagt gtgatagaac
      421 tttacctcac cgtcggcttc attggaggtt taggattagc attcaacctg caaccagcct
      481 taacaataat cggaaaatac ttctatagga agcgacccct tgcaaatggc tttgccatgg
      541 ctggaagtcc tgttttctta agcacactgg ctcctttcaa tcagttccta tttaacagct
      601 atggctggaa ggggagtttt ttgattttgg gggccatatt tttgcactcc tgtgtggccg
      661 ggtgcctcat gagacctgtc gggccaagtc cacgtgctgc gaagtctaaa agtaaggttg
      721 gctcaagaca agattcaagt acgaagagac tcagtaaggt atcaacagca gaaaagatta
      781 atcggttttt agatttcggc ctttttacac atagaggatt tttgatctac ctgtctggaa
      841 atgtcgtgtt gtttttaggg atgtttgccc ctattatatt cttggctccg tatgctaagg
      901 acaaaggagt ggatgactat aattcagctt tcttgctgtc tgtgatggct tttaccgata
      961 tgtttgctcg gccttcggta ggattaatag ccaacactag cttaatccgt ccacgaatcc
     1021 agtacttgtt cagcgtggca atcatgttca ctggcatatg ccatctcctc tgccccctag
     1081 cccattccta cacagctttg gtggtctacg ttatattttt tggaatagga tttggaagta
     1141 ttagcagtct cctctttgaa tgtcttatgg accaggttgg agcctccagg ttctccagtg
     1201 ctgtggggct cgtcactatc gtggagtgtt gcccagttct tttcggccct cccctggctg
     1261 gtaaattgct cgatataact ggacaatata aatacctgta catagccagt gggatagtcg
     1321 tgttatcatc aggcatttac ctactgattt gcaatgctat aaactataga cttctcgaga
     1381 aggaaaggaa gagagagaaa gcaaggagga agaaatcagc ctcgcaggca tccaaagaaa
     1441 tggaggcttt gagcagatct aaacaggacg atgttactgt gaaagtttca aatacacaca
     1501 atcctccctc agacagggac aaagaaagta gtatttaaca agtctcatct ccgaatcagt
     1561 gttcagaaat ttaattatga gtttctttgt gtttttttca atgaattgca aaggatttta
     1621 gctgcaacaa aagatcgcaa acagtaacga aactggtatc ttcctcaatg acgaactaaa
     1681 aatcagtgct ttaatatttg ttaaagatgg ttaacttttg agattgtgca cataaaaaat
     1741 ccacacagct gcttatctgc acaccaaagc tgtgatgaaa atgaattttt ttaaatcttc
     1801 tgccaacttt tacttttagc tatagaatga gatctgcatc ccagaccccg gctgacctaa
     1861 gcacaattca acattaattc cacataacta ccctcttcaa ggttcatttt tcgtcggata
     1921 ctaagtcatg aagtgaattg aagacaatca ttctttctat tcaacacaca aagaattaca
     1981 catgtagcca cgcaaacact gagtaacggg atatcataaa gaaataaatg aatttgaaaa
     2041 aattattatc atagtcattt ttaagtcaaa ggaaataaga ctctggaaag tgggaatgta
     2101 atatatttgt gtgcagtcat ccagtgtgga ttaaaaataa cagtctatgt tgaaaaaaaa
     2161 aaaaaaaaaa aaaaaaaa
//
